ABOUT ADVANCES IN STROKE RECOVERY REGISTRATION

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ABOUT ADVANCES IN STROKE RECOVERY Advances in Stroke Recovery is an annual meeting showcasing exciting new discoveries and research in stroke recovery.

The CPSR is a one-of-a-kind research partnership that brings together leading Canadian researchers, research institutions, and the Heart and Stroke Foundation with the aim of restoring the lives of

The objectives of the meeting are: to showcase recent innovation in the field of stroke recovery; to identify potential new areas of research and forge research collaborations; and to provide an

1 ABOUT ADVANCES IN STROKE RECOVERY Advances in Stroke Recovery is an annual meeting showcasing exciting new discoveries and research in stroke recovery. This year, the Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (CPSR) is delighted to be hosting Advances in Stroke Recovery in conjunction with the Canadian Stroke Congress. The CPSR is a one-of-a-kind research partnership that brings together leading Canadian researchers, research institutions, and the Heart and Stroke Foundation with the aim of restoring the lives of those affected by stroke. The objectives of the meeting are: to showcase recent innovation in the field of stroke recovery; to identify potential new areas of research and forge research collaborations; and to provide an interactive environment that fosters lively discussion and debate. REGISTRATION There is no registration fee to attend Advances in Stroke Recovery. However, because space is limited, all attendees are required to pre-register at: Please note that the meeting will run from 8:30 a.m. - 12:30 p.m. on Thursday September 17 th immediately prior to the opening session of the Canadian Stroke Congress. Registration for the Canadian Stroke Congress is separate, i.e. registration for Advances in Stroke Recovery will not provide attendees with access to the Canadian Stroke Congress. Join the conversation! Follow us on Facebook 1

2 PROGRAM All sessions will take place in the Mirvish Room of the Toronto Congress Centre 8:30-9:00 Advances in Stroke Recovery Dr. Dale Corbett An overview of recent research advances in stroke recovery worldwide, and within Canada, the research progress and plans of the Heart and Stroke Foundation Canadian Partnership for Stroke Recovery. Mr. Hockey and Stem Cells: Getting Canada in the Game Chair: Dr. Dale Corbett Speakers: Dr. Dale Corbett, Dr. Dar Dowlatshahi, Dr. Cindi Morshead Dr. Duncan Stewart 9:00-10:30 How can Canada, with its rich history and expertise in stem cells, lead the global race to discover a safe and effective stem cell therapy for stroke? This dynamic discussion will feature the perspectives one of Canada s leading stroke and stem cell researchers (Dr. Morshead), a leading stroke clinical researcher and neurologist (Dr. Dowlatshahi), and one of the world s leading stem cell clinical researchers who personally visited, with W5, the clinic in Mexico where Gordie Howe received his stem cell therapy (Dr. Stewart). 10:30-10:45 Break 10:45-12:15 Looking Ahead: New Approaches to Stroke Recovery Chair: Dr. Robert Teasell Speakers: Dr. Mark Bayley, Dr. Paul Albert, Dr. Janice Eng, Dr. Leigh Anne Swayne, Dr. Annie Rochette, Dr. Jed Meltzer CPSR researchers will provide brief snapshots of their exciting new approaches in stroke recovery, which could dramatically change the lives of those affected by stroke. Promising large-scale clinical trials, drug therapies, technologies, and approaches to sensory-motor, cognitive and mood disorders will be covered. 12:15-12:30 Closing Remarks and Reflections on Living with Stroke Dr. Dale Corbett 2

