Table S5. Disease pairs that have a significant comorbidity and are connected in either KEGG or BiGG database

Transcription

1 Table S5. Disease pairs that have a significant comorbidity and are connected in either KEGG or BiGG database Coincide nce Expected coincidence Maximum possible comorbidity Disease1 Disease2 Link(KEGG) Link(BiGG) Comorbidity COPD, rate of decline of lung function in, Emphysema Connected Disconnected E Connected Disconnected E Hemolytic anemia Spherocytosis, hereditary Disconnected Connected E Diabetes mellitus, gestational, Obesity, adrenal insufficiency, and red hair Connected Connected E Coronary spasms, susceptibility to Connected Connected E Cone dystrophy-1, Leber congenital amaurosis I, Connected Connected E E Leber congenital amaurosis I, Retinal cone dystrophy 3, Connected Connected E E Hemosiderosis, systemic, due to aceruloplasminemia, Hyperthyroidism, congenital Anxiety-related personality traits, HARP syndrome, Iron deficiency anemia, susceptibility to Connected Disconnected E Total iodide organification defect, Connected Connected E Obsessive-compulsive disorder 1, Disconnected Connected E Obesity, adrenal insufficiency, and red hair Connected Disconnected E Apparent mineralocorticoid excess, hypertension due to Connected Disconnected E Diabetes mellitus, gestational, HARP syndrome, Connected Disconnected E Glaucoma 1, open angle, E, Connected Disconnected E Warfarin resistance, Connected Disconnected E Endometrial carcinoma Ovarian cancer Connected Connected E Gallbladder disease 1, Cholestasis, benign recurrent intrahepatic, Disconnected Connected E Diabetes mellitus, gestational, Connected Disconnected E Parkinson disease 13, Schizoaffective disorder, susceptibility to, Connected Disconnected E

2 Crigler-Najjar syndrome, type I, Hyperbilirubinemia, familial transcient neonatal, Connected Disconnected E Gilbert syndrome, Glutathione synthetase deficiency, Hyperbilirubinemia, familial transcient neonatal, Connected Disconnected E Myocardial infarcation, susceptibility to Connected Connected E encephalomyopathy syndrome, Connected Disconnected E Lhermitte-Duclos syndrome Oligodendroglioma, Connected Connected E Hemolytic anemia Connected Disconnected E Alcoholism, susceptibility to, Epilepsy with grand mal seizures on awakening, Connected Connected E Goiter, congenital Hyperthyroidism, congenital Connected Connected E susceptibility to, Goiter, congenital Total iodide organification defect, Connected Disconnected E Total iodide organification defect, Connected Connected E encephalomyopathy syndrome, Nucleoside phosphorylase deficiency, immunodeficiency due to Connected Disconnected E Achondrogenesis Ib, Deafness, X-linked 1, progressive Disconnected Connected E Diabetes mellitus, gestational, Hyperinsulinemic hypoglycemia, familial, 3, Connected Connected E Warfarin resistance, Connected Disconnected E HDL deficiency, familial, Disconnected Connected E Enolase-beta deficiency Myopathy due to CPT II deficiency, Connected Connected E Norum disease, Disconnected Connected E to CMO I deficiency, Connected Connected E Glaucoma 1, open angle, E, Connected Disconnected E Agammaglobulinemia, COPD, rate of decline of lung function in, Connected Disconnected E Favism Hemolytic anemia Connected Connected E

