System simulation modelling of TBI care added value for health care decision making?

Size: px
Start display at page:

Download "System simulation modelling of TBI care added value for health care decision making?"

Transcription

1 System simulation modelling of TBI care added value for health care decision making? 1 st Turku Traumatic Brain Injury Symposium Peter Ylén VTT Technical Research Centre of Finland

2 Purpose A dynamic simulation model for evaluating long-term socioeconomic effects of different choices in traumatic brain injury treatment Starting from prevention of the incident to decades after the rehabilitation Includes many different interest groups, such as, patient, accute phase hospital, society, rehabilitation unit, patient s relatives, emergency room, etc What-if scenarios and sensitivity analysis

3 Contents System dynamics model Structure: Feedback loops in the model Simulation Results Scenarios Base (no changes to current policies) New diagnostic tools (improves the accuracy of diagnoses) Advertisement Campaign (increases the willingness of patients to get to a doctor after a head injury) TBI Prevention (e.g. lower speed limits) All policy improvements Sensitivity tests Conclusions

4 Manageable complexity Models for decision making Simulation Mathematical formulation Fit models to data Systems thinking Shared and formalized mental models Mental models Expert opinion Unanalyzed written case reports Exactness and detail of representation

5 What is system dynamics Identifying complex cause and effect relationships Tool to help communicate mental models Understanding the long- and short-term consequences of actions Foreseeing unintended consequences Finding leverage seeing where actions and change can lead to significant and enduring improvements Simulating policies under different assumptions and uncertainties

6 Health care services - the model dependencies

7 Patient flow

8 TBI care System model of treatment chain Incidence ER Hospital Life with TBI Rehabilitation

9 ER and hospital Incorrect diagnoses Discharge Secondary injuries More difficult readmissions Resource inadequacy More incorrect diagnoses Patients less willing to wait if they have only mild symptoms Worst case scenario Readmissions spiral out of control, consume resources Expensive and ineffective

10 Long term problems More prone to new TBI Rehabilitation increases quality of life and reduces long term costs Less stress on health care system

11 The Main Feedback Loops

12 Resource Inadequacy at ER Leads to Secondary Injuries and Readmissions Lack of resources causes hurry and inaccurate diagnoses If the injury is not diagnosed early enough it has tendency to generate severe secondary injuries Red Loop

13 Long Queueing Times Decreases Willingness to Go to ER in Time Long queuing time has tendency to decrease the willingness to get to a doctor Sometimes this leads to secondary injuries Green Loop

14 Discharging Based on Inaccurate Diagnoses tends to lead Readmissions Blue Loop

15 Resource Inadequacy in Hospital Leads to Readmissions and sec. injuries Lack of resources in hospital leads to inaccurate diagnoses and sometimes to secondary injuries Violet Loop

16 Patients after TBI tend to get more Injuries In long term the patients are more prone to injuries and other long term problems (e.g. depression and alcoholism) Yellow Loop

17 Detailed view to the Model The detailed model is rather complex due to myriads of interdependencies between parts of the system

18 About the model The model consists of several feedback loops most of which are positive (reinforcing) The system tends to be unstable The most important negative (balancing) feedback loops are those that adjust the capacities of TBI treatment and rehabilitation

19 Simulation Results

20 Example Scenario Simulations Base No changes to current policies New diagnostic tools are adopted Improves the accuracy of diagnoses Prevention policies (e.g. lower speed limits) are adopted Decreased incidence rate Advertisement campaign to increase awareness of TBIs Increases the willingness of patients to get to a doctor after a head injury All policy improvements together (mentioned above)

21 Resource Spending (~money)

22 TBI Deaths per Year

23 Costs on Society

24 About the Results Based on the preliminary simulations it seems that preventing TBIs is clearly the best policy to reduce costs on society and to improve the quality of life of the population This is rather expected - nevertheless Some of the results show so called worse-before-betterbehaviour (see advertisement campaign for example) See also the minor improvement of the results due to new and improved diagnosis tools This needs more elaboration!!

25 Sensitivity to uncertainties

26 Some Sensitivity Tests Several uncertain parameters were varied Left column: No diagnosis tools in use Right column: Diagnosis tools in use

27 About sensitivity tests Diagnosis tools improve the accuracy of the diagnoses Especially when the accuracy of the diagnoses is otherwise poor (in a hurry and by inexperienced doctors) Diagnosis tools make the system significantly more robust under uncertainty

28 Conclusions

29 Conclusions Preliminary simulations of the socio-economic model are possible Validation needs to be completed Parameter values need to be set according to all the data collected

1st Turku Traumatic Brain Injury Symposium Turku, Finland, January 2014

1st Turku Traumatic Brain Injury Symposium Turku, Finland, January 2014 The TBIcare decision support tool aid for the clinician Jyrki Lötjönen & Jussi Mattila, VTT Technical Research Centre of Finland Validation of the decision support tool Ari Katila University of Turku 1st

More information

Neonatal hearing screening: modelling cost and effectiveness of hospital- and communitybased

Neonatal hearing screening: modelling cost and effectiveness of hospital- and communitybased Neonatal hearing screening: modelling cost and effectiveness of hospital- and communitybased screening Grill E, Uus K, Hessel F, Davies L, Taylor R S, Wasem J, Bamford J Record Status This is a critical

