APA-accredited: YES NO X. Brown University. Stephen Salloway, M.D. (Primary Supervisor) Paul Malloy, Ph.D.

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1 Clinical Psychlgy Training Prgrams at Brwn: A Cnsrtium f the Prvidence VA Medical Center, Lifespan, and Care New England Pstdctral Fellwship Training Prgram Pstdctral Fellwship Descriptin: RESEARCH FOCUS Title: Pstdctral Fellwship in Alzheimer s Research-MD r PhD APA-accredited: YES NO X Site: Supervisr(s): Brwn University Stephen Sallway, M.D. (Primary Supervisr) Paul Mally, Ph.D. Fellwship Psitin Overview: This fellwship psitin is part f the Research Fellwship Prgram (RFP) within the Pstdctral Fellwship Training Prgram f Brwn s Clinical Psychlgy Training Cnsrtium. Fr didactic and prfessinal scializatin issues, the fellw will be cnsidered part f the Neurpsychlgy Track. Interested fellws frm the fllwing disciplines may be cnsidered fr this psitin including neurlgists, psychiatrists, neurpsychlgists, psychlgists, cgnitive neurscientists, r ther disciplines aligned with the psitin aims (listed belw). Irrespective f the fellws discipline, the fellw s training hme will be in the Neurpsychlgy Track f the RFP with clse alignment with the CNSP. Clinical Research Activities: The fellw will devte apprximately 70% time t research activities in the Memry and Aging Prgram (MAP) at Butler Hspital under Primary Supervisr, Stephen Sallway, M.D. Clinical Care Activities: The fellw will devte apprximately 20% time t clinical care activities in the Butler Hspital Memry and Aging Prgram (MAP). NOTE: Fellws in this psitin frm nn-clinical disciplines (e.g., neurscience, research psychlgists) may pt t perfrm up t 90% clinical research activities and as little as 0% supervised clinical care activities depending n their training and career gals. Didactics: 10% time will be devted t didactics. The specific required didactics will depend n the fellw s backgrund and training and career gals. Descriptin f Site Funded in 1844, Butler Hspital is a private, nnprfit psychiatric hspital fr adults, adlescents, children, and senirs. Butler is affiliated with the Alpert Medical Schl f Brwn University. The fellw will wrk in the Butler Hspital Memry and Aging Prgram (MAP), directed by Drs. Stephen Sallway and Paul Mally. The MAP, ne f the leading clinical trial centers fr Alzheimer s disease (AD) in the United States, is cmmitted t accelerating drug and bimarker develpment fr AD and t training yung investigatrs fr careers in AD research. The prgram evaluates apprximately 200 new patients with cgnitive 1

2 impairment annually. Patients underg extensive wrkups, including neurlgic examinatin, neurpsychlgical testing, MRI scan, labratry tests, and gentyping. Patients may underg bimarker testing as well, such as CSF prtein assay r amylid PET scan. Thus, fellws are expsed t state-f-theart diagnstic and treatment methds. The clinic has been in peratin fr ver 20 years, resulting in a database f ver 5000 patients with cmprehensive diagnstic data. The prgram is develping innvative utreach strategies fr AD preventin and the Butler Hspital Alzheimer s Preventin Registry has mre than 1,000 participants. The MAP has a large clinical trials prgram fcusing n bimarker and drug develpment fr Alzheimer s disease with an emphasis n preventin, early detectin and treatment. The prgram is cnducting landmark NIH, fundatin and industry-spnsred clinical and investigatrinitiated studies including ADNI, DIAN, LEADS, develpment f tau PET, tau-based treatments, deep brain stimulatin and primary and secndary preventin trials fr autsmal dminant and spradic AD. Neurpsychlgy has a strng presence at Brwn and the MAP is develping nvel cgnitive assessments, retinal imaging techniques and risk disclsure prtcls t identify individuals at risk fr preventin studies. Brwn als ffers a rich multi-disciplinary training envirnment and the fellw will have the pprtunity t cllabrate with clleagues frm many departments n translatinal research in AD and neurdegenerative disrders. Fellwship Aims T prvide the fellw with expertise in the design, cnduct, and management f clinical trials fr cgnitive disrders (bth preventative and symptmatic). T prvide the fellw with expertise in design, executin, analysis and publicatin f independent research prjects in aging and dementia. T prvide the fellw with experience wrking as a clinician-researcher-teacher and team leader in a clinical research center fcused n the early diagnsis and treatment f Alzheimer s disease and ther late-life causes f cgnitive decline. Fellwship Timeline The duratin f the fellwship is 1 r 2 years cntingent upn satisfactry prgress. The anticipated start date is July-September. Cnsistent with Training Cmmittee plicy, the fellw and the mentr will ntify each ther in December whether the cmmitment will be made fr a secnd year. Research Activity Plan The fellw will devte 70% time t research activities pertaining t Alzheimer s disease and ther frms f dementia. The fellw may devte up t ne day f this research time t research n Alzheimer s and ther dementias at MAP-affiliated research prgrams. The fellw will serve as an investigatr n clinical trials f Alzheimer s disease and/r ther latelife frms f dementia. This activity includes, but is nt limited t, participatin in prtcls regarding disclsure f AD risk, participant recruitment and screening fr eligibility fr clinical trails; cnducting neurlgic examinatins and ther utcme assessments per clinical trial prtcls and in accrdance with the fellws clinical scpe f practice. Activities als include reprting and clinical management f adverse events, attendance at pre-study r interim-study Investigatr Meetings as apprpriate, and serving as a team leader in the preventin, utreach and clinical trial interdisciplinary Butler Hspital Memry and Aging Prgram (MAP). Participates in weekly MAP research team meetings and cnsensus cnference. Attends reginal, natinal, and internatinal cnferences pertinent t the fellw s clinical research activities in the MAP. Prvides mentred clinical-research supervisin f and teaching t ther MAP trainees and staff. 2

