Neuroanatomy of Emotion, Fear, and Anxiety
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1 Neuroanatomy of Emotion, Fear, and Anxiety
2 Outline Neuroanatomy of emotion Critical conceptual, experimental design, and interpretation issues in neuroimaging research Fear and anxiety Neuroimaging research on anxiety Anxiety-related processes in healthy volunteers and patients Brain functional activation fmri Brain functional connectivity fmri Brain structural connectivity diffusion tensor imaging (DTI) Brain morphometry anatomical MRI Therapeutically communicating brain research to patients
3 What is Emotion?
4 Key Brain Areas for Emotion Dagleish (2004) Nat. Rev. Neurosci.
5 Key Brain Areas for Emotion
6 Neuroanatomy of Emotion Key Brain Areas and Their Affect-related Functions Orbitofrontal cortex: Affective evaluation; decoding punishment and reward value Dorsolateral PFC: Approach-related positive affect (left) Withdrawal-related negative affect; threatrelated vigilance (right) Insula: Representation of the body s internal state; interoception Amygdala: Vigilance for motivationally salient events; threat detection; emotional memory Hippocampus: Declarative memory; spatial navigation; contextual fear Anterior cingulate cortex (ACC): Top-down modulation; conflict detection Insula and ACC: Integration of sensory, affective, cognitive, and autonomic processing
7 Neuroanatomy of Emotion Key Brain Areas and Their Affect-related Functions Nucleus Accumbens: Reward processing; positive emotion; salience detection
8 DLPFC ACC Insula Thalamus Visual Cortex OFC Amygdala Hippocampus
9 Neuroimaging of Anxiety and Depression Critical Conceptual, Design, and Interpretation Issues Emotion perception emotion experience emotion production Conditions and stimuli must be appropriately matched (e.g., physical characteristics) Asymmetries can be concluded only on basis of appropriate statistical tests
10 Hariri et al. (2002) Science
11 Hariri et al. (2002) Science
12 Hariri et al. (2002) Science
13 Thomas et al. (2001) Arch. Gen, Psychiatry
14 Neuroimaging of Anxiety and Depression Critical Conceptual, Design, and Interpretation Issues Emotion perception emotion experience emotion production Conditions and stimuli must be appropriately matched (e.g., physical characteristics) Asymmetries can be concluded only on basis of appropriate statistical tests Go beyond merely documenting which brain areas show group differences in functional activation Associations with brain structural differences, brain connectivity, and behavior Develop a paradigm relevant to anxiety/depression symptoms Ground the paradigm in basic neuroscience research with healthy populations Replication
15 Imaging Research on Anxiety Disorders Summary Neural responses to anxiety-provoking stimuli (symptom provocation paradigms) Social (SAD) Phobogenic (specific phobia) Traumatic (PTSD) Obsessional (OCD) Panic-inducing (panic disorder) Worry (GAD) Neural responses to generic emotion stimuli Emotional faces IAPS slides
16 Imaging Research on Anxiety Disorders Summary Etkin & Wager (2007) Am. J. Psychiatry
17 Imaging Research on Anxiety Disorders Summary Neural responses to anxiety-provoking stimuli (symptom provocation paradigms) Social (SAD) Phobogenic (specific phobia) Traumatic (PTSD) Obsessional (OCD) Panic-inducing (panic disorder) Worry (GAD) Neural responses to generic emotion stimuli Emotional faces IAPS slides Does this get at heart of anxiety and what is debilitating about it?
18 What is Fear? What is Anxiety?
19 What is Anxiety? An emotional state characterized by anticipatory affective, cognitive, and behavioral changes in response to uncertainty about potential future threat Uncertainty and Anticipation Model of Anxiety (UAMA) Grupe & Nitschke (2013) Nature Rev. Neurosci
20 Uncertainty and Anticipation Model of Anxiety Five Key Psychological Processes A central feature of all anxiety disorders is aberrant and excessive anticipatory responding under conditions of threat uncertainty This model identifies five processes involved in adaptive responses to threat uncertainty that function maladaptively in anxiety 1. Inflated estimates of threat cost and probability 2. Increased threat attention and hypervigilance 3. Deficient safety learning 4. Behavioral and cognitive avoidance 5. Heightened reactivity to threat uncertainty Grupe & Nitschke (2013) Nature Rev. Neurosci.
21 Uncertainty and Anticipation Model of Anxiety Brain Circuitry of Five Key Psychological Processes Grupe & Nitschke (2013) Nature Rev. Neurosci.
22 Neuroanatomy of Anxiety Disorders Key Brain Areas Orbitofrontal cortex (OFC) Dorsolateral prefontal cortex (dlpfc) Ventromedial prefrontal cortex (vmpfc) Insula Anterior cingulate cortex (ACC) Amygdala Hippocampus
23 Neural Circuitry of Anticipating Aversion Anticipation of and Response to Aversive compared to Neutral Pictures Amygdala Anterior Cingulate Right Dorsolateral PFC Hippocampus Insula Orbitofrontal Cortex n = 21 Nitschke et al. (2006) NeuroImage
24 Group Differences in Amygdala GAD Patients Show Elevated Anticipatory Activity R n = 26 Nitschke et al. (2009) Am. J. Psychiatry
25 ACC Activity and Treatment Response Pretreatment Anticipatory ACC Activity Predicts Response to Effexor r = r = n = 14 Nitschke et al. (2009) Am. J. Psychiatry
26 Uncinate Fasciculus DTI-based Tractography
27 Group Differences in Uncinate Fasciculus GAD Patients Show Reduced Structural Connectivity n = 88 Tromp et al. (2012) Arch. Gen. Psychiatry
28 Uncinate Fasciculus Structural Connectivity Associations with Anticipatory Amygdala-ACC Functional Connectivity n = 88 Tromp et al. (2012) Arch. Gen. Psychiatry
29 Group Differences in Functional Connectivity GAD Patients Show Reduced ACC-Amygdala Negative Coupling n = 88 Tromp et al. (2012) Arch. Gen. Psychiatry
30 Neuroanatomy of Anxiety Disorders Conclusions Anxiety cannot be reduced to abnormalities in a single brain region or system Understanding the neuroanatomy of anxiety disorders and their treatment will come through research simultaneously examining multiple domains Genes, brain anatomy and physiology (morphology, volume, activation, structural and functional connectivity, chemistry), peripheral psychophysiology, behavior, interpersonal relations, environmental factors, cultural and socioeconomic influences Appreciate complexity of the brain and of anxiety disorders Are we on the right track in our current conceptualization and labeling of anxiety pathology? Careful not to be wowed by pretty pictures, even in Science, Nature, JAMA, and American Journal Be good consumers of neuroimaging research
31 Using Brain Research in Therapy What will be most helpful for patients? Amygdala and emotional salience Insula and emotional experience Emotion regulation regions and pathways VMPFC and its connections to the amygdala and insula Hippocampus Seat of learning and memory Neurogenesis
32 Using Brain Research in Therapy What will be most helpful for patients? Neural pathways that support dysfunctional thinking and behavior patterns Self-critical thinking, anger outbursts, anxiety Fear learning Classical and context conditioning, stimulus generalization Practice/repetition leads to strengthened neural connections Same mechanisms as in learning math, chess, or piano These neural connections will not go away and cannot be excised They are here for the rest of patient s life This is the bad news (but makes evolutionary sense) Anxiety and anger co-opted these evolutionarily preserved and often beneficial mechanisms But brain did provide for a way out neuroplasticity (tune in 2 wks from now) Traumatic experiences Neural connections supporting associations with trauma are here for the rest of patient s life
33
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