More information

Asthma: A Multi-factorial Disease Requiring Multi-Level Interventions

Asthma: A Multi-factorial Disease Requiring Multi-Level Interventions Asthma: A Multi-factorial Disease Requiring Multi-Level Interventions Ted Schettler Science and Environmental Health Network Primary Prevention of Asthma: A Symposium Boston April 23, 2013 Asthma: a complex

More information

First Turku Traumatic Brain Injury Symposium

First Turku Traumatic Brain Injury Symposium First Turku Traumatic Brain Injury Symposium Harri Siitari, Ph.D, Senior Principal Scientist Project Manager Click to edit Master Biggest title multitechnological style applied research organisation in

More information

Study population The study population comprised the general population of Senegal inhabitants aged 1 to 30 years.

Study population The study population comprised the general population of Senegal inhabitants aged 1 to 30 years. Comparison of cost-effectiveness of preventive and reactive mass immunization campaigns against meningococcal meningitis in West Africa: a theoretical modeling analysis Parent du Chatelet I, Gessner B

More information

Economic Evaluation. Introduction to Economic Evaluation

Economic Evaluation. Introduction to Economic Evaluation Economic Evaluation Introduction to Economic Evaluation This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of

More information

Critical Thinking: Science, Models, & Systems

Critical Thinking: Science, Models, & Systems Critical Thinking: Science, Models, & Systems tutorial by Paul Rich Brooks/Cole Publishing Company / ITP Outline 1. Science & Technology What is science? What is technology? scientific process 2. Systems

More information

Complexity, Networking, and Effects-Based Operations

Complexity, Networking, and Effects-Based Operations Complexity, Networking, and Effects-Based Operations Approaching the how to of EBO Dr. Ed Smith +1-703-872-4028 edward.a.smith-jr@boeing.com The Way Ahead Boeing Boeing 1 The Way Ahead 2 1. Why and What

More information

Setting The setting was primary care. The economic study was carried out in the UK.

Setting The setting was primary care. The economic study was carried out in the UK. A probabilistic cost-effectiveness analysis of escitalopram, generic citalopram and venlafaxine as a first-line treatment of major depressive disorder in the UK Wade A G, Toumi I, Hemels M E Record Status

More information

Identifying best practice in actions on tobacco smoking to reduce health inequalities

Identifying best practice in actions on tobacco smoking to reduce health inequalities Identifying best practice in actions on tobacco smoking to reduce health inequalities An Matrix Knowledge Report to the Consumers, Health and Food Executive Agency, funded by the Health Programme of the

More information

Ignorance and politically correct worst case scenarios of sociopolitical phenomena

Ignorance and politically correct worst case scenarios of sociopolitical phenomena CRACOW UNIVERSITY OF ECONOMICS mesjaszc@uekkrakowpl Ignorance and politically correct worst case scenarios of sociopolitical phenomena The presentation is a draft of a broader project and of publication

More information

New Effects-Based Operations Models in War Games. Lee W. Wagenhals Larry K. Wentz

New Effects-Based Operations Models in War Games. Lee W. Wagenhals Larry K. Wentz New Effects-Based Operations Models in War Games Lee W. Wagenhals Larry K. Wentz 2003 ICCRTS 8th International Command and Control Research and Technology Symposium June 19, 2002 National Defense University

More information

Position Paper: How Certain is Recommended Trust-Information?

Position Paper: How Certain is Recommended Trust-Information? Position Paper: How Certain is Recommended Trust-Information? Uwe Roth University of Luxembourg FSTC Campus Kirchberg 6, rue Richard Coudenhove-Kalergi L-1359 Luxembourg uwe.roth@uni.lu ABSTRACT Nowadays

More information

Key Ideas. Explain how science is different from other forms of human endeavor. Identify the steps that make up scientific methods.

Key Ideas. Explain how science is different from other forms of human endeavor. Identify the steps that make up scientific methods. Key Ideas Explain how science is different from other forms of human endeavor. Identify the steps that make up scientific methods. Analyze how scientific thought changes as new information is collected.

More information

ARE STROKE UNITS COST EFFECTIVE? EVIDENCE FROM A NEW ZEALAND STROKE INCIDENCE AND POPULATION-BASED STUDY

ARE STROKE UNITS COST EFFECTIVE? EVIDENCE FROM A NEW ZEALAND STROKE INCIDENCE AND POPULATION-BASED STUDY ARE STROKE UNITS COST EFFECTIVE? EVIDENCE FROM A NEW ZEALAND STROKE INCIDENCE AND POPULATION-BASED STUDY Braden Te Ao, Ph.D. Centre for Health Services Research & Policy, University of Auckland, National

More information

Cost-effectiveness of uterine artery embolization and hysterectomy for uterine fibroids Beinfeld M T, Bosch J L, Isaacson K B, Gazelle G S

Cost-effectiveness of uterine artery embolization and hysterectomy for uterine fibroids Beinfeld M T, Bosch J L, Isaacson K B, Gazelle G S Cost-effectiveness of uterine artery embolization and hysterectomy for uterine fibroids Beinfeld M T, Bosch J L, Isaacson K B, Gazelle G S Record Status This is a critical abstract of an economic evaluation

