A NEW ROBOT-BASED SETUP FOR EXPLORING THE STIFFNESS OF ANATOMICAL JOINT STRUCTURES. [Frey, Burgkart,

Size: px
Start display at page:

Download "A NEW ROBOT-BASED SETUP FOR EXPLORING THE STIFFNESS OF ANATOMICAL JOINT STRUCTURES. [Frey, Burgkart,"

Transcription

1 A NEW ROBO-BASED SEUP FOR EXPLORING HE SIFFNESS OF ANAOMICAL JOIN SRUCURES Martin Frey 1, Rainer Burgkart 2, Feli Regenfelder 2, and Robert Riener 1 1 Institute of Automati Control Engineering, ehnishe Universität Münhen, Germany 2 Clini for Orthopedis and Sport Orthopedis, ehnishe Universität Münhen, Germany [Frey, Burgkart, Riener]@vr-om INRODUCION One method for analyzing the biomehanis of human joints is to apply fores and torques to the joint and detet the resulting displaement From this ontet between load and displaement the elasti aspets of the knee joint an be estimated Many groups work on olleting suh data and many different setups eist for performing suh measurements Several authors tried to measure elasti aspets of human knee joints in vivo A setup to measure the laity of the ollateral ligaments not at adavers but at patients is used in [Moore] Varus and valgus torques were applied to the knee joint and the displaement was measured he problem when applying torques or measure displaement in vivo is the moving soft tissue between fiation of the measurement apparatus and the bones of the leg Eat measurements an hardly be perfor Furthermore, no measurements of both the intat and injured knee joint at a single patient are possible hus, most groups use human adaver knee joints for aquiring biomehanial data Markolf presented lots of measured biomehanial data from human adaver knee joints [Markolf] He built up several setups for measuring the elasti harateristis for various degrees of freedom he displaement was measured with eternal fied potentiometers, the fores with strain gauges mounted to the handle and the fiation of the adaver bones Woo in Pittsburgh, USA [Fujie, Woo] presented the idea of using an industrial robot ombined with a universal fore torque sensor for performing biomehanial measurements he idea was realized with a 6 DOF industrial robot In the meantime other working groups piked up this idea Neme [Neme] at the Jozef Stefan Institute Ljubljana, Slovenia is using a Riko 16 robot for testing kinematis of synovial joints Hurshler [Hurshler] of the Hanover Medial Shool, Germany is using a KUKA 16 robot for simulating arm fores while testing the shoulder joint he setup presented in this artile is using the high preision industrial robot Stäubli RX9-B, whih is well known as Ortho Marquet s Caspar Novel is the ustom made highly dynami losed loop ontrol hard- and software of the robot his enables to do fast measurements, so a lot of tests an be perfor with a single adaver A speifi hybrid ontrol arhiteture has been implemented for testing knee joints with various load onstellations Figure 1: Coordinate systems COORDINAE SYSEMS he oordinate systems (CS) used in this artile are shown in Figure 1 he referene is the world CS Σ he thigh CS Σ is fied at the middle of the ompromising rotation ais of the knee joint, whih is assu as the line between the femur ondyles When the leg is strethed (fleion angle ) the thigh ( Σ ) and the shank ( Σ S ) CS are mathed Leaned on ial terms the position of the shank relative to the thigh is ribed by three translations and three rotations as follows: First the shank is rotated around the ais by the angle ϕ (fleion-etension, fe) After that the shank is translated along the atual ais (ial-lateral) by the distane and y ais (anterior-posterior) by y Afterwards the leg is rotated around the atual y ais by the angle ψ (varus-valgus, VV) and around the atual z ais (internal-eternal) by ϑ At last the translation along the atual z ais (distal-proimal) is perfor by the distane z Note that the translations of the displaement ribed by the vetor ( y z ϕ ψ ϑ ) are not orthogonal As an (of ourse very theoretial) eample: a displaement of 5mm is the same than a displaement of z 5mm at a VV angle of ψ 9 Beause of this, the displaement ribed in ial oordinates is transfor to an orthogonal nial oordinate system ribed by

2 y z ϕ ψ ϑ + z sin( ψ y z os( ψ ) ϕ ψ ϑ ) y z ϕ ψ ϑ he position of the shank in nial oordinates is ribed by a rotation around the ais After that all translations, y and z are perfor At least the rotations ψ and ϑ around the atual ais eah time are perfor he sueeding rotations ribe Euler angles as introdued in [Siaviio] Synta Vetor ontaining transversal and rotatory displaements f Generalized fore vetor with 3 fores and 3 torques Medial lateral translation (ML) y Anterior posterior translation (AP) z Distal proimal translation (DP) ϕ Etension fleion rotation ( : strethed leg) (EF) ψ Varus valgus rotation (VV) ϑ Internal eternal rotation (IE) MEHODS he elasti aspets of a knee joint an be ribed by its stiffness that is the ontet between load and displaement: hange of fore or torque Stiffness hange of translatory or rotatory displaement s dfi( ) d i fi i ; i 16 o detet the stiffness of the knee joint s different degrees of freedom as they are ribed above, the hange of fores/torques as a funtion of the displaement has to be measured Setup he key element of the setup for detetion of the knee joint s stiffness is the high preision industrial robot Stäubli RX9- B It is apable to apply fores up to 1N and torques up to 1Nm he position auray is better than 1mm It is equipped with a pneumati safety devie (IPR GmbH) and a 6 DOF fore torque sensor (JR3 In) he bones of thigh and shank of the human adaver leg are sealed with epoy resin in tubes made of aluminum Additionally, there are three srews fiing the bones he tube with the thigh is mounted to a fied position at the fundament of the robot he shank is mounted to a plate that an be fied and dismantled within seonds to and from the fore torque sensor (Figure 2) he position of the adaver leg relative to the robot was hosen in that way that no singular onstellations of the robot ourred in the required work spae A robot singularity would redue the number of DOF of the robot s end effetor, so the robot annot move into all diretions in that onstellation [Siaviio] (1) Figure 2: Setup for measuring knee joint harateristis in 6 DOF Control hardware he original ontroller (Stäubli CS7-B) of the robot is not powerful enough he maimal possible sampling rate is 625 Hz for eah hannel his ontroller was used in the first setup for measuring knee joint harateristis he perfor measurements have been very slow and during the measurement of rather high stiffness osillations ourred In the seond setup, whih is presented in this work, the original ontroller was replaed by a Real ime Linu based one developed in our lab [Hoogen] It works on a Pentium IV with 19 MHz he interfae to the robot is realized with adequate PCI ards for the fore torque sensor, input of joint enoder values and voltage output ontrolling the urrent of the robot s joints his setup enables to inrease the sampling rate up to 4 khz for eah hannel Control strategy A hybrid losed loop fore torque position ontrol enables to drive eah DOF either position or fore ontrolled he simplified struture of the losed loop ontrol is shown in Figures 3 and 4 he input for eah hannel is either the ired fore/torque or the ired translational/rotational displaement depending on the hoie weather the DOF is fore/torque or position ontrolled he input is set in ial oordinates introdued above

