C-MP4 in amci, AD and LBD

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1 WP.2: Identification of novel neuroimaging targets in neurodegenerative disease P 36 UniHSR ilano Responsible: D. Perani WP.2: Identification of novel neuroimaging targets in neurodegenerative disease 11 C-P4 in aci, and Patients demographics and neuropsychological testing 1

2 WP.2 11 C-P4 in aci, and Tracer Clinical 11C-P4A 1. We developed a quantification and analysis method (Presentation by Dr. I. lorea, afternoon session) 2. We acquired aci 7 probable 4 4 healthy controls 3. We are still currently recruiting aci,, patients and possibly healthy controls Study sample: sociodemographical data N o of subjects Age (y) at inclusion (mean±sd) Gender : Education (mean±sd) aci 67.6±2.4 1:4 7.2± ±9. 3:4 7.6± ±.3 2:2.±1.7 2

3 Clinical data Age at onset (mean±sd) aci Single:multiple domain Rate of conversion aci (24 mo) aci () 6.±2.9 3:2 4/ converted to Probable (7) 72.1± (4) 72± Neuropsychological data CDR SE RAVLT immediate RAVLT delayed RC copy RC delayed TT A (sec) TT B (sec) aci () 0. 2 ± ± ± ± ±4 60 ± ±14 (7) 1.2 ± ± ± ± ± ± ±27.4 (4) 1.9 ± ± ± ± ±7 7. ±.4 n.a. n.a. ALL SCORES CORRECTED OR AGE, GENDER, EDUCATION 3

4 Neuropsychological data SE RAVLT immediate RAVLT delayed RC copy RC delayed TT A (sec) TT B (sec) aci () 2 ±2. 23 ±1.2 2 ± ± ±6 42. ± ±72. (7) 21.9 ± ±. 0.7 ±0.6. ± ± ±246. (4) 20. ± ±. 2 ±3. 1. ± ±3. n.a. n.a. ALL RAW SCORES Other neuropsychological tests available Verbal LT emory - Short story Verbal ST emory - Digit span Test Non Verbal ST emory - Corsi Block-Tapping Test Attention - Attentional atrices Reasoning - Wisconsin Card Sorting Test - Raven atrices Visuospatial abilities - Benton Lines Test - Token Test Executive functions - rontal Assessment Battery - Constructional Apraxia Test - Discriminazione di sgorbi (Spinnler e Tognoni, 197) Language - Aachen Aphasia Test - luency (semantic and phonetic) 4

5 Other behavioral tests available Global assessment - ilan Overall Dementia Assessment - AScog unctional impairment - IL - BL Psychiatric symptoms - Neuropsychiatric Inventory - Hamilton Anxiety Scale - Geriatric Depression Scale P36 other projects WP.2 1. DOPAINE TRANSPORTERS (DAT) EASUREENT IN PD AND PARKINSONISS (, SA, CBD, PSP) 2. AYLOID IAGING IN and aci

6 WP.2 1. DAT in PD and Parkinsonisms Tracers Clinical 11C-E-CIT and 123I-ioflupane 1. We completed the study of early onset PD and late onset PD with 11C-E-CIT images (paper under submission) 2. We studied with 11C-ECIT and PET two patients with genetically determined PD (results under submission) 3. We are studying patients with sporadic PD and parkinsonisms (PSP, CBD, ) to compare C-11-E-CIT PET and I-123- ioflupane SPECT and their diagnostic value WP.2 2. Amyloid imaging in and aci Tracers Clinical 11C-PIB 1. We are currently selecting, aci, TD patients for inclusion in the PET study 2. We are planning PET acquisitions during the next 24 months, to contribute to a common database within WP.2 6

7 P36 current projects WP 9 1. NEUROINLAATION: PRECLINICAL STUDIES 2. NEUROINLAATION IN PRION DISEASES WP 9 1. Neuroinflammation: tracers and preclinical studies Tracers Preclinical 11C-PK1119 and 11C-VC We developed 11C-VC701, an alternative tracer for PBBS (Belloli et al., 2004; Cappelli et al., 2006). 2. We are currently planning 1 labelling of VC We validated animal models for neuroinflammation (HD, LD, PD); we tested dopamine D2, adenosine A2 receptors and microglial activation both in vivo and in vitro in a HD model (oresco, DII meeting, 2007; paper under revision) 7

8 WP 9 2. Neuroinflammation in prion diseases Tracers Clinical 11C-PK We studied patients with Creutzfeld Jacob 4 subjects included: 3 Classic CJ and 1 Variant CJ (Bertoldo et al., NR, 2006 ; paper under submission). 2. We are studying a selected population of carriers of atal amilial Insomnia (I): subjects already acquired. 3. We are currently developing a quantification method for 11C-PK1119

9 Patient Gender Education Age Age onset Years onths P P P P P P P P CI P9 CI P10 CI P11 CI P12 CI 66 6 P P P P Additional data 1. RI scan acquired in 11/16 subjects 2. 99m Tc ECD SPECT perfusion study acquired in 7/16 subjects 9

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