2015 Global Cardio-Oncology Summit

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1 Thursday, October 15, Global Cardio-Oncology Summit 7:00 7:50 Breakfast & Registration Mezzanine 7:50 8:00 Welcome Address & Introduction Co-Chairs: Susan Dent, MD & 8:00 8:20 Comprehensive cancer care includes addressing potential impact of cardiovascular toxicity Kathleen Pritchard, MD Senior Scientist, Sunnybrook Health Sciences Centre, Toronto, ON SESSION 1: Tyrosine Kinase Inhibitors in Hematologic Malignancy: Should We Be Concerned? Moderators: Thomas Force, MD & Javid Moslehi, MD 8:20 8:40 A revolution in the treatment of leukemia, but opening of Pandora s Box? 8:40 9:00 Is dasatinib related pulmonary hypertension a concern and manageable? 9:00 9:20 Newer CML therapy, nilotinib and ponatinib: A major advance but are vascular complications serious? 9:20 9:45 Session 1 Discussion: Should vascular effects of newer treatments be addressed more completely? Michael R. Savona, MD Director, Hematology Early Therapeutics Program, Vanderbilt Ingram Cancer Center, Nashville, TN Sebastian Szmit, MD, PhD Department of Pulmonary Circulation and Thromboembolic Disease; European Health Centre Otwock, Otwock, Poland Michael Deininger, MD, PhD Chief, Division of Hematology/BMT, University of Utah, Huntsman Cancer Institute Salt Lake City, UT Session 1 9:45 10:00 Break SESSION 2: Imaging for Cardiotoxicity: Many Issues, Many Questions Moderators: James White, MD & Juan Carlos Plana Gomez, MD 10:00 10:20 The use of strain and newer echocardiography imaging techniques Dinesh Thavendiranathan, MD Cardiologist, Toronto General Hospital, University Health Network, Toronto, ON 10:20 10:40 MRI: Utility for evaluation of cardiotoxicity Sanjeev Francis, MD Director, Cardio-Oncology Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA

2 Thursday, October 15, :40 11:00 Is it the best practice to use imaging core labs for all major studies? 11:00 11:25 Session 2 Discussion: Should the Echo guidelines be followed? 11:25 12:15 Keynote Debate: Should all HER2 positive breast cancer patients still undergo serial imaging every 3 months? Michel Khouri, MD Division of Cardiology, Duke University Medical Center, Durham, NC Session 2 Yes: Giuseppe Curigliano, MD, PhD No: Clifford Hudis, MD 12:15 1:00 Lunch Open Atrium SESSION 3: Cardiovascular Concerns from Radiation Therapy and Other Radiation Exposure Moderators: Eric Harrison, MD & S. Kishore Thain, MD 1:00 1:20 Cardiovascular issues in breast cancer patients undergoing radiation therapy 1:20 1:40 Autonomic dysfunction in patients treated with mediastinal or neck radiation 1:40 2:00 Radionuclide ventriculography and guidelines provide effective evidence based management strategies for limiting cardiac risks without measurable cancer risk and are preferable for monitoring 2:00 2:25 Session 3 Discussion: What adjustments can be made to minimize CV radiation effects? Gary Freedman Associate Professor of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA Anju Nohria, MD Associate Physician, Brigham and Women s Hospital; Assistant Professor, Harvard Medical School, Boston, MA Ronald Schwartz, MD Professor of Medicine and Imaging Sciences, Director of Nuclear Cardiology, University of Rochester Medical Center, Rochester, NY Session 3 2:25 2:40 Break SESSION 4: Childhood Cancer Survivorship, Late Cardiotoxicity, and CV Prevention Moderator: Melissa Hudson, MD 2:40 3:00 Late onset cardiotoxicity: Incidence, risk and individual risk prediction Greg Armstrong, MD Pediatric Oncologist, St. Jude Children s Research Hospital, Memphis, TN

3 Thursday, October 15, :00 3:20 Genetic variants and the risk for cardiac toxicity Smita Bhatia, MD, MPH Professor, University of Alabama at Birmingham, Birmingham, AL 3:20 3:40 Screening and intervention for cardiomyopathy Saro Armenian, DO, MPH Pediatric Hematologist/Oncologist; Medical Director, Pediactric Survivorship Clinic, City of Hope Comprehensive Cancer Center, Duarte, CA 3:40 4:00 Session 4 Discussion: Can a survivorship care plan really help change practice? Session 4 4:00 4:15 Break Session 5: Ongoing Research Developments in Cardio-Oncology Moderator: Edward TH Yeh, MD 4:15 4:30 Abstract Selection 1 Discussion: 5 minutes 4:30 4:45 Abstract Selection 2 Discussion: 5 minutes 4:45 5:00 Abstract Selection 3 Discussion: 5 minutes TBD Abstracts now being accepted for consideration TBD Abstracts now being accepted for consideration TBD Abstracts now being accepted for consideration 5:00 5:10 Closing Statements Co-Chairs: Susan Dent, MD & 5:10 6:30 Poster Presentations Wine & Cheese Reception Moderators: Jean-Bernard Durand, MD & David Slosky, MD 6:30 Adjourn

