ZNZ Advanced Course in Neuroscience Mon Limbic System II. David P. Wolfer MD
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1 ZNZ Advanced Course in Neuroscience Mon Limbic System II David P. Wolfer MD Institute of Anatomy, University of Zurich Institute for Human Movement Sciences and Sport, ETH Zurich
2 Limbic system outline 1 Introduction 4 Emotions -history - general properties - definition - rodent models: fear and anxiety 2 Theories of hippocampal 5 Anatomy of the Amygdala Function rodent tests - components - declarative memory - extended amygdala - episodic memory -cognitive map - relational memory 6 Amygdala and fear conditioning - behavioral model - brain circuits 3 The hippocampus beyond memory - exploratory behavior and anxiety - species typical behaviors 7 Amygdala and anxiety - behavioral model - brain circuits - home cage behavior
3 Emotions conscious sensation feeling stimulus cortical processing subcortical processing motor and autonomic control systems periphery behavioral response autonomic and endocrine response amygdala hypothalamus brainstem
4 Fear and anxiety in rodents Fear Anxiety defensive emotional response to specific and immediate threatening stimulus; rodent models: fear conditioning, fear of predator odor. Contextual fear: contextual fear conditioning Generalized fear: context / cue discrimination sustained state of heightened apprehension in the absence of immediate threat; rodent models: elevated O- and plus-maze, open field, light-dark transition test, Vogel-test behavior: - avoidance, flight - risk assessment - freezing - vocalization - feeding suppression - drinking suppression - analgesia - reflex potentiation autonomic arousal: - blood pressure increase - heart rate increase - respiration increase - hyperthermia endocrine responses: - HPA axis activation
5 Amygdaloid complex - components AA* anterior amygdaloid area LBNC laterobasal complex unclassified cell groups extended amygdala superficial cortical-like nuclei LOT* nc of lateral olfactory tract BAOT** bed nc of accessory olfactory tract ACo* anterior cortical nc PLCo* posterolateral cortical nc PMCo** posteromedial cortical nc APir* amygdalopiriform transition area AHi** amygdalohippocampal transition area La lateral nc BL = B basolateral nc = basal nc BM = AB basomedial nc = accessory basal nc BLV ventral basolateral nc I(M) intercalated masses AStr amygdalostriatal zone IMG intramedullary gray * ** CeL central nc, lateral CeM central nc, medial Me** medial nc olfactory amygdala vomeronasal amygdala CEXA central division of extended amygdala MEXA medial division of extended amygdala
6 Extended amygdala amygdaloid complex bed nucleus of stria terminalis substantia innominata CEXA central division of extended amygdala CeL central nc, lateral CeM central nc, medial BSTL lateral bed nc of stria terminalis SLEAC central sublenticular extended amygdala IPAC interstitial nucleus of posterior limb of anterior commissure BSTS supracapsular bed nc of stria terminalis MEXA medial division of extended amygdala Me medial nc BSTM medial bed nc of stria terminalis SLEAM medial sublenticular extended amygdala BSTIA intraamygdaloid bed nc of stria terminalis
7 Classical (Pavlovian) conditioning conditioned stimulus neutral + conditioned stimulus associated with unconditioned stimulus appetitive or aversive UR unconditioned response CR conditioned response testing
8 Pavlovian (cued) fear conditioning test test baseline 1-3 cycles baseline test measured response - defensive behavior (freezing, vocalization, flight) - reflex potentiation (startle) - hypoalgesia - autonomic arousal (blood pressure, heart rate) - HPA axis stimulation
9 Cued and contextual fear conditioning tests test baseline test baseline 1-3 cycles Co-termination of and Variant: context discrimination context test
10 Trace fear conditioning tests test baseline test baseline 5+ cycles trace interval between and context test
11 Extinction of conditioned fear extinction test baseline repeated baseline 1-3 cycles test reappearance of CR after extinction: - recovery (with time) - reinstatement ( exposure) - renewal (new context) baseline repeated
12 Amygdala: cytoarchitecture and flow of information 90% 10% 100% 95% 5% ~ Glu GABA GABA GABA other Glu GABA La B I I CeL CeM BST Output to subcortical targets - La, B share cortex-like cytoarchitecture with majority of pyramidal projection neurons - Ce has striatum-like cytoarchitecture with majority of medium spiny projection neurons - Ce and BST (extended amygdala) are the principal output structures - Ce projections inhibits target neurons, BST output is mostly excitatory - overall information flow is from laterobasal complex to extended amygdala
13 -on and -off cells as a fear gate in the CeL off on La B I I CeL CeM BST Output to subcortical targets - -on cells in the CeL acquire positive response to with learning - -off cells in the CeL acquire negative response to with learning - cell-type specific plasticity in the CeL to CeM pathway may gate fear expression - conditioned fear responses are driven by activity of CeM output neurons Ciocchi S et al. Nature 468:277,2010
14 Amygdala: sensory and cortical inputs sensory thalamus sensory cortex hipp PL IL La B I I CeL CeM BST Output to subcortical targets - quick and dirty sensory input from thalamus - slower and more precise input from sensory cortex to basal and extended amygdala - multimodal and contextual input from hippocampus - bidirectional modulation by medial prefrontal cortex (IL, PL) - extinction signal mediated by IL prefrontal cortex via intercalated cells
15 Amygdala: output and prediction error signal PAG brainstem La B I I CeL CeM BST medial HT lateral - brainstem output controls behavioral responses (mainly PAG) HT - output to medial hypothalamus (PVN) controls hormonal response - output to lateral hypothalamus controls autonomic and behavioral responses - convergence of and prediction signals in periaqueductal gray - prediction error may be fed to LA and PL/IL via intralaminar/mediodorsal thalamus
16 Amygdala: output and prediction error signal IL & MD PL IL thalamus PAG brainstem La B I I CeL CeM BST medial HT lateral - brainstem output controls behavioral responses (mainly PAG) HT - output to medial hypothalamus (PVN) controls hormonal response - output to lateral hypothalamus controls autonomic and behavioral responses - convergence of and prediction signals in periaqueductal gray - prediction error may be fed to LA and PL/IL via intralaminar/mediodorsal thalamus
17 Rodent tests of anxiety-related responses openfield exploration elevated O-maze light/dark transition emergence test object exploration forced exploration exploration zone home zone free exploration with safe zone
18 Bidirectional control of anxiety through the BST La B I I CeL CeM BST brainstem medial HT - optogenetic stimulation (1) of GABAergic interneurons in the BST increases PM open arm time and decreases respiration rate - optogenetic stimulation (2) of basolateral input to BST decreases PM open arm time and increases respiration rate lateral HT Kim SY et al. Nature 496:219,2013
19 Bidirectional control of anxiety by the amygdala brainstem La B I I CeL CeM BST medial HT - optogenetic stimulation (1) or inhibition (3) of basolateral input to CeL decreases or increases anxiety, respectively - optogenetic stimulation (2) of basolateral output increases anxiety lateral HT Tye KM et al. Nature 471:358,2011
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