3 Paraganglioma, familial chromaffin, 4, Pheochromocytoma, Connected Connected E Myelodysplasia syndrome-1 Myelogenous leukemia, acute Connected Disconnected E Immunodeficiency due to defect in CD3-epsilon Connected Disconnected E Asthma, Atopy, Connected Connected E Vitamin D-dependent rickets, type I, Warfarin resistance, Connected Disconnected E Tangier disease, Disconnected Connected E Diabetes mellitus, gestational, Sucrase-isomaltase deficiency, congenital, Disconnected Connected E Connected Disconnected E to Connected Connected E Gallbladder disease 1, Colon adenocarcinoma Disconnected Connected E Leber congenital amaurosis I, Retinitis pigmentosa 35, Connected Connected E Alcoholism, susceptibility to, Alcohol intolerance, acute Connected Disconnected E Exertional myoglobinuria due to Cystathioninuria, deficiency of LDH-A Connected Disconnected E Exertional myoglobinuria due to deficiency of LDH-A Homocysteine, total plasma, elevated Connected Disconnected E Meningioma, Oligodendroglioma, Connected Connected E Warfarin resistance, Connected Disconnected E Gallbladder disease 1, Norum disease, Disconnected Connected E beta-hydroxysteroid dehydrogenase, type II, deficiency Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency, Cortisone reductase deficiency, to CMO I deficiency, Connected Disconnected E to CMO I deficiency, Connected Connected E to CMO I deficiency, Connected Disconnected E Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency to CMO I deficiency, Connected Disconnected E Alcoholism, susceptibility to, Fructose intolerance Connected Disconnected E Schizoaffective disorder, Alcoholism, susceptibility to, susceptibility to, Connected Disconnected E Diabetes mellitus, gestational, Sulfite oxidase deficiency, Connected Disconnected E

4 Glucose/galactose malabsorption, Hypothyroidism, autoimmune, Disconnected Connected E Hypothyroidism, autoimmune, Pendred syndrome, Disconnected Connected E Asthma, Atherosclerosis, susceptibility to Connected Connected E Cholestasis, benign recurrent Bile acid malabsorption, primary intrahepatic, Disconnected Connected E Agammaglobulinemia, Emphysema Connected Disconnected E Lung cancer, Warfarin resistance, Connected Disconnected E Deafness, X-linked 1, progressive Hypothyroidism, autoimmune, Disconnected Connected E Glutathione synthetase deficiency, Hemolytic anemia Connected Connected E susceptibility to, Hyperthyroidism, congenital Connected Disconnected E Hyperammonemia with hypoornithinemia, hypocitrullinemia, hypoargininemia, and hypoprolinemia Hyperprolinemia, type I, Connected Connected E Colon adenocarcinoma Ovarian cancer Connected Connected E Diabetes mellitus, gestational, Hemolytic anemia Connected Connected E Orthostatic intolerance, Disconnected Connected E Colon adenocarcinoma Cowden disease, Connected Connected E Charcot-Marie-Tooth disease, axonal, type 2F, Neuropathy, congenital hypomyelinating, 1, Connected Disconnected E Ossification of posterior longitudinal ligament of spine, Connected Disconnected E Hyperoxaluria, primary, type 1, Lactate dehydrogenase-b deficiency Disconnected Connected E Citrullinemia, beta-hydroxysteroid dehydrogenase, type II, deficiency Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency, Epilepsy with grand mal seizures on awakening, Disconnected Connected E Connected Disconnected E Connected Connected E Cortisone reductase deficiency, Connected Disconnected E Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency Connected Disconnected E HDL deficiency, familial, Norum disease, Disconnected Connected E

5 Hemosiderosis, systemic, due to aceruloplasminemia, Protoporphyria, erythropoietic Connected Disconnected E Nucleoside phosphorylase deficiency, immunodeficiency due to Connected Disconnected E Cerebellar ataxia, Iron deficiency anemia, susceptibility to Connected Disconnected E Galactosialidosis Sialic acid storage disorder, infantile, Disconnected Connected E Crohn disease, ileal, protection against, Rheumatoid arthritis, progression of, Disconnected Connected E Malonyl-CoA decarboxylase deficiency, Propionicacidemia, Disconnected Connected E Combined hyperlipidemia, familial, Hepatic lipase deficiency Connected Disconnected E Diabetes mellitus, gestational, Apparent mineralocorticoid excess, hypertension due to Apparent mineralocorticoid excess, hypertension due to Neurodegeneration, pantothenate kinase-associated, Connected Disconnected E Severe combined immunodeficiency due to ADA deficiency, Connected Disconnected E Connected Connected E to Connected Disconnected E Aromatic L-amino acid decarboxylase deficiency, Asthma, Connected Disconnected E Leukemia, Philadelphia chromosomepositive, resistant to imatinib Vitamin D-dependent rickets, type I, Connected Disconnected E Glaucoma 1, open angle, E, Warfarin resistance, Connected Disconnected E susceptibility to, Citrullinemia, Connected Connected E susceptibility to, Hyperornithinemiahyperammonemia-homocitrullinemia syndrome, Disconnected Connected E HDL deficiency, familial, Tangier disease, Disconnected Connected E Lipoprotein lipase deficiency, Hepatic lipase deficiency Connected Disconnected E HPRT-related gout, encephalomyopathy syndrome, Connected Disconnected E Connected Disconnected E