More information

Best Practices for Specialty Pharmacy Usage Management. Neil S. Shah, PharmD Specialty Pharmacist, Blue Cross Blue Shield of NC

Best Practices for Specialty Pharmacy Usage Management. Neil S. Shah, PharmD Specialty Pharmacist, Blue Cross Blue Shield of NC Best Practices for Specialty Pharmacy Usage Management Neil S. Shah, PharmD Specialty Pharmacist, Blue Cross Blue Shield of NC Overview Provide a background to specialty pharmacy Identify key industry

More information

A Brief Introduction to Bayesian Statistics

A Brief Introduction to Bayesian Statistics A Brief Introduction to Statistics David Kaplan Department of Educational Psychology Methods for Social Policy Research and, Washington, DC 2017 1 / 37 The Reverend Thomas Bayes, 1701 1761 2 / 37 Pierre-Simon

More information

Health and economic consequences of HCV lookback Pereira A

Health and economic consequences of HCV lookback Pereira A Health and economic consequences of HCV lookback Pereira A Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a

More information

Climate-Related Decision Making Under Uncertainty. Chris Weaver February 2016

Climate-Related Decision Making Under Uncertainty. Chris Weaver February 2016 Climate-Related Decision Making Under Uncertainty Chris Weaver February 2016 Why is climate change decision making hard? Climate change is a uniquely tricky problem But effective, science-based decision

More information

Developing a Risk Minimization Action Plan (RiskMAP): Developing Interventions

Developing a Risk Minimization Action Plan (RiskMAP): Developing Interventions Developing a Risk Minimization Action Plan (RiskMAP): Developing Interventions Louis A. Morris, Ph.D. Louis A. Morris & Associates, Inc. www.lamainc.com April 11, 2005 RiskMAP Tools are categorized into

More information

Modelling FMD at European scale

Modelling FMD at European scale Modelling FMD at European scale No movement ban County level movement ban Buhnerkempe, Tildesley, Lindström, Grear, Portacci, Miller, Lombard, Werkman, Keeling, Wennergren, Webb. 2014. PLoS One The process

More information

Systems Thinking Rubrics

Systems Thinking Rubrics Systems Thinking Rubrics Systems Thinking Beginner (designed for instructor use), pages 1-2 These rubrics were designed for use with primary students and/or students who are just beginning to learn systems

More information

Risk Assessment Terminology, Expression of Nature and level of Risk and Uncertainties

Risk Assessment Terminology, Expression of Nature and level of Risk and Uncertainties Risk Assessment Terminology, Expression of Nature and level of Risk and Uncertainties Professor Tony Hardy, Chair of EFSA PPR Panel Brussels 13 th November 2008 Comparative Review of Risk Terminology of

More information

A Strategy for Evaluating ICD-10 Implementation and Updating Process: 2005 Status Report

A Strategy for Evaluating ICD-10 Implementation and Updating Process: 2005 Status Report WHO-FIC NETWORK MEETING Recommendations Marjorie S. Greenberg, Head, North American Collaborating Center National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville,

More information

Discrimination and Generalization in Pattern Categorization: A Case for Elemental Associative Learning

Discrimination and Generalization in Pattern Categorization: A Case for Elemental Associative Learning Discrimination and Generalization in Pattern Categorization: A Case for Elemental Associative Learning E. J. Livesey (el253@cam.ac.uk) P. J. C. Broadhurst (pjcb3@cam.ac.uk) I. P. L. McLaren (iplm2@cam.ac.uk)

More information

GROUP DECISION MAKING IN RISKY ENVIRONMENT ANALYSIS OF GENDER BIAS

GROUP DECISION MAKING IN RISKY ENVIRONMENT ANALYSIS OF GENDER BIAS GROUP DECISION MAKING IN RISKY ENVIRONMENT ANALYSIS OF GENDER BIAS Andrea Vasiľková, Matúš Kubák, Vladimír Gazda, Marek Gróf Abstract Article presents an experimental study of gender bias in group decisions.

More information

Access to newly licensed medicines. Scottish Medicines Consortium

Access to newly licensed medicines. Scottish Medicines Consortium Access to newly licensed medicines Scottish Medicines Consortium Modifiers The Committee has previously been provided with information about why the SMC uses modifiers in its appraisal process and also

More information

Exploring uncertainty in cost effectiveness analysis. Francis Ruiz NICE International (acknowledgements to: Benjarin Santatiwongchai of HITAP)

Exploring uncertainty in cost effectiveness analysis. Francis Ruiz NICE International (acknowledgements to: Benjarin Santatiwongchai of HITAP) Exploring uncertainty in cost effectiveness analysis Francis Ruiz NICE International (acknowledgements to: Benjarin Santatiwongchai of HITAP) NICE International and HITAP copyright 2013 Why uncertainty

More information

Non-Technical Summary of: The War on Illegal Drug Production and Trafficking: An Economic Evaluation of Plan Colombia 1

Non-Technical Summary of: The War on Illegal Drug Production and Trafficking: An Economic Evaluation of Plan Colombia 1 Non-Technical Summary of: The War on Illegal Drug Production and Trafficking: An Economic Evaluation of Plan Colombia 1 by: Daniel Mejía and Pascual Restrepo Fedesarrollo and Universidad de los Andes Original

More information

Study population The study population comprised a hypothetical cohort of poorly reversible COPD patients with a history of exacerbations.