3 SPEAKER PROFILES Paul Albert, PhD Dr. Albert is a Senior Scientist at the Ottawa Hospital Research Institute, Associate Director Neuroscience Program a CIHR/Novartis Michael Smith Chair in Neurosciences Professor, Department of Medicine, Faculty of Medicine, University of Ottawa and Director, Neuroscience Graduate Program, University of Ottawa. He obtained a Ph.D., Pharmacology from Harvard University in Professor Albert is working in the area of molecular mechanisms of autoreceptor desensitization. Professor Albert has established research collaborations with the Royal Ottawa Hospital (Institute for Mental Health Research) to apply this work in the areas of depression, anxiety and schizophrenia and is active CPSR researcher and recipient of the 2015 Hakim Award for the top-ranked catalyst grant from he CPSR. Mark Bayley, MD, FRCPC Mark Bayley is a specialist physician in physical medicine and rehabilitation. Dr. Bayley is currently the medical director of Brain and Spinal Cord Rehabilitation Program and a clinician scientist at the neurorehabilitation program of the Toronto Rehabilitation Foundation & University Health Network in Toronto, Canada. He is also an associate professor at the University of Toronto. He has research interests in the areas: knowledge translation, development of best practice guidelines, rehabilitation outcome measurement and recovery and rehabilitation after stroke and acquired brain injury. He is co-chair of the Best Practices committee and author of the Best Practice Guidelines for the Canadian Stroke Strategy. He has recently taken on the role of evaluation champion and chair for the Stroke Evaluation Advisory Committee of the Ontario Stroke Network. He also has an interest in brain injury and chairs the Brain Injury Committee at the Ontario Neurotrauma Foundation. Current projects focus on the implementation of evidence based practice and he is one of the principle investigators on the Ontario Neuro Trauma Foundation International Cognitive (INCOG) rehab Guidelines and author of the evidence based review of the Acquired Brain injury Rehabilitation ( Dr. Bayley is also active in the health system engaged in development of an electronic referral system for stroke rehab and the Health Quality Ontario stroke expert panel for the development of quality based payment procedures. Dale Corbett, PhD Dr. Dale Corbett is a Professor of Neurosciences in the Department of Cellular and Molecular Medicine at the University of Ottawa and Scientific Director and CEO of the Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (CPSR). Prior to his relocation to the University of Ottawa in September 2010, Dr. Corbett held a Tier I Canada Research Chair in Stroke and Neuroplasticity at Memorial University in St. John's Newfoundland. Dr. Corbett obtained 3

4 his PhD from Concordia University followed by post-doctoral studies at McGill University. Subsequently, Dr. Corbett was a faculty member at Harvard University and also an Alfred P. Sloan Research Fellow from His laboratory is well known for pioneering research on the protective effects of prolonged, mild hypothermia that culminated in the use of "therapeutic hypothermia " in the treatment of cardiac arrest and stroke. His current research concerns recovery of sensory-motor and cognitive function following stroke where he has made pivotal translational discoveries regarding the importance of early and intensive rehabilitation. He uses a variety of approaches to enhance neuroplasticity and stroke recovery including novel forms of rehabilitation, exercise and mobilization of endogenous neural precursor and stem cells. Related work focuses on exercise and cognition and the metabolic and vascular consequences of obesity and a sedentary lifestyle. His research is funded by the Canadian Institutes of Health Research (CIHR), the Heart and Stroke Foundation of Canada, the CPSR, the Canadian Vascular Network and the Canadian Consortium on Neurodegeneration and Aging. He has published extensively in leading Neuroscience journals devoted to brain injury and repair. Dar Dowlatshahi, MD, PhD FRCPC Dr. Dowlatshahi is a Stroke Neurologist at the Ottawa Hospital and an Assistant professor in the Department of Medicine, and Cross Appointed to Epidemiology and Community Medicine, University of Ottawa. He is the Scientific Director of the Ottawa Stroke Program and recently promoted to Scientist, Neuroscience, Ottawa Hospital Research Institute. He is also a member of the Faculty of Graduate and Postdoctoral Studies. Dr. Dowlatshahi obtained his MD and PhD from McMaster University. He then completed a residency in Neurology at the University of Ottawa, followed by a Stroke Fellowship at the University of Calgary. He joined the University of Ottawa and OHRI in July 2010 and is both a Clinician Scientist and the Scientific Director of the Ottawa Stroke Program. In 2014 he was awarded the inaugural Department of Medicine Clinician-Scientist Chair Award, and a Heart & Stroke Foundation of Canada New Investigator Award. His clinical research program in acute stroke and intracerebral hemorrhage focuses on multi-modal neuroimaging. Through collaborative trials and observational studies, Dr. Dowlatshahi hopes to discover a treatment for intracerebral hemorrhage. Janice Eng, PT/OT, PhD Dr. Janice Eng is a professor in the UBC Department of Physical Therapy at the University of British Columbia. She studied as an undergraduate at UBC in the combined Physical Therapy and Occupational Therapy (PT/OT) program. At the masters level, she studied at the University of Toronto, graduating with an MSc in Biomedical Engineering. Lastly, she completed her doctorate in Kinesiology at the University of Waterloo. Dr. Eng also completed her post-doctoral training in Neurophysiology at Simon Fraser University. Currently, most of Dr. Eng s time is spent doing research as she is a recipient of a Senior Scholar Award from the Michael Smith Foundation for 4

