Becoming a PI. Dr Emily Henderson

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1 Becoming a PI Dr Emily Henderson Consultant Geriatrician, RUH Bath Honorary Consultant Senior Lecturer, University of Bristol 1

2 Disclosures Research funding: Parkinson s UK, National Institute of Health Technology (NIHR), Gatsby Foundation Honoraria: Profile, Bial, Medicys, Abbvie. 2

3 Scope Becoming a PI R and D Portfolio EoI Recruit Repeat 3

4 Orbiting the research sphere 4

5 Scope 5

6 My story. 6

7 Falls gait automaticity Insufficient attentional resource Cognitive resource 7

8 The hypothesis

9 Trajectory of happiness.. 9

10 CONSORT N=931 n=130 n=65 n=65 Henderson EJ, Lord SR, Brodie MA, et al. Rivastigmine for gait stability in patients with Parkinson s disease (ReSPonD): a randomised, 10 double-blind, placebo-controlled, phase 2 trial. Lancet Neurol 2016; 15:

11 Skylark Satsuma Super apple truck animal

12 Results Gait variability 28% (p=0.002) Gait speed 0.09m/s (p=0.003) Leaning balance Low score (good) vs med & high MoCA 0.99 (0.93 to 1.06) p=0.78 The ReSPonD trial 12

13 Fall rate The ReSPonD trial 13

14

15 There were a few disasters.. 15

16 5 Decem ber 2018

17 I found the whole experience interesting and I was impressed by the care and attention taken by the team both on my visits and when supporting from a distance.

18 Trajectory of happiness.. 18

19 Translational research portfolio Modelling complex motor behaviour ReSPonD Trial Phase III PRIME-PD Proactive, Integrated Management and Empowerment in PD 19

20 Opportunity PhD 20

21 What are your options? Research in own hospital OTHERS OWN 21

22 What are your options? 22

23 Loss of women across the career pipeline and the absence of women from senior academic, professional and support roles. 23

24 Final thoughts Yes no Publish Network and collaborate Skills Balance 24

25 Conclusion Iden%fy where you are orbi%ng A world of opportunity This really is the best job in the world 25

26 05/12/2018 Acknowledgements CHIEF-PD team: Jess Pooley, Prof C Metcalf, Prof W Hollingworth, Di Steeds RUH PD team: Dr R Fackrell, Dr V Lyell, Dr S Evans. ReSPonD team: Prof Ben-Shlomo, Prof J Close, Prof S Lord, Prof A Lawrence, Dr A Whone, Alex Hill, Veronica Lyell, Shanna Wilson, Sarah Dunn, Maria Davies, Louise Gethin, Rebecca Sadler, Kingsley Powell, Celia Gregson, Deborah Howcroft Marissa Walsh, Cara George, Alison Diaper, Steph Lambert, Kingsley Powell, David Carmichael, Patty Raminez. Collaborators: Dr C Kobylecki, Dr M Silverdale, Prof M Richards Funders: Parkinson s UK, NIHR Health Technology Assessment, TheGatsby Foundation 26

27 Thank you DrEmHenderson 27

28 Calling all medical students! Would you like to attend the BGS MDS conference in Birmingham on 1 st Feb 2019 for FREE?!* *including a bursary for travel costs We are looking for people to help during the educational sessions For further information: g.collingridge@bgs.org.uk

29 BGS Movement Disorder Section Essay Prize 2018/19 Open to medical, nursing and therapy students Title: The art of Parkinson s Closing date: 22 nd February 2019 Submissions via scientificofficer@bgs.org.uk Prizes for top 3 essays: 500, 300, 200 Word Limit: 1500 Reference limit: 20

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