Zika virus: clinical and epidemiological features

Size: px
Start display at page:

Download "Zika virus: clinical and epidemiological features"

Transcription

1 Zika virus: clinical and epidemiological features Dominic Dwyer Medical Virologist, Westmead Hospital Director, ICPMR and Pathology West NSW Health Pathology

2 Zika virus Flavivirus first isolated in 1947 in a rhesus monkey in the Zika forest, Uganda enveloped RNA virus ~11 kb closely related to dengue, yellow fever, Japanese encephalitis, Murray Valley encephalitis viruses

3 Zika virus Yap Island 2007 Brazil 2015 Zika 1947 French Polynesia 2013

4 New mosquito-borne Zika virus infections Jan 2013-Feb 2017 WHO Situation Report: Feb 2, 2017

5 Zika virus ecology Mammalian Hosts Africa: primate-mosquito cycle with low endemic activity and occasional epidemics Asia and Americas: possible sylvatic cycles involving primates (orangutans, capuchins etc) Human-mosquito cycle Mosquito vectors Aedes aegypti is the dominant vector French Polynesia, New Caledonia, Americas, Africa Others: Aedes albopictus (Gabon, Africa), Aedes hensilli (Yap), Aedes polynesiensis (French Polynesia) Other species but less important (Aedes luteocephalus, Aedes vittatus) Aedes africanus in the sylvatic cycle in Africa Chouin-Carneiro T et al. PLoS Negl Trop Dis Mar 3;10(3):e

6 Zika virus transmission arthopod-borne via Aedes spp. (Aedes aegypti) mosquitoes mother to child sexual transfusion (needlestick/laboratory acquired, non-sexual direct contact) (potential - transplantation, saliva, breast milk)

7 Predicted distribution of Aedes aegypti Kramer elife 2015

8 Molecular phylogeny of ZIKV in the Americas Faria NR et al. Science /science.aaf5036 (2016)

9 Zika virus At least two Asian lineages with spread to the Pacific and Americas Yap 2007, Singapore 2016: Asian lineage virus similar to Malaysian (1967) and recent Thai strains French Polynesia: Asian lineage virus closer to the Cambodian 2010 than to the Yap 2007 strain Recent evolution of American lineage/sublineage Epidemiological markers or significant biological change? ZIKV strains from Asia and the Americas show N-linked glycosolation of ASN-154 in the E protein, which has been associated with neuroinvasiveness in West Nile virus. Not present in most African strains. Several prm coding sequence mutations in Asian/Americas strains possibly increase pathogenicity NS1 mutations in human brain isolate from Brazil Possible adaptations to increased replication in Aedes aegypti in Americas May M et al. PLoSONE 2016; 11(9):e , Wang L et al. Cell Host & Microbes 2016; 19:

10 ZIKV RNA in body fluids, and serum ZIKV-specific IgM, days after symptom onset ]* Paz-Bailey et al. NEJM, Feb 14, 2017

11 9.9 million visitors depart Brazilian airports annually 65% to Americas, 27% to Europe and 5% to Asia Bogoch Lancet 2016

12 Zika: clinical picture typical rash, fever, conjunctivitis, arthralgia and arthritis headache, retro-orbital pain, myalgia etc hospitalisation uncommon asymptomatic true rate? (quoted ~80% in Yap outbreak, but 38% Zika-IgM seropositive were symptomatic) 1:1 asymptomatic:symptomatic in French Polynesia complicated congenital Zika syndrome neurological Duffy MR et al, NEJM 2009;360:2536, Aubry M et al, EID 2017 in press

13 Clinical picture - neurological disease Guillain-Barré syndrome (GBS) acute inflammatory demyelinating polyneuropathy type other variants estimated 0.24/1000 cases (Tahiti*) shorter onset (median 6-7 days) *Cao-Lormeau et al, EID 2014;20:1085 Parra B et al, NEJM 2016;375:1513

14 Clinical picture - neurological disease acute myelitis meningoencephalitis/seizures retinitis/uveitis/chorioretinal atrophy/maculopathy/papilloedema hearing loss congenital Zika syndrome Duca LM et al. Curr Infect Dis Rep 2017DOI /s x

15 Zika virus in pregnancy Miscarriage Stillbirth Alive microcephalic baby Abnormal baby Normal baby, infected Normal baby, uninfected Normal baby, post-natal infection Krauer F et al. PLoS Medicine 2017 doi.org/ /journal.pmed

16 Time series and cartography of reported ZIKV infections and microcephaly cases in Brazil Weekly ZIKV notifications in 5596 municipalities in Brazil (n=2791 cases) ZIKV cases/100,000 people in each state Suspected microcephaly cases/100,000 people in each state Faria NR et al. Science /science.aaf5036 (2016)

17 Timeline: Symptoms, Radiographic and Laboratory Studies Driggers RW et al. N Engl J Med DOI: /NEJMoa

18 Zika virus microcephaly Brain development arrest Intracerebral calcifications, astrogliosis Reduced parenchymal volume Ventricular enlargement Cortical, subcortical and retinal atrophy No brain destruction (necrosis) Mainly at weeks gestation CSF often normal cell count, protein

19 Zika virus microcephaly Estimated risk ~1% in the 1 st trimester congenital CMV after primary infection 18% congenital rubella % 10% adverse fetal outcomes in parvovirus B19 But High Zika virus attack rates (66-73% in Pacific) CMV in pregnancy 1-4% congenital rubella rare % parvovirus B19 in pregnancy Cauchemez S et al. Lancet 2016 doi.org/ /s (16)

