Αίηια ανδρικής οζηεοπόρωζης - Βιβλιογραθικές πηγές

Size: px
Start display at page:

Download "Αίηια ανδρικής οζηεοπόρωζης - Βιβλιογραθικές πηγές"

Transcription

1 Αίηια ανδρικής οζηεοπόρωζης - Βιβλιογραθικές πηγές 1. National Osteoporosis Foundation. Clinician s guide to prevention and treatment of osteoporosis. Washington, DC: National Osteoporosis Foundation, Bailey DA et al. Calcium accretion in girls and boys during puberty: a longitudinal analysis. Journal of Bone and Mineral Research 2000; 15: Seeman E. Sexual dimorphism in skeletal size, density, and strength. Journal of Clinical Endocrinology and Metabolism 2001; 86: Seeman E. The pathogenesis of bone fragility in women and men. Lancet 2002; 359: Khosla S et al. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based non-invasive in vivo assessment. Journal of Bone and Mineral Research 2006; 21: Aaron JE et al. The microanatomy of trabecular bone loss in normal aging men and women. Clinical Orthopaedics and Related Research 1987; 215: Kirmani S et al. Bone structure at the distal radius during adolescent growth. Journal of Bone and Mineral Research 2009; 24: Riggs BL et al. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. Journal of Bone and Mineral Research 2004; 19: Marshall LM et al. Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men. Journal of Bone and Mineral Research 2006; 21: Riggs BL et al. A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. Journal of Bone and Mineral Research 2008; 23: Silva MJ & Gibson LJ. Modeling the mechanical behavior of vertebral trabecular bone: effects of age-related changes in microstructure. Bone 1997; 21: Morishima A et al. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. Journal of Clinical Endocrinology and Metabolism 1995; 80: Vanderschueren D et al. Gonadal sex steroid status and bone health in middle-aged and elderly European men. Osteoporosis International 2010; 21: Patsch J et al. Gender aspects of osteoporosis and bone strength. Wiener Medizinische Wochenschrift 2011; 161/5 6: DOI /s Goemaere S et al. Inverse association between bone turnover rate and bone mineral density in communitydwelling men >70 years of age: no major role of sex steroid status. Bone 2001; 29:

2 Αίηια ανδρικής οζηεοπόρωζης - Βιβλιογραθικές πηγές (2) 16. Szulc P et al. Biochemical assessment of bone turnover and bone fragility in men. Osteoporosis International 2007; 18: Riggs BL, Khosla S & Melton LJ. Sex steroids and the construction and conservation of the adult skeleton. Endocrine Reviews 2002; 23: Seeman E. The structural basis of bone fragility in men. Bone 1999; 25: Daniell HW. Osteoporosis after orchiectomy for prostate cancer. Journal of Urology 1997; 157: Gennari L et al. Aromatase activity and bone homeostasis in men. Journal of Clinical Endocrinology and Metabolism 2004; 89: Smith EP et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. New England Journal of Medicine 1994; 331: Bilezikian JP et al. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. New England Journal of Medicine 1998; 339: Vandenput L & Ohlsson C. Estrogens as regulators of bone health inmen. Nature Reviews Endocrinology 2009; 5: Falahati-Nini A et al. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. Journal of Clinical Investigation 2000; 106: Leder BZ et al. Differential effects of androgens and estrogens on bone turnover in normal men. Journal of Clinical Endocrinology and Metabolism 2003; 88: Gielen E et al. Osteoporosis in men. Best Practice & Research Clinical Endocrinology & Metabolism 2011; 25: doi: /j.beem Legrand E et al. Osteoporosis in men: a potential role for the sex hormone binding globuline. Bone 2001; 29: LeBlanc ES et al. The effects of serum testosterone, estradiol, and sex hormone binding globuline levels on fracture risk in older men. Journal of Clinical Endocrinology and Metabolism 2009; 94: Kelepouris N et al. Severe osteoporosis in men. Annals of Internal Medicine 1995; 123: Bours SPG et al. Contributors to Secondary Osteoporosis and Metabolic Bone Diseases in Patients Presenting with a Clinical Fracture. Journal of Clinical Endocrinology and Metabolism 2011; 96: Reid IR. Glucocorticoid osteoporosis mechanisms and management. European Journal of Endocrinology 1997; 137:

3 Αίηια ανδρικής οζηεοπόρωζης - Βιβλιογραθικές πηγές (3) 32. Van Staa TP et al. The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis. Osteoporosis International 2002; 13: Vanderschueren D et al. Androgens and bone. Endocrine Reviews 2004; 25: Vanderschueren D et al. Clinical review: Sex steroids and the periosteum Reconsidering the roles of androgens and estrogens in periosteal expansion. Journal of Clinical Endocrinology and Metabolism 2006; 91: Ferlin A et al. Osteoporosis in Klinefelter s syndrome. Molecular Human Reproduction 2010; 16(6): Ferlin A et al. Bone Mass in Subjects with Klinefelter Syndrome: Role of Testosterone Levels and Androgen Receptor Gene CAG Polymorphism. Journal of Clinical Endocrinology and Metabolism 2011; 96: E739 E Kamischke A et al. Testosterone levels in men with chronic obstructive pulmonary disease with and without glucocorticoid therapy. European Respiratory Journal 1998; 11: Biskobing DM. COPD and osteoporosis. Chest 2002; 121: Cawthon PM et al. Alcohol intake and its relationship with bone mineral density, falls, and fracture risk in older men. Journal of the American Geriatrics Society 2006; 54: Tucker KL et al. Effects of beer, wine and liquor intakes on bone mineral density in men and premenopausal women of the Framingham Offspring cohort. Journal of Bone and Mineral Research 2004; 19: Kanis JA et al. Alcohol intake as a risk factor for fracture. Osteoporosis International 2005; 16: Szulc P et al. Increased bone resorption in moderate smokers with low body weight: the Minos study. Journal of Clinical Endocrinology and Metabolism 2002; 87: Khosla S et al. Epidemiology and clinical features of osteoporosis in young individuals. Bone 1994; 15: Zerwekh JE et al. Impaired bone formation in male idiopathic osteoporosis: further reduction in the presence of concomitant hypercalciuria. Osteoporosis International 1992; 2: Epstein S & Leroith D. Diabetes and fragility fractures a burgeoning epidemic? Bone 2008; 43: Saller A,Maggi S, Romanato G et al.diabetes and osteoporosis. Aging Clinical and Experimental Research 2008; 20: Cohen A & Shane E. Osteoporosis after solid organ and bone marrow transplantation. Osteoporosis International 2003; 14: Marie P & Kassem M. Extrinsic Mechanisms Involved in Age-Related Defective Bone Formation. Journal of Clinical Endocrinology and Metabolism 2011; 96:

