Course Program. São Paulo, BRAZIL N OV E MB E R 9-1 0, Ataxias and Spastic Paraplegias: From Molecular Biology to Bedside and Treatment
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1 São Paulo, BRAZIL N OV E MB E R 9-1 0, Ataxias and Spastic Paraplegias: From Molecular Biology to Bedside and Treatment MDS Course Program
2 International Parkinson and Movement Disorder Society International Secretariat 555 East Wells Street, Suite 1100 Milwaukee, WI USA Tel: +1 (414) Fax: +1 (414) The International Parkinson and Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals who are interested in Parkinson s disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic Movement Disorders, and abnormalities in muscle tone and motor control. The Ataxias and Spastic Paraplegias: From Molecular Biology to Bedside and Treatment course has received corporate support from the following: Quest Diagnostics Do Brasil Ltda EPP Diagnóstico da América S/A Beaufour Ipsen Farmaceutica Ltda Creta - Centro Reumatologico de Terapia Avancada Ltda Centogene AG Mendelics Análise Genômica S.A The Ataxias and Spastic Paraplegias: From Molecular Biology to Bedside and Treatment is supported in part due to a generous contribution from the following: MDS Associate Membership Non-Members now have the opportunity to become a member of MDS absolutely free for a year! Participants of this course (who are eligible for this offer) will be contacted one month following the activity. Contact will consist of an providing a link to apply for and obtain the free Associate Membership for one year. Once individuals apply online and receive acceptance to the Society, they will have immediate access to all online content and member benefits. If you were registered for this course by someone else, please check with your MDS Secretariat liaison onsite to ensure that your correct address is on file for this offer to reach you. Visit the MDS Website for eligibility and further information:
3 TABLE OF CONTENTS Course Venue Map... Course Faculty.. CME & Program Information... Course Agenda. Notes.. Course Venue Associação Paulista de Medicina (APM) 9 th Floor Av. Brigadeiro Luís Antônio, 278 Bela Vista São Paulo / SP Brazil Course Materials To access the course presentations please visit the website listed below. Presentations are available for 60 days after the course. Molecular-Biology-to-Bedside-and-Treatment-So-Paulo-Brazil.htm
4 Course Venue Map Associação Paulista de Medicina (APM) 9 th Floor Av. Brigadeiro Luís Antônio, 278 Bela Vista São Paulo / SP Brazil Please arrive via the main entrance on Av. Brigadeiro Luis Antonio Signs will guide you to registration. 1
5 COURSE DIRECTORS Orlando G. P. Barsottini, MD, PhD Federal University of São Paulo José Luiz Pedroso, MD, PhD Federal University of São Paulo COURSE FACULTY Pedro Braga-Neto, MD, PhD Universidade Federal do Ceará Fortaleza, Brazil Giovana Diaféria, MS Centro de Estudos Da Voz & Associação Brasil Parkinson Henrique B. Ferraz, MD Federal University of São Paulo Marcondes C. França Junior, MD, PhD University of Campinas Campinas, Brazil Antonio Orlacchio, MD, PhD IRCCS Santa Lucia Rome, Italy Francisco Cardoso, MD, PhD, FAAN The Federal University of Minas Gerais Belo Horizonte, Brazil Chien Hsin Fen, MD, PhD University of Sao Paulo Laura B. Jardim, MD, PhD Universidade Federal Do Rio Grande Do Sul Porto Alegre, Brazil Fernando Kok, MD, PhD University of São Paulo Henry Paulson, MD, PhD University of Michigan Medical Center Ann Arbor, MI, USA Hélio A. G. Teive, MD, PhD Federal University of Parana Curitiba, Brazil INVITED GUESTS Henrique B. Ferraz, MD Federal University of São Paulo 2
6 COURSE PROGRAM INFORMATION COURSE DESCRIPTION Hereditary ataxias and spastic paraplegias are complex genetic disorders. The knowledge, information and concepts have expanded and evolved substantially during the past few years. The advances have established a solid base to potential therapeutic approaches. This course will discuss clinical manifestations, physiopathology, rehabilitation, genetic aspects, management, as well as future directions in the field of ataxias and spastic paraplegias. This will be an interactive course with audience participation and patient videos on clinical cases. LEARNING OBJECTIVES After participating in this activity, the learner will be able to: Recognize typical and