Cochrane Library via Wiley 14 february 2013 (CDSR, DARE & CENTRAL) Erythropoietin

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1 Bilaga 1 Sökstrategi Cochrane Library via Wiley 14 february 2013 (CDSR, DARE & CENTRAL) Erythropoietin Search terms Items found Population: cancer induced anemia or anemia associated with kidney disorders 1. Neoplasms[MeSH] Medical Oncology[MeSH] "Kidney Failure, Chronic"[Mesh] "Renal Insufficiency"[Mesh] OR 2 OR 3 OR Anemia[MeSH] AND ((Anemia OR anaemia) AND ("Kidney failure" OR "Renal disease" OR chemotherapy OR cancer OR oncology OR tumour* OR kidney OR renal)):ti 9. 7 OR Intervention: erythropoietin 10. "Erythropoietin"[MeSH:NoExp] (Erythropoietin OR Epoetin OR Eprex OR "recombinant human EPO" OR r-huepo OR rhuepo OR "erythropoiesis-stimulating agent" OR "erythropoiesis-stimulating agents"):ti OR Outcome: anti-drug antibodies, hemoglobin, pure red cell aplasia etc 13. "Antibodies, Blocking"[Mesh] "Antibodies"[Mesh] "Antibodies, Neutralizing"[Mesh] "Therapeutic Equivalency"[MeSH Terms] "red-cell aplasia, pure"[mesh Terms] 18. Hemoglobins[MeSH:NoExp] Blood Transfusion[MeSH:NoExp] Erythrocyte Transfusion[MeSH] "anti-drug antibody" OR "anti-drug antibodies" OR "anti-epo antibody" OR "anti-epo antibodies" OR "anti erythropoietin antibody" OR "anti erythropoietin antibodies" OR "Antiepoetin antibody" OR "Antiepoetin antibodies" OR "anti-epo neutralizing antibody" OR "anti-epo neutralizing antibodies" OR "Neutralizing antibodies" OR "neutralizing antibody" OR "immune reaction" OR "immune reactions" OR Immunologic* OR Allergic* OR haemoglobin OR "haematopoietic response" OR "hematopoetic respons" OR transfusion* OR "hematological response" OR "Haematological response" OR Haemoglobin OR Hemoglobin OR "Hb level" OR "Hb levels" OR "Hb concentration" OR "Hb concentrations" OR "red cell aplasia" OR PRCA OR 14 OR 15 OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 Combined sets AND 12 AND 22 CDSR/8 DARE/14 ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 1

2 Central/36 2 HTA/1 The search result, usually found at the end of the documentation, forms the list of abstracts [AU] = Author [MAJR] = MeSH Major Topic [MeSH] = Term from the Medline controlled vocabulary, including terms found below this term in the MeSH hierarchy [MeSH:NoExp] = Does not include terms found below this term in the MeSH hierarchy Systematic[SB] = Filter for retrieving systematic reviews [TI] = Title [TIAB] = Title or abstract [TW] = Text Word * = Truncation = Citation Marks; searches for an exact phrase CDSR = Cochrane Database of Systematic Review CENTRAL = Cochrane Central Register of Controlled Trials, trials CRM = Method Studies DARE = Database Abstracts of Reviews of Effects, other reviews EED = Economic Evaluations HTA = Health Technology Assessments ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 2