4 Αίηια ανδρικής οζηεοπόρωζης - Βιβλιογραθικές πηγές (4) 49. Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocrine Reviews 2010; 31: Ryall JG et al. Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology 2008; 9: Marie PJ & Zerath E. Role of growth factors in osteoblast alterations induced by skeletal unloading in rats. Growth Factors 2000; 18: Aguirre JI et al. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. Journal of Bone and Mineral Research 2006; 21: David V et al. Mechanical loading downregulates peroxisome proliferator-activated receptor γ in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology 2007; 148: Luu YK et al. Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesiswhile preventing dietary-induced obesity. Journal of Bone and Mineral Research 2009; 24: Heaney RP. Dairy and bone health. Journal of the American College of Nutritionists 2009; 28: 82S 90S 56. Bonjour JP. Dietary protein: an essential nutrient for bone health. Journal of the American College of Nutritionists 2005; 24: 526S 536S 57. Boonen S et al. Age-associated endocrine deficiencies as potential determinants of femoral neck (type II) osteoporotic fracture occurrence in elderly men. International Journal of Andrology 1997; 20: Bischoff HA et al. In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochemical Journal 2001; 33: Bischoff-Ferrari HA et al. Vitamin D receptor expression in human muscle tissue decreases with age. Journal of Bone and Mineral Research 2004; 19: Gerdhem P et al. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA study of elderly women. Osteoporosis International 2005; 16: Ammann P et al. Protein undernutrition-induced bone loss is associated with decreased IGF-I levels and estrogen deficiency. Journal of Bone and Mineral Research 2000; 15: Rizzoli R et al. Protein intake and bone disorders in the elderly. Joint Bone Spine 2001; 68:

5 Αίηια ανδρικής οζηεοπόρωζης - Βιβλιογραθικές πηγές (5) 63. Reed BY et al. Serum IGF 1 is low and correlated with osteoblastic surface in idiopathic osteoporosis. Journal of Bone and Mineral Research 1995; 10: Cooper MS. 11β-Hydroxysteroid dehydrogenase: a regulator of glucocorticoid response in osteoporosis. Journal of Endocrinological Investigation 2008; 31(7 Suppl): Weinstein RS et al. Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell 2010; 9: Kaufman J & Goemaere S. Osteoporosis in men. Best Practice & Research Clinical Endocrinology & Metabolism 2008; 22(5): Pernow Y et al. Osteoblast dysfunction in male idiopathic osteoporosis. Calcified Tissue International 2006; 78: Donovan MS et al. Low bone formation in premenopausal women with idiopathic osteoporosis. Journal of Clinical Endocrinology and Metabolism 2005; 90: Van Pottelbergh I et al. Deficient acquisition of bone during maturation underlies idiopathic osteoporosis in men. Journal of Bone and Mineral Research 2003; 18: Legrand E et al. Trabecular bone microarchitecture, bone mineral density and vertebral fractures in male osteoporosis. Journal of Bone and Mineral Research 2000; 15: Kurland ES et al. Insulin-like growth factor-1 in men with idiopathic osteoporosis. Journal of Clinical Endocrinology and Metabolism 1997; 82: Peris P et al. Aetiology and clinical characteristics of male osteoporosis. Have they changed in the last few years? Clinical and Experimental Rheumatology 2008; 26: Gennari L & Brandi L. Genetics of male osteoporosis. Calcified Tissue International 2001; 69: Patsch J et al. Of mice and men: pathophysiology of male osteoporosis. Journal of Men s Health 2007; 4:

BAD TO THE BONE. Peter Jones, Rheumatologist QE Health, Rotorua. GP CME Conference Rotorua, June 2008

BAD TO THE BONE. Peter Jones, Rheumatologist QE Health, Rotorua. GP CME Conference Rotorua, June 2008 BAD TO THE BONE Peter Jones, Rheumatologist QE Health, Rotorua GP CME Conference Rotorua, June 2008 Agenda Osteoporosis in Men Vitamin D and Calcium Long-term treatment with Bisphosphonates Pathophysiology

More information

Analysis of correlation between estradiol and fracture of femur neck

Analysis of correlation between estradiol and fracture of femur neck Analysis of correlation between estradiol and fracture of femur neck Mohammad Davood Sharifi (1)*, Masoud Mohebbi (2), Mahmood Farrokhfar (3)*, Roohie Farzaneh (1), Hamideh Feiz Disfani (1), Amir Masoud

More information

Best Practice & Research Clinical Endocrinology & Metabolism

Best Practice & Research Clinical Endocrinology & Metabolism Best Practice & Research Clinical Endocrinology & Metabolism 25 (2011) 321 335 Contents lists available at ScienceDirect Best Practice & Research Clinical Endocrinology & Metabolism journal homepage: www.elsevier.com/locate/beem

More information

Disclosure and Conflicts of Interest Steven T Harris MD Osteoporosis Diagnosis: BMD, FRAX and Assessment of Secondary Osteoporosis

Disclosure and Conflicts of Interest Steven T Harris MD Osteoporosis Diagnosis: BMD, FRAX and Assessment of Secondary Osteoporosis Osteoporosis Diagnosis: BMD, FRAX and Assessment of Secondary Osteoporosis Steven T Harris MD FACP Clinical Professor of Medicine University of California, San Francisco Disclosure and Conflicts of Interest