20 Congenital Zika Syndrome Moore CA et al. JAMA Pediatrics 2016:doi: /jamapediatrics

21 Cranial morphology in Congenital Zika Syndrome Moore CA et al. JAMA Pediatrics 2016:doi: /jamapediatrics

22 Brain findings in Congenital Zika Syndrome Moore CA et al. JAMA Pediatrics 2016:doi: /jamapediatrics

23 Microcephaly and arthrogryphosis in CZS Moore CA et al. JAMA Pediatrics 2016:doi: /jamapediatrics

24 Cohort study of pregnancy and rash in Rio, Brazil Brasil P et al. NEJM 2016;375:

25 Cohort study of pregnancy and rash in Rio, Brazil Brasil P et al. NEJM 2016;375:

26 Traveller advice Mosquito advice/control Prevention as no antivirals or vaccine Smart Traveller (DFAT) High/moderate/low risk based on widespread/sporadic/historical transmission Reconsider travel to ZIKV regions if pregnant Testing on return Symptomatic/asymptomatic Management of pregnancy/sexual transmission

Zika virus: a new global threat for Dr Gina McAllister Clinical Scientist, Virology

Zika virus: a new global threat for Dr Gina McAllister Clinical Scientist, Virology Zika virus: a new global threat for 2016 Dr Gina McAllister Clinical Scientist, Virology Moritz U. G. Kraemer and others The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus

More information

Outbreaks of Zika Virus: What Do We Know? Presented by Dr Jonathan Darbro Mosquito Control Lab, QIMR Berhgofer 15 September 2016

Outbreaks of Zika Virus: What Do We Know? Presented by Dr Jonathan Darbro Mosquito Control Lab, QIMR Berhgofer 15 September 2016 Outbreaks of Zika Virus: What Do We Know? Presented by Dr Jonathan Darbro Mosquito Control Lab, QIMR Berhgofer 15 September 2016 Overview History Distribution Modes of Transmission Symptoms Some Causal

More information

Public Health Image Library. CDC/ Cynthia Goldsmith. Image #

Public Health Image Library. CDC/ Cynthia Goldsmith. Image # Zika Virus Fredrick M. Abrahamian, D.O., FACEP, FIDSA Clinical Professor of Medicine UCLA School of Medicine Director of Education Department of Emergency Medicine Olive View-UCLA Medical Center Sylmar,

More information

What s Lurking out there??????

What s Lurking out there?????? What s Lurking out there?????? Dave Warshauer, PhD, D(ABMM) Deputy Director, Communicable Diseases Wisconsin State Laboratory of Hygiene david.warshauer@slh.wisc.edu WISCONSIN STATE LABORATORY OF HYGIENE

More information

Epidemiology and entomology of the Zika virus outbreak

Epidemiology and entomology of the Zika virus outbreak Epidemiology and entomology of the Zika virus outbreak M A T T H E W B A Y L I S I N S T I T U T E O F I N F E C T I O N A N D G L O B A L H E A L T H U N I V E R S I T Y O F L I V E R P O O L Zika in

More information

Zika Virus Update. Partner Webinar 05/12/2016

Zika Virus Update. Partner Webinar 05/12/2016 Zika Virus Update Partner Webinar 05/12/2016 Today s presenters Patricia Quinlisk, MD, MPH, Medical Director /State Epidemiologist Ann Garvey, DVM, MPH, MA, State Public Health Veterinarian/ Deputy State

More information

Zika Virus: The Olympics and Beyond

Zika Virus: The Olympics and Beyond Zika Virus: The Olympics and Beyond Alice Pong, MD Pediatric Infectious Diseases Rady Children s Hospital-San Diego University of California, San Diego Disclosures I have no disclosures to report 1 Objectives

More information

ZIKA VIRUS. John J. Russell MD May 27, 2016

ZIKA VIRUS. John J. Russell MD May 27, 2016 John J. Russell MD May 27, 2016 HISTORY Discovered 1947 Zika Forest of Uganda in rhesus monkeys, thus the name Found in humans in Africa in 1952 Not considered a public health threat until outbreak in

More information

Zika Virus. Centers for Disease Control and Prevention

Zika Virus. Centers for Disease Control and Prevention Centers for Disease Control and Prevention Zika Virus Ingrid Rabe Medical Epidemiologist Arboviral Diseases Branch Centers for Disease Control and Prevention February 1, 2016 Zika Virus Single stranded

More information

Zika Virus. Maternal & Fetal Effects. John P. Elliott, MD Medical Director, Valley Perinatal Services Phoenix, Arizona

Zika Virus. Maternal & Fetal Effects. John P. Elliott, MD Medical Director, Valley Perinatal Services Phoenix, Arizona Zika Virus Maternal & Fetal Effects John P. Elliott, MD Medical Director, Valley Perinatal Services Phoenix, Arizona Objective of Presentation Sneeka Peeka at Zika Disclosure I have nothing to disclose

More information

ZIKA: is South Africa at risk? Lucille Blumberg National Institute for Communicable Diseases South Africa

ZIKA: is South Africa at risk? Lucille Blumberg National Institute for Communicable Diseases South Africa ZIKA: is South Africa at risk? Lucille Blumberg National Institute for Communicable Diseases South Africa 18 th April 1947; Rhesus macaque (no 766) with fever Filtrable transmissable agent The absence

More information

Zika Virus Dr Conor Doherty

Zika Virus Dr Conor Doherty Zika Virus Dr Conor Doherty Zika Virus Single stranded RNA enveloped icosahedral virus Flavivirus (e.g. dengue, yellow feve er) First described in Zika forest in Uganda in 1947 Initial enzootic monkey

More information

European Centre for Disease Prevention and Control. Zika virus disease

European Centre for Disease Prevention and Control. Zika virus disease European Centre for Disease Prevention and Control Zika virus disease Stockholm, 19 February 2016 Background information Zika virus is a member of the Flaviviridae family and transmitted by mosquitoes

More information

Zika Virus. Robert Wittler, MD

Zika Virus. Robert Wittler, MD Zika Virus Robert Wittler, MD Disclosure I have no relevant financial relationships with the manufacturers(s) of any commercial products(s) and/or provider of commercial services discussed in this CME