3 veloities q& with the inverse Jaobian matri of the robot [Siaviio] q& and the robot joint onstellation q are the inputs of a robot joint subsidiary position veloity ontrol his lose loop ontrol is alulating the ired urrent for the robot joint motors he losed urrent ontrol loop is not displayed in figure 4 he atual robot joint onstellation q is a result of the dynamis of the robot and the atual urrents for the robot Figure 3: Simplified ontrol struture of the setup f C y 1 + z + ϕ y ψ ϑ ( E C) f f is the input vetor, z ϕ ψ ϑ f the ired position vetor, f the ired fore vetor, E is the identity matri and C the hoie matri By setting the i th diagonal element ii 1 position ontrol is hosen for the i th DOF, fore ontrol is hosen when ii he diagonal elements of the matri C are olleted in the vetor ( y z ϕ ψ ϑ ) (2) With equation (1) the input f is transfor to the orthogonal nial CS he result is error e is the ired input f he ontrol f minus the atual state f f is obtained by merging atual fores/torques and displaement as it is done with the input vetor: f C + ( E C) f he error e is the input of a p-ontroller that is adapted online by the atual fores and torques he output of the ontroller is a vetor of ired translatori and rotatori veloities & & is transfor to ired robot joint Figure 4: Control sheme for data aquisition VWL: forward kinematis of the robot onsidering the loation of the tool enter point FS: Fore torque sensor J: Jaobian Matri of the robot Figure 5: omparison of intat knee joint and knee joint

4 joint motors he robot ats to the human adaver leg and auses fores and torques that are measured with the fore torque sensor (FS) ransformation of the fores/torques to the nial oordinate system and ompensation of gravity fores and moments are not displayed in Figure 4 he atual displaement of the knee joint is alulated with the robot s kinematis (VWL) All the ribed steps are done 4 times per seond A user interfae has been developed for ontrolling the robot (Figure 6) With this menu-driven program it is possible to do all settings required for measuring knee joint harateristis his are the maimum fore/torque and the maimum and minimum displaements for eah DOF, the resolution to be measured, hoose of ontrol mode (position or fore/torque ontrolled), initialization data and other parameters Furthermore, it is possible to plot the measured data imiately after measurements have been perfor Initialization Before the start of measurements some initialization routines have to be driven he tool enter point of the robot has to be set to the middle of the ompromising rotation ais of the knee joint he tool enter point is the point where fores/torques are measured It influenes the VWL of the robot and the transformation /W (Figure 4) as well he line between the femoral epiondylar uberula is hosen as the ompromising rotation ais Until now the loation of this ais is done by manual measurements But an advaned initialization routine will be implemented using C data and a robot based loation of the bones soon Furthermore, estimation of the lower leg mass and the enter of mass is done for the use with the gravity ompensation routine inreasing the fleion angle position ontrolled from to 12 while all other DOF were zero fore ontrolled: ( 1 ), f ( ( 12 /1 ) ) Varus-valgus stiffness: For measuring VV stiffness all translatory DOF (PD, ML, AP) have been zero fore ontrolled he reorded information about the neutral position ϑ ( ϕ) of the IE rotation as a funtion of the fleion angle is used as an input for the position ontrolled IE rotation DOF he fleion angle is position ontrolled to a fi angle while VV torque varies between -1 and 1 Nm: ( 1 1), f ( ( 12 / 2 ) ( 11/1Nm) ϑ ( )) ϕ he knee joint is loaded alternately several times with the maimum and the minimum VV torque to avoid measuring fleion dependent hysteresis effets hen the fore is inreased and dereased up to ± 1Nm in steps of 2 Nm After that the fleion angle inreases to the net onstellation to be measured (Figure 7) his proedure was also done with the same adaver but ruptured ial ligament and both ruptured ial and lateral ligament As a result hysteresis urves like that ones in Figure 5 are obtained he single urves are shifted by a VV angle, so they are displayed one by eah other Proessing Zero internal-eternal rotation: At first zero internal eternal (IE) rotation ϑ ( ϕ) as a funtion of the fleion angle [Wilson] has been deteted his was done by Figure 6: user interfae for the setup

5 Figure 8: Hyperetesion as funtion of the fleion angle Figure 7: Varus-valgus load and fleion angle while measuring Fleion-etension stiffness: Measurements of hyperetension have been perfor with the same adaver knee joint herefore all DOF have been fore ontrolled he hyperetension fore has been inreased up to 8/1Nm in steps by 2 Nm while all other have been zero fore/torque ontrolled, f ( ( 1/ 2Nm) ) Figure 8 displays the reorded data for the intat knee, the knee joint with ruptured ial ligament and the knee joint with ruptured ial and lateral ligament Auray he auray of the setup was determined by fiing the mounting attahed to the fore torque sensor diret to an aluminium tube as it is used for fiing the thigh Fores and torques have been applied to the tube and displaement was measured he resulting transversal stiffness is at least 44kN/m up to 188kN/m depending on the robot s onstellation his stiffness orresponds to a displaement of 22mm and 5mm at a load of 1N he rotatory stiffness is between 22 Nm/ for fleion DOF and 4 Nm/ for IE rotation of the knee joint At the maimum load of 1 Nm this stiffness orresponds to a displaement of 45 and 25, respetively RESULS AND DISCUSSION he eperimental setup works very satisfatory and a lot of data ould be olleted from a single adaver All the measurements shown in able 1 have been perfor in less than one and a half hours time of work with the robot Beause of the high stiffness of the setup the measured positions are rather aurate he repetition auray is also very satisfying as there is only a slight differene between two sequened measurements Of ourse, there are some soures of errors that have to be onsidered For eample the manually done initialization routine is error-prone but when done arefully it works Furthermore, the preession is limited by the resolution of the fore sensor and the nonlinear stiffness harateristis of the robot With the implemented adaptive hybrid fore torque position ontrol it is possible to ontrol eah DOF either position or fore ontrolled Furthermore, any ombination of loads in different DOF is possible eg the detetion of VV stiffness as a funtion of the IE rotation torque and the fleion angle he data shown in Figure 8 indiate no ontribution of the ial or lateral ligament to hyperetension stiffness All reorded urves are nearly idential Valgus Varus stiffness (Nm/ ) Valgus Varus load (Nm) -5 fleion ( ) Intat Joint Detahed ial ligament Detahed ial and lateral ligament Figure 9: Valgus stiffness with various loads Figure 5 displays the varus-valgus torque as funtions of the varus-valgus angle of the intat and insured knee joint he urves for the different fleion angles are shifted to eah other with angle offsets he data indiate no ontribution of the ial ligament to varus harateristis for a varus load larger than 1 Nm 1 5 9

