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1 PHARMACOLOGICAL EVALUATION OF AV MEMVITA CAPSULES FOR ANTIPARKINSON ACTIVITY Project Coordinators Dr. Vikram Naharwar Dr. Pratima Tatke Ms. Sonal Kasbe Managing Director Research Guide Junior Research Fellow Amsar Pvt. Ltd Asst. Prof. Pharm Chem Goa. C.U. Shah College of Pharmacy SNDT Women s University Juhu Campus, Santacruz West Mumbai 5.

2 ABSTRACT: Ayurveda, the ancient Indian medical science, dealing not only with treatment of some diseases but is a complete way of life which emphasizes prevention of disease to avoid the need for cure. Herbal medicine remains as one of the common forms of therapies available, since the drugs from the plant origin have no side effect and more efficacy than synthetic ones. Parkinsonism is one of the commonest neurodegenerative diseases, which is characterized by a selective and progressive degeneration of dopaminergic neurons, causing a series of symptoms which might ultimately induce programmed cell death. Plant drugs are frequently considered to be effective, less toxic or freer from side effects and relatively cost effective as compared to synthetic ones. Thus, the present study aims to open new avenues for the improvement of medicinal uses of indigenous herbal formulations in selected area for parkinsonism. A. Sanction of protocol: The protocol for the study was passed under the title Evaluation of Anti-parkinsonism activity of AV memvita capsules. All the animal study will be carried out according to the Ethics Committee Guidelines. B. EXPERIMENTAL WORK: I. Acute toxicity study: Animals : The Swiss albino female mice weighing to 5 grams were used for the study. They were fed with standard pelleted laboratory diet and water. The study was designed to evaluate acute toxicity of the AV memvita capsules.

3 Procedure: The objective of the present study was to investigate potential adverse effects, if any, of AV Memvita capsules in mice. The dose level to be used as the starting dose is 5 mg/ bw. Animals were observed individually after dosing at least once during the first 3 minutes, periodically during the first hours, with special attention given during the first hours and daily thereafter, for a total of 1 days. Dose level (mg/ body wt Observation of mortality (upto 1 days Weight of animal (g Initial wt. Final wt. Normal Control (. NaCl AV Memvita Capsules 5 No mortality.±. 5.5±.76 5 No mortality.83±. 6.67±. 3 No mortality.83±1..33±.83 No mortality 3.33±.73 5.±.87 5 No mortality.3± ±.5 5 No mortality 3.67±.7 6.±.81 3 No mortality.3± ±. No mortality 3.± ±. II. Antiparkinson activity: The activity was studied using Haloperidol induced Parkinson in mice. Animals were housed individually and were maintained on a normal diet and water ad libitum. Parkinson was induced by injecting Haloperidol at a dose of.5mg/ i.p to the animals after 3 mins of administration of the formulation. The animals were maintained under careful observation, throughout the experimental period and motor tests such as catalepsy and muscle rigidity using rota rod was carried out for evaluation of antiparkinsonism activity.

4 Table 1: rotarod test (AV Memvita capsules Fall of time (mins Normal control(. saline Positive control (haloperidol -.5 mg/ Standard (syndopa mg/ 3 5.3± ± ±1.53.8± ± ± ± ± ±..5± ± ± ±1..33±1..5± ± ± ± ±1..17 ± ±1.1.±1.1.17± ± ± ±1.6.83± ± ±1. 17.±1.6.67± ±.8 Treatment ±1.3.5± ± ± ± ± ± ±.5 activity (formulation mg / activity (standard

5 Table : Chimney test (AV Memvita capsules Fall of time (mins Normal control(. saline ± ± ±. 1.33± ± ± ± ±.5 Positive control (haloperidol -.5 mg/ Standard (syndopa 7.67± ± ± ±1. 1.± ± ± ± ± ± ± ± ±. 5.83± ± ±1.5 8 mg/ Treatment 1.5± ± ± ± ±.67 ± ± ± ±.88. ± ± ± ± ± ± ±1.17 activity (formulation mg / activity (standard

6 Table 3: catalepsy test (AV Memvita capsules Fall of time (mins Normal control(. saline Positive control (haloperidol -.5 mg/ Standard (syndopa mg/ 3 53± ±1. 15± ± ± ±1.5 13± ±3.3 8± ±1.5 1± ± ± ±1.8 13±.7 11± ± ± ± ± ±11. 1±1. 13± ± ± ±1.8 13±1.8 1±. 7 31± ± ± ±5.5 Treatment ± ± ± ± ± ± ± ±.6 activity (formulation mg / activity (standard Results : According to the results obtained the AV Memvita capsules shows significant results when compared with standard. Future plan of work: The same studies will be carried out for reserpine induced Parkinson model.

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