Study population The study population comprised a hypothetical cohort of poorly reversible COPD patients with a history of exacerbations. Development of an economic model to assess the cost-effectiveness of treatment interventions for chronic obstructive pulmonary disease Spencer M, Briggs A H, Grossman R F, Rance L Record Status This is

More information

Like others here today, we are very conflicted on the FDA s proposal on behind-thecounter medications, but thank you for raising the issue.

Like others here today, we are very conflicted on the FDA s proposal on behind-thecounter medications, but thank you for raising the issue. Statement of Consumers Union William Vaughan, Senior Policy Analyst before the US Food and Drug Administration Public Meeting on Behind the Counter Availability of Drugs November 14, 2007 Consumers Union

More information

ONLINE TECHNICAL APPENDIX TO: UK ALCOHOL INDUSTRY S BILLION UNITS PLEDGE : INTERIM EVALUATION FLAWED

ONLINE TECHNICAL APPENDIX TO: UK ALCOHOL INDUSTRY S BILLION UNITS PLEDGE : INTERIM EVALUATION FLAWED ONLINE TECHNICAL APPENDIX TO: UK ALCOHOL INDUSTRY S BILLION UNITS PLEDGE : INTERIM EVALUATION FLAWED This appendix provides additional technical critiques of the UK Department of Health s second interim

More information

EVIDENCE IN BRIEF OVERALL CLINICAL BENEFIT

EVIDENCE IN BRIEF OVERALL CLINICAL BENEFIT into consideration the concerns of the patient. Upon reconsideration of the perc Initial Recommendation,the Committee discussed feedback from the patient advocacy group reporting concerns that the definition

More information

Evaluation of breast cancer risk assessment techniques: a cost-effectiveness analysis Ozanne E M, Esserman L J

Evaluation of breast cancer risk assessment techniques: a cost-effectiveness analysis Ozanne E M, Esserman L J Evaluation of breast cancer risk assessment techniques: a cost-effectiveness analysis Ozanne E M, Esserman L J Record Status This is a critical abstract of an economic evaluation that meets the criteria

More information

Data inputs for HIV models and how they inform HIV prevention interventions Dobromir Dimitrov

Data inputs for HIV models and how they inform HIV prevention interventions Dobromir Dimitrov Data inputs for HIV models and how they inform HIV prevention interventions Dobromir Dimitrov Vaccine & Infectious Disease Division Fred Hutchinson Cancer Research Center Dynamic model integration The

More information

Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia

Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia Single Technology Appraisal 2 nd Committee meeting: 16 March 2017 Committee C FOR PUBLIC Key issues Absence of direct

More information

An Economic Framework to Inform the Scheduling of Medicines

An Economic Framework to Inform the Scheduling of Medicines An Economic Framework to Inform the Scheduling of Medicines Dr Bonny Parkinson Senior Research Fellow Centre for the Health Economy Dr Mutsa Gumbie Research Fellow Dr Henry Cutler Director Special thanks

More information

Cost-effectiveness of a community anti-smoking campaign targeted at a high risk group in London Stevens W, Thorogood M, Kayikki S

Cost-effectiveness of a community anti-smoking campaign targeted at a high risk group in London Stevens W, Thorogood M, Kayikki S Cost-effectiveness of a community anti-smoking campaign targeted at a high risk group in London Stevens W, Thorogood M, Kayikki S Record Status This is a critical abstract of an economic evaluation that

More information

Financial Literacy Trajectories

Financial Literacy Trajectories Financial Literacy Trajectories Paul Gerrans paul.gerrans@uwa.edu.au Two roads diverged in a wood, and I I took the one less traveled by, And that has made all the difference. Robert Frost Financial Literacy

More information

The Danger of Incorrect Expectations In Driving: The Failure to Respond

The Danger of Incorrect Expectations In Driving: The Failure to Respond University of Iowa Iowa Research Online Driving Assessment Conference 2007 Driving Assessment Conference Jul 11th, 12:00 AM The Danger of Incorrect Expectations In Driving: The Failure to Respond Martin

More information

The use of antivirals to reduce morbidity from pandemic influenza

The use of antivirals to reduce morbidity from pandemic influenza The use of antivirals to reduce morbidity from pandemic influenza Raymond Gani, Iain Barrass, Steve Leach Health Protection Agency Centre for Emergency Preparedness and Response, Porton Down, Salisbury,

More information

Self enhancement and voting intentions: A proposal for questions to be included in the

Self enhancement and voting intentions: A proposal for questions to be included in the Self enhancement and voting intentions: A proposal for questions to be included in the ANES pilot study and in the following surveys Abstract: Self enhancement entails perceiving oneself more positively