More information

Forteo (teriparatide) Prior Authorization Program Summary

Forteo (teriparatide) Prior Authorization Program Summary Forteo (teriparatide) Prior Authorization Program Summary FDA APPROVED INDICATIONS DOSAGE 1 FDA Indication 1 : Forteo (teriparatide) is indicated for: the treatment of postmenopausal women with osteoporosis

More information

Bone Cell Biology. David W. Dempster, PhD. Professor of Clinical Pathology Columbia University. Bone Remodeling

Bone Cell Biology. David W. Dempster, PhD. Professor of Clinical Pathology Columbia University. Bone Remodeling Bone Cell Biology David W. Dempster, PhD Professor of Clinical Pathology Columbia University Bone Remodeling The skeleton, out of site and often out of mind, is a formidable mass of tissue occupying about

More information

Bone Cell Biology. The Remodeling Cycle. Bone Remodeling. Remodeling Maintains Mechanical Strength. David W. Dempster, PhD

Bone Cell Biology. The Remodeling Cycle. Bone Remodeling. Remodeling Maintains Mechanical Strength. David W. Dempster, PhD Bone Remodeling Bone Cell Biology David W. Dempster, PhD Professor of Clinical Pathology Columbia University The skeleton, out of site and often out of mind, is a formidable mass of tissue occupying about

More information

Skeletal Manifestations

Skeletal Manifestations Skeletal Manifestations of Metabolic Bone Disease Mishaela R. Rubin, MD February 21, 2008 The Three Ages of Women Gustav Klimt 1905 1 Lecture Outline Osteoporosis epidemiology diagnosis secondary causes

More information

It is estimated that more than 2

It is estimated that more than 2 Vonda J. Wright, MD Abstract Osteoporosis is a significant threat to aging bone in men. Thirty percent of hip fractures occur in men; during initial hospitalization and the first year after fracture, the

More information

Osteoporosis: Not Just for Women Anymore. Osteoporosis is characterized by low bone. By Lisanne G. Laurier, MD, PhD, FRCPC.

Osteoporosis: Not Just for Women Anymore. Osteoporosis is characterized by low bone. By Lisanne G. Laurier, MD, PhD, FRCPC. Focus on CME at the University of Western Ontario Osteoporosis: Not Just for Women Anymore By Lisanne G. Laurier, MD, PhD, FRCPC Osteoporosis is characterized by low bone mass and microarchitectural deterioration

More information

Submission to the National Institute for Clinical Excellence on

Submission to the National Institute for Clinical Excellence on Submission to the National Institute for Clinical Excellence on Strontium ranelate for the prevention of osteoporotic fractures in postmenopausal women with osteoporosis by The Society for Endocrinology

More information

BMD: A Continuum of Risk WHO Bone Density Criteria

BMD: A Continuum of Risk WHO Bone Density Criteria Pathogenesis of Osteoporosis Osteoporosis Diagnosis: BMD, FRAX and Assessment of Secondary Osteoporosis AGING MENOPAUSE OTHER RISK FACTORS RESORPTION > FORMATION Bone Loss LOW PEAK BONE MASS Steven T Harris

More information

CASE 1 WHY IS IT IMPORTANT TO TREAT? FACTS CONCERNS

CASE 1 WHY IS IT IMPORTANT TO TREAT? FACTS CONCERNS 4:30-5:15pm Ask the Expert: Osteoporosis SPEAKERS Silvina Levis, MD OSTEOPOROSIS - FACTS 1:3 older women and 1:5 older men will have a fragility fracture after age 50 After 3 years of treatment, depending

More information

Osteoporosis, Osteomalasia & rickets. Bone disorders

Osteoporosis, Osteomalasia & rickets. Bone disorders Osteoporosis, Osteomalasia & rickets Bone disorders Thank You for Your comments Voice--- Ok Lecture too long--- this is in schedule??? More interaction--- I can do that inshalla Slides are crowded--- but

More information

Download slides:

Download slides: Download slides: https://www.tinyurl.com/m67zcnn https://tinyurl.com/kazchbn OSTEOPOROSIS REVIEW AND UPDATE Boca Raton Regional Hospital Internal Medicine Conference 2017 Benjamin Wang, M.D., FRCPC Division

More information

8/6/2018. Glucocorticoid induced osteoporosis: overlooked and undertreated? Disclosure. Objectives. Overview

8/6/2018. Glucocorticoid induced osteoporosis: overlooked and undertreated? Disclosure. Objectives. Overview Disclosure Glucocorticoid induced osteoporosis: overlooked and undertreated? I have no financial disclosure relevant to this presentation Tasma Harindhanavudhi, MD Division of Diabetes and Endocrinology

More information

Horizon Scanning Centre March Denosumab for glucocorticoidinduced SUMMARY NIHR HSC ID: 6329

Horizon Scanning Centre March Denosumab for glucocorticoidinduced SUMMARY NIHR HSC ID: 6329 Horizon Scanning Centre March 2014 Denosumab for glucocorticoidinduced osteoporosis SUMMARY NIHR HSC ID: 6329 This briefing is based on information available at the time of research and a limited literature

More information

Osteoporosis in Men. Until recently, the diagnosis of osteoporosis. A New Type of Patient. Al s case. How is the diagnosis made?

Osteoporosis in Men. Until recently, the diagnosis of osteoporosis. A New Type of Patient. Al s case. How is the diagnosis made? A New Type of Patient Rafat Faraawi, MD, FRCP(C), FACP Until recently, the diagnosis of osteoporosis in men was uncommon and, when present, it was typically described as a consequence of secondary causes.

