NAVIGATE DISTAL AND TORTUOUS ANATOMY

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1 PROGREAT ALPHA PUSHINGBOUNDARIES Terumo Interventional Systems is committed to your success with innovative procedural solutions and ongoing support for your most challenging cases. We are relentlessly seeking new ways to help you apply effective solutions and achieve better outcomes for more patients. NEW!.8 Fr cm Radial Length Coaxial System PROGREAT MICROCATHETER.4Fr MC*PB4Y MC*PB43Y PROGREAT ALPHA.0 Fr size.7fr MC*PV45Y TM MC*PC7Y 0 MC*PC73Y 30 MC*PB8Y 0 7 Designed to enhance access 30 to small MC*PB83Y, peripheralmc*pv85y vessels.8fr, Includes uniquespecifically 0.0" GLIDEWIRE wire stopper,vasculature guidewire introducer, hemostatic valve,.5ml syringe and shaping mandrel forgt, peripheral PROGREAT COAXIAL MICROCATHETER SYSTEM TERUMO Glide Technology for navigation through, tortuous anatomy MC*PE7Y 0 7 MC*PE8YB 0 MC*PE83YB 30, Thin-wall design with large 0.09 lumen Tungsten coil reinforcement for kink resistance MC*PE85YV 3.8Fr mm/0.09in 60 MC*PE73Y 30 Designed to confidently deliver embolotherapy3.8fr 0.0" GLIDEWIRE GT.7Fr 4 Designed to improve the efficiency of your Dead Space Inner Embolic Guidewire Diameter Length Compatibility Volume (ml) embolization procedures Distal/ Proximal Supports µm 0 cmthe delivery of large embolics up to " Coils/.4/.9Fr 0.0"/0.57mm 0.08" 30 cm 0.53 spherical particles, and the AZUR CX0µm 0.08 Peripheral (0.80/0.97mm) cm 0.58 Coil System.7/.9Fr (0./0.97mm) 0 cm " Coils/ 0.05"/0.65mm 0.0" 0µm Designed superior PSI, cmto provide clear images, with, cm to similar-sized microcatheters compared.8/3.0fr (0.93/.00mm) 30 cm 0.07"/0.mm 0.0" 0.08" Coils/ µm mm/.0Fr Actual Flow Rate* (ml/sec) 7 psi psi cm *Flow rates taken at 37 using ISOVUE 300. Phone: FIND OUT MORE Pre Y- embolization 07 Terumo Medical Corporation. All rights reserved. All brand names are trademarks or registered trademarks of their respective owners. ISOVUE 300 is a registered trademark of BRACCO Diagnostics. TIS /LG terumois.com Fax: NAVIGATE DISTAL AND TORTUOUS ANATOMY

2 PROGREAT ALPHA PUSHINGBOUNDARIES Terumo Interventional Systems is committed to your success with innovative procedural solutions and ongoing support for your most challenging cases. We are relentlessly seeking new ways to help you apply effective solutions and achieve better outcomes for more patients. NEW!.8 Fr cm Radial Length Coaxial System PROGREAT MICROCATHETER.4Fr MC*PB4Y MC*PB43Y PROGREAT ALPHA.0 Fr size.7fr MC*PV45Y TM MC*PC7Y 0 MC*PC73Y 30 MC*PB8Y 0 7 Designed to enhance access 30 to small MC*PB83Y, peripheralmc*pv85y vessels.8fr, Includes uniquespecifically 0.0" GLIDEWIRE wire stopper,vasculature guidewire introducer, hemostatic valve,.5ml syringe and shaping mandrel forgt, peripheral PROGREAT COAXIAL MICROCATHETER SYSTEM TERUMO Glide Technology for navigation through, tortuous anatomy MC*PE7Y 0 7 MC*PE8YB 0 MC*PE83YB 30, Thin-wall design with large 0.09 lumen Tungsten coil reinforcement for kink resistance MC*PE85YV 3.8Fr mm/0.09in 60 MC*PE73Y 30 Designed to confidently deliver embolotherapy3.8fr 0.0" GLIDEWIRE GT.7Fr 4 Designed to improve the efficiency of your Dead Space Inner Embolic Guidewire Diameter Length Compatibility Volume (ml) embolization procedures Distal/ Proximal Supports µm 0 cmthe delivery of large embolics up to " Coils/.4/.9Fr 0.0"/0.57mm 0.08" 30 cm 0.53 spherical particles, and the AZUR CX0µm 0.08 Peripheral (0.80/0.97mm) cm 0.58 Coil System.7/.9Fr (0./0.97mm) 0 cm " Coils/ 0.05"/0.65mm 0.0" 0µm Designed superior PSI, cmto provide clear images, with, cm to similar-sized microcatheters compared.8/3.0fr (0.93/.00mm) 30 cm 0.07"/0.mm 0.0" 0.08" Coils/ µm mm/.0Fr Actual Flow Rate* (ml/sec) 7 psi psi cm *Flow rates taken at 37 using ISOVUE 300. Phone: FIND OUT MORE Pre Y- embolization 07 Terumo Medical Corporation. All rights reserved. All brand names are trademarks or registered trademarks of their respective owners. ISOVUE 300 is a registered trademark of BRACCO Diagnostics. TIS /LG terumois.com Fax: NAVIGATE DISTAL AND TORTUOUS ANATOMY

