1. The cerebellum coordinates fine movement through interactions with the following motor-associated areas:

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Roderick Patrick
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1 DENT/OBHS Take-home test 4 Week 6: Take-home test (2/11/09 close 2/18/09) 1. The cerebellum coordinates fine movement through interactions with the following motor-associated areas: Hypothalamus Motor neurons Inferior olive and vestibular nuclei Area postrema 2. Motor-learning is associated with: Long-term depression of parallel fiber synapses Tonic activation of climbing fibers Long-term potentiation of interneuron firing Rearrangement of deep cerebellar nuclei 3. Damage to the supplementary motor cortex will MOST LIKELY result in: Apraxia Ataxia Ipsilateral paralysis Rigidity e) Chorea 4. You insert a stimulating electrode into the cortex. You focally stimulate a few cells locally and notice that the subject s finger twitches. You may be in: Layer IV of Brodman s area 3 Layer V of Brodman s area 4 Layer IV of Brodman s area 1 Layer IV of Brodman s area 4 e) Layer V of Brodman s area 1 5. Typical symptoms in adult onset Huntington's disease include all of the following EXCEPT: Chorea Personality changes Rest tremor Incoordination 1

2 Robin Lester DENT/OBHS Amyotrophic lateral sclerosis (ALS Lou Gehrig s disease) TYPICALLY involves cells of the spinal cord centered in the: Spinothalamic tracts Posterior columns Corticospinal tracts All of the above 7. Which of the following is NOT a cardinal symptom of Parkinson's disease? e) Bradykinesia Dystonia Resting tremor Gait instability Rigidity 8. A lesion of the nucleus marked by the asterisk COULD result in: e) Athetosis Hemiballismus Parkinson s disease Huntington s disease Hemiplegia 9. In your never-ending quest to destroy at least one of your course directors, you invent a poison that destroys only gamma-motor neurons. You put this on your course master s favorite candy bar and he eats them. You then check his muscle stretch reflexes by tapping on his patellar tendon. His reflexes MAY be: Normal Hyporeflexive Hyperreflexive 2

3 10. Neurons in the anterior part of the right superior colliculus code for: Small, rightward saccades. Small, leftward saccades. Large, rightward saccades. Large, leftward saccades. e) Leftward smooth pursuit movements. 11. A patient is admitted to the hospital with wild, involuntary flinging movements of the right arm and leg. Which of the following statements is most accurate regarding this patient? There is a lacunar stroke in the left subthalamic nucleus. There is a lacunar stroke in the right subthalamic nucleus. There is a hemorrhage in anterior limb of the left internal capsule. There is a hemorrhage in anterior one-third of the posterior limb of the left internal capsule. e) There is a hemorrhage in posterior one-third of the posterior limb of the right internal capsule. 12. In your never-ending quest to destroy your other course director, you invent a drug that destroys neurons whose cell bodies are found in the molecular layer of the cerebellar cortex. Thus, neurons will fire more and final cerebellar output from the deep cerebellar nuclei will be. Golgi cells; less Golgi cells; more Purkinje cells; less Purkinje cells; more 13. A patient has a stroke, which has left him profoundly uncoordinated (ataxi. His muscle strength is normal, and there are no upper or lower motor neuron signs. CT and MRI scans reveal that the cerebellum itself is completely normal morphologically. If you assume that the stroke produced a single focal lesion, what would be the MOST LIKELY location? Medulla, near floor of 4th ventricle Cervical cord, ventral horns Pontine reticular formation, near midline Midbrain, ventral to inferior colliculi, near midline 14. Which of the following is correctly matched with its neurotransmitter? Substantia nigra pars compacta and neuromelanin Purkinje cells and serotonin VA and VL thalamic nuclei and GABA Locus coeruleus and epinephrine e) Striatal interneurons and acetylcholine 3

4 15. Long term depression in the cerebellum is THOUGHT to require which of the following: Simultaneous activation of climbing fiber and Golgi fibers onto the Purkinje cells Activation of mglur in the granule cell Internalization of AMPA receptors on the Purkinje cell Complex spikes in the climbing fibers 16. Which statement regarding the cerebellum is CORRECT? The archicerebellum projects to the dentate nucleus The spinocerebellum is the origin of the cerebellospinal tract A lesion in the left cerebrocerebellum will cause left sided ataxia The fastigial nucleus is part of the interposed nuclear complex. 17. Which of the following signs and symptoms would NOT be detected after degeneration of the cerebellum? Resting tremor Hypotonia Dysmetria Impaired check reflex 18. The rostral interstitial nucleus of the MLF is important for: The VOR Eye Abduction Vertical eye movements Horizontal eye movements 19. A rightward angular acceleration (rotation or yaw) of the head about the central vertical axis would result in: Depolarization of the hair cells in the right posterior semicircular duct. Depolarization of the hair cells in the left horizontal semicircular duct. Hyperpolarization of the hair cells in the right semicircular duct Hyperpolarization of the hair cell sin the left semicircular duct. e) Increase in firing in the neurons in the left Scarpa s ganglion. 20. For which of the following eye movements is the ascending medial longitudinal fasciculus (MLF) NOT an essential component: VOR OKN Smooth pursuit Saccades e) Vergence 4

5 21. For conjugate eye movements, damage to the left ascending medial longitudinal fasciculus (MLF) would result in reduced: Adduction of the right eye beyond the midline. Adduction of the left eye beyond the midline. Abduction of the right eye beyond the midline. Abduction of the left eye beyond the midline. e) Adduction of the right and left eye beyond the midline. 5

Cerebellum. Steven McLoon Department of Neuroscience University of Minnesota

Cerebellum. Steven McLoon Department of Neuroscience University of Minnesota Cerebellum Steven McLoon Department of Neuroscience University of Minnesota 1 Anatomy of the Cerebellum The cerebellum has approximately half of all the neurons in the central nervous system. The cerebellum