More information

Osteoporosis in Men Professor Peter R Ebeling

Osteoporosis in Men Professor Peter R Ebeling Osteoporosis in Men MD FRACP Head, Department of Medicine, School for Clinical Sciences Monash Health Translation Precinct Monash University, Clayton, Victoria 1 MonashHealth Potential Conflicts Departmental

More information

PEAK BONE MASS can be defined as the maximal bone

PEAK BONE MASS can be defined as the maximal bone 0021-972X/00/$03.00/0 Vol. 85, No. 11 The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright 2000 by The Endocrine Society CLINICAL REVIEW 117 Hormonal Determinants and Disorders

More information

As many as 85% of all hip fractures and 90% of all vertebral fractures in men are attributed to osteoporosis. Unlike the usual situation in women,

As many as 85% of all hip fractures and 90% of all vertebral fractures in men are attributed to osteoporosis. Unlike the usual situation in women, OSTEOPOROSIS IN MEN Osteoporosis is a significant threat to aging bone in men 30% of hip fractures occur in men; during initial hospitalization and the first year after fracture, the mortality rate is

More information

Research Article Testosterone and the Male Skeleton: A Dual Mode of Action

Research Article Testosterone and the Male Skeleton: A Dual Mode of Action SAGE-Hindawi Access to Research Osteoporosis Volume 2011, Article ID 240328, 7 pages doi:10.4061/2011/240328 Research Article Testosterone and the Male Skeleton: A Dual Mode of Action Mieke Sinnesael,

More information

Study of secondary causes of male osteoporosis

Study of secondary causes of male osteoporosis Study of secondary causes of male osteoporosis Suárez, S.M., Giunta J., Meneses G., Costanzo P.R., Knoblovits P. Department of Endocrinology, Metabolism and Nuclear Medicine of Hospital Italiano of Buenos

More information

Calcium Nephrolithiasis and Bone Health. Noah S. Schenkman, MD

Calcium Nephrolithiasis and Bone Health. Noah S. Schenkman, MD Calcium Nephrolithiasis and Bone Health Noah S. Schenkman, MD Associate Professor of Urology and Residency Program Director, University of Virginia Health System; Charlottesville, Virginia Objectives:

More information

Osteoporosis. Open Access. John A. Kanis. Diseases, University of Sheffield, UK

Osteoporosis. Open Access. John A. Kanis. Diseases, University of Sheffield, UK Journal of Medical Sciences (2010); 3(3): 00-00 Review Article Osteoporosis Open Access John A. Kanis WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, UK incorporated into

More information

Osteoporosis. When we talk about osteoporosis, we have to be familiar with the constituents of bone and what it is formed of.

Osteoporosis. When we talk about osteoporosis, we have to be familiar with the constituents of bone and what it is formed of. Osteoporosis When we talk about osteoporosis, we have to be familiar with the constituents of bone and what it is formed of. Osteoblasts by definition are those cells present in the bone and are involved

More information

Review Article Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis

Review Article Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis International Journal of Endocrinology, Article ID 235060, 25 pages http://dx.doi.org/10.1155/2014/235060 Review Article Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis Vittorio Locatelli 1 and

More information

ESPEN Congress Cannes Education and Clinical Practice Programme

ESPEN Congress Cannes Education and Clinical Practice Programme ESPEN Congress Cannes 2003 Organised by the Israel Society for Clinical Nutrition Education and Clinical Practice Programme Session: Dietitian Symposium: Nutrition throughout the woman life cycle Prevention

More information

Index. B BMC. See Bone mineral content BMD. See Bone mineral density Bone anabolic impact, Bone mass acquisition

Index. B BMC. See Bone mineral content BMD. See Bone mineral density Bone anabolic impact, Bone mass acquisition A Acid base balance dietary protein detrimental effects of, 19 Acid base balance bicarbonate effects, 176 in bone human studies, 174 mechanisms, 173 174 in muscle aging, 174 175 alkali supplementation

More information

Fractures: Epidemiology and Risk Factors. July 2012 CME (35 minutes) 7/24/ July12 1. Osteoporotic fractures: Comparison with other diseases

Fractures: Epidemiology and Risk Factors. July 2012 CME (35 minutes) 7/24/ July12 1. Osteoporotic fractures: Comparison with other diseases Financial Disclosures Fractures: Epidemiology and Risk Factors Research grants, speaking or consulting: Amgen, Lilly, Merck, Novartis, Radius Dennis M. Black, PhD Department of Epidemiology and Biostatistics

More information

Male osteoporosis: clinical approach and management in family practice

Male osteoporosis: clinical approach and management in family practice Singapore Med J 2014; 55(7): 353-357 doi: 10.11622/smedj.2014085 CMEArticle Male osteoporosis: clinical approach and management in family practice Lay Hoon Goh 1,2, MMed, FCFP, Choon How How 1, MMed, FCFP,

More information

BREAST CANCER AND BONE HEALTH

BREAST CANCER AND BONE HEALTH BREAST CANCER AND BONE HEALTH Rowena Ridout, MD, FRCPC Toronto Western Hospital Osteoporosis Program University Health Network / Mount Sinai Hospital rowena.ridout@uhn.ca None to declare Conflicts of Interest

More information

Osteoporosis in Men Eric Orwoll Oregon Health & Science University

Osteoporosis in Men Eric Orwoll Oregon Health & Science University Osteoporosis in Men Eric Orwoll Oregon Health & Science University Ris k Factor Risk factors for hip fracture in men Multivariate HR + 95% CI Age 2.3 (1.6, 2.4) FN BMD 3.0 (2.5, 3.7) 5994 men age >65 yrs

More information

What Is FRAX & How Can I Use It?

