PET Imaging of Mild Traumatic Brain Injury and Whiplash Associated Disorder Vállez García, David
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1 University of Groningen PET Imaging of Mild Traumatic Brain Injury and Whiplash Associated Disorder Vállez García, David IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2015 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Vállez García, D. (2015). PET Imaging of Mild Traumatic Brain Injury and Whiplash Associated Disorder [Groningen]: University of Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:
2 PET Imaging of Mild Traumatic Brain Injury and Whiplash Associated Disorder David Vállez García
3 The research reported in this thesis was carried out in the Department of Nuclear Medicine and Molecular Imaging of the University Medical Center Groningen. The research reported in this thesis was financially supported by a bursary from the research school of Behavioral and Cognitive Neurosciences (BCN), and by the Graduate School of Medical Sciences, the University Medical Center Groningen. Printing of this thesis was financially supported by the University Medical Center Groningen, and the research school of Behavioral and Cognitive Neurosciences (BCN). Cover design: David Vállez and Erika Chorén, with the support of Michiel Mellens Printed by: NetzoDruk Groningen ISBN: (Electronic version) ISBN: (Hard copy) Dissertation of University of Groningen, Groningen, The Netherlands Copyright 2015 David Vállez García
4 PET Imaging of Mild Traumatic Brain Injury and Whiplash Associated Disorder PhD thesis to obtain the degree of PhD at the University of Groningen on the authority of the Rector Magnificus Prof. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 2 December 2015 at hours by David Vállez García born on 26 November 1981 in Madrid, Spain
5 Supervisor Prof. R.A.J.O Dierckx Prof. A. Otte Co-supervisors Dr. J. Doorduin Assessment committee Prof. B. Kremer Prof. A. Lammertsma Prof. I. Carrio
6 Paranymphs Erika Chorén Iglesias Mónica López López
7
8 Contents Introduction Chapter 1. General Introduction... 9 Methodology Chapter 2. Chapter 3. A standardized method for the construction of tracer specific PET and SPECT rat brain templates: validation and implementation of a toolbox Evaluation of [ 11 C]CB184 for imaging and quantification of TSPO overexpression in rat model of herpes encephalitis Traumatic Brain Injury Chapter 4. Nuclear Medicine Imaging in Traumatic Brain Injury Chapter 5. Three months follow-up of rat mild traumatic brain injury: a combined [ 18 F]FDG and [ 11 C]PK11195 PET study Whiplash Associated Disorder Chapter 6. Whiplash, real or not real? A review and new concept Chapter 7. Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorder Chapter 8. Chronic whiplash-associated disorder Final chapters Chapter 9. Concluding remarks and future perspectives Chapter 10. Summary Chapter 11. Nederlandse Samenvatting Chapter 12. Acknowledgments
9
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