More information

Basic Economic Analysis. David Epstein, Centre for Health Economics, York

Basic Economic Analysis. David Epstein, Centre for Health Economics, York Basic Economic Analysis David Epstein, Centre for Health Economics, York Contents Introduction Resource use and costs Health Benefits Economic analysis Conclusions Introduction What is economics? Choices

More information

Supporting Information for How Public Opinion Constrains the U.S. Supreme Court

Supporting Information for How Public Opinion Constrains the U.S. Supreme Court Supporting Information for How Public Opinion Constrains the U.S. Supreme Court Christopher J. Casillas Peter K. Enns Patrick C. Wohlfarth Christopher J. Casillas is a Ph.D. Candidate in the Department

More information

COACH IN RUNNING FITNESS SUPPORT COACH GUIDE

COACH IN RUNNING FITNESS SUPPORT COACH GUIDE COACH IN RUNNING FITNESS SUPPORT COACH GUIDE CONTENTS INTRODUCTION CONTENTS introduction 02 When to get involved 03 how You Can help 04 STRUCTURE OF THE COACH IN RUNNING FITNESS COURSE AND WHEN A MAY BECOME

More information

Statistical Bulletin

Statistical Bulletin Statistical Bulletin Health & Social Care Series Long-term Monitoring of Health Inequalities October 2013 Report Date: 29 October 2013 Main Findings An Official Statistics Publication for Scotland Healthy

More information

Bayesian Tolerance Intervals for Sparse Data Margin Assessment

Bayesian Tolerance Intervals for Sparse Data Margin Assessment Bayesian Tolerance Intervals for Sparse Data Margin Assessment Benjamin Schroeder and Lauren Hund ASME V&V Symposium May 3, 2017 - Las Vegas, NV SAND2017-4590 C - (UUR) Sandia National Laboratories is

More information

Appendix: Instructions for Treatment Index B (Human Opponents, With Recommendations)

Appendix: Instructions for Treatment Index B (Human Opponents, With Recommendations) Appendix: Instructions for Treatment Index B (Human Opponents, With Recommendations) This is an experiment in the economics of strategic decision making. Various agencies have provided funds for this research.

More information

2011 International Coaching Symposium

2011 International Coaching Symposium 2011 International Coaching Symposium Injuries in Pro Hockey Dusan Benicky Specific adaptation to imposed demands Theory 1. Introduction 2. Prehabilitation - Performance - Rehabilitation Practical Concepts

More information

Health technology The use of oseltamivir for the treatment of influenza in otherwise healthy children.

Health technology The use of oseltamivir for the treatment of influenza in otherwise healthy children. Effect of influenza treatment with oseltamivir on health outcome and costs in otherwise healthy children Reisinger K, Greene G, Aultman R, Sander B, Gyldmark M Record Status This is a critical abstract

More information

NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE

NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE Health Technology Appraisal Rituximab for the treatment of relapsed or refractory stage III or IV follicular non-hodgkin s lymphoma (review of technology

More information

Progress in improving cancer services and outcomes in England. Report. Department of Health, NHS England and Public Health England

Progress in improving cancer services and outcomes in England. Report. Department of Health, NHS England and Public Health England Report by the Comptroller and Auditor General Department of Health, NHS England and Public Health England Progress in improving cancer services and outcomes in England HC 949 SESSION 2014-15 15 JANUARY

More information

Sustainability of the CONSENSO project

Sustainability of the CONSENSO project Sustainability of the CONSENSO project Ippoliti R. November 8, 2017 Ippoliti, R., CONSENSO and sustainability - Ljubljana, 2017 1 Table of contents Theoretical background 1 Theoretical background Targets

More information

UNESCO EOLSS. This article deals with risk-defusing behavior. It is argued that this forms a central part in decision processes.

UNESCO EOLSS. This article deals with risk-defusing behavior. It is argued that this forms a central part in decision processes. RISK-DEFUSING BEHAVIOR Oswald Huber University of Fribourg, Switzerland Keywords: cognitive bias, control, cost of risk-defusing operators, decision making, effect of risk-defusing operators, lottery,

More information

KEVIN J. BIANCHINI, PH.D., ABPN

KEVIN J. BIANCHINI, PH.D., ABPN KEVIN J. BIANCHINI, PH.D., ABPN Slick et al., 1999 Bianchini et al., 2005 4 4 Criterion A: Evidence of significant external incentive Criterion B: Evidence from physical evaluation 1. Probable effort

More information

1 + denotes a higher variable value for the deletion or depletion than the control scenario; - denotes a lower value.

1 + denotes a higher variable value for the deletion or depletion than the control scenario; - denotes a lower value. Table S1. Significant changes in granuloma variables at 200 days post-infection for deletion and depletion of combinations of two individual TNF activities versus the baseline control scenario 1. Sample

More information

INSTRUCTOR S NOTE. Copyright 2018, The Johns Hopkins University and Teaching Vaccine Economics Everywhere.