What Is FRAX & How Can I Use It? What Is FRAX & How Can I Use It? Jacqueline Osborne PT, DPT Board Certified Geriatric Clinical Specialist Certified Exercise Expert for the Aging Adult Brooks Rehabilitation; Jacksonville, FL Florida Physical

More information

Pathophysiology of Postmenopausal & Glucocorticoid Induced Osteoporosis. March 15, 2016 Bone ECHO Kate T Queen, MD

Pathophysiology of Postmenopausal & Glucocorticoid Induced Osteoporosis. March 15, 2016 Bone ECHO Kate T Queen, MD Pathophysiology of Postmenopausal & Glucocorticoid Induced Osteoporosis March 15, 2016 Bone ECHO Kate T Queen, MD Review: normal bone formation Bone Modeling Remodeling Peak Bone Mass Maximum bone mass

More information

Osteoporosis update. Dr. Claire Vandevelde Consultant Rheumatologist, LTHT

Osteoporosis update. Dr. Claire Vandevelde Consultant Rheumatologist, LTHT Osteoporosis update Dr. Claire Vandevelde Consultant Rheumatologist, LTHT Outline Background BMD Tools for assessing fracture risk Case study Denosumab Treatment breaks BMD BMD predicts fracture risk but

More information

Interpreting DEXA Scan and. the New Fracture Risk. Assessment. Algorithm

Interpreting DEXA Scan and. the New Fracture Risk. Assessment. Algorithm Interpreting DEXA Scan and the New Fracture Risk Assessment Algorithm Prof. Samir Elbadawy *Osteoporosis affect 30%-40% of women in western countries and almost 15% of men after the age of 50 years. Osteoporosis

More information

Assessment and Treatment of Osteoporosis Professor T.Masud

Assessment and Treatment of Osteoporosis Professor T.Masud Assessment and Treatment of Osteoporosis Professor T.Masud Nottingham University Hospitals NHS Trust University of Nottingham University of Derby University of Southern Denmark What is Osteoporosis? Osteoporosis

More information

Review Article The Endocrine Role of Estrogens on Human Male Skeleton

Review Article The Endocrine Role of Estrogens on Human Male Skeleton International Journal of Endocrinology Volume 2015, Article ID 165215, 15 pages http://dx.doi.org/10.1155/2015/165215 Review Article The Endocrine Role of Estrogens on Human Male Skeleton Vincenzo Rochira,

More information

Because the low bone mass and deterioration

Because the low bone mass and deterioration OSTEOPOROSIS A look at recent expert guidelines and key studies in bone health, the findings of which affect your patients young and old Steven R. Goldstein, MD Dr. Goldstein is Professor of Obstetrics

More information

Chapter 39: Exercise prescription in those with osteoporosis

Chapter 39: Exercise prescription in those with osteoporosis Chapter 39: Exercise prescription in those with osteoporosis American College of Sports Medicine. (2010). ACSM's resource manual for guidelines for exercise testing and prescription (6th ed.). New York:

More information

Changes in Skeletal Systems over the Lifespan. Connie M. Weaver, Ph.D. Purdue University

Changes in Skeletal Systems over the Lifespan. Connie M. Weaver, Ph.D. Purdue University Changes in Skeletal Systems over the Lifespan Connie M. Weaver, Ph.D. Purdue University Disclosures Boards/Scientific Advisory Committees ILSI Showalter Pharmavite Grants NIH Dairy Research Institute Nestle

More information

Hormones Impact on Bone Health Throughout the Lifespan. Outline. Sex differences in: Osteoporosis and fracture rates. Secondary causes of osteoporosis

Hormones Impact on Bone Health Throughout the Lifespan. Outline. Sex differences in: Osteoporosis and fracture rates. Secondary causes of osteoporosis Hormones Impact on Bone Health Throughout the Lifespan Meryl S. LeBoff, MD Director, Skeletal Health and Osteoporosis Chief, Calcium and Bone Section Brigham and Women s Hospital Professor of Medicine,

More information

Using the FRAX Tool. Osteoporosis Definition

Using the FRAX Tool. Osteoporosis Definition How long will your bones remain standing? Using the FRAX Tool Gary Salzman M.D. Director Banner Good Samaritan/ Hayden VAMC Internal Medicine Geriatric Fellowship Program Phoenix, Arizona Using the FRAX

More information

Outline. Estrogens and SERMS The forgotten few! How Does Estrogen Work in Bone? Its Complex!!! 6/14/2013

Outline. Estrogens and SERMS The forgotten few! How Does Estrogen Work in Bone? Its Complex!!! 6/14/2013 Outline Estrogens and SERMS The forgotten few! Clifford J Rosen MD rosenc@mmc.org Physiology of Estrogen and estrogen receptors Actions of estrogen on bone BMD, fracture, other off target effects Cohort

More information

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 4,100 116,000 120M Open access books available International authors and editors Downloads Our

More information

Inadequate Dietary Calcium and Vitamin D Intake in Patients with Osteoporotic Fracture

Inadequate Dietary Calcium and Vitamin D Intake in Patients with Osteoporotic Fracture J Bone Metab 2016;23:55-61 http://dx.doi.org/10.11005/jbm.2016.23.2.55 pissn 2287-6375 eissn 2287-7029 Original Article Inadequate Dietary Calcium and Vitamin D Intake in Patients with Osteoporotic Fracture

More information

Osteoporosis: A Tale of 3 Task Forces!

Osteoporosis: A Tale of 3 Task Forces! Osteoporosis: A Tale of 3 Task Forces! Robert A. Adler, MD McGuire Veterans Affairs Medical Center Virginia Commonwealth University Richmond, Virginia, USA Disclosures The opinions are those of the speaker

More information

DISEASES WITH ABNORMAL MATRIX

DISEASES WITH ABNORMAL MATRIX DISEASES WITH ABNORMAL MATRIX MSK-1 FOR 2 ND YEAR MEDICAL STUDENTS Dr. Nisreen Abu Shahin CONGENITAL DISEASES WITH ABNORMAL MATRIX OSTEOGENESIS IMPERFECTA (OI): also known as "brittle bone disease" a group

More information

ADOLESCENT OBESITY: IS IT BAD FOR THE BONES

ADOLESCENT OBESITY: IS IT BAD FOR THE BONES ADOLESCENT OBESITY: IS IT BAD FOR THE BONES Babette S. Zemel, PhD Director, Nutrition And Growth Laboratory Division Of Gastroenterology, Hepatology And Nutrition The Children s Hospital Of Philadelphia