6 Cerebellar ataxia, Hemosiderosis, systemic, due to aceruloplasminemia, Connected Disconnected E Norum disease, Tangier disease, Disconnected Connected E Allan-Herndon-Dudley syndrome, Total iodide organification defect, Disconnected Connected E Breast and colorectal cancer, susceptibility to Oligodendroglioma, Connected Connected E Down syndrome, susceptibility to, Neural tube defects, Connected Connected E Lipoprotein lipase deficiency, Combined hyperlipidemia, familial, Connected Connected E Proguanil poor metabolizer Warfarin resistance, Connected Connected E Immunodeficiency due to defect in CD3- epsilon encephalomyopathy syndrome, Connected Disconnected E Cholestasis, benign recurrent intrahepatic, Colon adenocarcinoma Disconnected Connected E Lung cancer, Connected Connected E Lhermitte-Duclos syndrome Meningioma, Connected Connected E Cystathioninuria, Thrombophilia due to HRG deficiency Connected Connected E Homocysteine, total plasma, elevated Thrombophilia due to HRG deficiency Connected Connected E Homocystinuria due to MTHFR deficiency, Thrombophilia due to HRG deficiency Connected Connected E Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase Thrombophilia due to HRG deficiency Connected Connected E Alpha-methylacetoacetic aciduria, Fatty liver, acute, of pregnancy Connected Connected E Fabry disease, Krabbe disease, Disconnected Connected E Fabry disease, Metachromatic leukodystrophy due to deficiency of SAP-1, Disconnected Connected E Gaucher disease, atypical, Krabbe disease, Disconnected Connected E Cholesteryl ester storage disease Hepatic lipase deficiency Connected Disconnected E Wolman disease Hepatic lipase deficiency Connected Disconnected E Connected Disconnected E Hemolytic anemia Myopathy due to CPT II deficiency, Connected Connected E HMG-CoA lyase deficiency Succinyl CoA:3-oxoacid CoA transferase deficiency, Disconnected Connected E

7 Agammaglobulinemia, Argininemia, Hemorrhagic diathesis due to \`antithrombin\' Pittsburgh Connected Disconnected E Hypothyroidism, autoimmune, Disconnected Connected E Elliptocytosis, Malaysian-Melanesian type Hemolytic anemia Disconnected Connected E COPD, rate of decline of lung function in, Hemorrhagic diathesis due to \`antithrombin\' Pittsburgh Connected Disconnected E Retinitis pigmentosa 35, Cerebral infarction, susceptibility to, Connected Disconnected E Biotinidase deficiency, Hyperornithinemiahyperammonemia-homocitrullinemia syndrome, Disconnected Connected E Cholestasis, benign recurrent intrahepatic, Norum disease, Disconnected Connected E Adenosine deaminase deficiency, partial, Connected Disconnected E G6PD deficiency Hyperinsulinemic hypoglycemia, familial, 3, Connected Disconnected E encephalomyopathy syndrome, Severe combined immunodeficiency due to ADA deficiency, Connected Disconnected E Diabetes mellitus, gestational, Favism Connected Disconnected E Hypercalciuria, absorptive, susceptibility Cerebral infarction, susceptibility to, to, Connected Connected E Iron deficiency anemia, susceptibility to Protoporphyria, erythropoietic Connected Disconnected E Hyperbilirubinemia, familial transcient neonatal, Mucopolysaccharidosis II Connected Disconnected E Glaucoma 1, open angle, E, Peters anomaly, Connected Connected E Apparent mineralocorticoid excess, hypertension due to to CMO I deficiency, Connected Disconnected E Fatty liver, acute, of pregnancy Isovaleric acidemia, Connected Disconnected E Fatty liver, acute, of pregnancy Segawa syndrome, recessive Cystinuria, Homozygous 2p16 deletion syndrome, Asthma, Succinyl CoA:3-oxoacid CoA transferase deficiency, Disconnected Connected E Unipolar depression, susceptibility to, Disconnected Connected E Sucrase-isomaltase deficiency, congenital, Disconnected Connected E Sucrase-isomaltase deficiency, congenital, Disconnected Connected E Platelet disorder, familial, with associated myeloid malignancy, Connected Connected E