6 No Perfor measurements 1 Zero rotation as a funtion of fleion 2 Varus-valgus (VV) of the intat joint 3 VV with detahed ial ligament 4 VV with detahed and lat lig 5 Hyperetension 6 Hyp with detahed lig 7 Hyp with detahed and lat lig able 1: perfor measurements he varus stiffness has been alulated and is displayed in Figure 9 his was done with the data shown in Figure 5 Additional there is onsidered the stiffness with both ruptured ial and lateral ligament he stiffness urves for ruptured ial and that one for ruptured ial and lateral ligament are lose together for loads bigger than 1 Nm his indiates no ontribution of the lateral ligament to valgus stiffness for loads bigger than 1Nm OULOOK With the presented setup we obtained biomehanial data in 6 DOF with high data resolution In near future we are going to analyze ross oupling of more than two DOF, eg the stiffness of rotation as a funtion of VV load and fleion angle Furthermore, we are going to onsider other pathologies suh as ruptured anterior and posterior ruial ligament With an advaned method for initialization we will be able to obtain aurate data about the absolute position of thigh and shank he data obtained in this study will be used for the Munih Knee Joint Simulator [Riener], that requires a biomehanial model of the knee joint [Frey] REFERENCES Frey, M, et al (23) Varus valgus model of the knee identified by a robot based approah Pro ISB Congress 3 Fujie, H, et al (1993) J Bio Eng, 115, Fujie, H, et al (1995) J Bio Eng, 117, 1-7 Hoogen, J, et al (22) A roboti hapti interfae for kinaestheti knee joint simulation Pro Robotis in Alpe- Adria-Danube Region Hurshler, C et al (2) A nique for the measurement of musle moment arms during simulated ative elevation of the shoulder Pro 12 th Conf Europ So Biomeh, 163 Hurshler, C, et al (21) Am J Sports Med, 29(3), Moore,, et al (1976) J Bone & Joint Surg, 594 ff Neme, B, et al (2) he use of robotis nology for kinemati test of synovial joints in iine Pro 9 th International Workshop Riener, R, et al (23) IEEE rans Inform eh in Bio, submitted Siaviio, L, Siiliano, B (2) Modelling and Control of Robot Manipulators, London: Springer-Verlag Wilson, DR, et al (2): J Biomeh 33, Woo, SLY, et al (2) Pro Int Conf Bio Eng ACKNOWLEDGEMENS We thank Prof G Shmidt, J Hoogen, homas Pröll, Stefan Pelhak and Werner Mairegger for their support in this study his work was supported by German Ministry for Eduation and Researh within the projet network on Virtual Orthopedi Reality (VOR) (1IRA15)

PARKINSON S DISEASE: MODELING THE TREMOR AND OPTIMIZING THE TREATMENT. Keywords: Medical, Optimization, Modelling, Oscillation, Noise characteristics.

PARKINSON S DISEASE: MODELING THE TREMOR AND OPTIMIZING THE TREATMENT. Keywords: Medical, Optimization, Modelling, Oscillation, Noise characteristics. PARKINSON S DISEASE: MODELING THE TREMOR AND OPTIMIZING THE TREATMENT Mohammad Haeri, Yashar Sarbaz and Shahriar Gharibzadeh Advaned Control System Lab, Eletrial Engineering Department, Sharif University

More information

Utilizing Bio-Mechanical Characteristics For User-Independent Gesture Recognition

Utilizing Bio-Mechanical Characteristics For User-Independent Gesture Recognition Utilizing Bio-Mehanial Charateristis For User-Independent Gesture Reognition Farid Parvini, Cyrus Shahabi Computer Siene Department University of Southern California Los Angeles, California 90089-0781

More information

Every Flex is Quite Complex

Every Flex is Quite Complex Name Class Date Every Flex is Quite Complex Struture and Funtion in a Chiken Wing Investigative Lab 27 8 Question How do the tissues of a hiken wing work together during movement? Lab Overview In this

More information

Detection and Classification of Brain Tumor in MRI Images

Detection and Classification of Brain Tumor in MRI Images PrahiGadpayle and Prof.P.S.Mahajani 45 Detetion and Classifiation of Brain Tumor in MRI Images PrahiGadpayleand Prof.P.S.Mahajani Abstrat Brain tumor detetion in Magneti Resonane Imaging (MRI) is important

More information

Measurement of Dose Rate Dependence of Radiation Induced Damage to the Current Gain in Bipolar Transistors 1

Measurement of Dose Rate Dependence of Radiation Induced Damage to the Current Gain in Bipolar Transistors 1 Measurement of Dose Rate Dependene of Radiation Indued Damage to the Current Gain in Bipolar Transistors 1 D. Dorfan, T. Dubbs, A. A. Grillo, W. Rowe, H. F.-W. Sadrozinski, A. Seiden, E. Spener, S. Stromberg,

More information

Reading a Textbook Chapter

Reading a Textbook Chapter HENR.546x.APPBpp001-013 7/21/04 9:37 AM Page 1 APPENDIX B Reading a Textbook Chapter Copyright 2005 Pearson Eduation, In. 1 2 Read the following hapter from the ollege textbook Total Fitness: Exerise,

More information

Overview. On the computational aspects of sign language recognition. What is ASL recognition? What makes it hard? Christian Vogler

Overview. On the computational aspects of sign language recognition. What is ASL recognition? What makes it hard? Christian Vogler On the omputational aspets of sign language reognition Christian Vogler Overview Problem statement Basi probabilisti framework Reognition of multiple hannels Reognition features Disussion Gallaudet Researh

More information

describing DNA reassociation* (renaturation/nucleation inhibition/single strand ends)

describing DNA reassociation* (renaturation/nucleation inhibition/single strand ends) Pro. Nat. Aad. Si. USA Vol. 73, No. 2, pp. 415-419, February 1976 Biohemistry Studies on nulei aid reassoiation kinetis: Empirial equations desribing DNA reassoiation* (renaturation/nuleation inhibition/single

More information

Channel Modeling Based on Interference Temperature in Underlay Cognitive Wireless Networks

Channel Modeling Based on Interference Temperature in Underlay Cognitive Wireless Networks Channel Modeling Based on Interferene emperature in Underlay Cognitive Wireless Networks Manuj Sharma # *, Anirudha Sahoo #2, K. D. Nayak * # Dept. of Computer Siene & Engineering Indian Institute of ehnology

More information

Sequence Analysis using Logic Regression

Sequence Analysis using Logic Regression Geneti Epidemiology (Suppl ): S66 S6 (00) Sequene Analysis using Logi Regression Charles Kooperberg Ingo Ruzinski, Mihael L. LeBlan, and Li Hsu Division of Publi Health Sienes, Fred Huthinson Caner Researh

More information

Effect of Curing Conditions on Hydration Reaction and Compressive Strength Development of Fly Ash-Cement Pastes

Effect of Curing Conditions on Hydration Reaction and Compressive Strength Development of Fly Ash-Cement Pastes Effet of Curing Conditions on Hydration Reation and Development of Fly Ash-Cement Pastes Warangkana Saengsoy Candidate for the degree of Dotor of Philosophy Supervisor: Prof. Dr. Toyoharu Nawa Division

More information

Non-contact ACL injuries in female athletes: an International Olympic Committee current concepts statement

Non-contact ACL injuries in female athletes: an International Olympic Committee current concepts statement 1 IOC Medial Commission and Karolinska Institutet, Stokholm, Sweden; 2 IOC Medial Commission, Lausanne, Switzerland; 3 Department of Orthopedis, University of Minnesota, Minnesota, USA; 4 University of