INSTRUCTOR S NOTE. Copyright 2018, The Johns Hopkins University and Teaching Vaccine Economics Everywhere. INSTRUCTOR S NOTE This case study can be used to motivate several learning objectives and can be tied to specific course objectives in the modules. In case studies the students are not spoon-fed. Instead,

More information

Supporting Information

Supporting Information 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 Supporting Information Variances and biases of absolute distributions were larger in the 2-line

More information

Optimal control of an emergency room triage and treatment process

Optimal control of an emergency room triage and treatment process Optimal control of an emergency room triage and treatment process Gabriel Zayas-Cabán 1 Mark E. Lewis 1 Jungui Xie 2 Linda V. Green 3 1 Cornell University Ithaca, NY 2 University of Science and Technology

More information

CHANCE YEAR. A guide for teachers - Year 10 June The Improving Mathematics Education in Schools (TIMES) Project

CHANCE YEAR. A guide for teachers - Year 10 June The Improving Mathematics Education in Schools (TIMES) Project The Improving Mathematics Education in Schools (TIMES) Project CHANCE STATISTICS AND PROBABILITY Module 15 A guide for teachers - Year 10 June 2011 10 YEAR Chance (Statistics and Probability : Module 15)

More information

The cost-effectiveness of omega-3 supplements for prevention of secondary coronary events Schmier J K, Rachman N J, Halpern M T

The cost-effectiveness of omega-3 supplements for prevention of secondary coronary events Schmier J K, Rachman N J, Halpern M T The cost-effectiveness of omega-3 supplements for prevention of secondary coronary events Schmier J K, Rachman N J, Halpern M T Record Status This is a critical abstract of an economic evaluation that

More information

Applications with Bayesian Approach

Applications with Bayesian Approach Applications with Bayesian Approach Feng Li feng.li@cufe.edu.cn School of Statistics and Mathematics Central University of Finance and Economics Outline 1 Missing Data in Longitudinal Studies 2 FMRI Analysis

More information

RESEARCH OBJECTIVE(S) List study objectives.

RESEARCH OBJECTIVE(S) List study objectives. CRITICALLY APPRAISED PAPER (CAP) Zickefoose, S., Hux, K., Brown, J., & Wulf, K. (2013). Let the games begin: A preliminary study using Attention Process Training-3 and Lumosity brain games to remediate

More information

List of issues and questions with regard to the consideration of periodic reports

List of issues and questions with regard to the consideration of periodic reports United Nations Convention on the Elimination of All Forms of Discrimination against Women CEDAW/C/BFA/Q/6 Distr.: General 6 April 2010 Original: English Committee on the Elimination of Discrimination against

More information

FRAMEWORK FOR A HEALTHIER FUTURE:

FRAMEWORK FOR A HEALTHIER FUTURE: SEPTEMBER 2018 FRAMEWORK FOR A HEALTHIER FUTURE: A CONCEPTUAL FRAMEWORK FOR TAKING ACTION TO IMPROVE MEN AND BOYS HEALTH This paper was prepared by Glen Poole, Development Officer at the Australian Men

More information

Enabling Greater Market Awareness for Hernia Practitioners. Applying the Centers of Excellence Model to Hernia Health Care

Enabling Greater Market Awareness for Hernia Practitioners. Applying the Centers of Excellence Model to Hernia Health Care Enabling Greater Market Awareness for Hernia Practitioners Applying the Centers of Excellence Model to Hernia Health Care A Hernia Centers of Excellence (HCoE) White Paper Executive Summary Situation:

More information

Mohammad Amin Asadi Zarch et al.,2015

Mohammad Amin Asadi Zarch et al.,2015 A discusion on the paper "Droughts in a warming climate: A global assessment of Standardized precipitation index (SPI) and Reconnaissance drought index (RDI)" Mohammad Amin Asadi Zarch et al.,2015 Reporter:PanCongcong

More information

Reference Guide for Group Education

Reference Guide for Group Education A p l a n o f a c t i o n f o r l i f e Reference Guide for Group Education Session 5 Plan of Action: Part I Overview of the Plan of Action and Management of Respiratory Infections Plan of Action: Objectives

More information

Implementation in the Multilevel Context of Routine Practice and Policy

Implementation in the Multilevel Context of Routine Practice and Policy Implementation in the Multilevel Context of Routine Practice and Policy Michael K. Gould, MD, MS Leader, Care Improvement Research Team (CIRT) Department of Research and Evaluation Kaiser Permanente Southern

More information

MBACATÓLICA JAN/APRIL Marketing Research. Fernando S. Machado. Experimentation

MBACATÓLICA JAN/APRIL Marketing Research. Fernando S. Machado. Experimentation MBACATÓLICA JAN/APRIL 2006 Marketing Research Fernando S. Machado Week 5 Experimentation 1 Experimentation Experimental Research and Causality Experimental Designs Lab versus Field Experiments Test Marketing

More information

Generalization and Theory-Building in Software Engineering Research

Generalization and Theory-Building in Software Engineering Research Generalization and Theory-Building in Software Engineering Research Magne Jørgensen, Dag Sjøberg Simula Research Laboratory {magne.jorgensen, dagsj}@simula.no Abstract The main purpose of this paper is

More information

Remarks on Bayesian Control Charts

Remarks on Bayesian Control Charts Remarks on Bayesian Control Charts Amir Ahmadi-Javid * and Mohsen Ebadi Department of Industrial Engineering, Amirkabir University of Technology, Tehran, Iran * Corresponding author; email address: ahmadi_javid@aut.ac.ir