More information

Zika Virus. Disclosure. Zika Virus 8/26/2016

Zika Virus. Disclosure. Zika Virus 8/26/2016 Zika Virus Robert Wittler, MD Disclosure I have no relevant financial relationships with the manufacturers(s) of any commercial products(s) and/or provider of commercial services discussed in this CME

More information

When infections go viral Zika Virus

When infections go viral Zika Virus When infections go viral Zika Virus John Fangman, MD Associate Professor of Medicine (Infectious Diseases) Senior Medical Director of Ambulatory, Medical College Physicians Medical College of Wisconsin

More information

Welcome All. Western Australia Oncology Menopause Endometriosis New Mothers

Welcome All. Western Australia Oncology Menopause Endometriosis New Mothers Welcome All Western Australia ZIKA VIRUS What s the latest? Dr Clay Golledge COUNTRIES WITH ONGOING ZIKA CIRCULATION American Samoa Curacao Guyana Nicaragua Tonga Barbados Dominican Republic Haiti Panama

More information

The problem with TORCH screening

The problem with TORCH screening : Beyond TORCHeS TORCH or STORCH-a helpful mnemonic? Toxoplasma Other Rubella CMV HSV (HIV) Syphilis 3 The problem with TORCH screening TORCH-first proposed by Nahmias et.al. (Pediatr Res 1971) Toxo, Rubella,

More information

Zika Virus. Division of Infectious Disease Department of Internal Medicine Global Health Program Conference Dora Lebron, MD Alexandra Stang, MD

Zika Virus. Division of Infectious Disease Department of Internal Medicine Global Health Program Conference Dora Lebron, MD Alexandra Stang, MD Zika Virus Division of Infectious Disease Department of Internal Medicine Global Health Program Conference Dora Lebron, MD Alexandra Stang, MD Zika Virus ZIKV is a mosquito-borne ssrna flavivirus from

More information

Presentation Overview

Presentation Overview Presentation Overview Characteristics of Zika virus Characteristics of Zika virus infection Epidemiology and outbreaks Vector and transmission Clinical symptoms Diagnosis and testing Treatment and prevention

More information

Zika Virus. ZIKA VIRUS & PREGNANCY Stephen Champlin, M.D. FLAVIVIRIDAE VIRUS SPECTRUM. Virus family Flaviviridae

Zika Virus. ZIKA VIRUS & PREGNANCY Stephen Champlin, M.D. FLAVIVIRIDAE VIRUS SPECTRUM. Virus family Flaviviridae ZIKA VIRUS & PREGNANCY Stephen Champlin, M.D. Zika Virus Virus family Flaviviridae Positive sense, single-stranded RNA virus FLAVIVIRIDAE VIRUS SPECTRUM Arbovirus - spread by arthropods to mammals Flaviviridae

More information

FY 2017 President s Budget Request Overview for the National Center on Birth Defects and Developmental Disabilities

FY 2017 President s Budget Request Overview for the National Center on Birth Defects and Developmental Disabilities National Center on Birth Defects and Developmental Disabilities FY 2017 President s Budget Request Overview for the National Center on Birth Defects and Developmental Disabilities Sascha Chaney Associate

More information

Everything you ever wanted to know about Zika Virus Disease

Everything you ever wanted to know about Zika Virus Disease Everything you ever wanted to know about Zika Virus Disease (in 14 slides) Jon Temte, MD/PhD University of Wisconsin School of Medicine and Public Health 28 January 2016 Zika Virus mosquito-borne flavivirus

More information

Zika Virus Update for Emergency Care Providers

Zika Virus Update for Emergency Care Providers Zika Virus Update for Emergency Care Providers What is this Zika Virus? Jeff Doerr Epidemiologist Southeastern Idaho Public Health Zika Virus Single stranded RNA virus Genus Flavivirus, Family Flaviviridae

More information

ZIKA VIRUS. Epic and aspects of management

ZIKA VIRUS. Epic and aspects of management ZIKA VIRUS Epic and aspects of management Classification - Belong to the family Flaviviridae which are mosquitoes borne viruses such as Dengue virus ( DEN V ), West Nile virus ( WN V ), Yellow fever Virus

More information

A RELOOK AT ZIKA VIRAL INFECTION AND ITS LATEST OUTBREAK IN INDIA

A RELOOK AT ZIKA VIRAL INFECTION AND ITS LATEST OUTBREAK IN INDIA 24 th December 2018 A RELOOK AT ZIKA VIRAL INFECTION AND ITS LATEST OUTBREAK IN INDIA BACKGROUND Zika virus infection, which erupted on a large scale in 2015-2016, has infected more than 1.5 million people.

More information

10/6/2016. Outline. Zika, Dengue, and Chikungunya Viruses in the Americas Oh My! Some Mosquito-Borne Arboviruses

10/6/2016. Outline. Zika, Dengue, and Chikungunya Viruses in the Americas Oh My! Some Mosquito-Borne Arboviruses Zika, Dengue, and Chikungunya Viruses in the Americas Oh My! Geoffrey A. Weinberg, M.D., FAAP, FIDSA, FPIDS Professor of Pediatrics Director, Pediatric HIV Program Division of Pediatric Infectious Diseases

More information

Guidance for Investigation and Management of Zika Virus Infection

Guidance for Investigation and Management of Zika Virus Infection Guidance for Investigation and Management of Zika Virus Infection Update: February 11, 2016 Public Health Agency of Canada has issued recommendations from the Committee to Advise on Tropical Medicine and

More information

Module Three About Zika Virus: What is Known and Not Known

Module Three About Zika Virus: What is Known and Not Known Module Three About Zika Virus: What is Known and Not Known HOUSEKEEPING For educational and quality improvement purposes, this TeleECHO Clinic will be recorded By participating in this clinic, you are

More information

Objectives. Dengue, Chikungunya and Zika Virus Infection: Answers to Common Questions. Case 1. Dengue Introduction 10/15/2018