3 Designed to enable rapid, precise positioning with optimal visibility OPTIMAL TRACKABILITY THROUGH TORTUOUS ANATOMY Radiopaque 0.7 mm platinum/iridium microcatheter markers engineered into 0, 30, and cm microcatheters PROGREAT microcatheters are designed to allow navigation through tortuous peripheral vessels for optimal access and delivery of therapeutic embolization. Single Marker Distal Proximal Designed to confidently deliver embolotherapy 0.7 mm platinum/iridium marker Tungsten coil reinforcement for kink resistance PROGREAT ALPHA.0 Fr 0 cm, 30 cm, cm 3 cm radiopaque gold coil on 0.0" GLIDEWIRE GT PTFE inner layer is designed for exceptional guidewire tracking, with virtually frictionless delivery of coils and other embolics PROGREAT.4 Fr,.7 Fr,.8 Fr 0 cm, 30 cm Double Marker 3 mm. mm PTFE inner layer Designed to enhance access to small, distal vessels Distal TERUMO Glide Technology hydrophilic coating enhances navigation through tortuous anatomy 0.7 mm radiopaque platinum/iridium marker Unique varied tungsten coil pitch construction provides distal flexibility and proximal pushability, enhancing vessel selectivity and catheter placement Unique tungsten coil layer Varied tungsten coil pitch Proximal 0.7 mm platinum/iridium marker First Marker Second Marker PROGREAT.4 Fr,.8 Fr cm PROGREAT COAXIAL MICROCATHETER SYSTEM Preloaded with uniquely designed 0.0 GLIDEWIRE GT Distal High density Low density Proximal Enables simultaneous preparation of microcatheter and guidewire, which may save time and increase procedural efficiency TERUMO Glide Technology Coating Achieve effective embolization when used in combination with and PROGREAT.7 Fr /.8 Fr coaxial microcatheter system (coaxial type with catheter and guidewire)

