Expanded Programme on Immunization (EPI)
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1 Bhutan 2017 Expanded Programme on Immunization (EPI) FACT SHEET
2 Acronyms AD Auto disable MCV1 First dose measles containing vaccine AEFI Adverse events following immunization MCV2 Second dose measles containing vaccine AFP Acute flaccid paralysis MICS Multiple indicator cluster survey BCG Bacillus Calmette-Guérin vaccine MMR Measles mumps rubella vaccine CES Coverage evaluation survey MNT Maternal and neonatal tetanus cmyp Comprehensive multi-year plan MR Measles rubella vaccine CRS Congenital rubella syndrome NCIP National committee on immunization practices DHS Demographic health survey NID National immunization day DT Diphtheria tetanus toxoid, pediatric NTAGI National technical advisory group on immunization DTP Diphtheria tetanus pertussis vaccine NPEV Non-polio enterovirus DTP-Hib-HepB Pentavalent vaccine NT Neonatal tetanus DTP-Hib-HepB3 3rd dose pentavalent vaccine OPV Oral poliovirus vaccine EPI Expanded programme on immunization bopv Bivalent OPV GDP Gross domestic product topv Trivalent OPV HCW Health care worker PCV Pneumococcal conjugate vaccine HepB Hepatitis B vaccine SEAR WHO South-East Asia Region Hib Haemophilus influenzae type b SIA Supplementary immunization activities HPV Human papilloma virus SNID Subnational immunization day IgM Immunoglobulin M Td Tetanus diphtheria toxoid; older children, adults IPV Inactivated poliovirus vaccine TT Tetanus toxoid JE Japanese encephalitis TT2+ 2 or more doses TT JE_Live-Atd JE live attenuated vaccine VDPV Vaccine derived poliovirus JRF WHO UNICEF joint reporting form VPD Vaccine preventable diseases LB Live birth WCBA Women of child bearing age M Measles WPV Wild poliovirus
3 Contents Impact of routine immunization EPI history 5 Basic information 2016 Table 1 5 Immunization schedule 2016 Table 2 5 National immunization coverage Figure 1 6 Immunization system highlights Table 3 6 DTP3 coverage, diphtheria and pertussis cases Figure 2 7 Reported cases of vaccine preventable diseases Table 4 7 DTP-Hib-HepB3 coverage by district 2015 Figure 3 7 DTP-Hib-HepB3 coverage by district 2016 Figure 4 7 Maternal and neonatal tetanus elimination is sustained TT2+ coverage and NT cases Figure 5 8 Polio-free status is maintained Page No. Page No. Page No. AFP surveillance indicators Table 5 9 Non-polio AFP rate by district 2015 Figure 6 9 Non-polio AFP rate by district 2016 Figure 7 9 Adequate stool specimen collection percentage by district 2015 Figure 8 10 Adequate stool specimen collection percentage by district 2016 Figure 9 10 OPV supplementary immunization activities Table 6 10 Towards measles elimination and rubella/congenital rubella syndrome control Page No. MCV1 and MCV2 coverage, measles and rubella cases, Figure MCV supplementary immunization activities Table 7 11 MCV1 coverage by district 2015 Figure MCV1 coverage by district 2016 Figure MCV2 coverage by district 2015 Figure MCV1 coverage by district 2016 Figure Immunity against measles immunity profile by age in 2016 Figure Subnational risk assessment for measles and rubella Figure Sporadic and outbreak associated measles cases by month Figure Immunization status of confirmed (laboratory and Epi linked) measles outbreak associated cases by age Figure Quality of field and laboratory surveillance for measles and rubella Table 8 14 Performance of laboratory surveillance Table 9 14 WHO supported laboratory network for VPD surveillance Figure 19 15
4 WHO South-East Asia Region Bhutan: district level map Disclaimer: The boundaries and names shown and the designations used on all the maps do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area of its authorities, or concerning the delimitation of its frontiers or boundaries. 4
5 Impact of routine immunization Table 1: Basic information EPI history EPI launched on 15 November 1979 TT for pregnant women introduced in 1983 HepB vaccine introduced in 1997 DTP-HepB vaccine introduced in 2003 AD syringes introduced in 2003 MR vaccine introduced in 2006 DTP-Hib-HepB vaccine introduced in 2009 HPV vaccine introduced in 2010 HepB birth dose introduced in 2012 TT vaccine replaced by Td vaccine in 2012 IPV vaccine introduced in 2015 topv to bopv switched on 25 April 2016 MMR vaccine introduced in October Source: cmyp and VPDP/MOH Total population 757,042 Live births 12,869 Children <1 year 11,227 Children <5 years 82,561 Children <15 years 229,796 Pregnant women 11,680 WCBA (15-49 years) 186,509 Neonatal mortality rate 18.3 (per 1,000 LB) Infant mortality rate (per 1,000 LB) Under-five mortality rate 32.9 (per 1,000 LB) Maternal mortality ratio (per 100,000 LB) 1 SEAR annual EPI reporting form, 2016 and WHO, World Health Statistics VPDP/MOH Table 2: Immunization schedule, 2016 Vaccine Age of administration BCG Birth HepB Birth OPV Birth, 6 weeks, 10 weeks and 14 weeks DTP-Hib-HepB 6 weeks, 10 weeks and 14 weeks IPV 14 weeks MMR 9 months and 24 months DTP 24 months HPV Females 12 years and grade VI girls Td 6 and 12 years Vitamin A 6 to 30 months (6 months interval) Source: WHO/UNICEF JRF,, Division/Province/State/Region - Dzongkhag/District 20 Gewog/Block 205 Sub-block/Ward 1,050 Village (approx.) 