5 Health Research which protects her research time. She is also a faculty member of the International Collaboration on Repair Discoveries (ICORD), UBC graduate program in neuroscience, and UBC Brain Research Centre. Dr. Eng s professional recognition includes: Award for Excellence in Mentoring Early Career Faculty, 2010, Women of Distinction, YWCA, 2010, Jonas Salk Award for Lifetime Achievement, 2009, and Fellow, Canadian Academy of Health Sciences Dr. Eng is also involved in the following professional activities: Editorial Board, Physical Therapy Journal and Registered Physical Therapist, College of Physical Therapists of BC. Jed Meltzer, PhD Dr. Meltzer is an Assistant Professor, Psychology, University of Toronto and an Assistant Professor, Speech-Language Pathology, University of Toronto. Previously, he was a Postdoctoral Fellow, Language Section, National Institute on Deafness and Other Communication Disorders, Bethesda, MD. Dr. Meltzer completed a Ph.D., Neuroscience, Yale University and a BS/BA in Neuroscience, Linguistics, at University of Pittsburgh. Dr. Meltzer s research explores the potential of magnetoencephalography (MEG) as a mapping tool in neurolinguistics, providing the spatial and temporal resolution necessary to measure the involvement of specific neural pathways on a time scale relevant to everyday language use. In current work, he is using MEG to evaluate the brain's response to transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (TDCS), two techniques that may help promote beneficial plasticity in recovery from brain injury, but are as yet poorly understood. Cindi Morshead, PhD Dr. Morshead's area of expertise is in stem cell biology and specifically, in the field of adult neural stem cells. She did her PhD at the University of Toronto and acquired a faculty position in the Department of Surgery, Division of Anatomy in She has appointments in the Department of Rehabilitation Science and the Institute of Biomaterials and Biomedical Engineering (IBBME). She is a member of the Networks for Centres of Excellence Stem Cell Network and the Canadian Stroke Network. She is a scientist at the McLaughlin Centre for Molecular Medicine, and a member of the University of Toronto, Program in Neuroscience. Dr. Morshead is the recipient of a Premiers Research Excellence Award (2004) and the George Armstrong Peters Prize (2008). Her lab has received funding from CIHR, Stem Cell Network, Canadian Stroke Network, Heart and Stroke Foundation, NSERC, PRO, Ortho-Biotech, and the MCMM. Annie Rochette, OT, PhD Dr. Rochette is a full member of the CRIR - Centre de réadaptation Lucie-Bruneau of the CIUSSS CEIM and Associate Professor, Occupational Therapy Program, School of Rehabilitation, 5