More information

Parathyroid Hormone Analog for Osteoporosis Prior Authorization with Quantity Limit Criteria Program Summary

Parathyroid Hormone Analog for Osteoporosis Prior Authorization with Quantity Limit Criteria Program Summary Parathyroid Hormone Analog for Osteoporosis Prior Authorization with Quantity Limit Criteria Program Summary This prior authorization program applies to Commercial, NetResults A series, NetResults F series

More information

The Skeletal System:Bone Tissue

The Skeletal System:Bone Tissue The Skeletal System:Bone Tissue Dynamic and ever-changing throughout life Skeleton composed of many different tissues cartilage, bone tissue, epithelium, nerve, blood forming tissue, adipose, and dense

More information

Osteoporosis Screening and Treatment in Type 2 Diabetes

Osteoporosis Screening and Treatment in Type 2 Diabetes Osteoporosis Screening and Treatment in Type 2 Diabetes Ann Schwartz, PhD! Dept. of Epidemiology and Biostatistics! University of California San Francisco! October 2011! Presenter Disclosure Information

More information

COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP)

COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) European Medicines Agency London, 20 January 2010 Doc. Ref. EMA/CHMP/EWP/15912/2010 COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) CONCEPT PAPER ON THE NEED FOR AN ADDENDUM ON THE CLINICAL INVESTIGATION

More information

Fragile Bones and how to recognise them. Rod Hughes Consultant physician and rheumatologist St Peter s hospital Chertsey

Fragile Bones and how to recognise them. Rod Hughes Consultant physician and rheumatologist St Peter s hospital Chertsey Fragile Bones and how to recognise them Rod Hughes Consultant physician and rheumatologist St Peter s hospital Chertsey Osteoporosis Osteoporosis is a skeletal disorder characterised by compromised bone

More information

Osteoporosis/Fracture Prevention

Osteoporosis/Fracture Prevention Osteoporosis/Fracture Prevention NATIONAL GUIDELINE SUMMARY This guideline was developed using an evidence-based methodology by the KP National Osteoporosis/Fracture Prevention Guideline Development Team

More information

Breast Cancer and Bone Health. Robert Coleman, Cancer Research Centre, Weston Park Hospital, Sheffield

Breast Cancer and Bone Health. Robert Coleman, Cancer Research Centre, Weston Park Hospital, Sheffield Breast Cancer and Bone Health Robert Coleman, Cancer Research Centre, Weston Park Hospital, Sheffield Breast Cancer and Bone Health Normal Bone Health Impact of Cancer Therapies on Bone Health Therapeutic

More information

Osteoporosis Agents Drug Class Prior Authorization Protocol

Osteoporosis Agents Drug Class Prior Authorization Protocol Osteoporosis Agents Drug Class Prior Authorization Protocol Line of Business: Medicaid P&T Approval Date: February 21, 2018 Effective Date: April 1, 2018 This policy has been developed through review of

More information

TEAM SCIENCE AT A PROGRAMMATIC LEVEL. Sundeep Khosla, M.D. Mayo Clinic College of Medicine

TEAM SCIENCE AT A PROGRAMMATIC LEVEL. Sundeep Khosla, M.D. Mayo Clinic College of Medicine TEAM SCIENCE AT A PROGRAMMATIC LEVEL Sundeep Khosla, M.D. Mayo Clinic College of Medicine APPROACH TO TRANSLATIONAL RESEARCH IN OSTEOPOROSIS Epidemiological Studies Clinical Investigation Mouse and Cellular

More information

AETNA BETTER HEALTH Prior Authorization guideline for Injectable Osteoporosis Agents

AETNA BETTER HEALTH Prior Authorization guideline for Injectable Osteoporosis Agents AETNA BETTER HEALTH Prior Authorization guideline for Injectable Osteoporosis Agents Injectable Osteoporosis Agents Forteo (teriparatide); zoledronic acid Prolia (denosumab)] Authorization guidelines For

More information

Managing the Patient with Osteoporosis Undergoing Spinal Surgery

Managing the Patient with Osteoporosis Undergoing Spinal Surgery 11/4/16 DISCLOSURES Managing the Patient with Osteoporosis Undergoing Spinal Surgery MEDTRONIC LILLY MISONIX SHANE BURCH MD, MS, FRCSC Associate Professor in Residence UCSF Department of Orthopedic Surgery

More information

Functions of the Skeletal System. Chapter 6: Osseous Tissue and Bone Structure. Classification of Bones. Bone Shapes

Functions of the Skeletal System. Chapter 6: Osseous Tissue and Bone Structure. Classification of Bones. Bone Shapes Chapter 6: Osseous Tissue and Bone Structure Functions of the Skeletal System 1. Support 2. Storage of minerals (calcium) 3. Storage of lipids (yellow marrow) 4. Blood cell production (red marrow) 5. Protection

More information

Effects of Anti RANK ligand Denosumab on Beta Thalassemia induced osteoporosis

Effects of Anti RANK ligand Denosumab on Beta Thalassemia induced osteoporosis Effects of Anti RANK ligand Denosumab on Beta Thalassemia induced osteoporosis Mohamed Yassin 1 Ashraf T. Soliman2, Mohamed O. Abdelrahman3, Vincenzo De Sanctis 4 Departments of, 1 Hematology 2Pediatric

More information

HRT and Risedronate Combined Anabolic and Antiresorptive Therapy

HRT and Risedronate Combined Anabolic and Antiresorptive Therapy Optimizing Combined and Sequential Osteoanabolic and Antiresorptive Therapy Benjamin Leder, M.D. Endocrine Unit Massachusetts General Hospital Boston, MA Antiresorptive and Osteoanabolic Therapies Increase

More information

BONE REMODELLING. Tim Arnett. University College London. Department of Anatomy and Developmental Biology