More information

Comment: OCTET does not prove community treatment orders are ineffective

Comment: OCTET does not prove community treatment orders are ineffective Comment: OCTET does not prove community treatment orders are ineffective Andy Owen, Loopinder Sood. The Lancet Psychiatry 2 (2015) pp. 373375. The original published article is available from The Lancet

More information

CDC and Bridging the Gap: Introducing New State Appropriation, Grants, and Expenditure Data in the STATE System

CDC and Bridging the Gap: Introducing New State Appropriation, Grants, and Expenditure Data in the STATE System CDC and Bridging the Gap: Introducing New State Appropriation, Grants, and Expenditure Data in the STATE System Frank Chaloupka, PhD (University of Illinois-Chicago) Jidong Huang, PhD (University of Illinois-Chicago)

More information

Implementing EBPs in a Community Treatment Program: Beyond Instruction

Implementing EBPs in a Community Treatment Program: Beyond Instruction Implementing EBPs in a Community Treatment Program: Beyond Instruction APA Convention San Francisco August 17, 2007 Joan E. Zweben, Ph.D. Executive Director The 14 th Street Clinic & EBCRP Clinical Professor

More information

CHAPTER 8 ESTIMATION OF THE OUTBREAK COST

CHAPTER 8 ESTIMATION OF THE OUTBREAK COST 59 CHAPTER 8 ESTIMATION OF THE OUTBREAK COST Due to uncertainty about the dissemination rate and the large disparity from previously published simulations of FMD, seven scenarios reflecting different assumptions

More information

SOSIAALI- JA TERVEYSMINISTERIÖ. Communication during influenza pandemics

SOSIAALI- JA TERVEYSMINISTERIÖ. Communication during influenza pandemics Communication during influenza pandemics Worst-case scenario in Finland 1st wave lasts 8 to 12 weeks. 35 per cent fall ill. 11,000 to 36,000 patients are hospitalised. 3,000 to 9,000 patients die. Possible

More information

WOMEN S EMPOWERMENT IN TUNISIA

WOMEN S EMPOWERMENT IN TUNISIA EVALUATION: NOVEMBER 2016 PUBLICATION: MAY 2018 WOMEN S EMPOWERMENT IN TUNISIA Impact evaluation of the project AMAL: Supporting Women s Transformative Leadership in Tunisia Effectiveness Review Series

More information

COACH IN RUNNING FITNESS SUPPORT COACH GUIDE

COACH IN RUNNING FITNESS SUPPORT COACH GUIDE COACH IN RUNNING FITNESS SUPPORT COACH GUIDE CONTENTS CONTENTS INTRODUCTION 02 WHEN TO GET INVOLVED 03 HOW YOU CAN HELP 04 WHAT SUPPORT IS REQUIRED 06 WHAT TO BE AWARE OF 07 Dear Support Coach, First of

More information

NICE decisions on health care provisions in England

NICE decisions on health care provisions in England NICE decisions on health care provisions in England Matt Stevenson, Professor of Health Technology Assessment (HTA), ScHARR, University of Sheffield, UK A quick introduction I am Technical Director of

More information

Structural assessment of heritage buildings

Structural assessment of heritage buildings Defence Sites 69 Structural assessment of heritage buildings M. Holicky & M. Sykora Klokner Institute, Czech Technical University in Prague, Czech Republic Abstract Reliability assessment of heritage buildings

More information

HEALTHY AND FULFILLING LIFESTYLE

HEALTHY AND FULFILLING LIFESTYLE Reference Guide for Individual Patient Education Keeping a Healthy and Fulfilling Lifestyle Educational topics: 1. Healthy and Fulfilling Lifestyle Health and COPD Healthy Life Habits o No smoking o Medication

More information

ECOWAS Policy for Gender Mainstreaming in Energy Access: Draft Policy and Implementation Strategy

ECOWAS Policy for Gender Mainstreaming in Energy Access: Draft Policy and Implementation Strategy ECOWAS Policy for Gender Mainstreaming in Energy Access: Draft Policy and Implementation Strategy Regional Validation Workshop Theme: Promoting Social Inclusion for Sustainable Energy for All Sustainable

More information

Dynamic Simulation of Medical Diagnosis: Learning in the Medical Decision Making and Learning Environment MEDIC

Dynamic Simulation of Medical Diagnosis: Learning in the Medical Decision Making and Learning Environment MEDIC Dynamic Simulation of Medical Diagnosis: Learning in the Medical Decision Making and Learning Environment MEDIC Cleotilde Gonzalez 1 and Colleen Vrbin 2 1 Dynamic Decision Making Laboratory, Carnegie Mellon

More information

SAKURA 3 Open-Label Phase 3 Safety Study with DaxibotulinumtoxinA for Injection (RT002) for the Treatment of Moderate to Severe Glabellar Lines

SAKURA 3 Open-Label Phase 3 Safety Study with DaxibotulinumtoxinA for Injection (RT002) for the Treatment of Moderate to Severe Glabellar Lines SAKURA 3 Open-Label Phase 3 Safety Study with DaxibotulinumtoxinA for Injection (RT002) for the Treatment of Moderate to Severe Glabellar Lines Presented by Dan Browne, Co-Founder, President & CEO, and