3 Pubmed via NLM, 12 February 2013 Erythropoietin Search terms Population: cancer induced anemia or anemia associated with kidney disorders 1. (Neoplasms[MeSH] OR Medical Oncology[MeSH] OR "Kidney Failure, Chronic"[Mesh] OR "Renal Insufficiency, Chronic"[Mesh] OR "Renal Insufficiency"[Mesh]) AND (Anemia[MeSH]) 2. Items found ((Anemia[tiab] OR anaemia[tiab]) AND (Kidney failure[tiab] OR Renal disease[tiab] OR chemotherapy[tiab] OR cancer[tiab] OR oncology[tiab] OR tumour*[tiab] OR kidney[ti] OR renal[ti])) NOT (medline[sb] OR oldmedline[sb]) 3. 1 OR Intervention: erythropoietin 4. ("Erythropoietin"[MeSH Terms] AND "Recombinant Proteins"[MeSH Terms]) OR "Erythropoietin/therapeutic use"[mesh] OR "Erythropoietin/administration and dosage"[mesh] OR "Erythropoietin"[MAJR] OR epoetin zeta [Supplementary Concept] OR epoetin alfa [Supplementary Concept] OR epoetin theta [Supplementary Concept] OR epoetin beta [Supplementary Concept] OR darbepoetin alfa [Supplementary Concept] 5. Erythropoietin[tiab] OR Epoetin[tiab] OR Eprex[tiab] OR recombinant human EPO[tiab] OR r-huepo[tiab] OR rhuepo[tiab] OR erythropoiesis-stimulating agent*[tiab] 6. 4 OR Outcome: anti-drug antibodies, hemoglobin, pure red cell aplasia etc 7. "Antibodies, Blocking"[Mesh] OR "Antibodies"[Mesh] OR "Antibodies, Neutralizing"[Mesh] OR "Therapeutic Equivalency"[MeSH Terms] OR "redcell aplasia, pure"[mesh Terms] OR Hemoglobins/metabolism[MeSH:NoExp] OR Blood Transfusion[MeSH:NoExp] OR Erythrocyte Transfusion[MeSH] 8. anti-drug antibod*[tiab] OR anti-epo antibod*[tiab] OR anti erythropoietin OR antibod*[tiab] OR Antiepoetin antibod*[tiab] OR anti-epo neutralizing antibody*[tiab] OR Neutralizing antibodies[tiab] OR neutralizing antibody[tiab] OR immune reaction*[tiab] OR Immunologic*[tiab] OR Allergic*[tiab] OR haemoglobin[tiab] OR haematopoietic response[tiab] OR hematopoetic respons[tiab] OR transfusion*[tiab] OR hematological response[tiab] OR Haematological response[tiab] OR Haemoglobin[tiab] OR Hemoglobin[tiab] OR Hb level*[tiab] OR Hb concentration*[tiab] OR red cell ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA aplasia[tiab] OR PRCA[tiab] 9. 7 OR Study types 10. Systematic[SB] OR "Clinical Trial" [Publication Type:NoExp] OR "Clinical Trial, Phase II" [Publication Type] AND "Clinical Trial, Phase III" [Publication Type] OR "Clinical Trial, Phase IV" [Publication Type] OR "Controlled Clinical Trial" [Publication Type] OR "Multicenter Study" [Publication Type] OR "Randomized Controlled Trial" [Publication Type] OR "Epidemiologic Studies"[Mesh] OR (((clinical[title/abstract] AND trial[title/abstract]) OR clinical trials[mesh Terms] OR clinical trial[publication Type] OR

4 random*[title/abstract] OR random allocation[mesh Terms] OR therapeutic use[mesh Subheading]) NOT (Medline[SB] OR oldmedline[sb]))) Combined sets AND 6 AND AND 6 AND 9 AND The search result, usually found at the end of the documentation, forms the list of abstracts [MeSH] = Term from the Medline controlled vocabulary, including terms found below this term in the MeSH hierarchy [MeSH:NoExp] = Does not include terms found below this term in the MeSH hierarchy [MAJR] = MeSH Major Topic [TIAB] = Title or abstract [TI] = Title [AU] = Author [TW] = Text Word Systematic[SB] = Filter for retrieving systematic reviews * = Truncation = Citation Marks; searches for an exact phrase ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 4