More information

Opening and Closing Transitions for BK Channels Often Occur in Two

Opening and Closing Transitions for BK Channels Often Occur in Two 72 Biophysial Journal Volume 65 August 1993 72-714 Opening and Closing Transitions for BK Channels Often Our in Two Steps via Sojourns through a Brief ifetime Subondutane State William B. Ferguson, Owen

More information

Contact mechanics and wear simulations of hip resurfacing devices using computational methods

Contact mechanics and wear simulations of hip resurfacing devices using computational methods Ata of Bioengineering and Biomehanis Vol. 16, No. 2, 2014 Original paper DOI: 10.5277/abb140212 Contat mehanis and wear simulations of hip resurfaing devies using omputational methods MURAT ALI*, KEN MAO

More information

MR Imaging of the Optic Nerve and Sheath: Correcting

MR Imaging of the Optic Nerve and Sheath: Correcting 249 MR Imaging of the Opti Nerve and Sheath: Correting the Chemial Shift Misregistration Effet David L. Daniels 1 J. rue Kneeland 1 nn Shimakawa 2 Kathleen W. Pojunas 1 John F. Shenk 3 Howard Hart, Jr.3

More information

The comparison of psychological evaluation between military aircraft noise and civil aircraft noise

The comparison of psychological evaluation between military aircraft noise and civil aircraft noise The omparison of psyhologial evaluation between military airraft noise and ivil airraft noise Makoto MORINAGA ; Ippei YAMAMOTO ; Hidebumi TSUKIOKA ; Koihi MAKINO 2, Sonoko KUWANO 3, Mitsuo MATSUMOTO 4

More information

Evaluation of a prototype for a reference platelet

Evaluation of a prototype for a reference platelet 932 Royal Postgraduate Medial Shool, Duane Road, London W12 ONN S M Lewis Western Infirmary, Glasgow R M Rowan Toa Medial Eletronis, Kobe, Japan F Kubota Correspondene to: Dr S M Lewis Aepted for publiation

More information

A HEART CELL GROUP MODEL FOR THE IDENTIFICATION OF MYOCARDIAL ISCHEMIA

A HEART CELL GROUP MODEL FOR THE IDENTIFICATION OF MYOCARDIAL ISCHEMIA A HEART CELL GROUP MODEL FOR THE IDENTIFICATION OF MYOCARDIAL ISCHEMIA Mohamed A. Mneimneh, Miheal T. Johnson and Rihard J. Povinelli Eletrial and Computer Engineering, Marquette University, 55 Wisonsin

More information

Cyclic Fluctuations of the Alveolar Carbon Dioxide Tension during the Normal Menstrual Cycle

Cyclic Fluctuations of the Alveolar Carbon Dioxide Tension during the Normal Menstrual Cycle Cyli Flutuations of the Alveolar Carbon Dioxide Tension during the Normal Menstrual Cyle Ruth L. Goodland, M.S., and W. T. Pommerenke, Ph.D., M.D. THE SHORT spa~ of funtional life of the unfertilized human

More information

SUPPLEMENTARY INFORMATION

SUPPLEMENTARY INFORMATION SUPPLEMENTARY INFORMATION DOI: 1.138/NPHYS2355 Mehanial waves during tissue expansion Supplementary Figures 2.2 Relative mrna levels 2. 1.8 1.6 1.4 1.2 1. hours 3 hours 7 hours.8.6 vimentin ZO1 β-atenin

More information

i Y I I Analysis of Breakdown Voltage and On Resistance of Super-junction Power MOSFET CoolMOSTM Using Theory of Novel Voltage Sustaining Layer

i Y I I Analysis of Breakdown Voltage and On Resistance of Super-junction Power MOSFET CoolMOSTM Using Theory of Novel Voltage Sustaining Layer Analysis of Breakdown Voltage and On Resistane of Super-juntion Power MOSFET CoolMOSTM Using Theory of Novel Voltage Sustaining Layer P. N. Kondekar, Student Member ZEEE, C.D. Parikh, Member ZEEE and M.

More information

ENE-306 Open Channel Hydraulics Class 3 rd Teaching Scheme: (1 hour lecture + 1 hour tutorial + 2 hours practical) per week Credits: 4

ENE-306 Open Channel Hydraulics Class 3 rd Teaching Scheme: (1 hour lecture + 1 hour tutorial + 2 hours practical) per week Credits: 4 ENE-06 Open Channel Hdraulis Class rd Teahing Sheme: ( hour leture + hour tutorial + hours pratial per week Credits: 4 Course desription: This ourse desribes the basi theories and priniples of open hannel

More information

Gait mechanics after ACL reconstruction: implications for the early onset of knee osteoarthritis

Gait mechanics after ACL reconstruction: implications for the early onset of knee osteoarthritis Gait mehanis after ACL reonstrution: impliations for the early onset of knee osteoarthritis R J Butler, 1 K I Minik, 1 R Ferber, 2 F Underwood 1 1 Department of Physial Therapy, University of Evansville,

More information

Systematic Review of Trends in Fish Tissue Mercury Concentrations

Systematic Review of Trends in Fish Tissue Mercury Concentrations Systemati Review of Trends in Fish Tissue Merury Conentrations Tom Grieb 1, Roxanne Karimi 2, Niholas Fisher 2, Leonard Levin 3 (1) Tetra Teh, In., Lafayette, CA, USA; (2) State University of New York,

More information

4th. generally by. Since most. to the. Borjkhani 1,* Mehdi. execution [2]. cortex, computerized. tomography. of Technology.

4th. generally by. Since most. to the. Borjkhani 1,* Mehdi. execution [2]. cortex, computerized. tomography. of Technology. 4th Internatiional Conferene of Fuzzy Information & Engineering 14 15 Otober 0100 Shomal University, Amol, Iran Diagnosiss of Parkinson diseases based on handwriting kinematis using fuzzy lassifier Mehdi

More information

Model of α-linolenic acid metabolism

Model of α-linolenic acid metabolism Model of α-linoleni aid metabolism N.Kokulan, C.-H. Lai Shool of Computing and Mathematial Sienes University of Greenwih London, UK RAE2012 Competitive Grant with Shool of Siene Projet progress meeting

More information

Supplementary Information Computational Methods

Supplementary Information Computational Methods Supplementary Information Computational Methods Data preproessing In this setion we desribe the preproessing steps taken to establish the data matrix of hepatoyte single ell gene expression data (Table

More information

Mark J Monaghan. Imaging techniques ROLE OF REAL TIME 3D ECHOCARDIOGRAPHY IN EVALUATING THE LEFT VENTRICLE TIME 3D ECHO TECHNOLOGY

Mark J Monaghan. Imaging techniques ROLE OF REAL TIME 3D ECHOCARDIOGRAPHY IN EVALUATING THE LEFT VENTRICLE TIME 3D ECHO TECHNOLOGY Take the online multiple hoie questions assoiated with this artile (see page 130) Correspondene to: Dr Mark J Monaghan, Department of Cardiology, King s College Hospital, Denmark Hill, London SE5 9RS,

More information

Rate of processing and judgment of response speed: Comparing the effects of alcohol and practice