Objectives. Dengue, Chikungunya and Zika Virus Infection: Answers to Common Questions. Case 1. Dengue Introduction 10/15/2018 Dengue, Chikungunya and Zika Virus Infection: Answers to Common Questions Wayne Ghesquiere MD FRCPC Infectious Diseases Consultant Clinical Assistant Prof, UBC Victoria, BC Objectives Discuss common Arbovirus

More information

Wrapping Our Heads Around the Outbreak

Wrapping Our Heads Around the Outbreak Wrapping Our Heads Around the Outbreak An Update on the Zika Virus P. Zach White, PharmD PGY1 Pharmacy Resident Mayo Eugenio Litta Children s Hospital Pharmacy Grand Rounds June 7, 2016 2015 MFMER slide-1

More information

Geographic distribution ZIKV

Geographic distribution ZIKV Shelley M. Wood, RN, BSN, CEN March 16, 2016 Geographic distribution ZIKV 1947 2007 http://www.ncbi.nlm.nih.gov/pmc/articles/pmc2819875/ 1 Current Active Zika transmission WHO declared global health threat

More information

Zika Virus Outbreak in the Americas. J. David Beckham MD Associate Professor of Medicine Division of Infectious diseases University of Colorado SOM

Zika Virus Outbreak in the Americas. J. David Beckham MD Associate Professor of Medicine Division of Infectious diseases University of Colorado SOM Zika Virus Outbreak in the Americas J. David Beckham MD Associate Professor of Medicine Division of Infectious diseases University of Colorado SOM Learning Objectives Understand the pathogenesis of West

More information

Zika Virus (ZIKV) Rosanna W Peeling London School of Hygiene & Tropical Medicine Director, International Diagnostics Centre.

Zika Virus (ZIKV) Rosanna W Peeling London School of Hygiene & Tropical Medicine Director, International Diagnostics Centre. Zika Virus (ZIKV) Rosanna W Peeling London School of Hygiene & Tropical Medicine Director, International Diagnostics Centre www.idx-dx.org ZiKa Virus (ZIKV) Zika virus (ZIKV) is an RNA virus of the Flaviviridae

More information

Zika Virus in the Primary Care Setting

Zika Virus in the Primary Care Setting Zika Virus in the Primary Care Setting Monica McArthur, MD PhD Assistant Professor of Pediatrics Center for Vaccine Development University of Maryland School of Medicine Maryland Chapter ACP Meeting 17

More information

ZIKA Jordan H. Perlow MD Banner University Medical Center Division of Maternal Fetal Medicine Phoenix Perinatal Asoociates

ZIKA Jordan H. Perlow MD Banner University Medical Center Division of Maternal Fetal Medicine Phoenix Perinatal Asoociates ZIKA Jordan H. Perlow MD Banner University Medical Center Division of Maternal Fetal Medicine Phoenix Perinatal Asoociates Disclosures I have no relevant financial relationships to disclose or conflicts

More information

Zika Virus. It may be devastating, But we might just get one step ahead of it. Learning in Retirement Winter 2017 Daniel Burnside. photo: Newsweek.

Zika Virus. It may be devastating, But we might just get one step ahead of it. Learning in Retirement Winter 2017 Daniel Burnside. photo: Newsweek. Zika Virus It may be devastating, But we might just get one step ahead of it Learning in Retirement Winter 2017 Daniel Burnside photo: Newsweek.com INTRODUCTION TO VIRUSES STRUCTURE GENOME LIFE CYCLE

More information

Zika Virus What Every Woman Needs to Know

Zika Virus What Every Woman Needs to Know Zika Virus What Every Woman Needs to Know Carrie L. Byington, MD The Jean and Thomas McMullin Professor and Dean of Medicine Senior Vice President Health Science Center Vice Chancellor for Health Services

More information

Zika Virus Basics. Flaviviridae Flavivirus Disease Vector Vaccine *Dengue (serotypes 1-4) Zika Virus Basics. Zika Virus Transmission Cycle

Zika Virus Basics. Flaviviridae Flavivirus Disease Vector Vaccine *Dengue (serotypes 1-4) Zika Virus Basics. Zika Virus Transmission Cycle Zika: Infection,, and Protection Roxanne P. Liles, Ph.D., MLS(ASCP) CM Assistant Professor of Biology Louisiana State University at Alexandria 318-473-6518 rliles@lsua.edu Zika Virus Basics Virion: Enveloped

More information

Keeping Microbes at our Doorstep

Keeping Microbes at our Doorstep Keeping Microbes at our Doorstep Mark Loeb MD McMaster University AMMI CANADA-CACMID Plenary on Global Health, Vancouver March 31, 2016 Infection Control Objectives The challenge of anticipating risk Proving

More information

Relevant Communicable Diseases in HCT/Ps

Relevant Communicable Diseases in HCT/Ps Relevant Communicable Diseases in HCT/Ps Phyllis I. Warkentin, MD Professor of Pathology and Pediatrics University of Nebraska Medical Center FACT Chief Medical Officer Relevant Communicable Diseases in

More information

Zika Virus. Lee Green Vector-Borne Epidemiologist Indiana State Department of Health. April 13, 2016

Zika Virus. Lee Green Vector-Borne Epidemiologist Indiana State Department of Health. April 13, 2016 Zika Virus Lee Green Vector-Borne Epidemiologist Indiana State Department of Health April 13, 2016 What Is It? Flavivirus WNV Dengue St. Louis Encephalitis Yellow Fever Tick Borne Encephalitis Single stranded

More information

As suggested by one fellow student, please consider the CDC's "Final Rules for Control of Communicable Diseases: Interstate and Foreign

As suggested by one fellow student, please consider the CDC's Final Rules for Control of Communicable Diseases: Interstate and Foreign As suggested by one fellow student, please consider the CDC's "Final Rules for Control of Communicable Diseases: Interstate and Foreign http://www.cdc.gov/quarantine/ aboutlawsregulationsquarantineisolatio

More information

Zika: Deet, There It Is. Anna Powell, MD Reproductive Infectious Disease Fellow THEGOS

Zika: Deet, There It Is. Anna Powell, MD Reproductive Infectious Disease Fellow THEGOS Zika: Deet, There It Is Anna Powell, MD Reproductive Infectious Disease Fellow THEGOS Disclosure I have no financial disclosures or conflicts of interest Lessons from Rubella At peak of rubella epidemic

More information

ZIKA Virus and Mosquito Management. ACCG Rosmarie Kelly, PhD MPH 30 April 16

ZIKA Virus and Mosquito Management. ACCG Rosmarie Kelly, PhD MPH 30 April 16 ZIKA Virus and Mosquito Management ACCG Rosmarie Kelly, PhD MPH 30 April 16 What is Zika Virus? Zika virus (ZIKV) is a flavivirus related to yellow fever, dengue, West Nile, and Japanese encephalitis viruses.