4 Friday, October 16, :00 7:50 Breakfast Mezzanine 7:50 8:00 Opening Remarks & Day 1 Review Co-Chairs: Susan Dent, MD & 8:00 8:20 The spirit of cooperation in cardiac and cancer care is vital for the future Thomas J. Wang, MD Professor of Medicine; Gottlieb C. Friesinger II Chair in Cardiovascular Medicine; Director, Division of Cardiovascular Medicine, Vanderbilt University Medical Center; Physician-in-Chief, Vanderbilt Heart & Vascular Institute, Nashville, TN SESSION 6: Cardiac Biomarkers and Early Detection of Cardiotoxicity Moderators: Richard Steingart, MD & Joerg Herrmann, MD 8:20 8:40 The practical use of cardiac biomarkers to optimally treat cardiac issues in patients treated with traditional chemotherapy 8:40 9:00 Can we use cardiac biomarkers to assist in cardiac management with newer targeted based treatment? 9:00 9:20 Can novel biomarkers be used to assess tumor responsiveness and risk of cardiotoxicity? 9:20 9:45 Session 6 Discussion: How can using biomarkers lead to actionable and beneficial events? Daniela Cardinale, MD, PhD Director, Cardioncology Unit, European Institute of Oncology, Milan, Italy Ronald Witteles, MD Stanford University Medical Center, Stanford, CA Luis A. Diaz, MD Associate Professor of Oncology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD Session 6 9:45 10:00 Break SESSION 7: Cardio-Oncology: What is the Future? Moderators: Jeanne DeCara, MD & Charles Porter, MD 10:00 10:20 Establishing a cardio-oncology clinic Susan Dent, MD Medical Oncologist, The Ottawa Hospital Cancer Centre, Ottawa,

5 ON Friday, October 16, :20 10:40 Can cardio-oncology really deliver improved practice internationally? Zaza Iakobishvili, MD, PhD Director, Emergency Cardiology Services, Beilinson Hospital, Rabin Medical Center, Tel Aviv University, Petah-Tikva, Israel 10:40 11:00 Developing a dedicated cardio-oncology journal Giorgio Minotti, MD G. d Annunzio University School of Medicine, Centro Studi sull Invecchiamento, Chieti, Italy 11:00 11:25 Session 7 Discussion: How can we formalize and improve the presence of cardio-oncology? 11:25 12:15 Keynote Debate: To Strain or Not to Strain Should we be doing this on all Echos for cardiotoxicity? Session 7 Yes: Bonnie Ky, MD, MSCE No: Ana Barac, MD, PhD 12:15 1:00 Lunch Open Atrium SESSION 8: Bone Marrow Transplantation How Can We Maximize Cardiac Status? Moderators: Joseph Carver, MD & Kathryn Culos, PharmD, BCOP 1:00 1:20 Stem cell transplant: Current role and emerging strategies 1:20 1:40 QT prolongation and device therapy in cancer patients undergoing stem cell therapy 1:40 2:00 Exercise in a cancer patient Is this the way to enhance cardiac reserve? 2:00 2:25 Session 8 Discussion: What is an adequate pre-stem cell cardiac evaluation? Madan Jagasia, MBBS Director, Outpatient Transplant Program; Professor of Medicine, Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN Michael Fradley, MD Division of Cardiology, University of South Florida, Moffitt Cancer Center, Tampa, FL Lee W. Jones, PhD Exercise Scientist, Memorial Sloan Kettering Cancer Center, New York, NY Session 8 2:25 2:40 Break

6 Friday, October 16, 2015 SESSION 9: Myeloma and Amyloid A True Case Study in Cardio-Oncology Moderators: Anne Blaes, MD & Douglas Sawyer, MD, PhD 2:40 3:00 Contemporary treatment of multiple myeloma Paul Richardson, MD R.J. Corman Professor, Department of Medicine, Harvard Medical School, Boston, MA 3:00 3:20 Proteasome Inhibition: Is there any concern? Alexander Lyon, MD Clinical Senior Lecturer in Heart Failure, Imperial College London; Consultant Cardiologist, Royal Brompton Hospital, London, England, UK 3:20 3:40 Amyloidosis: A systemic disease with a host of complications, particularly cardiac 3:40 4:00 Session 9 Discussion: Does the treatment of myeloma and amyloidosis require active cardiology and oncology collaboration? R. Frank Cornell, MD Vanderbilt University Medical Centre, Nashville, TN Session 9 4:00 4:10 Closing Statements Co-Chairs: Susan Dent, MD &

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