Rate of processing and judgment of response speed: Comparing the effects of alcohol and practice Pereption & Psyhophysis 1989, 45 (4), 431-438 Rate of proessing and judgment of response speed: Comparing the effets of alohol and pratie E. A. MAYLOR, P. M. A. RABBITT, and S. A. V. CONNOLLY University

More information

What causes the spacing effect? Some effects ofrepetition, duration, and spacing on memory for pictures

What causes the spacing effect? Some effects ofrepetition, duration, and spacing on memory for pictures Memory & Cognition 1975, Vol. 3 (3), 287 294 What auses the spaing effet? Some effets ofrepetition, duration, and spaing on memory for pitures DOUGLAS 1. HNTZMAN, JEFFERY J. SUMMERS, and RCHARD A. BLOCK

More information

The effects of bilingualism on stuttering during late childhood

The effects of bilingualism on stuttering during late childhood Additional information is published online only at http:// ad.bmj.om/ontent/vol93/ issue11 1 Division of Psyhology and Language Sienes, University College London, London, UK; 2 Department of Language and

More information

Regulation of spike timing in visual cortical circuits

Regulation of spike timing in visual cortical circuits Regulation of spike timing in visual ortial iruits Paul Tiesinga*, Jean-Mar Fellous and Terrene J. Sejnowski Abstrat A train of ation potentials (a spike train) an arry information in both the average

More information

Determination of Parallelism and Nonparallelism in

Determination of Parallelism and Nonparallelism in JOURNAL OF CLINICAL MICROIOLOGY, OCt. 1994, p. 2441-2447 95-1137/94/$4.+ Copyright 1994, Amerian Soiety for Mirobiology Vol. 32, No. 1 Determination of Parallelism and Nonparallelism in ioassay Dilution

More information

The Development and Validation of a Finite Element Model of a Canine Rib For Use With a Bone Remodeling Algorithm.

The Development and Validation of a Finite Element Model of a Canine Rib For Use With a Bone Remodeling Algorithm. The Development and Validation of a Finite Element Model of a Canine Rib For Use With a Bone Remodeling Algorithm. A Thesis Presented to the Faulty of the College of Engineering California Polytehni State

More information

RIGID BODY MODEL OF THE HYBRID III DUMMY LOWER LIMB INCLUDING MUSCLE TENSION UNDER CAR CRASH CONDITIONS

RIGID BODY MODEL OF THE HYBRID III DUMMY LOWER LIMB INCLUDING MUSCLE TENSION UNDER CAR CRASH CONDITIONS RIGID BODY MODEL OF THE HYBRID III DUMMY LOWER LIMB INCLUDING MUSCLE TENSION UNDER CAR CRASH CONDITIONS Philipps PETIT, Laurent PORTIER ", Xavier TROSSEILLE "' * CEESAR 132, rue des Suisses, 92000 Nanterre

More information

Abnormality Detection for Gas Insulated Switchgear using Self-Organizing Neural Networks

Abnormality Detection for Gas Insulated Switchgear using Self-Organizing Neural Networks Abnormality Detetion for Gas Insulated Swithgear using Self-Organizing Neural Networks Hiromi OGI, Hideo TANAKA, Yoshiakira AKIM OTO Yoshio IZUI Tokyo Eletri Power Company Computer & Communiation Researh

More information

Spatial Responsiveness of Monkey Hippocampal Neurons to Various Visual and Auditory Stimuli

Spatial Responsiveness of Monkey Hippocampal Neurons to Various Visual and Auditory Stimuli HPPOCAMPUS, VO. 2, NO. 3, PAGES 37-322, JUY 1992 Spatial Responsiveness of Monkey Hippoampal Neurons to Various Visual and Auditory Stimuli Ryoi Tamura, Taketoshi Ono, Masaji Fukuda, and Kiyomi Nakamura

More information

Data Retrieval Methods by Using Data Discovery and Query Builder and Life Sciences System

Data Retrieval Methods by Using Data Discovery and Query Builder and Life Sciences System Appendix E1 Data Retrieval Methods by Using Data Disovery and Query Builder and Life Sienes System All demographi and linial data were retrieved from our institutional eletroni medial reord databases by

More information

Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics

Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics Kim et al. RESEARCH arxiv:63.2773v [q-bio.nc] 9 Mar 26 Onset, timing, and exposure therapy of stress disorders: mehanisti insight from a mathematial model of osillating neuroendorine dynamis Lae Kim, Maria

More information

Effects of training to implement new working methods to reduce knee strain in floor layers. A twoyear

Effects of training to implement new working methods to reduce knee strain in floor layers. A twoyear Department of Oupational Mediine, Region Hospital Skive, Denmark Correspondene to: Dr L K Jensen, Department of Oupational Mediine, Region Hospital Skive, Resenvej 25, DK- 7800 Skive, Denmark; lilli.kirkeskov.jensen@

More information

mouths before diffusional equilibration can occur at the

mouths before diffusional equilibration can occur at the PRSYNAPTI ALIUM DIFFUSION FROM VARIOUS ARRAYS OF SINGL HANNLS Impliations for Transmitter Release and Synapti Failitation AARON L. FOGLSON AND ROBRT S. ZUKR Departments ofmathematis and Physiology-Anatomy,

More information

Incentive Downshifts Evoke Search Repertoires in Rats

Incentive Downshifts Evoke Search Repertoires in Rats Journal of Experimental Psyhology: Animal Behavior Proesses 1999, Vol. 25, No. 2,153-167 Copyright 1999 by the Amerian Psyhologial Assoiation, In. 0097-7403/99/$3.00 Inentive Downshifts Evoke Searh Repertoires

More information

Supplementary Figure 1. Schematic illustrating major conclusions of this study.

Supplementary Figure 1. Schematic illustrating major conclusions of this study. ORNs GABA A GABA B glomeruli LN PNs Supplementary Figure 1. Shemati illustrating major onlusions of this study. This study represents the most diret evidene to date of inhiitory interations etween olfatory

More information

DTousoulis,CAntoniades,CStefanadis

DTousoulis,CAntoniades,CStefanadis Coronary disease EVALUATING ENDOTHELIAL FUNCTION IN HUMANS: A GUIDE TO INVASIVE AND NON-INVASIVE TECHNIQUES INVASIVE See end of artile for authors affiliations Correspondene to: Dr Dimitris Tousoulis,

More information

Road Map to a Delirium Detection, Prevention and Management Program

Road Map to a Delirium Detection, Prevention and Management Program Road Map to a Delirium Detetion, Prevention and Management Program Delirium Prevention 2014 Minnesota Hospital Assoiation The Road Map to a Delirium Detetion, Prevention, and Management Program provides

More information

THE ATP-DEPENDENT CONCENTRATION OF CALCIUM BY A GOLGI APPARATUS-RICH FRACTION ISOLATED FROM RAT LIVER

THE ATP-DEPENDENT CONCENTRATION OF CALCIUM BY A GOLGI APPARATUS-RICH FRACTION ISOLATED FROM RAT LIVER J. Cell Si. 30, 117-128 (1978) Printed in Great Britain Company of Biologists Limited igys THE ATP-DEPENDENT CONCENTRATION OF CALCIUM BY A GOLGI APPARATUS-RICH FRACTION ISOLATED FROM RAT LIVER STUART HODSON