More information

Background Information on Simulation Created for

Background Information on Simulation Created for Background Information on Simulation Created for Lesson 2: Romeo and Juliet: In Rapturous Oscillation? by Jennifer Andersen and Anne LaVigne in collaboration with the Creative Learning Exchange Permission

More information

Racial Disparity in Deceased Donor Kidney Transplantation: Causes and Solutions

Racial Disparity in Deceased Donor Kidney Transplantation: Causes and Solutions ERASMUS UNIVERSITY ROTTERDAM OPERATIONS RESEARCH AND QUANTITATIVE LOGISTICS MASTER THESIS Racial Disparity in Deceased Donor Kidney Transplantation: Causes and Solutions Author: Jeroen Kremer Student Number:

More information

THEORY OF REASONED ACTION

THEORY OF REASONED ACTION THEORY OF REASONED ACTION INTRODUCTION The roots of theory: Socio - psychology Explain how and why attitude influence behavior 1872, Charles Darwin the study about the attitude toward behavior, define

More information

Application of system dynamics in the analysis of economic impacts of Rift valley fever in Kenya

Application of system dynamics in the analysis of economic impacts of Rift valley fever in Kenya Application of system dynamics in the analysis of economic impacts of Rift valley fever in Kenya Karl M. Rich and Francis Wanyoike International Livestock Research Institute Presented at a Dynamic Drivers

More information

Reporting and Interpreting Results of Economic Evaluation

Reporting and Interpreting Results of Economic Evaluation Reporting and Interpreting Results of Economic Evaluation This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of

More information

PDHPE: STAGE 6 PRELIMINARY COURSE. Preliminary HSC Core 1: BETTER HEALTH FOR INDIVIDUALS. FOCUS QUESTION 2: What influences the health of individuals?

PDHPE: STAGE 6 PRELIMINARY COURSE. Preliminary HSC Core 1: BETTER HEALTH FOR INDIVIDUALS. FOCUS QUESTION 2: What influences the health of individuals? PDHPE: STAGE 6 PRELIMINARY COURSE Preliminary HSC Core 1: BETTER HEALTH FOR INDIVIDUALS FOCUS QUESTION 1: What does health mean to individuals? FOCUS QUESTION 2: What influences the health of individuals?

More information

Assessment of cost-effectiveness of universal hepatitis B immunization in a low-income country with intermediate endemicity using a Markov model

Assessment of cost-effectiveness of universal hepatitis B immunization in a low-income country with intermediate endemicity using a Markov model Assessment of cost-effectiveness of universal hepatitis B immunization in a low-income country with intermediate endemicity using a Markov model Aggarwal R, Ghoshal U C, Naik S R Record Status This is

More information

Analyzing Bongaarts model and its applications in the context of Bangladesh

Analyzing Bongaarts model and its applications in the context of Bangladesh 9th International ongress on Modelling and Simulation, Perth, Australia, 6 December 0 http://mssanz.org.au/modsim0 Analyzing Bongaarts model and its applications in the context of Bangladesh Tanha Mahjabeen

More information

1. Comparative effectiveness of liraglutide

1. Comparative effectiveness of liraglutide Cost-effectiveness of liraglutide (Victoza ) for the treatment of adults with insufficiently controlled type 2 diabetes as an adjunct to diet and exercise. The NCPE has issued a recommendation regarding

More information

Health technology The study examined two first-line treatments for mild to moderate psoriasis.

Health technology The study examined two first-line treatments for mild to moderate psoriasis. Cost-effectiveness model of topical treatment of mild to moderate psoriasis vulgaris in Germany: a comparison of calcipotriol/betamethasone (Daivobet/Dovobet/Taclonex) once daily and a morning/evening

More information

Introduction to Social Network Analysis for Dissemination and Implementation Research

Introduction to Social Network Analysis for Dissemination and Implementation Research Introduction to Social Network Analysis for Dissemination and Implementation Research Miruna Petrescu-Prahova, PhD mirunapp@uw.edu Health Promotion Research Center Department of Health Services University

More information

Application of ecological interface design to driver support systems

Application of ecological interface design to driver support systems Application of ecological interface design to driver support systems J.D. Lee, J.D. Hoffman, H.A. Stoner, B.D. Seppelt, and M.D. Brown Department of Mechanical and Industrial Engineering, University of

More information

CHAPTER 10 CANCER REPORT. Angela Webster Germaine Wong

CHAPTER 10 CANCER REPORT. Angela Webster Germaine Wong CHAPTER 10 Angela Webster Germaine Wong ANZDATA Registry 2008 Report This year the cancer report contains results of a new ANZDATA analysis on survival after cancer diagnosis, and also shows how ANZDATA

More information

Determining the optimal stockpile level for combination vaccines

Determining the optimal stockpile level for combination vaccines Rochester Institute of Technology RIT Scholar Works Theses Thesis/Dissertation Collections 10-12-2017 Determining the optimal stockpile level for combination vaccines Sheetal Aher ssa8811@rit.edu Follow

More information