More information

ZIKA UPDATE NOVEMBER Ministry of Health, Barbados

ZIKA UPDATE NOVEMBER Ministry of Health, Barbados ZIKA UPDATE NOVEMBER 2016 Ministry of Health, Barbados Zika Virus Disease Objectives By the end of this presentation you should be able: To recount the track of the current global Zika virus epidemic To

More information

*This response is constantly evolving and recommendations in this presentation may change over time, please call your district epidemiologist or a

*This response is constantly evolving and recommendations in this presentation may change over time, please call your district epidemiologist or a *This response is constantly evolving and recommendations in this presentation may change over time, please call your district epidemiologist or a GDPH epidemiologist 404-657-2588, 8-5 pm M-F for current

More information

ZIKA VIRUS OUTBREAK. JANET B. EDDY M.D. KU-WICHITA PGY2 OBSTETRICS AND GYNECOLOGY RESIDENCY Dominican Republic 2016

ZIKA VIRUS OUTBREAK. JANET B. EDDY M.D. KU-WICHITA PGY2 OBSTETRICS AND GYNECOLOGY RESIDENCY Dominican Republic 2016 ZIKA VIRUS OUTBREAK JANET B. EDDY M.D. KU-WICHITA PGY2 OBSTETRICS AND GYNECOLOGY RESIDENCY Dominican Republic 2016 Zika time line 1947: 1 st isolated in rhesus monkey in Zika forest of Uganda 1 12/2013:

More information

General Description. Significance

General Description. Significance General Description The Zika virus is a member of the Flavivirus family, and is a small, enveloped virus (easy to kill with a hospital disinfectant). Zika virus is an emerging mosquito-borne virus that

More information

Vector-Borne Diseases Update: Maricopa County

Vector-Borne Diseases Update: Maricopa County Vector-Borne Diseases Update: Maricopa County Craig Levy, Epizoologist, Office of Epidemiology WeArePublicHealth.org twitter.com/maricopahealth facebook.com/mcdph Emerging Arboviruses Zika Virus Chikungunya

More information

Zika Virus Not your daddy s arbovirus (hopefully) Michael Libman MD J.D. MacLean Centre for Tropical Diseases McGill University

Zika Virus Not your daddy s arbovirus (hopefully) Michael Libman MD J.D. MacLean Centre for Tropical Diseases McGill University Zika Virus Not your daddy s arbovirus (hopefully) Michael Libman MD J.D. MacLean Centre for Tropical Diseases McGill University NO CONFLICT OF INTEREST TO DECLARE (EXCEPT ON CATMAT GUIDELINES COMMITTEE)

More information

Zika Outbreak Discussion

Zika Outbreak Discussion Zika Outbreak Discussion May 10, 2016 2016 Zurich Healthcare Customer Symposium Speakers Krishna Lynch Senior Healthcare Risk Consultant Zurich Clayton Shoup Business Director, Workers Compensation Zurich

More information

Zika Virus Outbreak An Update and Overview of the New York State Response

Zika Virus Outbreak An Update and Overview of the New York State Response Zika Virus Outbreak An Update and Overview of the New York State Response Elizabeth Dufort, MD, FAAP Medical Director Division of Epidemiology New York State Department of Health Zika Virus- The Basics

More information

Zika Virus and Control Efforts in Arizona

Zika Virus and Control Efforts in Arizona Zika Virus and Control Efforts in Arizona Irene Ruberto, MPH, PhD Epidemiologist Office of Infectious Disease Services Arizona Department of Health Services November 10, 2016 Goal by Humbletree (cc by-nc

More information

From Mosquitos to Humans: Genetic evolution of Zika Virus

From Mosquitos to Humans: Genetic evolution of Zika Virus Article: From Mosquitos to Humans: Genetic evolution of Zika Virus Renata Pellegrino, PhD Director, Sequencing lab Center for Applied Genomics The Children s Hospital of Philadelphia Journal Club Clinical

More information

Zika infection - the clinical problems

Zika infection - the clinical problems Zika infection - the clinical problems Dr Emma Aarons Rare and Imported Pathogens Laboratory, PHE Porton Zika virus Typical symptoms Asymptomatic infection Zika and neurological sequelae Zika and other

More information

FIRST CONFIRMED CASE OF IMPORTED ZIKA VIRUS IN HOUSTON, TEXAS. Preventing Transmission

FIRST CONFIRMED CASE OF IMPORTED ZIKA VIRUS IN HOUSTON, TEXAS. Preventing Transmission FIRST CONFIRMED CASE OF IMPORTED ZIKA VIRUS IN HOUSTON, TEXAS Preventing Transmission Objectives Discuss the epidemiology of Zika virus Describe the Zika case investigation of the first confirmed case

More information

Updates in Infectious Diseases. Kelley Struble, DO, MS St. John Physicians Infectious Disease September 30, 2016

Updates in Infectious Diseases. Kelley Struble, DO, MS St. John Physicians Infectious Disease September 30, 2016 Updates in Infectious Diseases Kelley Struble, DO, MS St. John Physicians Infectious Disease September 30, 2016 Disclosures No financial relationships or affiliations to disclose Overview Activity Pre-Test