4 PROGREAT ALPHA PUSHINGBOUNDARIES Terumo Interventional Systems is committed to your success with innovative procedural solutions and ongoing support for your most challenging cases. We are relentlessly seeking new ways to help you apply effective solutions and achieve better outcomes for more patients. NEW!.8 Fr cm Radial Length Coaxial System PROGREAT MICROCATHETER.4Fr MC*PB4Y MC*PB43Y PROGREAT ALPHA.0 Fr size.7fr MC*PV45Y TM MC*PC7Y 0 MC*PC73Y 30 MC*PB8Y 0 7 Designed to enhance access 30 to small MC*PB83Y, peripheralmc*pv85y vessels.8fr, Includes uniquespecifically 0.0" GLIDEWIRE wire stopper,vasculature guidewire introducer, hemostatic valve,.5ml syringe and shaping mandrel forgt, peripheral PROGREAT COAXIAL MICROCATHETER SYSTEM TERUMO Glide Technology for navigation through, tortuous anatomy MC*PE7Y 0 7 MC*PE8YB 0 MC*PE83YB 30, Thin-wall design with large 0.09 lumen Tungsten coil reinforcement for kink resistance MC*PE85YV 3.8Fr mm/0.09in 60 MC*PE73Y 30 Designed to confidently deliver embolotherapy3.8fr 0.0" GLIDEWIRE GT.7Fr 4 Designed to improve the efficiency of your Dead Space Inner Embolic Guidewire Diameter Length Compatibility Volume (ml) embolization procedures Distal/ Proximal Supports µm 0 cmthe delivery of large embolics up to " Coils/.4/.9Fr 0.0"/0.57mm 0.08" 30 cm 0.53 spherical particles, and the AZUR CX0µm 0.08 Peripheral (0.80/0.97mm) cm 0.58 Coil System.7/.9Fr (0./0.97mm) 0 cm " Coils/ 0.05"/0.65mm 0.0" 0µm Designed superior PSI, cmto provide clear images, with, cm to similar-sized microcatheters compared.8/3.0fr (0.93/.00mm) 30 cm 0.07"/0.mm 0.0" 0.08" Coils/ µm mm/.0Fr Actual Flow Rate* (ml/sec) 7 psi psi cm *Flow rates taken at 37 using ISOVUE 300. Phone: FIND OUT MORE Pre Y- embolization 07 Terumo Medical Corporation. All rights reserved. All brand names are trademarks or registered trademarks of their respective owners. ISOVUE 300 is a registered trademark of BRACCO Diagnostics. TIS /LG terumois.com Fax: NAVIGATE DISTAL AND TORTUOUS ANATOMY

5 PROGREAT ALPHA PROGREAT ALPHA TM.0 Fr size Designed to enhance access to small peripheral vessels, specifically for peripheral vasculature, TERUMO Glide Technology for navigation through tortuous anatomy, Designed to confidently deliver embolotherapy 3 Thin-wall design with large 0.09 lumen, Tungsten coil reinforcement for kink resistance mm/0.09in 4 Designed to improve the efficiency of your embolization procedures Supports the delivery of large embolics up to 0 µm spherical particles, and the AZUR CX 0.08 Peripheral Coil System Designed to provide clear images, with superior PSI, compared to similar-sized microcatheters, 0.67mm/.0Fr Pre Y- embolization

6 PUSHING BOUNDARIES Terumo Interventional Systems is committed to your success with innovative procedural solutions and ongoing support for your most challenging cases. We are relentlessly seeking new ways to help you apply effective solutions and achieve better outcomes for more patients. PROGREAT ALPHA TM.0 Fr Peripheral Microcatheter ORDERING INFORMATION PROGREAT ALPHA PERIPHERAL MICROCATHETER Fr SIZE.0 Fr PRODUCT CODE LENGTH MAX PRESSURE (PSI) RO MARKERS TIP SHAPE HYDROPHILIC COATING LENGTH MC*PC0Y 0 Straight MC*PC03Y 30 7 Straight MC*PC05Y Straight Distal/Proximal.0/.7 Fr (0.67/ 0.mm) LENGTH INNER DIAMETER MAX GUIDEWIRE EMBOLIC COMPATIBILITY DEAD SPACE VOLUME (ml) ACTUAL FLOW RATE* (ml/sec) 7 psi AZUR CX / Coils/0 µm *Flow rates taken at 37 using ISOVUE 300 Shapeable tip includes shaping mandrel PROGREAT MICROCATHETER Also available in.4 Fr /.7 Fr /.8 Fr (without guidewire) PROGREAT COAXIAL MICROCATHETER SYSTEM Available in.7 Fr /.8 Fr (coaxial type with catheter and guidewire) Includes unique 0.0 GLIDEWIRE GT Guidewire, wire stopper, guidewire introducer, hemostatic valve,.5 ml syringe, and shaping mandrel References:. PROGREAT Catheter [Instructions for Use]. Somerset, NJ: Terumo Medical Corporation; 04.. Data on File. Terumo Medical Corporation. 3. PROGREAT Catheter (k); PROGREAT DMSO Compatibility Statement Letter. dam/terumopublic/products/progreat/progreat_dmso_compatibility_statement_letter. pdf. September 8, 06. Accessed July 8, Terumo Medical Corporation. All rights reserved. All brand names are trademarks or registered trademarks of their respective owners. TIS /LG

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