Louise Mehrotra Vice President Investor Relations

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2 Louise Mehrotra Vice President Investor Relations

3 Safe Harbor Statement This presentation may contain forward-looking statements as defined in the Private Securities Litigation Reform Act of These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from the Company s expectations and projections. Risks and uncertainties include general industry conditions and competition; economic conditions, such as interest rate and currency exchange rate fluctuations; technological advances and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approvals; domestic and foreign health care reforms and governmental laws and regulations; and trends toward health care cost containment. A further list and description of these risks, uncertainties and other factors can be found in Exhibit 99 to the Company s Annual Report on Form 10-K for the fiscal year ended December 30, Copies of this Form 10-K, as well as subsequent filings, are available online at or on request from the Company. The Company does not undertake to update any forward-looking statements as a result of new information or future events or developments.

4 Michael Mahoney Company Group Chairman - DePuy

5 Today s Agenda DePuy Franchise Mike Mahoney Company Group Chairman DePuy Orthopaedics David Floyd President - DePuy Orthopaedics DePuy Spine Gary Fischetti WW President - DePuy Spine DePuy Trauma Gordon Van Ummersen & Extremities General Manager - Trauma & Extremities DePuy Mitek Mike McBreen VP Sales; General Manager ORTHOVISC DePuy Mitek

6 Orthopaedic market Highlights Strong and relatively stable DePuy The market leader and gaining momentum Executing an innovative pipeline Entering into new high growth segments Global scale and growth

7 EARLY INTERVENTION INTERMEDIATE INTERVENTION ARTHROPLASTY TRAUMA SPINAL AND NEUROLOGICAL DISORDERS

8 DePuy Franchise Sales YE 2007 Operational Growth 2007 Market Position 2007* $4.6B 8.4% #1 DePuy Orthopaedics #1 share in US hips *Internal Estimates DePuy Trauma DePuy Spine DePuy Mitek Codman Hand Innovations acquisition fueling growth Enhanced US sales network, Disc-O-Tech acquisition Double-digit growth in core business and new business segments (FMS, Orthovisc ) Solid international growth

9 2007 Wrap Up: WW Results Strong Quarterly Growth Trend & Faster Than Market in Most Segments Q1 Q4 Quarterly Sales Trend DePuy WW Market Share Operational DePuy Growth Market Growth (Int Est) Hips Knees Trauma Spine Sports Neuro /3 2 12% 9% 8% 9% 26%* 11% 7% 12% 18% 8% 5% 3% Above Market Below Market *Excludes sales to Japanese trauma distributor

10 Product Launches Hips GRIPTION coating ULTAMET XL Metal-on-Metal Bearings COMPEL (OUS) Knees Ci Essential Computer Assisted Surgery Mobile Bearing Revision Enhancements Shoulder GLOBAL AP Shoulder DELTA Xtend Reverse Shoulder 2007: More than 20 New Product Launches/3 PMAs Selected Technologies Trauma PEAK FX SNP Shoulder Nail Plate F3 Fragment Plating System Spine EXPEDIUM 6.35 Rod and Screw System CONCORDE Bullet VIPER 2 Sports Medicine BioknotlessBP/Lupine BR Fluid Management - VAPR S 50 PMAs Submitted Articular Surface Replacement Hip Ceramic-on-Ceramic Hip MEDSTREAM Programmable Infusion Pump

11 Orthopaedic Market Trends Increasing patient demand Less invasive procedures MIS Global expansion/developing markets Changing compliance landscape Increasing economic influence: reimbursement and pricing

12 DePuy Growth Strategies Portfolio execution: leading and innovative Early intervention/mis Solutions to improve customer productivity Continue to expand into new and high growth segments Global market expansion

13 Over 25 New Products HEALIX DePuy ASR TRI-LOCK CONFIDENCE SIGMA/LCS Enhancements ALPS CAIS (OUS)

14 David Floyd President DePuy Orthopaedics, U.S.

15 Joints Market Hips Knees 2007 Sales Growth* 12% 8% 2007 Market Position 2 2 WW Recon Market CAGR** 7% 8% WW Projected Total Market Revenue** $7.5B $9.0B Growth Drivers: *Operational **Internal Estimates Favorable demographics Earlier intervention/less invasive Innovative new products

16 Growth Strategies: Hip Introduce a steady cadence of new product offerings High performance bearings Tissue-sparing, bone preserving stems Promote anterior approach Sustain tribology leadership

17 Growth Strategies: Hip Focus on emerging markets Target younger and more active patients Educate through direct-to-patient communication

18 Hip Portfolio Biolox Delta DePuy ASR AltrX LD Proxima Corail ASR XL Ceramax Ceramic-on-Ceramic TRI-LOCK Gription Coating Pinnacle Acetabular Cup Ultamet XL Summit Hip System AltrX S-ROM Hip System Marathon AML Hip System

19 TRI-LOCK with Anterior Approach GRIPTION fixation technology improves stability Bone preserving stem Smaller incision for minimally invasive surgery with anterior approach Faster recovery

20 BHR ASR Advanced Tribology Advanced Fixation Advanced Bone Preservation Articular Surface Replacement Advanced Biomechanics Advanced Instrumentation

21 Growth Strategies: Knee Target broad-based patient needs with more personalized knee solutions Enhanced portfolio with wide range of sizes, shapes and advanced materials New instrumentation Introduce steady cadence of new products More than 10 product introductions over the next 18 months Professional education to support introduction of new instruments and products Direct-to-patient communication