3 Part f the fellw s clinical research activities will invlve either an independent research prject r literature review. The fellw is required t present their research activities r literature review at natinal r internatinal cnferences. The fellw is strngly encuraged t submit their research wrk r literature review fr peer-reviewed publicatin. Fsters research cllabratins between the Butler Hspital Memry and Aging Prgrams and ther lcal, reginal, natinal and internatinal Alzheimer s disease research prgrams. Clinical Activity Plan The fellw will devte apprximately 20% time t clinical care activities in the Butler Hspital Memry and Aging Prgram (MAP) under the supervisin f the Primary Supervisr r apprpriate designee. The specific clinical care activities and level f supervisin will depend n the fellw s discipline and level f experience. Neurpsychlgy and psychlgy fellws will receive clinical supervisin in accrdance with guidelines set by Brwn s Pstdctral Fellwship Training Prgram. Depending n the fellw s discipline, a prtin f this clinical time may be spent prviding clinical care in the Butler Hspital clinics ther than the MAP. Examples include the Mvement Disrders Prgram r Geriatric Psychiatry Prgram. Fr Neurlgists r Psychiatrists: The fellw will prvide clinical evaluatins and nging care t patients in the Memry and Aging Prgram, The fellw will prvide back-up clinical cverage fr the Directr f the Memry and Aging Prgram. Prvides neurlgy cnsultatins at Butler Hspital, cmpensated by separate arrangement with Care New England Medical Grup. The fellw will participate in and at times lead (under supervisin) weekly multidisciplinary MAP Diagnstic Cnsensus Cnference, where staff will review histry, neurlgic exam, neurimaging, neurpsychlgical and genetic wrkup and make diagnsis and treatment recmmendatins. These cnferences are cnducted as teaching runds with trainees called upn t make judgments and defend their reasning (1 hur per week). The fellw will be expected t regularly cntribute t the infrmal didactic prtin f the Diagnstic Cnsensus Cnference. This will typically take the frm f prviding very brief updates, apprpriate fr cnsumptin by the multidisciplinary MAP team, n scientific advances in Alzheimer s disease and ther dementia with emphasis n disease mechanisms, risk and prtective factrs, and prgress in evidence-based diagnsis and treatment. The fellw will have the pprtunity t prvide supervisin t trainees frm a variety f disciplines (e.g., psychiatry, neurpsychlgy, psychlgy). Path tward licensure: N/A unless fellw is a nn-licensed physician. Fr Neurpsychlgists & Psychlgists: The fellw will cnduct ne r tw neurpsychlgical evaluatins per week n patients frm the Memry and Aging Prgram, prviding the pprtunity fr training in neurpsychlgical assessment and differential diagnsis. Cnsultatins may als cme frm ur Hydrcephalus Clinic, Mvement Disrders prgram, and cmmunity referrals. (4 t 7 hurs per week) 3