3,717 Population density (per sq. km) 18 Population living in urban areas 37% Population using improved drinkingwater sources % Population using improved sanitation % Total expenditure on health as % of GDP 3.6% Births attended by skilled health 74.6% personnel 2 Neonates protected at birth against NT 83%
6 Figure 1: National immunization coverage, % Coverage BCG DTP OPV MCV Source: WHO/UNICEF estimates of national immunization coverage, July 2017 revision Table 3: Immunization system highlights cmyp for immunization NTAGI fully functional Spending on vaccines financed by the government 41% Spending on routine immunization programme financed by the government 24% Updated micro-plans that include activities to improve immunization coverage 20 districts (100%) National policy for health care waste management including waste from immunization activities National system to monitor AEFI in place in place Most recent EPI CES National Health Survey 2012 >80% coverage for DTP-Hib-HepB3 20 districts (100%) >90% coverage for MCV1 16 districts (80%) >10% drop-out rate for DTP-Hib-HepB1 to DTP-Hib-HepB3 1 district (5%) Source: WHO/UNICEF JRF,
7 Figure 2: DTP3 coverage 1, diphtheria and pertussis cases 2, DTP-Hib-HepB3 coverage by district Figure 3: No. of cases % Coverage Source: SEAR annual EPI reporting form, 2015 (administrative data) Year Diphtheria Cases Pertussis Cases DTP3 Coverage 1 WHO/UNICEF estimates of national immunization coverage, July 2017 revision 2 WHO vaccine-preventable diseases: monitoring system 2016 Figure 4: 2016 Table 4: Reported cases of vaccine preventable diseases, Year Polio Diphtheria Pertussis NT (% of all tetanus) Measles Rubella Mumps JE CRS ND Source: SEAR annual EPI reporting form, 2016 (administrative data) Source: WHO/UNICEF JRF, (multiple years) ND=No data <70% 70% - 79% 80% - 89% > 90% 7
8 Maternal and neonatal tetanus elimination is sustained Figure 5: TT2+ coverage 1 and NT cases 2, MNT elimination before 2000 No. of cases No data Year % Coverage NT Cases TT2+ Coverage 1 WHO/UNICEF JRF, Country official estimates, WHO vaccine-preventable diseases: monitoring system
9 Polio-free status is maintained Table 5: AFP surveillance performance indicators, Last clinically-confirmed polio case was reported in Indicator AFP cases Wild poliovirus confirmed cases Compatible cases Non-polio AFP rate Adequate stool specimen collection percentage 2 83% 70% 80% 73% 67% 73% Total stool samples collected % NPEV isolation % Timeliness of primary result reported Number of discarded AFP cases per 100,000 children under 15 years of age. 2 Percent with 2 specimens, at least 24 hours apart and within 14 days of paralysis onset. 3 Results reported within 14 days of sample received at laboratory. Non-polio AFP rate by district Figure 6: 2015 Figure 7: 2016 WHO/Bhutan/S Bahadur < >2 No non-polio AFP case 9
10 Adequate stool specimen collection % by district Figure 8: 2015 Figure 9: 2016 <60% 60% - 79% >80% No AFP Table 6: OPV SIAs Year Vaccine Geographic coverage Target age Target population Coverage (%) Round 1 Round 2 Round 1 Round OPV NID <5 years 80, OPV SNID <5 years 37, OPV SNID <5 years 37, OPV SNID <5 years 36, OPV SNID <5 years 36, OPV SNID <5 years 38, OPV SNID <5 years 36, OPV SNID <5 years 37, Source: WHO/UNICEF JRF, (multiple years) 10
11 Towards measles elimination and rubella/crs control Figure 10: MCV1 and MCV2 coverage 1, measles and rubella cases 2, Table 7: MCV SIAs Year Antigen Geographic coverage Target group Target Coverage % M nationwide 9 months to 15 years 69, % No. of cases % Coverage 2000 M nationwide 2006 MR nationwide 9 months to 15 years 9 months to 14 years children and 15 years to 44 years women 214, % 338,040 98% Year Measles Cases Rubella MCV1 Coverage MCV2 Coverage 2016 MR subnational % Source: WHO/UNICEF (multiple years) 1 WHO/UNICEF estimates of national immunization coverage, July 2017 revision 2 WHO vaccine-preventable diseases: monitoring system