22 CR Porocoat Ci Essential Sigma HP Partial Knee RP-F Sigma HP Instruments Sigma CR F TC3 RP Sigma Sizes Sigma AO Poly* Sigma PS Femur Sigma Fixed Bearing * In development

23 Porocoat HP Ci Essential HP Instruments LCS RPS Flexion LCS Duofix LCS RP HP Poly* Complete Revision * In development

24 Advanced surgical instrumentation Largest DePuy introduction in last 10 years Benefits: Efficiency, Precision, Flexibility Optimizes computer assisted and manual surgery

25 Patient outreach to connect patients to surgeons who use DePuy products: National print advertising Online marketing Web education/surgeon locator Local patient education events

26 In Conclusion Sustaining leadership position in hips with cadence of new products Expanding knee portfolio with series of new products and instrumentation Educating patients through direct-to-consumer communication

27 Gary Fischetti WW President DePuy Spine

28 DePuy Spine Poised for Growth Core portfolio continues to show strength and consistent growth Realigned and invested in distributor network 8 new products in 2007 Investments in new and adjacent key growth markets Continued momentum in international markets DISCOVER, EXPEDIUM, MOUNTAINEER, SKYLINE

29 Spine Market 2007 Sales Growth* 7% 2007 Market Position 2 WW Market Opportunity CAGR** 9% WW Projected Total Market Revenue 2012** $11B Today s Spine Market is Dynamic New technologies and procedures will drive growth Growing aging population Increasing adoption and access in OUS markets *Operational Growth **Internal Estimates Challenges Insurance coverage and reimbursement issues remain Higher costs and data requirements for bringing new technology to market Changing compliance landscape

30 2008 Additions to Core Portfolio Complex Spine Minimally Invasive Surgery Cervical X-MESH * MOUNTAINEER EXPEDIUM 4.5 BENGAL Stackable* VIPER 2 EXPEDIUM PEEK Rods* VG1 Cervical * EAGLE / SWIFT + *Not yet available for market release

31 DePuy Spine Investing in new and adjacent key growth markets NEW MARKETS Genetic Based Diagnostics with Axial Biotech Annular Repair with Biomerix Facet Replacement ADJACENT MARKETS Posterior Dynamic Stabilization Represents the next evolution of spinal treatments Part of EXPEDIUM System Incorporates flexible nitinol rod VCF with CONFIDENCE

32 Strategic Fit CONFIDENCE Spinal Cement System DePuy Spine enters new >$500 Million high growth segment Central to our aging spine portfolio Features Controlled Delivery of Highly Viscous Cement Reduced Radiation Exposure Streamlined Procedure with Reduced Steps Seamless Mixing and Transfer of Cement

33 DePuy Spine Poised for Growth Core portfolio continues to show strength and consistent growth Investments in new and adjacent key growth markets Continued momentum in international markets Well positioned for dynamic marketplace

34 Gordon Van Ummersen General Manager WW Trauma and Extremities

35 Trauma Market 2007 Sales Growth* 26%** 2007 Market Position 4 WW Market Opportunity CAGR*** 9% WW Projected Total Market Revenue 2012*** $5B Growth Drivers *Operational **Excludes sales to Japanese trauma distributor ***Internal Estimates Among fastest growing areas in medical devices Predictable patient population, favorable demographics New technology driving more procedures Reimbursement and positive pricing trends Under penetrated global markets

36 DePuy Orthopaedics, Inc. Trauma Significant Investment in Trauma Building on Successful Hand Innovations Acquisition Enhanced Commercial Capabilities

37 DePuy Orthopaedics Inc. Trauma Winning Capabilities TM

38 Small Fragment Set Launched Feb Large Fragment Set* Launch = Mar-Apr Elbow System* FDA Sub = Q2 Q Q Q Q Ankle System* Launch = Mar-Apr Proximal Tibia Set* FDA Sub = Q2 Foot System* FDA Sub = Q4 *Pending approval in U.S.

39 DePuy Orthopaedics, Inc. Extremities Building on WW Leadership Position in Shoulder/Ankle Markets DELTA Xtend, GLOBAL AP and AGILITY LP

40 Mike McBreen VP US Sales; General Manager ORTHOVISC DePuy Mitek

41 Sports Medicine Market 2007 Sales Growth* 2007 Market Position WW Market CAGR** WW Projected Total Market Revenue** 18% 2 9% $3.5B Growth Drivers *Operational **Internal Estimates Fastest growing fellowship area 30% of Orthopaedic fellowships are Sports Medicine Active population with increasing expectations Under developed global markets Less invasive surgical approaches Focus on innovation (absorbable materials, biologics)

42 Growth Strategies Gateway to orthopaedic care for DePuy Franchise Leverage global distribution capabilities Expand surgeon training Capitalize on proprietary material innovation in BIOCRYL RAPIDE TM Invest in OA disease state through ORTHOVISC Viscosupplement Expand leadership positions through portfolio enhancements

43 Arthroscopic Shoulder Repair Broad DePuy Mitek portfolio, strong position 400,000 Rotator Cuff surgeries in US annually* HEALIX TM PEEK Suture Anchor System Bone specific threads to reduce risk of anchor pull-out US Launched AAOS International mid 2008 *AAOS Estimates

44 Over 100,000 ACL repairs annually* FEMORAL INTRAFIX ACL Fixation System Anatomical ACL reconstruction US Launched AAOS Internationally Mid 2008 ACL Repair *AAOS Estimates

45 DePuy Key Summary Points Orthopaedic market Strong and relatively stable DePuy The market leader and gaining momentum Executing an innovative pipeline Entering into new high growth segments Global scale and growth

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