8 Acromesomelic dysplasia, Hunter- Thompson type, Hypercalciuria, absorptive, susceptibility to, Connected Disconnected E Hypophosphatasia, childhood, Phenylketonuria Connected Disconnected E Breast and colorectal cancer, susceptibility to Meningioma, Connected Connected E Obesity, adrenal insufficiency, and red hair Sulfite oxidase deficiency, Connected Disconnected E Alcoholism, susceptibility to, Aldolase A deficiency Connected Disconnected E Statins, attenuated cholesterol HMG-CoA lyase deficiency lowering by Connected Connected E Alpha-methylacetoacetic aciduria, Succinyl CoA:3-oxoacid CoA transferase deficiency, Disconnected Connected E Alcoholism, susceptibility to, Sjogren-Larsson syndrome, Connected Connected E Cowden disease, Ovarian cancer Connected Connected E Leiomyomatosis and renal cell cancer, Multiple cutaneous and uterine leiomyomata, Connected Connected E Enolase-beta deficiency Pyruvate carboxylase deficiency, Connected Disconnected E Aromatase deficiency Warfarin resistance, Connected Disconnected E Deafness, X-linked 1, progressive Enlarged vestibular aqueduct, Disconnected Connected E Glaucoma 1, open angle, E, Connected Disconnected E Glycogen storage disease I Hemolytic anemia Connected Disconnected E Achondrogenesis Ib, Pendred syndrome, Disconnected Connected E Aldolase A deficiency 3-beta-hydroxysteroid dehydrogenase, type II, deficiency Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency, Adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency, Cortisone reductase deficiency, Cortisone reductase deficiency, Epilepsy with grand mal seizures on awakening, Connected Connected E to Connected Disconnected E Connected Disconnected E to Connected Connected E Connected Connected E to Connected Disconnected E Hyperandrogenism, nonclassic type, due to 21-hydroxylase deficiency to Connected Disconnected E Hemolytic anemia Sucrase-isomaltase deficiency, Connected Disconnected E

9 congenital, Amish infantile epilepsy syndrome, GM1-gangliosidosis Connected Disconnected E Isovaleric acidemia, Maple syrup urine disease, type II, Disconnected Connected E Hemolytic anemia Myocardial infarcation, susceptibility to Connected Connected E Fabry disease, Hemolytic anemia Connected Disconnected E Leukemia, Philadelphia chromosomepositive, resistant to imatinib Warfarin resistance, Connected Disconnected E Thiamine-responsive megaloblastic anemia syndrome, Basal ganglia disease, adult-onset, Disconnected Connected E susceptibility to, Goiter, congenital Connected Disconnected E Fabry disease, Sucrase-isomaltase deficiency, congenital, Connected Disconnected E Fructose-bisphosphatase deficiency Wernicke-Korsakoff syndrome, susceptibility to, Connected Disconnected E Fructose intolerance Wernicke-Korsakoff syndrome, susceptibility to, Connected Disconnected E Fabry disease, Glycogen storage disease I Connected Disconnected E Galactosialidosis Gaucher disease, atypical, Disconnected Connected E Mental retardation syndrome, X-linked, Cabezas type, Myelogenous leukemia, acute Connected Disconnected E Peters anomaly, Connected Disconnected E Ornithine transcarbamylase deficiency, Coronary spasms, susceptibility to Connected Disconnected E Breast and colorectal cancer, susceptibility to Ovarian cancer Connected Connected E