4 The fellw will attend weekly multidisciplinary Diagnstic Cnsensus Cnference, where staff will review histry, neurlgic exam, neurimaging, neurpsychlgical, and genetic wrkup and make diagnsis and treatment recmmendatins. These cnferences are cnducted as teaching runds with trainees called upn t make judgments and defend their reasning. (1 hur per week). The fellw will have the pprtunity t prvide supervisin t practicum students frm reginal clinical psychlgy graduate prgrams wh are training in the MAP. Path tward licensure: YES X NO Fr nn-physician and nn-psychlgist fellws (e.g., neurscience): Path tward licensure: YES NO x Didactics (10% time) Required didactic activities fr nn-psychlgist fellws will be determined cllabratively between the fellw and the Primary Supervisr. Optins include, but are nt limited t: MAP Clinical Cnsensus Cnference (weekly) Department f Psychiatry & Human Behavir (DPHB) Grand Runds (mnthly) Department f Neurlgy Grand Runds (weekly) DPHB Research Fridays (weekly) DPHB Research Runds (Tracie Shea s runds) Neurpsychlgy Research Interest Grup (mnthly) Clinical Neurpsychlgy Specialty Prgram Seminar Series Department f Pathlgy Brain Cuttings Department f Diagnstic Imaging Runds DPHB T32 Cre Seminars (1 per week, Butler Hspital)). Bistatistics Seminar (mnthly, Rich Jnes) Fr nn-psychlgist fellws, the Primary Supervisr is respnsible fr tracking the fellw s participatin in the didactic activities that the fellw and Primary Supervisr agree t be required. Psychlgist fellws are required t attend the didactic venues listed belw. DPHB Academic Grand Runds (1 st Wednesday f mnth, Sept-May, 11 AM nn, Butler Hspital) Brwn Psychlgy Training Cre Seminars (1 per mnth, Butler Hspital). Clinical Ethics Seminar (1 st Wednesday f mnth, Oct-May 10AM, Butler Hspital Neurpsychlgy fellws are required t attend: Clinical Neurpsychlgy Specialty Prgram Seminar Series (1 per week, Thursday Sept-May 4-5:30 PM, RIH). Attendance at this CNSP Seminar Series is ptinal fr psychlgy fellws (i.e., nn-neurpsychlgy) Nn-neurpsychlgy psychlgy fellws are required t attend: DPHB T32 Cre Seminars (1 per week, Butler Hspital). Attendance is ptinal fr neurpsychlgy fellws. Academic Fridays (Friday mrnings, Butler Hspital). Attendance is ptinal fr neurpsychlgy fellws 4

5 Neurpsychlgy and psychlgy fellws may attend at ther ptinal didactics series at the discretin f the Primary Supervisr. Supervisin and Evaluatin Research and clinical supervisin fr physician r neurscience fellws will ccur regularly as determined by agreement with between the fellw and the Primary Supervisr and ther supervisrs. Fr neurpsychlgy r psychlgy fellws, supervisin will be prvided in the frm f bth daily individual supervisin and weekly grup supervisin. Dr. Mally will be the primary clinical supervisr fr these fellws. Dr. Sallway and Dr. Mally will supervise research activities. Dr. Rich Jnes will prvide supervisin n study design and bistatistics. At a minimum, a full-time neurpsychlgy r psychlgy fellw will receive fur hurs structured learning activities per week, at least tw hurs f which will include individual, face-t-face supervisin. Every 6 mnths fr the duratin f the fellwship, the fellw and the supervisrs will prvide frmal evaluatins, and evaluatins f the prgram relative t the gals and learning bjectives f the fellwship. Resurce Requirements The fellw will be prvided with the fllwing resurces: Access t space apprpriate fr clinical care A cmputer and prject specific sftware Internet access Telephne Shared ffice space fr persnal use Reprting and apprval This fellwship psitin is part f the Neurpsychlgy Track f the Research Fellwship Prgram within the Pstdctral Fellwship Training Prgram f Brwn s Clinical Psychlgy Training Cnsrtium. The fellw will als be cnsidered part f the Neurpsychlgy Track in Research Fellwship Prgram (RFP) and may participate in Clinical Neurpsychlgy Specialty Prgram (CNSP) didactics (as described abve) and ther activities as apprpriate fr the fellw s discipline and fellwship gals. The psitin has been previusly discussed and apprved by the Neurpsychlgy Track faculty n June 05, The fellw will reprt t Directr f the Butler Hspital Memry and Aging Prgram Pstdctral Fellwship Track Crdinatr Assciate Directr, Research Fellwship Prgram Directr, Pstdctral Fellwship Training Prgram 5