12 MCV1 coverage by district MCV2 coverage by district Figure 11: 2015 Figure 12: 2016 Figure 13: 2015 Figure 14: 2016 Source: SEAR annual EPI reporting form, 2015 (administrative data) Source: SEAR annual EPI reporting form, 2016 (administrative data) Source: SEAR annual EPI reporting form, 2015 (administrative data) Source: SEAR annual EPI reporting form, 2016 (administrative data) <80% 80% - 89% 90% - 94% >95% Figure 15: Immunity against measles - immunity profile by age in 2016 Figure 16: Sub-national risk assessment - measles and rubella Percent of population 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% Age (in years) Protected by maternal antibodies Protected by routine vaccination with 1st dose Protected by routine vaccination with 2nd dose Protected by SIAs Immune due to past infection Susceptible * Modeled using MSP tool ver 2 assuming the schedule and MCV coverage remain unchanged and no SIAs between 2009 & Very high risk High risk Medium risk Low risk Not available Source: developed using WHO risk assessment tool based on JRF & ARF data base
13 Figure 17: Sporadic and outbreak associated measles cases* by month Sporadic measles Outbreak associated measles an-11 ar-11 ay-11 ul-11 ep-11 ov-11 an-12 ar-12 ay-12 ul-12 ep-12 ov-12 an-13 *Includes laboratory confirmed and epidemiologically linked cases Source: SEAR Monthly VPD reports. ar-13 Figure 18: Immunization status of confirmed (laboratory and EPI linked) measles outbreak associated cases, by age, ay-13 ul-13 ep-13 ov-13 an-14 ar-14 ay-14 ul-14 ep-14 ov-14 an-15 ar-15 ay-15 ul-15 ep-15 ov-15 an-16 ar-16 ay-16 ul-16 ep-16 ov WHO/Bhutan/S Bahadur 2 0 < 1 year 1-4 years 5-9 years years > 15 years < 1 year 1-4 years 5-9 years years > 15 years < 1 year 1-4 years 5-9 years years > 15 years < 1 year 1-4 years 5-9 years years > 15 years < 1 year 1-4 years 5-9 years years > 15 years < 1 year 1-4 years 5-9 years years > 15 years Immunized Not immunized/ Unknown Source: SEAR annual EPI reporting form ( ) 13
14 Table 8: Surveillance performance indicators for measles and rubella, Case classification (number) Indicators Year No. of suspected measles Lab-confirmed Measles EPI-linked Clinically-confirmed Lab-confirmed Rubella EPI-linked Discarded non-measles non-rubella cases Annual incidence of confirmed measles cases per million total population Annual incidence of confirmed rubella cases per million total population Proportion of all suspected measles and rubella cases that have had an adequate investigation initiated within 48 hours of notification Discarded non-measles non-rubella incidence per 100,000 total population Proportion of districts reporting at least two discarded non-measles non-rubella cases per 100,000 total population Proportion of sub-national surveillance units reporting to the national level on time Target % 2 80% 80% ND ND ND ND ND ND ND ND 3 ND ND 14 ND ND Source: SEAR annual EPI reporting form, ND=No data Table 9: Performance of laboratory surveillance, Year Serum specimen collected from suspected measles cases Serum specimen received in laboratory within 5 days of collection Specimen positive for measles IgM Specimen positive for rubella IgM % Results within 4 days of receipt % Positive cases tested for viral detection No (%) No (%) No. % No. % Measles Rubella (100) 50 (81) 1 1% 2 2% (100) 57 (69) 0 0% 6 6% (100) 30 (43) 0 0% 4 6% (100) 120 (100) 11 9% 1 1% (100) 146 (100) 40 27% 3 2% ND ND ND ND Source: SEAR annual EPI reporting form, ND=No data Genotypes detected 14
15 Figure 19: WHO supported laboratory network for VPD surveillance Public Health Laboratory National measles/rubella laboratory National Japanese encephalitis laboratory 15
16 For contact or feedback: Expanded Programme on Immunization Ministry of Health, Thimphu, Bhutan Tel: , Fax: Immunization and Vaccine Development (IVD) WHO-SEARO, IP Estate, MG Marg, New Delhi , India Tel: , Fax:
Expanded Programme on Immunization (EPI)
Timor-Leste 217 Expanded Programme on Immunization (EPI) FACT SHEET Acronyms AD Auto disable MCV1 First dose measles containing vaccine AEFI Adverse events following immunization MCV2 Second dose measles
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More informationTable 1: Basic information Total population 25,030, (per 100,000 LB) Division/Province/State/Region 11. District 210
EPI history EPI launched in 980 HepB vaccine introduced in 003 AD syringes introduced in 003 HepB birth dose introduced in 004 DTP-HepB vaccine introduced in 006 MCV introduced in 008 DTP-Hib-HepB vaccine
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EPI history EPI launched in 978 OPV and MCV introduced in 987 AD syringes introduced in 00 HepB vaccine introduced in 003 MCV introduced partially in 008 and made available nationwide in 0 DTP-Hib-HepB
More informationTable 1: Basic information (per 1,000 LB) 42.4 (per 1,000 LB) 49.7 (per 1,000 LB) 215 (per 100,000 LB)
EPI history EPI started in 978 EPI re-structured in March 000 DTP-HepB vaccine introduced in 007 DTP-Hib-HepB)vaccine introduced in 0 MR vaccine introduced in Feb 06 Second dose of MR introduced in Feb
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