Risk of Fractures Following Cataract Surgery in Medicare Beneficiaries

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1 Risk of Fractures Following Cataract Surgery in Medicare Beneficiaries Victoria L. Tseng, MD, Fei Yu, PhD, Flora Lum, MD, Anne L. Coleman, MD, PhD JAMA. 2012;308(5):

2 Background Visual impairment associated with an increased risk of fractures Cataracts are the most common cause Untreated cataract causing up to 49% in femoral neck fractures related to decreased vision

3 Background Limited number of studies examined the influence of cataract surgery on fall incidence No other studies have examined the association of cataract surgery and fracture incidence

4 Objective To determine the association of cataract surgery with subsequent fracture risk in US Medicare beneficiaries with a diagnosis of cataract.

5 Methods

6 Methods 5% random sample of Medicare beneficiaries Obtained from the Centers for Medicare&Medicaid Services (CMS).

7 Exclusion criteria Age < 65 years Residence outside the 50 US states Lack of Medicare Part B coverage Possession of health maintenance organization coverage not processed by the CMS History of cataract surgery before the study period

8 % random sample Cataracts Patient 1-year look back Cataract surgery group Cataract diagnosis group Follow up 1 year after surgery Follow up annually

9 Outcomes Primary: the occurrence of hip fracture during the follow-up period Secondary: the occurrence of any fracture during the follow-up period

10 Fracture occurrence First surgical or nonsurgical fracture related Medicare service Single and multiple fractures were not distinguished

11 Baseline characteristic Demographics Age, sex, self reported race/ethnicity, and US region of residence Categorized patients into 5-year age subgroups

12 Baseline characteristic Overall systemic health determined by the Charlson Comorbidity Index (CCI) score Score 0-6 Classified 1-year mortality 0 (12% mortality) 1 or 2 (26% mortality) 3 or 4 (52% mortality) 5 or greater (85% mortality)

13 Diseases in the CCI Myocardial infarction Congestive heart failure Peripheral vascular disease, Cerebrovascular disease Dementia Chronic pulmonary disease Rheumatologic disease Peptic ulcer disease Cirrhosis Hepatic failure Immunosuppression Diabetes mellitus with or without complications Hemiplegia or paraplegia Chronic renal disease Malignant neoplasms Multiple myeloma or leukemia Lymphomas Metastatic solid tumor AIDS

14 Baseline characteristic Systemic conditions that increase the risk of fractures Osteoporosis Hyperthyroidism Hyperparathyroidism Cushing syndrome

15 Baseline characteristic Other ocular co morbidities Glaucoma Age-related macular degeneration Diabetes mellitus with ophthalmic manifestations

16 Baseline characteristic Severe cataracts Anterior and posterior subcapsular cataracts, total/mature cataract, hypermature cataract, and combined forms of cataract Physically limiting conditions Conditions secondary to cerebrovascular events, hemiplegia or paraplegia, myopathy, neuropathy, and peripheral vascular disease

17 Statistical analysis

18 Statistical Analysis Baseline characteristics Descriptive statistics The association of cataract surgery with 1-year incidence of hip fractures and any fractures Multivariable logistic regression models

19 Potential confounders Age Sex Race/ethnicity US region CCI score Osteoporosis Hyperthyroidism Hyperparathyroidism Glaucoma Age related macular degeneration DM with ophthalmic manifestations Severe cataract Have 1 physically limiting conditions

20 The propensity score Logistic regression model Calculated for each patient Including all variables in the fully adjusted logistic regression for fractures Divided patient into 10 subgroups Age Race Sex Region of US residence, CCI score Osteoporosis Hyperthyroidism Hyperparathyroidism Age-related macular degeneration DM with ophthalmic manifestations Glaucoma Physically limiting conditions Severe cataract.

21 Results

22 % random sample Cataracts Patient N=1,113,640 1-year look back Cataract surgery group N=410,809 Cataract diagnosis group N=702,831 Follow up 1 year after surgery Follow up annually

23 Demographic data

24 65-69 years old (n=370,113; 33.2%) Mean age in surgery group = 75.7 Mean age in diagnosis group = 73 Female (n=667,454; 59.9%)

25 Baseline comorbidities

26

27 Fracture incidence

28

29 Cataract surgery group Cataract diagnosis group

30 Fracture risk

31 The absolute risk differences: hip fractures = 0.20% and any fractures = 0.24% The NNT: hip fractures = 507 and any fractures = 422

32 Risk of Fractures by Propensity Score Decile

33 OR 0.68, 95%CI

34 Risk of fractures by age

35

36 Risk of fractures by CCI score

37

38 Comment

39 Comment Cataract surgery group had a higher crude risk of hip fracture due to unequal age distributions and confounding Cataract surgery was associated with a 16% decrease in the adjusted odds of hip fracture 1 year after the procedure

40 Comment Lower odds of hip surgery in Severe cataracts Patients with higher propensity score Sicker (CCI 3)

41 Limitation Observational and retrospective Unmeasured confounders use propensity scores to adjust for selection bias and confounder Misclassification of existing codes occur in the same in both groups due to large sample size

42 Limitation Inability to identify patients who self-paid for cataract surgery in the control group likely to have ICD-9-CM code for pseudophakia excluded from the study

43 Limitation Droped out due to died or switched to insurance outside of Medicare

44 Advantage Largest comprehensive study Diverse patient population

45 Conclusion Cataract surgery may be associated with lower odds of subsequent fracture in patients aged 65 years and older in the US Medicare population Further prospective study? Cost effectiveness?

46 Critical appraisal

47

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FRACTURES SECONDARY TO FALLS

FRACTURES SECONDARY TO FALLS ORIGINAL CONTRIBUTION Scan for Author Video Interview Risk of Fractures Following Cataract Surgery in Medicare Beneficiaries Victoria L. Tseng, MD Fei Yu, PhD Flora Lum, MD Anne L. Coleman, MD, PhD Author

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