More information

HIP fractures are common, disabling, and sometimes fatal

HIP fractures are common, disabling, and sometimes fatal Journal of Gerontology: MEDICAL SCIENCES 1989. Vol.44. No. 4. MI07-III Copyright 1989 by The Geronlologial Soiety of Ameria A HYPOTHESIS: The Causes of Hip Fratures Steven R. Cummings and Mihael C. Nevitt

More information

The effects of question order and response-choice on self-rated health status in the English Longitudinal Study of Ageing (ELSA)

The effects of question order and response-choice on self-rated health status in the English Longitudinal Study of Ageing (ELSA) The effets of question order and response-hoie on self-rated health status in the English Longitudinal Study of Ageing (ELSA) A Bowling, J Windsor Theory and methods Department of Primary Care and Population

More information

Sexual and marital trajectories and HIV infection among ever-married women in rural Malawi

Sexual and marital trajectories and HIV infection among ever-married women in rural Malawi 1 Cartagene, Montreal, Canada; 2 MGill University, Montreal, Canada; 3 Université de Montréal, Montreal, Canada; 4 Brown University, Providene, USA; 5 University of Colorado at Boulder, Boulder, USA; 6

More information

Costly Price Discrimination

Costly Price Discrimination Costly Prie Disrimination Peter T. Leeson and Russell S. Sobel Department of Eonomis, West Virginia University February 16, 26 Abstrat In standard miroeonomi theory, perfet prie disrimination is soially

More information

Effect of Afterload on Force-Velocity Relations and Contractile Element Work in the Intact Dog Heart

Effect of Afterload on Force-Velocity Relations and Contractile Element Work in the Intact Dog Heart Effet of fterload on Fore-Veloity Relations and ontratile Element Work in the ntat Dog Heart By Herbert J. Levine, M.D., Stanley. Forwand, M.D., Kevin M. Mlntyre, M.D., and Eliot Shehter, M.D. n the past

More information

Interrelationships of Chloride, Bicarbonate, Sodium, and Hydrogen Transport in the Human Ileum

Interrelationships of Chloride, Bicarbonate, Sodium, and Hydrogen Transport in the Human Ileum Interrelationships of Chloride, Biarbonate, Sodium, and Hydrogen Transport in the Human Ileum LEsLE A. TURNBERG, FREDERICK A. BIEBERDORF, STEPHEN G. MORAWSKI, and JOHN S. FORDTRAN From the Department of

More information

The impact of smoking and quitting on household expenditure patterns and medical care costs in China

The impact of smoking and quitting on household expenditure patterns and medical care costs in China Researh paper Appendies are published online only at http:// tobaoontrol.bmj.om/ ontent/vol18/issue2 1 Center for Health Statistis and Information, Ministry of Health, Beijing, PR China; 2 International

More information

Urbanization and childhood leukaemia in Taiwan

Urbanization and childhood leukaemia in Taiwan C International Epidemlologial Assoiation 1998 Printed in Great Britain International Journal of Epidemiology 199827:587-591 Urbanization and hildhood leukaemia in Taiwan Chung-Yi Li, a Ruey S Iin b and

More information

clinical conditions using a tape recorder system

clinical conditions using a tape recorder system Thorax (1964), 19, 125 Objetive assessment of ough suppressants under linial onditions using a tape reorder system C. R. WOOLF AND A. ROSENBERG From the Respiratory Unit, Sunnybrook Hospital (Department

More information

Verification of Passive Power-Assist Device Using Humanoid Robot: Effect on Bending and Twisting Motion

Verification of Passive Power-Assist Device Using Humanoid Robot: Effect on Bending and Twisting Motion 15 IEEE-RAS 15th International Conference on Humanoid Robots (Humanoids) November 3-5, 15, Seoul, Korea Verification of Passive Power-Assist Device Using Humanoid Robot: Effect on Bending and Twisting

More information

CONTINUOUS SPIROMETRY: AN AID TO MONITORING VENTILATION DURING OPERATION

CONTINUOUS SPIROMETRY: AN AID TO MONITORING VENTILATION DURING OPERATION British Journal of Anaesthesia 1993; 71: 747-751 CONTINUOUS SPIROMTRY: AN AID TO MONITORING VNTILATION DURING OPRATION G. I. BARDOCZKY,. NGLMAN AND A. D'HOLLANDR SUMMARY We present six ase-reports of patients

More information

Is posture related craniospinal compliance shift caused by jugular vein collapse? A theoretical analysis

Is posture related craniospinal compliance shift caused by jugular vein collapse? A theoretical analysis DOI 10.1186/s12987-017-0053-6 Fluids and Barriers of the CNS RESEARCH Open Aess Is posture related raniospinal ompliane shift aused by jugular vein ollapse? A theoretial analysis Manuel Gehlen 1,2*, Vartan

More information

Southwest Fisheries Science Center National Marine Fisheries Service 8604 La Jolla Shores Dr. La Jolla, California 92037

Southwest Fisheries Science Center National Marine Fisheries Service 8604 La Jolla Shores Dr. La Jolla, California 92037 233 Abstrat We estimated the total number of pantropial spotted dolphin (Stenella attenuata) mothers killed without their alves ( alf defiit ) in all tuna purse-seine sets from 1973 90 and 1996 2000 in

More information

Are piglet prices rational hog price forecasts?

Are piglet prices rational hog price forecasts? AGRICULTURAL ECONOMICS ELSEVIER Agriultural Eonomis 13 (1995) 119-123 Are piglet pries rational hog prie foreasts? Ole GjQ)lberg * Department of Eonomis and Soial Sienes, The Agriultural University of

More information

Immediate Effect of Shavasana on Cardiac Output and S ystemic Peripheral Resistance in Untrained Young Adults

Immediate Effect of Shavasana on Cardiac Output and S ystemic Peripheral Resistance in Untrained Young Adults ISSN 2231-4261 ORIGINAL ARTICLE Immediate Effet of Shavasana on Cardia Output and S ystemi Peripheral Resistane in Untrained Young Adults Department of Physiology, Saraswathi Institute of Medial Sienes,

More information

A Casson Fluid Model for multiple Stenosed Artery in the Presence of Magnetic Field

A Casson Fluid Model for multiple Stenosed Artery in the Presence of Magnetic Field A Casson Fluid Model for multiple Stenosed Artery in the Presene of Magneti Field Rekha Bali* and Usha Awasthi ** Department of Mathematis Harourt Butler Tehnologial Institute, Nawabganj, Kanpur-8 (India)

More information

PRESENCE OF A GASTRIC MOTOR-STIMULATING PROPERTY IN DUODENAL EXTRACTS

PRESENCE OF A GASTRIC MOTOR-STIMULATING PROPERTY IN DUODENAL EXTRACTS GASTRONTROLOGY opyright 1967 by The Williams & Wilkins o. Vol. 52, No.2, Pat 1 Printed in U.S.A. PRSN OF A GASTR MOTOR-STMULATNG PROPRTY N DUODNAL XTRATS JOHN. BROWN, PH.D. Department of Physiology, University