More information

Zika Virus Identifying an Emerging Threat. Florida Department of Health in Miami-Dade County Epidemiology, Disease Control, & Immunization Services

Zika Virus Identifying an Emerging Threat. Florida Department of Health in Miami-Dade County Epidemiology, Disease Control, & Immunization Services Zika Virus Identifying an Emerging Threat Florida Department of Health in Miami-Dade County Epidemiology, Disease Control, & Immunization Services What is Zika Virus? Zika virus is a vector-borne disease

More information

Zika Virus e Embarazo. Marco Aurélio Palazzi Sáfadi, MD, PhD Santa Casa de São Paulo

Zika Virus e Embarazo. Marco Aurélio Palazzi Sáfadi, MD, PhD Santa Casa de São Paulo Zika Virus e Embarazo Marco Aurélio Palazzi Sáfadi, MD, PhD Santa Casa de São Paulo I have no competing interests to declare for this presentattion ZIKA VIRUS (ZIKV) ZIKV is a single-stranded stranded

More information

THE ZIKA VIRUS. August 3, Sonia G. Pandit, MPH MBA Chief Executive Officer The Pandit Group

THE ZIKA VIRUS. August 3, Sonia G. Pandit, MPH MBA Chief Executive Officer The Pandit Group THE ZIKA VIRUS August 3, 2016 Sonia G. Pandit, MPH MBA Chief Executive Officer The Pandit Group sonia@thepanditgroup.com 443-990-1372 www.thepanditgroup.com What Makes Zika Unique? Viral disease (Flavi

More information

Mercer MRC A Newsletter for and about our volunteers

Mercer MRC A Newsletter for and about our volunteers Mercer MRC A Newsletter for and about our volunteers May 2017 Volume 1, Issue 5 Brian Hughes, County Executive Marygrace Billek, Director, Dept. of Human Services Lyme Disease Awareness Month May is Lyme

More information

An Introduction to Dengue, Zika and Chikungunya Viruses

An Introduction to Dengue, Zika and Chikungunya Viruses An Introduction to Dengue, Zika and Chikungunya Viruses Natalie Marzec, MD, MPH Zoonoses Epidemiologist 2017 Global Health and Disasters Course Objectives Arbovirus Overview Public Health Activities Clinical

More information

Zika and Emerging Infectious Diseases. Clifford T. Mauriello, MD, FAAP Assistant Clinical Professor May 31, 2016

Zika and Emerging Infectious Diseases. Clifford T. Mauriello, MD, FAAP Assistant Clinical Professor May 31, 2016 Zika and Emerging Infectious Diseases Clifford T. Mauriello, MD, FAAP Assistant Clinical Professor May 31, 2016 Famous Last Words The time has come to close the book on infectious diseases. We have basically

More information

The scope of the Zika pandemic and implications for vaccine development

The scope of the Zika pandemic and implications for vaccine development The scope of the Zika pandemic and implications for vaccine development Jon Heinrichs, Ph.D. Associate Vice President & Segment Head Early and Pre-Development Projects Zika Vaccine Project Leader Emergence

More information

Zika Virus Disease: The New Public Health Emergency of International Concern

Zika Virus Disease: The New Public Health Emergency of International Concern COMMENTARY Zika Virus Disease: The New Public Health Emergency of International Concern Onkarnath Chattopadhyay* Abstract Zika virus is an emerging mosquito-borne virus that was first identified in Uganda

More information

Zika virus: Interim guidance information for LMCs (midwives), GPs and other health professionals dealing with Zika virus in pregnancy 5 February 2016

Zika virus: Interim guidance information for LMCs (midwives), GPs and other health professionals dealing with Zika virus in pregnancy 5 February 2016 Zika virus: Interim guidance information for LMCs (midwives), GPs and other health professionals dealing with Zika virus in pregnancy 5 February 2016 This interim guidance is the result of consultation

More information

UPDATE ON ZIKA VIRUS INFECTION

UPDATE ON ZIKA VIRUS INFECTION IMPORTANCE UPDATE ON ZIKA VIRUS INFECTION Robert A. Broughton, M.D. Professor of Pediatrics Division of Infectious Diseases E-mail: rbrough@uky.edu WHO declared Zika a Public Health Emergency of International

More information

Zika Virus and Prevention in Mississippi

Zika Virus and Prevention in Mississippi Mississippi State Department of Health Mississippi Morbidity Report Volume 32, Number 1 July 2016 Background: Zika Virus and Prevention in Mississippi Key Messages: Zika virus infection during pregnancy

More information

Jan Byrne, M.D. Cortesia Maisa Wanderley

Jan Byrne, M.D. Cortesia Maisa Wanderley Jan Byrne, M.D. University of Utah Maternal-Fetal Medicine Clinical Genetics National Birth Defects Prevention Network Utah Fetal Center at Primary Children s Cortesia Maisa Wanderley Dr. Byrne has no

More information

What is Zika virus? What are the symptoms and complications of Zika virus infection? Are cases expected in Canada?

What is Zika virus? What are the symptoms and complications of Zika virus infection? Are cases expected in Canada? What is Zika virus? Zika Virus Update for Healthcare Professionals Updated June 22, 2016; italicized text indicates clarification of wording contained in previous versions. Zika virus is a Flavivirus transmitted

More information

ZIKA PRESENTED BY DENNIS QUERTERMOUS, DIANNA HUNTER, MERCEDES RUTLEDGE, AND DRE'ANDRIA THOMPSON

ZIKA PRESENTED BY DENNIS QUERTERMOUS, DIANNA HUNTER, MERCEDES RUTLEDGE, AND DRE'ANDRIA THOMPSON ZIKA PRESENTED BY DENNIS QUERTERMOUS, DIANNA HUNTER, MERCEDES RUTLEDGE, AND DRE'ANDRIA THOMPSON ZIKA OVERVIEW Family: Flaviviridae Genus: Flavivirus Enveloped, single-stranded RNA virus First identified