5 Embase via Embase.com, 13 February 2013 Erythropoietin Search terms Population: cancer induced anemia or anemia associated with kidney disorders 13. (('anemia'/mj) AND ('neoplasm'/exp/mj OR 'kidney disease'/exp/mj OR 'chemotherapy'/exp/mj)) OR 'chemotherapy induced anemia'/exp/mj 14. (anemia:ti OR anaemia:ti) AND (chemotherapy:ti OR cancer:ti OR Items found 5,524 4,039 oncology:ti OR tumour*:ti OR kidney:ti OR renal:ti) OR 2 7,837 Intervention: erythropoietin 16. 'recombinant erythropoietin'/mj 7,056 12, Erythropoietin:ti OR Epoetin:ti OR Eprex:ti OR "recombinant human EPO":ti OR r-huepo:ti OR rhuepo:ti OR "erythropoiesis-stimulating agent":ti OR "erythropoiesis-stimulating agents":ti OR 5 14,174 Outcome: anti-drug antibodies, hemoglobin, pure red cell aplasia etc 19. 'blocking antibody'/exp OR 'antibody'/exp OR 'therapeutic equivalence'/de OR 'hemoglobin'/de OR 'erythrocyte transfusion'/de OR 'blood transfusion'/de OR 'pure red cell anemia'/de 735, "anti-drug antibody":ti:ab OR "anti-drug antibodies":ti:ab OR "anti-epo antibody":ti:ab OR "anti-epo antibodies":ti:ab OR "anti erythropoietin antibody":ti:ab OR "anti erythropoietin antibodies":ti:ab OR "Antiepoetin antibody":ti:ab OR "Antiepoetin antibodies":ti:ab OR "anti-epo neutralizing antibody":ti:ab OR "anti-epo neutralizing antibodies":ti:ab OR "Neutralizing antibodies":ti:ab OR "neutralizing antibody":ti:ab OR "immune reaction":ti:ab OR "immune reactions":ti:ab OR Immunologic*:ti:ab OR Allergic*:ti:ab OR haemoglobin:ti:ab OR "haematopoietic response":ti:ab OR "hematopoetic respons":ti:ab OR transfusion*:ti:ab OR "hematological response":ti:ab OR "Haematological response":ti:ab OR Haemoglobin:ti:ab OR Hemoglobin:ti:ab OR "Hb level":ti:ab OR "Hb levels":ti:ab OR "Hb concentration":ti:ab OR "Hb concentrations":ti:ab OR "red cell aplasia":ti:ab OR PRCA:ti:ab 406, OR Study types 22. 'meta analysis'/de OR 'systematic review'/de OR 'clinical trial'/de OR 'controlled clinical trial'/exp OR 'multicenter study'/de OR 'phase 2 clinical trial'/de OR 'phase 3 clinical trial'/de OR 'phase 4 clinical trial'/de OR 'observational study'/de OR 'cohort analysis'/de OR 'prospective study'/de OR 'case control study'/exp OR 'intervention study'/de OR 'major clinical study'/de OR 'retrospective study'/de Combined sets AND 6 AND 9 1, AND 6 AND 9 AND /de= Term from the EMTREE controlled vocabulary /exp= Includes terms found below this term in the EMTREE hierarchy /mj = Major Topic :ab = Abstract ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 5

6 :au = Author :ti = Article Title :ti:ab = Title or abstract * = Truncation = Citation Marks; searches for an exact phrase ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 6

7 Cochrane Library via Wiley 24 June 2013 (CDSR, DARE & CENTRAL) Title: Erythropoetin Search terms Items found Population: cancer induced anemia or anemia associated with kidney disorders 1. Neoplasms[MeSH] Medical Oncology[MeSH] Kidney Diseases[MeSH] "Kidney Failure, Chronic"[Mesh] "Renal Insufficiency, Chronic"[Mesh] "Renal Insufficiency"[Mesh] "Renal Dialysis"[Mesh] 8. ("Kidney failure" OR "Renal disease" OR chemotherapy OR cancer OR oncology OR tumour* OR kidney OR renal)):ti OR 2 OR 3 OR 4 OR 5 OR 6 OR 7 OR Anemia[MeSH] OR (Anemia OR anaemia):ti AND Intervention: erythropoietin 12. "Erythropoietin"[MeSH:NoExp] (Erythropoietin OR Epoetin OR Eprex OR "recombinant human EPO" OR r- HuEpo OR rhuepo OR "erythropoiesis-stimulating agent" OR "erythropoiesisstimulating agents"):ti OR Outcome: anti-drug antibodies, hemoglobin, pure red cell aplasia etc 15. "Antibodies, Blocking"[Mesh] "Antibodies"[Mesh] "Antibodies, Neutralizing"[Mesh] "Therapeutic Equivalency"[MeSH Terms] "red-cell aplasia, pure"[mesh Terms] 20. Hemoglobins[MeSH:NoExp] Blood Transfusion[MeSH:NoExp] Erythrocyte Transfusion[MeSH] ("anti-drug antibody" OR "anti-drug antibodies" OR "anti-epo antibody" OR "anti-epo antibodies" OR "anti erythropoietin" OR antibod* OR "Antiepoetin antibody" OR "antiepoetin antibodies" OR "anti-epo neutralizing antibody" OR "Neutralizing antibodies" OR "neutralizing antibody" OR "immune reaction" OR "immune reactions" OR Immunologic* OR Allergic* OR haemoglobin OR "haematopoietic response" OR "hematopoetic respons" OR transfusion* OR "hematological response" OR "Haematological response" OR Haemoglobin OR Hemoglobin OR "Hb level" OR "HB levels" OR "Hb concentration" OR "red cell aplasia" OR PRCA):ti,ab,kw OR 16 OR 17 OR 18 OR 19 OR 20 OR 21 OR 22 OR 23 Combined sets AND 14 AND 24 CDSR/3 DARE/1 5 Central /245 HTA/0 ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 7