More information

Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics

Onset, timing, and exposure therapy of stress disorders: mechanistic insight from a mathematical model of oscillating neuroendocrine dynamics Kim et al. RESEARCH Onset, timing, and exposure therapy of stress disorders: mehanisti insight from a mathematial model of osillating neuroendorine dynamis Lae Kim, Maria D Orsogna 2 and Tom Chou 3* *

More information

SIMULATION OF MUSCLE TENSING IN PRE-IMPACT BRACING. Gregory S. Klopp Jeff R. Crandall Edwin M. Sieveka Walter D. Pilkey

SIMULATION OF MUSCLE TENSING IN PRE-IMPACT BRACING. Gregory S. Klopp Jeff R. Crandall Edwin M. Sieveka Walter D. Pilkey SMULATON OF MUSCLE TENSNG N PRE-MPACT BRACNG Gregory S. Klopp Jeff R. Crandall Edwin M. Sieveka Walter D. Pilkey Shool of Engineering and Applied Siene The University of Virginia ABSTRACT Reflexive musular

More information

Navigator: 2 Degree of Freedom Robotics Hand Rehabilitation Device

Navigator: 2 Degree of Freedom Robotics Hand Rehabilitation Device Navigator: 2 Degree of Freedom Robotics Hand Rehabilitation Device Design Team Ray Adler, Katherine Bausemer, Joseph Gonsalves, Patrick Murphy, Kevin Thompson Design Advisors Prof. Constantinos Mavroidis,

More information

Computer simulation of hippocampal place cells

Computer simulation of hippocampal place cells Psyhobiology 1991,19 (2),103-115 Computer simulation of hippoampal plae ells PATRICIA E. SHARP Yale Uniuersity, New Hauen, Connetiut Hippoampal pyramidal ells show loation-speifi firing as animals navigate

More information

Department of Medicine, University of California, Irvine, California, U.S.A.

Department of Medicine, University of California, Irvine, California, U.S.A. PPR 16 RSTRUTON O LOO LOW N TRNSCNNTL MTTON R. VNN,.. WLSON, W.R. SMT, and M. MORTON epartment of Mediine, University of California, rvine, California, U.S.. Mar ked dereases in hepati and renal blood

More information

Lung function studies before and after a work shift

Lung function studies before and after a work shift British J6urnal ofindustrial Mediine 1983;40:153-159 Lung funtion studies before and after a work shift R G LOVE From the Institute of Oupational Mediine, Edinburgh EH8 9SU, UK ABSTRAT The lung funtion

More information

Monte Carlo dynamics study of motions in &s-unsaturated hydrocarbon chains

Monte Carlo dynamics study of motions in &s-unsaturated hydrocarbon chains Monte Carlo dynamis study of motions in &s-unsaturated hydroarbon hains Y. K. Levine Department of Moleular Biophysis, Buys Ballot Laboratory, The Netherlands University of Utreht, 3508 TA Utreht, A. Kolinski

More information

Superspreading and the impact of individual variation on disease emergence

Superspreading and the impact of individual variation on disease emergence Superspreading and the impat of individual variation on disease emergene Supplementary Information J.O. Lloyd-Smith,2, S.J. Shreiber 3, P.E. Kopp 4, W.M. Getz Department of Environmental Siene, Poliy &

More information

An Intelligent Decision Support System for the Treatment of Patients Receiving Ventricular Assist Device Support

An Intelligent Decision Support System for the Treatment of Patients Receiving Ventricular Assist Device Support Original Artiles 1 An Intelligent Deision Support System for the Treatment of Patients Reeiving Ventriular Assist Devie Support E. C. Karvounis 1,2 ; M. G. Tsipouras 1,2 ; A. T. Tzallas 1,2 ; N. S. Katertsidis

More information

Community-Based Bayesian Aggregation Models for Crowdsourcing

Community-Based Bayesian Aggregation Models for Crowdsourcing Community-Based Bayesian Aggregation Models for Crowdsouring Matteo Venanzi University of Southampton mvg@es.soton.a.uk Pushmeet Kohli Mirosoft Researh pkohli@mirosoft.om John Guiver Mirosoft Researh joguiver@mirosoft.om

More information

Reading and communication skills after universal newborn screening for permanent childhood hearing impairment

Reading and communication skills after universal newborn screening for permanent childhood hearing impairment 1 Shool of Psyhology, University of Southampton, Southampton, UK; 2 Shool of Mediine, Southampton General Hospital, University of Southampton, Southampton, UK; 3 UCL Institute of Child Health, London,

More information

MATERIAL PROPERTIES OF THE DEVELOPING PORCINE BRAIN

MATERIAL PROPERTIES OF THE DEVELOPING PORCINE BRAIN MATERIAL PROPERTIES OF THE DEVELOPING PORCINE BRAIN Kirk L Thibault and Susan S Margulies Dept of Bioengineering, University of PA, Philadelphia, PA USA ABSTRACT The objetive of this projet is to quantify

More information

A DESIGN ASSESSMENT TOOL FOR SQUEAK AND RATTLE PERFORMANCE

A DESIGN ASSESSMENT TOOL FOR SQUEAK AND RATTLE PERFORMANCE A DESIGN ASSESSMENT TOOL FOR SQUEAK AND RATTLE PERFORMANCE David E. Soine, Harold A. Evensen, and Charles D. Van Karsen Center for Applied Researh in Dynai Systes Mehanial Engineering-Engineering Mehanis

More information

Analysis of EEG background activity in Autism disease patients with Bispectrum and STFT measure

Analysis of EEG background activity in Autism disease patients with Bispectrum and STFT measure Proeedings of the th WSEAS International Conferene on COMMUNICATIONS, Agios Nikolaos, Crete Island, Greee, July 6-8, 007 8 Analysis of EEG bakground ativity in disease patients with Bispetrum and STFT

More information

Allocation of attention across saccades

Allocation of attention across saccades lloation of attention aross saades Donatas Jonikaitis, Martin Szinte, Martin Rolfs and Patrik Cavanagh J Neurophysiol 19:1425-1434, 213. First published 5 Deember 212; doi: 1.1152/jn.656.212 You might

More information

RATING SCALES FOR NEUROLOGISTS

RATING SCALES FOR NEUROLOGISTS iv22 RATING SCALES FOR NEUROLOGISTS Correspondene to: Dr Jeremy Hobart, Department of Clinial Neurosienes, Peninsula Medial Shool, Derriford Hospital, Plymouth PL6 8DH, UK; Jeremy.Hobart@ phnt.swest.nhs.uk

More information

Stress is an essential component of an organism s attempt

Stress is an essential component of an organism s attempt Timing and bistability in the hypothalami-pituitary-adrenal axis: a model for onset and exposure therapy of stress disorders Lae Un Kim, Maria D Orsogna, Tom Chou Department of iomathematis, UCL, Los ngeles,

