Saving Lives: Focusing on Severe Sepsis and Septic Shock
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1 Saving Lives: Focusing on Severe Sepsis and Septic Shock Deborah Cameron, RN, CPHQ Paul Pratt, RN Glenn Russ, RN Providence Little Company of Mary Medical Center San Pedro January 18, 2011 Objectives 1. Define severe sepsis and septic shock as a true medical emergency just like acute myocardial infarction and stroke. 2. Identify one rapid cycle test of change that you can do in your organization. 3. Identify the cost effect from a clinical quality outcome project. 4. Know the quote Every system is perfectly designed to achieve the results that it achieves. (Don Berwick) Providence Little Company of Mary Medical Center San Pedro one of 29 hospitals in the Providence Health & Services System located in the harbor are of Los Angeles 231 licensed beds (158 general acute) 115 average daily census 12-bed medical-surgical ICU associated w/long-term vent facility Joint Commission accredited w/stroke certification
2 Severe sepsis burning platform Condition US incidence No. of Deaths Mortality Rate AMI (1) , ,800 17% Stroke (1) , ,100 19% Severe sepsis (2) , ,000 29% Our team framework Sepsis Coordinator grant (1 day/week) 2 physician champions (ED Chief & ICU Medical Director) weekly steering committee meetings multi-disciplinary educational offerings population definition = & Every PI/Quality person s fantasy
3 Our story in a graph Percent Severe Sepsis and Septic Shock Mortality 100% Percent Mortality 90% 80% 70% 60% 50% 40% 30% 20% 10% begin protocol/order set begin ED MD data feedback 0% Aug-06 Feb-07 Aug-07 Feb-08 Aug-08 Feb-09 Aug-09 Feb-10 Aug-10 Time average percent mortality Comparing pre & post protocol time periods: Pearson Chi-Square = 7.807, DF = 1, P-Value = Fisher's exact test: P-Value = All mortality effect of severe sepsis program Observed/expected mortality index expected Pre project; 8/06 3/08 Post project; 4/08 9/10 Key Rapid Cycle Tests of Change implement protocol/pre-printed order set lactate/scvo2 measurement systems sepsis program integration with RRT sepsis simulation manikins/drills ED physician data feedback loop
4 ED Physician Feedback Loop Severe Sepsis Resuscitation Bundle 1. Serum lactate measured. 2. Blood cultures obtained prior to antibiotic administration. 3. From the time of presentation, broad-spectrum antibiotics administered within 3 hours for ED admissions and 1 hour for non-ed ICU admissions. 4. In the event of hypotension and/or lactate > 4 mmol/l (36 mg/dl): a) Deliver an initial minimum of 20 ml/kg of crystalloid (or colloid equivalent). b) Apply vasopressors for hypotension not responding to initial fluid resuscitation to maintain mean arterial pressure (MAP) > 65 mm Hg. 5. In the event of persistent hypotension despite fluid resuscitation (septic shock) and/or lactate > 4 mmol/l (36 mg/dl): a) Achieve central venous pressure (CVP) of > 8 mm Hg. b) Achieve central venous oxygen saturation (ScvO2) of > 70%.* Achieving a mixed venous oxygen saturation (SvO2) of 65% is an acceptable alternative. Severe Sepsis Management Bundle 1. Low-dose steroids administered for septic shock in accordance with a standardized ICU policy. 2. Recombinant Activated Protein C administered in accordance with a standardized ICU policy. 3. Glucose control maintained > lower limit of normal, but < 150 mg/dl (8.3 mmol/l). 4. Inspiratory plateau pressures maintained < 30 cm H2O for mechanically ventilated patients.
5 Overall severe sepsis program results 24% decrease severe sepsis mortality (Aug 2006 to Nov 2010) 61 additional lives saved (2Q08 to 4Q09) $7,643 reduction per case or ~$1.5 million/yr (2007 vs. first 21-months of project) 2 day reduction in ALOS (2007 vs. 21-month severe sepsis project) Our story benchmarked Percent Severe Sepsis and Septic Shock Mortality Percent Mortality 100% 90% 80% 70% 60% 50% 40% 30% 20% ''Every system is perfectly designed to achieve the results that it achieves''. -- Don Berwick 10% 0% Aug-06 Feb-07 Aug-07 Feb-08 Aug-08 Time Feb-09 Aug-09 Feb-10 Aug-10 Surviving Sepsis Campaign avg. mortality 30.8% Levy, MM. Crit Care Med 2010 Vol.38, No.2 Our story on video 2010 Providence Health & Services President s Award for Excellence ges/2010excellence.aspx
6 What s next? Next step #1: automated early warning system Pharmacy One Source: Sentri-7 severe sepsis early warning
7 Pharmacy One Source: Sentri-7 severe sepsis early warning Pharmacy One Source: Sentri-7 severe sepsis early warning Next step #2: severe sepsis timely antibiotics Surviving Sepsis Campaign benchmark Levy, MM. Crit Care Med 2010 Vol.38, No.2 Providence San Pedro
8 Early Antibiotics Kumar A, et al. Crit Care Med 2006; 34: Review of objectives 1. Severe sepsis and septic shock are just as much medical emergencies as stroke and heart attack. Code Sepsis??? Review of objectives 2. Sample rapid cycle tests of change: Sepsis Coordinator role implementation severe sepsis pre-printed order set sepsis program integration with RRT sepsis simulation manikins or drills ED physician data feedback loop Pre-mixed antibiotics in the ED Mark the chart or room in dramatic ways: abx NOT given Stat page to pharmacy / satellite pharmacy Adopt a screening tool Start with the resuscitation bundle first Broker an agreement for line placement -- ICU bed for ED line swap Consider ultrasound guidance ED training for CVP leave ScvO2 to ICU? Fluid Bolus Protocol Work patient safety angle
9 Review of objectives 3. Quality is cost effective! Review of objectives 4. ''Every system is perfectly designed to achieve the results that it achieves''. -- Don Berwick What will you re-design to benefit severe sepsis patients? Our thanks to Providence Health & Services Sean Townsend, MD, Surviving Sepsis Campaign Davis Balestracci, author Data Sanity: A Quantum Leap to Unprecedented Results Pharmacy One Source/Sentri 7 the Team at Providence San Pedro
10 the Team We welcome your questions
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