8 The search result, usually found at the end of the documentation, forms the list of abstracts [AU] = Author[MAJR] = MeSH Major Topic [MeSH] = Term from the Medline controlled vocabulary, including terms found below this term in the MeSH hierarchy [MeSH:NoExp] = Does not include terms found below this term in the MeSH hierarchy Systematic[SB] = Filter for retrieving systematic reviews [TI] = Title [TIAB] = Title or abstract [TW] = Text Word * = Truncation = Citation Marks; searches for an exact phrase CDSR = Cochrane Database of Systematic Review CENTRAL = Cochrane Central Register of Controlled Trials, trials CRM = Method Studies ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 8

9 Embase via Embase.com, 24 June 2013 Erythropoietin Search terms Population: cancer induced anemia or anemia associated with kidney disorders 1. (('anemia'/mj OR anemia:ti:ab OR anaemia:ti:ab) AND ('neoplasm'/exp/mj OR 'kidney disease'/exp/mj OR 'chemotherapy'/exp/mj OR 'hemodialysis'/de OR 'hemodialysis patient'/mj)) OR 'chemotherapy induced anemia'/exp/mj 2. (anemia:ti OR anaemia:ti) AND (chemotherapy:ti OR cancer:ti OR oncology:ti OR tumour*:ti OR kidney:ti OR renal:ti OR dialys:ti OR Haemodialysis:ti) Items found 25,554 3, OR 2 26,365 Intervention: erythropoietin 4. 'recombinant erythropoietin'/mj OR 'novel erythropoiesis stimulating protein'/mj OR 'continuous erythropoiesis receptor activator'/mj 7, Erythropoietin:ti OR Epoetin:ti OR Eprex:ti OR "recombinant human EPO":ti OR r-huepo:ti OR rhuepo:ti OR "erythropoiesis-stimulating agent":ti OR "erythropoiesis-stimulating agents":ti 12, OR 5 15,059 Outcome: anti-drug antibodies, hemoglobin, pure red cell aplasia etc 7. 'blocking antibody'/exp OR 'antibody'/exp OR 'therapeutic equivalence'/de OR 'hemoglobin'/de OR 'erythrocyte transfusion'/de OR 'blood transfusion'/de OR 'pure red cell anemia'/de OR 'hemoglobin analysis'/exp 770, "anti-drug antibody":ti:ab OR "anti-drug antibodies":ti:ab OR "anti-epo antibody":ti:ab OR "anti-epo antibodies":ti:ab OR "anti erythropoietin antibody":ti:ab OR "anti erythropoietin antibodies":ti:ab OR "Antiepoetin antibody":ti:ab OR "Antiepoetin antibodies":ti:ab OR "anti-epo neutralizing antibody":ti:ab OR "anti-epo neutralizing antibodies":ti:ab OR "Neutralizing antibodies":ti:ab OR "neutralizing antibody":ti:ab OR "immune reaction":ti:ab OR "immune reactions":ti:ab OR Immunologic*:ti:ab OR Allergic*:ti:ab OR haemoglobin:ti:ab OR "haematopoietic response":ti:ab OR "hematopoetic respons":ti:ab OR transfusion*:ti:ab OR "hematological response":ti:ab OR "Haematological response":ti:ab OR Haemoglobin:ti:ab OR Hemoglobin:ti:ab OR "Hb level":ti:ab OR "Hb levels":ti:ab OR "Hb concentration":ti:ab OR "Hb concentrations":ti:ab OR "red cell aplasia":ti:ab OR PRCA:ti:ab 418, OR 8 1,037,21 1 Study types 10. 'meta analysis'/de OR 'systematic review'/de OR 'clinical trial'/de OR 'controlled clinical trial'/exp OR 'multicenter study'/de OR 'phase 2 clinical trial'/de OR 'phase 3 clinical trial'/de OR 'phase 4 clinical trial'/de OR 'observational study'/de OR 'cohort analysis'/de OR 'prospective study'/de OR 'case control study'/exp OR 'intervention study'/de OR 'major clinical study'/de OR 'retrospective study'/de 2,897,06 8 Combined sets AND 6 AND 9 AND 10 1,324 /de= Term from the EMTREE controlled vocabulary /exp= Includes terms found below this term in the EMTREE hierarchy /mj = Major Topic :ab = Abstract ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 9

10 :au = Author :ti = Article Title :ti:ab = Title or abstract * = Truncation = Citation Marks; searches for an exact phrase ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 10