BONE REMODELLING. Tim Arnett. University College London. Department of Anatomy and Developmental Biology BONE REMODELLING Tim Arnett Department of Anatomy and Developmental Biology University College London The skeleton, out of sight and often out of mind, is a formidable mass of tissue occupying about 9%

More information

The Skeletal System:Bone Tissue

The Skeletal System:Bone Tissue The Skeletal System:Bone Tissue Dynamic and ever-changing throughout life Skeleton composed of many different tissues cartilage, bone tissue, epithelium, nerve, blood forming tissue, adipose, and dense

More information

Growth and DMD Endocrine aspects of care

Growth and DMD Endocrine aspects of care Growth and DMD Endocrine aspects of care Meilan Rutter, MB,BCh, FRACP Division of Endocrinology Cincinnati Children s Hospital Medical Center July 2007 Where are we now? Inactive Reactive Proactive CCHMC

More information

[If no, skip to question 10.] Y N. 2. Does the member have a diagnosis of Paget s disease of bone? Y N. [If no, skip to question 4.

[If no, skip to question 10.] Y N. 2. Does the member have a diagnosis of Paget s disease of bone? Y N. [If no, skip to question 4. Pharmacy Prior Authorization AETA BETTER HEALTH EW JERSE (MEDICAID) Zoledronic Acid (Medicaid) This fax machine is located in a secure location as required by HIPAA regulations. Complete/review information,

More information

Skeletal Tissues. Skeletal tissues. Frame; muscles, organs and CT attach. Brain, spinal cord, thoracic organs; heart and lungs.

Skeletal Tissues. Skeletal tissues. Frame; muscles, organs and CT attach. Brain, spinal cord, thoracic organs; heart and lungs. Skeletal Tissues Functions 1) support 2) protection 3) movement Skeletal tissues Frame; muscles, organs and CT attach. Brain, spinal cord, thoracic organs; heart and lungs. Aids muscle contraction; generate

More information

3. Has bone specific alkaline phosphatase level increased OR does the member have symptoms related to active Paget s?

3. Has bone specific alkaline phosphatase level increased OR does the member have symptoms related to active Paget s? Pharmacy Prior Authorization AETA BETTER HEALTH VIRGIIA CCC PLUS and MEDALLIO/FAMIS 4.0 Zoledronic Acid (Medicaid) This fax machine is located in a secure location as required by HIPAA regulations. Complete/review

More information

nogg Guideline for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK

nogg Guideline for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK nogg NATIONAL OSTEOPOROSIS GUIDELINE GROUP Guideline for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK Produced by J Compston, A Cooper,

More information

Hot Topics in Bone Disease in 2017: Building Better Bones Breaking News in Osteoporosis

Hot Topics in Bone Disease in 2017: Building Better Bones Breaking News in Osteoporosis Hot Topics in Bone Disease in 2017: Building Better Bones Breaking News in Osteoporosis Aromatase Inhibitor-Induced Bone Loss in Early Breast Cancer Rachel Pessah-Pollack, M.D., F.A.C.E. Mount Sinai School

More information

Osteoporosis. Overview

Osteoporosis. Overview v2 Osteoporosis Overview Osteoporosis is defined as compromised bone strength that increases risk of fracture (NIH Consensus Conference, 2000). Bone strength is characterized by bone mineral density (BMD)

More information

Monitoring Osteoporosis Therapy

Monitoring Osteoporosis Therapy Monitoring Osteoporosis Therapy SUZANNE MORIN DEPT OF MEDICINE, DIVISION OF GENERAL INTERNAL MEDICINE, MUHC CENTRE FOR OUTCOMES RESEARCH AND EVALUATION, RI MUHC November 2017 Conflict of Interest Disclosures

More information

This is a repository copy of Microarchitecture of bone predicts fractures in older women.

This is a repository copy of Microarchitecture of bone predicts fractures in older women. This is a repository copy of Microarchitecture of bone predicts fractures in older women. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/130351/ Version: Accepted Version

More information

T h e n e w e ng l a nd j o u r na l o f m e dic i n e

T h e n e w e ng l a nd j o u r na l o f m e dic i n e T h e n e w e ng l a nd j o u r na l o f m e dic i n e clinical practice Osteoporosis in Men Peter R. Ebeling, M.D. This Journal feature begins with a case vignette highlighting a common clinical problem.

More information

Feature Article. Volume 2 Number 2. Adrian S. Dobs, MD, MHS

Feature Article. Volume 2 Number 2. Adrian S. Dobs, MD, MHS Volume 2 Number 2 Adrian S. Dobs, MD, MHS Professor of Medicine and Oncology Johns Hopkins University School of Medicine Division of Endocrinology and Metabolism Baltimore, Maryland Editor s Letter Dear

More information

Pharmacy Management Drug Policy

Pharmacy Management Drug Policy SUBJECT: - Forteo (teriparatide), Prolia (denosumab), Tymlos (abaloparatide) POLICY NUMBER: Pharmacy-35 EFFECTIVE DATE: 9/07 LAST REVIEW DATE: 9/29/2017 If the member s subscriber contract excludes coverage

More information

Disclosures Fractures:

Disclosures Fractures: Disclosures Fractures: A. Schwartz Epidemiology and Risk Factors Research Funding: GlaxoSmithKline, Merck Ann V. Schwartz, PhD Department of Epidemiology and Biostatistics UCSF Outline Fracture incidence

More information

Treatments for Osteoporosis Expected Benefits, Potential Harms and Drug Holidays. Suzanne Morin MD FRCP FACP McGill University May 2014

Treatments for Osteoporosis Expected Benefits, Potential Harms and Drug Holidays. Suzanne Morin MD FRCP FACP McGill University May 2014 Treatments for Osteoporosis Expected Benefits, Potential Harms and Drug Holidays Suzanne Morin MD FRCP FACP McGill University May 2014 Learning Objectives Overview of osteoporosis management Outline efficacy