More information

STIR MR Imaging of the Orbit

STIR MR Imaging of the Orbit 969 STIR MR Imaging of the Orbit Sott W. tlas 1 Robert I. Grossman David. Hakney Herbert I. Goldberg Larissa T. ilaniuk Robert. Zimmerman Fifteen patients with CT-doumented orbital lesions were evaluated

More information

Daily Illness Characteristics and

Daily Illness Characteristics and Daily Illness Charateristis and Health Care Deisions of Older People Tom Hikey Hiroko Akiyama University of Mihigan William Rakowski Brown University Although investigations of health are deision making

More information

Estimation of Glomerular Podocyte Number: A Selection of Valid Methods

Estimation of Glomerular Podocyte Number: A Selection of Valid Methods Estimation of Glomerular Podoyte Number: A Seletion of Valid Methods Kevin V. Lemley,* John F. Bertram, Susanne B. Niholas, and Kathryn White *Division of Nephrology, Children s Hospital Los Angeles, Los

More information

Role of the actin cytoskeleton on epithelial Na

Role of the actin cytoskeleton on epithelial Na Kidney International, Vol. 48 (1995), pp. 970 984 Role of the atin ytoskeleton on epithelial Na hannel regulation Hoiio F. ANTIELLO Renal Unit, Massahusetts General Hospital and Department of Mediine,

More information

previously (Leff & Harper, 1989) this provides an experimental test for the operation of conditions under which erroneous

previously (Leff & Harper, 1989) this provides an experimental test for the operation of conditions under which erroneous Br. J. Pharmaol. (199), 11, 55-6 If--" MamiUan Press Ltd, 199 Pharmaologial estimation of agonist affinity: detetion of errors that may be aused by the operation of reeptor isomerisation or ternary omplex

More information

Our next questions are about Multisystemic Therapy.

Our next questions are about Multisystemic Therapy. II.B.10.01 01 Our next questions are about Multisys Therapy. The National Registry of Evidene-Based Praties and Programs (NREPP) desribes Multisys Therapy as follows: Multisys Therapy () for juvenile offenders

More information

BIOMECHANICS AND CONTEXT OF ACUTE KNEE INJURIES. Uwe Kersting MiniModule Idræt Biomekanik 2. Objectives

BIOMECHANICS AND CONTEXT OF ACUTE KNEE INJURIES. Uwe Kersting MiniModule Idræt Biomekanik 2. Objectives BIOMECHANICS AND CONTEXT OF ACUTE KNEE INJURIES Uwe Kersting MiniModule 06 2011 Idræt Biomekanik 2 1 Objectives Know about the static and dynamic organisation of the knee joint (anatomy & function) Be

More information

EMG-Driven Human Model for Orthosis Control

EMG-Driven Human Model for Orthosis Control EMG-Driven Human Model for Orthosis Control Christian Fleischer, Günter Hommel Institute for Computer Engineering and Microelectronics Berlin University of Technology, Germany {fleischer, hommel}@cs.tu-berlin.de

More information

The burden of smoking-related ill health in the United Kingdom

The burden of smoking-related ill health in the United Kingdom The burden of smoking-related ill health in the United Kingdom S Allender, R Balakrishnan, P Sarborough, P Webster, M Rayner Researh paper Department of Publi Health, University of Oxford, Oxford, UK Correspondene

More information

Luc A Piérard, Patrizio Lancellotti

Luc A Piérard, Patrizio Lancellotti Valve disease STRESS TESTING IN VALVE DISEASE Lu A Piérard, Patrizio Lanellotti 766 Take the online multiple hoie questions assoiated with this artile (see page 765) AORTIC S Heart 2007; 93:766 772. doi:

More information

Normal Venous Anatomy of the Brain: Demonstration with Gadopentetate

Normal Venous Anatomy of the Brain: Demonstration with Gadopentetate 1107 Normal Venous Anatomy of the Brain: emonstration with Gadopentetate imeglumine in Enhaned 3- MR Angiography onald W. Chakeres 1 Petra Shmalbrok 2 Martha Brogan 1 Chun Yuan 2 Lane Cohen 1 This investigation

More information

Computational Saliency Models Cheston Tan, Sharat Chikkerur

Computational Saliency Models Cheston Tan, Sharat Chikkerur Computational Salieny Models Cheston Tan, Sharat Chikkerur {heston,sharat}@mit.edu Outline Salieny 101 Bottom up Salieny Model Itti, Koh and Neibur, A model of salieny-based visual attention for rapid

More information

RADIATION DOSIMETRY INTRODUCTION NEW MODALITIES

RADIATION DOSIMETRY INTRODUCTION NEW MODALITIES RADIATION DOSIMETRY M. Ragheb 1/17/2006 INTRODUCTION Radiation dosimetry depends on the aumulated knowledge in nulear siene in general and in nulear and radio hemistry in partiular. The latter is onerned

More information

Spectral asymmetry index and Higuchi s fractal dimension for detecting microwave radiation effect on electroencephalographic signal

Spectral asymmetry index and Higuchi s fractal dimension for detecting microwave radiation effect on electroencephalographic signal Proeedings of the Estonian Aademy of Sienes, 2014, 63, 3, 322 327 doi: 10.3176/pro.2014.3.05 Available online at www.eap.ee/proeedings Spetral asymmetry index and Higuhi s fratal dimension for deteting

More information

In-vivo determination of lead in the skeleton after occupational exposure to lead

In-vivo determination of lead in the skeleton after occupational exposure to lead British Journal of Industrial Mediine 198;37:19-113 In-vivo determination of lead in the skeleton after oupational exposure to lead L AHLGREN,' BIRGITTA HAEGER-ARONSEN,2 S MATTSSON,' AND A SCHUTZ3 From

More information

Measurement strategies for hazard control will have to be efficient and effective to protect a

Measurement strategies for hazard control will have to be efficient and effective to protect a EXPOSURE Correspondene to: Dr H Kromhout, Environmental and Oupational Health Division, Institute for Risk Assessment Sienes, University of Utreht, PO Box 80176, Yalelaan, 3508 TD Utreht, The Netherlands;

More information

American Orthodontics Exhibit 1001 Page 1 of 6. US 6,276,930 Bl Aug. 21,2001 /IIIII

American Orthodontics Exhibit 1001 Page 1 of 6. US 6,276,930 Bl Aug. 21,2001 /IIIII (12) United States Patent Pozzi /IIIII 1111111111111111111111111111111111111111111111111111111111111 US006276930Bl (10) Patent No.: (45) Date of Patent: US 6,276,930 Bl Aug. 21,2001 (54) ORTHODONTIC AID

More information

DESIGN AND IMPLEMENTATION OF A MECHATRONIC SYSTEM FOR LOWER LIMB MEDICAL REHABILITATION

DESIGN AND IMPLEMENTATION OF A MECHATRONIC SYSTEM FOR LOWER LIMB MEDICAL REHABILITATION International Journal of Modern Manufacturing Technologies ISSN 2067 3604, Vol. IV, No. 2 / 2012 17 DESIGN AND IMPLEMENTATION OF A MECHATRONIC SYSTEM FOR LOWER LIMB MEDICAL REHABILITATION Ana-Maria Amancea

More information