less common forms of inherited ataxias and spastic paraplegias Identify pathophysiology (pharmacologic, genetic and biochemical) of ataxias and spastic paraplegias Acquire knowledge of pharmacological, rehabilitation and other treatment approaches on ataxias and spastic paraplegias. TARGET AUDIENCE Medical doctors, physiotherapists, speech therapists, physiatrists, medical students, and allied health professionals. COURSE LANGUAGE All printed course materials are in English. Lectures will be presented in either Portuguese or English at the discretion of the presenting faculty. Simultaneous translations of the lectures from Portuguese to Spanish are available. COURSE EVALUATION The course evaluation is available online. A link will be provided to you upon the conclusion of the course. CERTIFICATE OF ATTENDANCE A certificate of attendance will be available at the conclusion of the course. EDUCATION DISCLAIMER The primary purpose of MDS programming is to provide educational opportunities that enhance patient care. Information presented, as well as publications, technologies, products and/or services discussed are intended to inform attendees about the knowledge, techniques and experiences of physicians who are willing to share such information with colleagues. A diversity of opinions exists in the medical field, and the views of the workshop s faculty are offered solely for educational purposes. Faculty members views do not represent those of the MDS and do not constitute endorsement by MDS. RECORDINGS PROHIBITED Audio and videotaping are not allowed during the course. Photography of the presentations and slides is not allowed during the activity. This includes mobile phone photography. 3
7 Friday, November 9, :30 13:30 Registration 13:30 14:00 Opening Comments Co-Chairs: Orlando G. P. Barsottini, José Luiz Pedroso, and Henrique B. Ferraz Section 1 Anatomy, Function and Natural History of the Ataxias Chair: Orlando G.P. Barsottini 14:00 14:30 Anatomy and Function of the Cerebellum, and Phenomenology of the Ataxias Pedro Braga Neto 14:30 15:00 Experimental Models in Cerebellar Diseases Henry Paulson 15:00 15:30 The Natural History and Epidemiology of the Spinocerebellar Ataxias (SCAs) Pedro Braga Neto 15:30 15:40 Discussion with Question and Answer 15:40 16:00 Coffee Break Section 2 Genetics of Ataxias and Hereditary Spastic Paraplegias Chair: Henrique Ballalai Ferraz 16:00 16:30 New Genes in Ataxias Marcondes C. França Junior 16:30 17:00 Exome Sequencing and Genes for Undetermined Ataxias Fernando Kok 17:00 17:30 A New Group of Diseases: The Spastic Ataxias Marcondes C. França Junior 17:30 18:00 Update on the Genetics of Hereditary Spastic Paraplegia Jonas Saute 18:00 18:10 Discussion with Question and Answer 4
8 Saturday, November 10, :00 08:20 Opening Comments Chair: Marcondes C. França Junior 08:20 09:00 Update in Spinocerebellar Ataxias (SCAs) Orlando G. P. Barsottini 09:00 09:40 Clinical Trials in Ataxias Jonas Saute 09:40 10:00 Coffee Break Section 3 Update on Ataxias Chair: Francisco Cardoso 10:00 10:30 Acquired and Secondary Ataxias Hélio Teive 10:30 11:00 Unusual Ataxias (With Video) José Luiz Pedroso 11:00 11:30 Multiple System Atrophy (Cerebellar Form) Henrique Balallai Ferraz 11:30 12:00 Movement Disorders Associated with Ataxias José Luiz Pedroso 12:00 12:10 Discussion with Question and Answer 12:10 13:30 Lunch Section 4 Rehabilitation and Therapeutics in Ataxias and Hereditary Spastic Paraplegia Chair: Pedro Braga Neto 13:30 14:00 Measuring Ataxia and Spastic Paraplegia Severity. A Critical Review. Chien Hsin Fen 14:00 14:30 Speech Therapy in Ataxias Speech Ther. Giovana Diaferia 14:30 15:00 Rehabilitation in Ataxias and Hereditary Spastic Paraplegia Chien Hsin Fen 15:00 15:30 Treatable Ataxias Orlando G. P. Barsottini 15:30 15:40 Discussion with Question and Answer 15:40 16:00 Coffee Break Section 5 New Frontiers in Ataxias Chair: Helio A. G. Teive 16:00 16:30 Moving toward therapy for the SCAs Henry Paulson 16:30 17:00 Ataxia and Chorea: Huntington`s disease and Other Conditions Francisco Cardoso 17:00 17:30 Discussion with Question and Answer 17:30 18:00 Cocktail Espaco de Eventos (10 th Floor) 18:00 19:00 Video Challenge: Ataxias Chairs: Francisco Cardoso Orlando Barsottini José Luiz Pedroso 5
9 NOTES 6
10 NOTES 7
11 NOTES 8
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