More information

KILLER BITES: Mosquito-Borne Viruses Jon Mark Hirshon, MD, MPH, PhD

KILLER BITES: Mosquito-Borne Viruses Jon Mark Hirshon, MD, MPH, PhD KILLER BITES: Mosquito-Borne Viruses Jon Mark Hirshon, MD, MPH, PhD Professor, Department of Emergency Medicine University of Maryland School of Medicine Disclosures Conflicts of Interest: Pfizer consultant

More information

Zika Virus A Public Health Emergency of Olympic Proportions

Zika Virus A Public Health Emergency of Olympic Proportions Zika Virus A Public Health Emergency of Olympic Proportions Carrie L. Byington M.D.** HA and Edna Benning Presidential Professor Division of Pediatric Infectious Diseases ** With Thanks to Andrew Pavia,

More information

2017 SCAAP Summer Conference. Lilian Peake, MD, MPH

2017 SCAAP Summer Conference. Lilian Peake, MD, MPH 2017 SCAAP Summer Conference Lilian Peake, MD, MPH 1. Mosquito-borne Diseases 2. Challenges to Preventing and Controlling Mosquito-borne Diseases 3. Effects of Zika Virus on Child Health None Accelerating

More information

Emerging TTIs How Singapore secure its blood supply

Emerging TTIs How Singapore secure its blood supply Emerging TTIs How Singapore secure its blood supply Ms Sally Lam Acting Division Director I Blood Supply Management I Blood Services Group I Health Sciences Outline Risk Mitigation Strategies to secure

More information

Duane J. Gubler, ScD Professor and Founding Director, Signature Research Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore

Duane J. Gubler, ScD Professor and Founding Director, Signature Research Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore Duane J. Gubler, ScD Professor and Founding Director, Signature Research Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore AGENDA Other arboviruses with the potential for urban

More information

Zika Update. PSSNY 2016 Annual Convention June 25, Suzanna Gim, PharmD, MPH

Zika Update. PSSNY 2016 Annual Convention June 25, Suzanna Gim, PharmD, MPH Zika Update PSSNY 2016 Annual Convention June 25, 2016 Suzanna Gim, PharmD, MPH Email: suzannagim@gmail.com Learning Objectives Describe the epidemiology and prevalence of Zika virus disease Identify the

More information

The Zika Crisis: Where, What and USG/WHO? Brian R. Moyer BRMoyer & Associates, LLC Bedford, NH

The Zika Crisis: Where, What and USG/WHO? Brian R. Moyer BRMoyer & Associates, LLC Bedford, NH 2016 National Biotechnology Conference, Boston, May 18th The Zika Crisis: Where, What and USG/WHO? Brian R. Moyer BRMoyer & Associates, LLC Bedford, NH 03110 bmoyernh@gmail.com 2016 National Biotechnology

More information

Carol M. Smith, M.D., M.P.H. Commissioner of Health and Mental Health Ulster County Department of Health and Mental Health May 20, 2016

Carol M. Smith, M.D., M.P.H. Commissioner of Health and Mental Health Ulster County Department of Health and Mental Health May 20, 2016 Carol M. Smith, M.D., M.P.H. Commissioner of Health and Mental Health Ulster County Department of Health and Mental Health May 20, 2016 Michael Hein County Executive Zika virus was first discovered in

More information

Town of Wolfeboro New Hampshire Health Notice Wolfeboro Public Health Officer Information Sheet Zika Virus

Town of Wolfeboro New Hampshire Health Notice Wolfeboro Public Health Officer Information Sheet Zika Virus Aedes Zika Virus Information Sheet Town of Wolfeboro New Hampshire Health Notice Wolfeboro Public Health Officer Information Sheet Zika Virus The Zika Virus is a mosquito borne illness spread by the Aedes

More information

ZIKA VIRUS. Annanya Gangopadhyay*, Shubhrajit Mantry, Abhinay Chhetri, Sudip das

ZIKA VIRUS. Annanya Gangopadhyay*, Shubhrajit Mantry, Abhinay Chhetri, Sudip das ZIKA VIRUS Annanya Gangopadhyay*, Shubhrajit Mantry, Abhinay Chhetri, Sudip das, Himalayan Pharmacy Institute, Majhitar, Rangpo, E. Sikkim 737136, INDIA ARTICLE INFO: Article history: Received: 02 December

More information

Zika Outbreak: What Pharmacists Need to Know

Zika Outbreak: What Pharmacists Need to Know Zika Outbreak: What Pharmacists Need to Know Timothy Gauthier, PharmD, BCPS-AQ ID Miami Veterans Affairs Healthcare System Timothypgauthier@gmail.com, Social media: @IDstewardship Meghan Jeffres, PharmD

More information

Congenital Zika Virus Syndrome. Outline. Overview and Epidemiology of Zika Virus (ZIKV) ZIKV Genome and Structure. Whittney Barkhuff, MD

Congenital Zika Virus Syndrome. Outline. Overview and Epidemiology of Zika Virus (ZIKV) ZIKV Genome and Structure. Whittney Barkhuff, MD Congenital Zika Virus Syndrome http://www.nytimes.com/interactive/2016/01/16/health/what is zika virus.html Whittney Barkhuff, MD Outline Overview and epidemiology of Zika Virus Congenital Zika Virus Syndrome

More information

Zika Virus: Epidemiology and Preparedness NH Emergency Preparedness Conference June 9, 2016

Zika Virus: Epidemiology and Preparedness NH Emergency Preparedness Conference June 9, 2016 Zika Virus: Epidemiology and Preparedness NH Emergency Preparedness Conference June 9, 2016 Abigail Mathewson, DVM, MPH Surveillance Epidemiology Program Manager State Public Health Veterinarian Abigail.mathewson@dhhs.nh.gov

