Neuroscience and Mental Health: A clinical and molecular overview in neuropsychiatric and age-related neurodegenerative disorders April 1-5, 2019

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1 Neuroscience and Mental Health: A clinical and molecular overview in neuropsychiatric and age-related neurodegenerative disorders PhD Programme in Health Sciences (PhDHS), Faculty of Medicine, University of Coimbra (FMUC) [ edition] advanced course Date: April 1-5, 2019 & Molecular and cellular mechanisms of ageing and neurodegeneration EIT Health_EpiDEMPrev advanced course Date: April 2-5, 2019 Coordinators: Ana Cristina Rego (arego@fmed.uc.pt; a.cristina.rego@gmail.com) and João O. Malva (jomalva@fmed.uc.pt) Venue: icbr Auditorium, Faculty of Medicine, Universidade de Coimbra- polo III, Azinhaga de Santa Comba, Celas, Coimbra Introduction The advanced course on Neuroscience and Mental Health / Molecular and cellular mechanisms of ageing and neurodegeneration is integrated in the PhD programme of Health Sciences of FMUC and will focus on the latest research in the field of mental health diseases and chronic neurodegenerative disorders influenced by ageing. The course is intended to promote the understanding of molecular, biochemical and cellular mechanisms operating in these devastating diseases and their correlation with clinical outcomes and modifications. Furthermore, the course will cover novel detection methods and therapies that are under development or under clinical trials. Clinical, brain imaging and selective neuropathological aspects of these disorders will be discussed by experienced neurologists and neuroscientists. Objectives: * Distinguish the molecular and cellular mechanisms involved in the pathogenesis of diseases of the nervous system and the impact of ageing. * Analyse the use of different methodologies of diagnosis and the efficacy of different therapeutic strategies applied to diseases of the nervous system. * Present and interpret scientific results published in original articles in the neuropathological context. * Critically analyse the outcome of clinical trials for diseases of the nervous system. Programme: Monday (Apr 1) 14:00 14:30 Welcome and Introduction to the course (Ana Cristina Rego & João Malva) 14:30 15:15 Introduction to mental disorders and their impact in the portuguese population _ Manuel Quartilho (CHUC, FMUC) 15:15-16:00 Genetics and biomarkers of mental illness _ António Ferreira de Macedo (CHUC, FMUC) 16:00-16:15 Discussion 16:15-16:30 Break 16:30-17:15 Synaptic modifications in schizophrenia and autism _ João Peça (CNC) 17:15-18:00 Control of mood dysfunction by caffeine and adenosine receptors _ Rodrigo Cunha (CNC, FMUC) 18:00-18:15 Discussion Tuesday (Apr 2) 14:00-15:15 Clinical aspects of polyglutamine-expansion diseases and Parkinson s disease _ Cristina Januário (CHUC, FMUC) 15:15-16:00 Cellular mechanisms and neuroprotection in Huntington s disease _ Ana Cristina Rego (CNC, FMUC) 1

2 16:00-16:15 Break 16:15-17:00 Towards a therapy for polyglutamine diseases: lessons from preclinical studies _ Clévio Nóbrega (Dep. Biomedical Sci. and Medicine, Univ. Algarve) 17:00-17:45 Therapeutic strategies in Machado-Joseph disease _ Luís Pereira de Almeida (CNC, FFUC) 17:45-18:00 Discussion Wednesday (Apr 3) 14:00 15:00 Seminar: Using biomarkers to define disease risk in pre-clinical Alzheimer s disease _ Lefkos Middleton (Imperial College London, U.K.) 15:00-15:15 Discussion 15:15-16:00 Pre-clinical Alzheimer s disease staging and prevention _ Lefkos Middleton (Imperial College London, U.K.) 16:30-16:45 Break 16:45-17:30 Regenerative therapeutic approaches for Parkinson s disease _ Liliana Bernardino (Fac. Ciências da Saúde, Univ. Beira Interior, Covilhã) 17:30-18:15 Mitochondrial microbiome dance in prodromal Parkinson s disease _ Sandra M. Cardoso (CNC & FMUC) 18:15-18:30 Discussion Thursday (Apr 4) 14:00-15:00 Clinical features of Alzheimer s disease and dementia and novel clinical trials _ Isabel Santana (CHUC, FMUC) 15:00-15:45 Mitochondrial dysfunction in Alzheimer s disease/dementia _ Lene J. Rasmussen (Univ. Copenhagen, Denmark) 15:45-16:30 Influence of cardiometabolic disorders on the development of Alzheimer's disease _ Paula Moreira (CNC, FMUC) 16:15-16:30 Discussion & Break 16:30-17:15 Calcium dysregulation in neurodegenerative diseases, the case of stroke and amyotrophic lateral sclerosis (ALS) _ Agnese Secondo (Università degli Studi di Napoli Federico II, Napoli, Italy) 17:15-18:00 Whole-organism based screening of therapeutic compounds for neurodegenerative diseases: from worm to mouse to human? _ Patrícia Maciel (ICVS, Univ. Minho, Braga) 18:00-19:00 Cognitive markers of disease status, progression and risk _ Geraint J. Price (Imperial College London, U.K.) 19:00-19:15 Discussion Friday (April 5) Student s assignments: 13:00 13:30 Multiple choice questionnaire 13:30 14:00 Break 14:00 14:20 Presentation of paper #1 (Group 1) & Discussion 14:20 14:40 Presentation of paper #2 (Group 2) & Discussion 14:40 15:00 Presentation of paper #3 (Group 3) & Discussion 15:00 15:20 Presentation of paper #4 (Group 4) & Discussion 15:30-16:00 Break 16:00 17:00 Seminar: Store-operated calcium entry in stroke models _ Agnese Secondo (Università degli Studi di Napoli Federico II, Napoli, Italy) 17:00-17:15 Discussion 2