11 Pubmed via NLM, 17June 2013 Erythropoietin Search terms Population: cancer induced anemia or anemia associated with kidney disorders 1. (Neoplasms[MeSH] OR Medical Oncology[MeSH] OR Kidney Diseases[MeSH] OR "Kidney Failure, Chronic"[Mesh] OR "Renal Insufficiency, Chronic"[Mesh] OR "Renal Insufficiency"[Mesh] OR "Renal Dialysis"[Mesh]) AND (Anemia[MeSH] OR anemia[tiab] OR anaemia[tiab]) 2. ((Anemia[tiab] OR anaemia[tiab]) AND (Kidney failure[tiab] OR Renal disease[tiab] OR chemotherapy[tiab] OR cancer[tiab] OR oncology[tiab] OR tumour*[tiab] OR kidney[ti] OR renal[ti])) NOT (medline[sb] OR oldmedline[sb]) Items found ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA OR Intervention: erythropoietin 4. ("Erythropoietin"[MeSH Terms] AND "Recombinant Proteins"[MeSH Terms]) OR "Erythropoietin/therapeutic use"[mesh] OR "Erythropoietin/administration and dosage"[mesh] OR "Erythropoietin"[MAJR] OR epoetin zeta [Supplementary Concept] OR epoetin alfa [Supplementary Concept] OR epoetin theta [Supplementary Concept] OR epoetin beta [Supplementary Concept] OR darbepoetin alfa [Supplementary Concept] Erythropoietin[tiab] OR Epoetin[tiab] OR Eprex[tiab] OR recombinant human EPO[tiab] OR r-huepo[tiab] OR rhuepo[tiab] OR erythropoiesis-stimulating agent*[tiab] OR Outcome: anti-drug antibodies, hemoglobin, pure red cell aplasia etc 7. "Antibodies, Blocking"[Mesh] OR "Antibodies"[Mesh] OR "Antibodies, Neutralizing"[Mesh] OR "Therapeutic Equivalency"[MeSH Terms] OR "redcell aplasia, pure"[mesh Terms] OR Hemoglobins[MeSH:NoExp] OR Blood Transfusion[MeSH:NoExp] OR Erythrocyte Transfusion[MeSH] anti-drug antibod*[tiab] OR anti-epo antibod*[tiab] OR anti erythropoietin OR antibod*[tiab] OR Antiepoetin antibod*[tiab] OR anti-epo neutralizing antibody*[tiab] OR Neutralizing antibodies[tiab] OR neutralizing antibody[tiab] OR immune reaction*[tiab] OR Immunologic*[tiab] OR Allergic*[tiab] OR haemoglobin[tiab] OR haematopoietic response[tiab] OR hematopoetic respons[tiab] OR transfusion*[tiab] OR hematological response[tiab] OR Haematological response[tiab] OR Haemoglobin[tiab] OR Hemoglobin[tiab] OR Hb level*[tiab] OR Hb concentration*[tiab] OR red cell aplasia[tiab] OR PRCA[tiab] OR Study types 10. Systematic[SB] OR "Clinical Trial" [Publication Type:NoExp] OR "Clinical Trial, Phase II" [Publication Type] AND "Clinical Trial, Phase III" [Publication Type] OR "Clinical Trial, Phase IV" [Publication Type] OR "Controlled Clinical Trial" [Publication Type] OR "Multicenter Study" [Publication Type] OR "Randomized Controlled Trial" [Publication Type] OR "Epidemiologic Studies"[Mesh] OR (((clinical[title/abstract] AND trial[title/abstract]) OR clinical trials[mesh Terms] OR clinical trial[publication Type] OR random*[title/abstract] OR random allocation[mesh Terms] OR therapeutic use[mesh Subheading]) NOT (Medline[SB] OR oldmedline[sb]))) Combined sets AND 6 AND 9 AND

12 The search result, usually found at the end of the documentation, forms the list of abstracts [MeSH] = Term from the Medline controlled vocabulary, including terms found below this term in the MeSH hierarchy [MeSH:NoExp] = Does not include terms found below this term in the MeSH hierarchy [MAJR] = MeSH Major Topic [TIAB] = Title or abstract [TI] = Title [AU] = Author [TW] = Text Word Systematic[SB] = Filter for retrieving systematic reviews * = Truncation = Citation Marks; searches for an exact phrase ERYTROPOES-STIMULERANDE LÄKEMEDEL BILAGA 1 12