More information

CLINICAL CHARACTERISTICS AND METEOROLOGICAL PATTERNS OF ZIKA VIRUS INFECTION IN CHIANG MAI PROVINCE, THAILAND

CLINICAL CHARACTERISTICS AND METEOROLOGICAL PATTERNS OF ZIKA VIRUS INFECTION IN CHIANG MAI PROVINCE, THAILAND Zika virus infection in Chiang Mai, Thailand CLINICAL CHARACTERISTICS AND METEOROLOGICAL PATTERNS OF ZIKA VIRUS INFECTION IN CHIANG MAI PROVINCE, THAILAND Wasan Katip and Purida Wientong Department of

More information

What You Need to Know ZIKA VIRUS

What You Need to Know ZIKA VIRUS What You Need to Know ZIKA VIRUS What is Zika Virus? Zika virus is a flavivirus related to dengue, West Nile, yellow fever and Japanese encephalitis Zika virus first identified in 1947 and named for the

More information

Travel: Chikungunya, Zika,.. New worries

Travel: Chikungunya, Zika,.. New worries Travel: Chikungunya, Zika,.. New worries McGill Family Physician Refresher Course Dec 6, 2016 Makeda Semret, MD FRCP(C) Infectious Diseases/ Medical Microbiology Disclosures Funding from PHAC/CIHR/GSK/Novartis

More information

DENGUE AND BLOOD SAFETY. Ester C Sabino, MD, PhD Dep. of Infectious Disease/Institute of Tropical Medicine University of São Paulo

DENGUE AND BLOOD SAFETY. Ester C Sabino, MD, PhD Dep. of Infectious Disease/Institute of Tropical Medicine University of São Paulo DENGUE AND BLOOD SAFETY Ester C Sabino, MD, PhD Dep. of Infectious Disease/Institute of Tropical Medicine University of São Paulo Dengue virus Arbovirus (arthropod-borne virus) virus transmitted by mosquitoes:

More information

Zika Pregnancy and Birth Defects Surveillance

Zika Pregnancy and Birth Defects Surveillance Zika Pregnancy and Birth Defects Surveillance Sowmya Adibhatla, MPH Zika Surveillance and Response Coordinator Overview History/Background Zika cases update Zika virus infection Testing guidance Recommendations

More information

Review on Zika Virus

Review on Zika Virus 30 Nayan Jain*, Ashutosh Biswas, Kratika Vivek Daniel Mandsaur Institute of pharmacy, Mandsaur, MP, India nayanofficial499@gmail.com Review on Zika Virus ABSTRACT Today the world has suffered to the Zika

More information

Zika Preparedness: Lessons for the U.S. Public Health System

Zika Preparedness: Lessons for the U.S. Public Health System Zika Preparedness: Lessons for the U.S. Public Health System Jeffrey Duchin, MD Health Officer, Public Health - Seattle & King County Professor in Medicine, Division of Infectious Diseases Adjunct Professor,

More information

Research and Reviews: Journal of Ecology and Environmental Sciences

Research and Reviews: Journal of Ecology and Environmental Sciences Research and Reviews: Journal of Ecology and Environmental Sciences Zika Virus: A Recent Emerging Threat to Global Health Rituparna Sarkar* Department of Biotechnology, Haldia Institute of Technology,

More information

Focus. International #57. Dengue Fever, Chikungunya and the Zika Virus. Chikungunya

Focus. International #57. Dengue Fever, Chikungunya and the Zika Virus. Chikungunya Dengue Fever, Chikungunya and the Zika Virus Arboviruses are a group of virus that can be transmitted between animals and humans, and they are common to humans and many vertebrates (mammals, birds, reptiles,

More information

Zika Virus. Beata Casanas, DO FACP FIDSA. Associate Professor of Infectious Diseases University of South Florida

Zika Virus. Beata Casanas, DO FACP FIDSA. Associate Professor of Infectious Diseases University of South Florida Zika Virus Beata Casanas, DO FACP FIDSA Associate Professor of Infectious Diseases University of South Florida Zika Virus Definition: Arthropod-borne flavivirus transmitted by mosquitoes The virus is related

More information

Clinical Policy: Diagnostic Testing for Zika Virus Reference Number: CP.MP.111 Effective Date: 06/16

Clinical Policy: Diagnostic Testing for Zika Virus Reference Number: CP.MP.111 Effective Date: 06/16 Clinical Policy: Diagnostic Testing for Zika Virus Reference Number: CP.MP.111 Effective Date: 06/16 Last Review Date: 05/16 Revision Log See Important Reminder at the end of this policy for important

More information

Zika Virus Guidance for Medical Providers. Denise Smith, PHN, MPA Director of Disease Control Kern County Public Health Services Department

Zika Virus Guidance for Medical Providers. Denise Smith, PHN, MPA Director of Disease Control Kern County Public Health Services Department Zika Virus Guidance for Medical Providers Denise Smith, PHN, MPA Director of Disease Control Kern County Public Health Services Department Kern Perinatal Symposium March 3, 2017 CME DISCLOSURE The Planners,

More information

A Global Overview of the Chikungunya Virus Problem

A Global Overview of the Chikungunya Virus Problem A Global Overview of the Chikungunya Virus Problem Ann M. Powers, Ph.D. Division of Vector-Borne Infectious Diseases Centers for Disease Control and Prevention Chikungunya Virus Family Togaviridae,, genus

More information

Mosquito Control Update. Board of County Commissioners Work Session February 16, 2016

Mosquito Control Update. Board of County Commissioners Work Session February 16, 2016 Mosquito Control Update Board of County Commissioners Work Session February 16, 2016 1 Presentation Overview Mosquito Control Division Mosquito-borne Diseases Control Techniques Outlook 2 Mosquito Control

More information

Zika as a reportable condition Testing approval and result notification Zika pregnancy registry Is there a risk of local transmission?

Zika as a reportable condition Testing approval and result notification Zika pregnancy registry Is there a risk of local transmission? Zika as a reportable condition Testing approval and result notification Zika pregnancy registry Is there a risk of local transmission? Immediate NC surveillance activities Building entomologic capacity

More information