3 Student s assignments and distribution in Groups: Students (Groups 1-4) will be asked to present an original paper (focusing on results) and critically analyze the data; additionally, students will be asked to propose additional relevant experiments and their specific rationale and objectives as a mini-project/proposal. Each group will have up to 15 min for each presentation, followed by ~5 min discussion. Original papers and student s names (4 groups): Group 1: Paper 1: Escamilla CO, Filonova I, Walker AK, Xuan ZX, Holehonnur R, Espinosa F, Liu S, Thyme SB, López-García IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM. Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature Nov 9;551(7679): doi: /nature Group 2: Paper 2: Girasole AE, Lum MY, Nathaniel D, Bair-Marshall CJ, Guenthner CJ, Luo L, Kreitzer AC, Nelson AB. A subpopulation of striatal neurons mediates levodopa-induced dyskinesia. Neuron Jan 26. pii: S (18) doi: /j.neuron [Epub ahead of print] Group 3: Paper 3: Victor MB, Richner M, Olsen HE, Lee SW, Monteys AM, Ma C, Huh CJ, Zhang B, Davidson BL, Yang XW, Yoo AS. Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes. Nat Neurosci Feb 5. doi: /s [Epub ahead of print] Group 4: Paper 4: Faraco G, Brea D, Garcia-Bonilla L, Wang G, Racchumi G, Chang H, Buendia I, Santisteban MM, Segarra SG, Koizumi K, Sugiyama Y, Murphy M, Voss H, Anrather J, Iadecola C. Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nat Neurosci Feb;21(2): doi: /s z. Evaluation: Students will be evaluated based on the oral (paper) presentation and on the ability to establish an interactive participation along the course, namely by frequently questioning the lecturers. The final grade in the course will be also based on the mark obtained at a multiple-choice questionnaire (held on the last day of the course). The evaluation criteria (0-20 scale) include: - Active participation along the course Questions to lecturers (0-2) - Paper presentation and discussion (0-12): *Data presentation (0-6); *Critical view (0-3); *Proposed experimental research (0-3) - MC Questionnaire (0-6) Students participating at the Neuroscience and Mental Health course (2017/18 edition): PhDs, Master Student s names Programme Programa de 3

4 Ciências da Saúde (PDCS/PhDHS) Mestrado em Investigação Biomédica (MIB) Ciências Farmacêuticas Biociências 4

5 Faculty names and affiliations: External to the University of Coimbra Agnese Secondo (PhD) - Università degli Studi di Napoli Federico II, Napoli, Italy; secondo@unina.it Clévio Nóbrega (PhD) Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal; clevionobrega@gmail.com Geraint J. Price (DClinPsy) - Imperial College London (ICL), London, United Kingdom; g.price@imperial.ac.uk Lefkos Middleton (MD, PhD) - Imperial College London (ICL), London, United Kingdom; l.middleton@imperial.ac.uk Lene J. Rasmussen (PhD) University of Copenhagen, Copenhagen, Denmark; lenera@sund.ku.dk Liliana Bernardino (PhD) - Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal; E- mail: libernardino@gmail.com Patrícia Maciel (PhD) - Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal; pmaciel@med.uminho.pt At the University of Coimbra Ana Cristina Rego (PhD) - Faculty of Medicine, University of Coimbra (FMUC), and Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal; a.cristina.rego@gmail.com; acrego@cnc.uc.pt; arego@fmed.uc.pt António Ferreira de Macedo (MD, PhD) - Faculty of Medicine, University of Coimbra, Coimbra, Portugal; amacedo@ci.uc.pt Cristina Januário (MD, PhD) Center of University Hospital of Coimbra (CHUC), Neurology Service, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; cristinajanuario@gmail.com Isabel Santana (MD, PhD) Center of University Hospital of Coimbra (CHUC), Neurology Service, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; isabeljsantana@gmail.com João Peça (PhD) - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; jmpessa@gmail.com Luís Pereira de Almeida (PhD) - Faculty of Pharmacy (FFUC) and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; lpereiradealmeida@gmail.com Manuel João Quartilho (MD, PhD) Coimbra University Hospital (HUC), Clinical Psychiatry Unit, and Faculty of Medicine, University of Coimbra, Coimbra, Portugal; mjquarti@ci.uc.pt Paula Moreira (PhD) - Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; pimoreira@fmed.uc.pt; pismoreira@gmail.com Rodrigo Cunha (PhD) - Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; rcunha@fmed.uc.pt; cunharod@gmail.com Sandra Morais Cardoso (PhD) - Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; cardoso.sandra.m@gmail.com 5