6 Université de Montréal. She holds a B.Sc., Occupational Therapy, McGill University, 1993, an M.Sc., Clinical Sciences (Geriatrics), Université de Sherbrooke, 2000, a Ph.D., Clinical Sciences, Université de Sherbrooke, 2004, and a Postdoctorate, School of Physical and Occupational Therapy, McGill University, Her research interests include: social participation, coping, support, loved ones, information provision, education, knowledge application, and stroke. Dr. Rochette currently leads the development and management of StrokEngine, a web-based stroke best practice tool supported by the CPSR. Duncan J. Stewart, MD, FRCPC Dr. Duncan Stewart is a pioneering Canadian cardiovascular researcher, recognized for his many important discoveries in blood vessel biology, as well as his dedication to translating these discoveries into benefits for patients and society. After beginning his career in academic cardiology at McGill University in Montreal, he moved to Toronto as Head of Cardiology at St. Michael s Hospital and later became Director of the Division of Cardiology, and Executive Director of the McLaughlin Centre for Molecular Medicine at the University of Toronto. He was recruited to lead the Ottawa Hospital Research Institute (OHRI) in Dr. Stewart has published more than 200 peer-reviewed manuscripts and has received a number of distinctions and prizes, including the Dexter Man Chair of Cardiology and Research Achievement Award of the University of Toronto, and the Research Achievement Award of the Canadian Cardiovascular Society. Throughout his career, Dr. Stewart has demonstrated leadership in bringing diverse groups of clinicians and scientists together to put Canada on the world stage for translational cardiovascular and regenerative medicine research. As well as serving as CEO and Scientific Director of the Ottawa Hospital Research Institute, Dr. Stewart is a senior scientist in OHRI's Regenerative Medicine Program and holds the Evelyne and Rowell Laishley Chair. He is Vice-President of Research at The Ottawa Hospital and a Professor in the Department of Medicine at the University of Ottawa. Robert Teasell, MD, FRCPC Dr. Teasell completed an undergraduate degree in Biology (University of Western Ontairo, 1977) and completed his medical degree (University of Western Ontario, 1981). He completed a rotating internship (St. Joseph s Hospital, London 1982) and residency training in Physical Medicine and Rehabilitation (University of Ottawa, 1986). He was a consultant physiatrist at University Hospital in London from and Parkwood Hospital, St. Joseph s Health Care London from present. He was Chief of PM&R at University Hospital from , Chief of PM&R at London Health Sciences Center from and city-wide Chief from He was Acting Chair of the Western University Dept. of PM&R from and Chair from He is currently Research Director of the Department of PM&R, Western University. Dr. Teasell is past Chair of the Research Committee of the Canadian Association of Physical Medicine and Rehabilitation, a past member of the Ontario and Canadian Stroke Strategy Executive Committees, 6

7 and an past examiner for the Royal College of Physicians and Surgeons for Physical Medicine and Rehabilitation. He has been on the editorial board of the journal Stroke and the Journal of Rehabilitation, and is currently on the editorial boards for the journals Archives of Physical Medicine and Rehabilitation, Topics in Stroke Rehabilitation and the Journal of Pain Research and Management. He has received several awards including the Physician Staff Organization Reward and Recognition Award for St. Joseph s Health Care London (2008), the Merit Award from the Canadian Association of Physical Medicine and Rehabilitation (2010) and the Royal College of Physicians and Surgeons of Canada McLaughlin-Gallie Visiting Professor Award (2012). Dr. Teasell is a consultant physiatrist and medical director of the Stroke Rehabilitation Program at Parkwod Hospital and runs an outpatient chronic pain practice. Leigh Anne Swayne, PhD Dr. Leigh Anne Swayne is a basic biomedical researcher based in the Division of Medical Sciences at the University of Victoria. Born in the Prairies and raised in Ontario, Dr. Swayne trained in Canada and France before establishing her independent research lab, working to bridge critical knowledge gaps in the understanding of large, complicated proteins called ion channels. In order to function properly, both the brain and the heart rely on ion channels pores that stud cellular membranes to facilitate the controlled flow of ions in and out of cells. During brain injury, ion channels can render populations of neurons vulnerable to damage, but can also sensitize surviving neurons to respond, adapt and promote repair. Furthermore, mutations in the proteins that form ion channels can manifest in a spectrum of clinical neurological and heart conditions. Dr. Swayne s new lab has already made several novel discoveries with respect to a family of ion channels called pannexins of which very little had been previously known. Overall her work has important implications for neurodevelopment and associated disorders like Schizophrenia, as well as brain injury and stroke. 7

ALBERTA PRINCIPAL INVESTIGATORS

ALBERTA PRINCIPAL INVESTIGATORS Dr. Gregory Cairncross is Head of the Department of Clinical Neurosciences at the University of Calgary and holder of the Alberta Cancer Foundation Chair in Brain Tumor