More information

BONE HEALTH Dr. Tia Lillie. Exercise, Physical Activity and Osteoporosis

BONE HEALTH Dr. Tia Lillie. Exercise, Physical Activity and Osteoporosis BONE HEALTH Dr. Tia Lillie Exercise, Physical Activity and Osteoporosis Food for thought... How old would you be if you didn t know how old you were? DEFINITION: Osteoporosis Osteoporosis (OP) is a disease

More information

Comparison of Bone Density of Distal Radius With Hip and Spine Using DXA

Comparison of Bone Density of Distal Radius With Hip and Spine Using DXA ORIGINAL ARTICLE Comparison of Bone Density of Distal Radius With Hip and Spine Using DXA Leila Amiri 1, Azita Kheiltash 2, Shafieh Movassaghi 1, Maryam Moghaddassi 1, and Leila Seddigh 2 1 Rheumatology

More information

Although traditionally re -

Although traditionally re - Roger A.L. Sutton, DM, FRCPC, FRCP, FACP, Larry Dian, MD, FRCPC, Pierre Guy, MDCM, MBA, FRCSC Osteoporosis in men: An underrecognized and undertreated problem Important risk factors for male osteoporosis

More information

Objectives. Discuss bone health and the consequences of osteoporosis on patients medical and disability status.

Objectives. Discuss bone health and the consequences of osteoporosis on patients medical and disability status. Objectives Discuss bone health and the consequences of osteoporosis on patients medical and disability status. Discuss the pathophysiology of osteoporosis and major risk factors. Assess the major diagnostic

More information

COPD-Related Musculoskeletal Disease. Jessica Bon Field, MD, MS 2017 Update in Internal Medicine October 20, 2017

COPD-Related Musculoskeletal Disease. Jessica Bon Field, MD, MS 2017 Update in Internal Medicine October 20, 2017 COPD-Related Musculoskeletal Disease Jessica Bon Field, MD, MS 2017 Update in Internal Medicine October 20, 2017 A 60-year old man with COPD comes into your office for a routine office visit. He is a former

More information

ANATOMY C027A: MINERALIZED TISSUE BIOLOGY: SKELETAL TISSUES. Please answer THREE Questions. All questions carry equal marks.

ANATOMY C027A: MINERALIZED TISSUE BIOLOGY: SKELETAL TISSUES. Please answer THREE Questions. All questions carry equal marks. Module Code: C27A UNIVERSITY OF LONDON (University College London) BSc DEGREE 2001 ANATOMY C027A: MINERALIZED TISSUE BIOLOGY: SKELETAL TISSUES 16 May 2001, 10.00am 1) Discuss the roles of ph, po2, phosphate

More information

Review Article RANKL-Targeted Therapies: The Next Frontier in the Treatment of Male Osteoporosis

Review Article RANKL-Targeted Therapies: The Next Frontier in the Treatment of Male Osteoporosis SAGE-Hindawi Access to Research Osteoporosis Volume 2011, Article ID 941310, 6 pages doi:10.4061/2011/941310 Review Article RANKL-Targeted Therapies: The Next Frontier in the Treatment of Male Osteoporosis

More information

Osteoporosis. Current Trend in Osteoporosis Management for Elderly in HK- Medical Perspective. Old Definition of Osteoporosis

Osteoporosis. Current Trend in Osteoporosis Management for Elderly in HK- Medical Perspective. Old Definition of Osteoporosis Current Trend in Osteoporosis Management for Elderly in HK- Medical Perspective Dr Dicky T.K. Choy Physician Jockey Club Centre for Osteoporosis Care and Control, CUHK Osteoporosis Global public health

More information

S.L. Ferrari*, L.P. Nicod**, J. Hamacher**, A. Spiliopoulos +, D.O. Slosman ++, T. Rochat**, J-P. Bonjour*, R. Rizzoli*

S.L. Ferrari*, L.P. Nicod**, J. Hamacher**, A. Spiliopoulos +, D.O. Slosman ++, T. Rochat**, J-P. Bonjour*, R. Rizzoli* Eur Respir J, 1996, 9, 2378 2382 DOI: 1.1183/931936.96.9112378 Printed in UK - all rights reserved Copyright ERS Journals Ltd 1996 European Respiratory Journal ISSN 93-1936 Osteoporosis in patients undergoing

More information

The Skeletal Response to Aging: There s No Bones About It!

The Skeletal Response to Aging: There s No Bones About It! The Skeletal Response to Aging: There s No Bones About It! April 7, 2001 Joseph E. Zerwekh, Ph.D. Interrelationship of Intestinal, Skeletal, and Renal Systems to the Overall Maintenance of Normal Calcium

More information

TREATMENT OF OSTEOPOROSIS

TREATMENT OF OSTEOPOROSIS TREATMENT OF OSTEOPOROSIS Summary Prevention is the key issue in the management of osteoporosis. HRT is the agent of choice for prevention of postmenopausal osteoporosis. Bisphosphonates and Calcitonin

More information

Current and Emerging Strategies for Osteoporosis

Current and Emerging Strategies for Osteoporosis Current and Emerging Strategies for Osteoporosis I have nothing to disclose. Anne Schafer, MD Assistant Professor of Medicine Division of Endocrinology & Metabolism December 12, 2014 Outline Osteoporosis

More information

support optimum bone mass accrual during rapid weight loss to prevent fracture and early onset osteoporosis.

support optimum bone mass accrual during rapid weight loss to prevent fracture and early onset osteoporosis. The BOW Study (Bone in Weight Loss): The effect of profound weight loss following intragastric balloon placement on skeletal integrity in severely obese adolescents. Background: The effect of profound

More information

O. Bruyère M. Fossi B. Zegels L. Leonori M. Hiligsmann A. Neuprez J.-Y. Reginster

O. Bruyère M. Fossi B. Zegels L. Leonori M. Hiligsmann A. Neuprez J.-Y. Reginster DOI 10.1007/s00296-012-2460-y ORIGINAL ARTICLE Comparison of the proportion of patients potentially treated with an anti-osteoporotic drug using the current criteria of the Belgian national social security

More information

INSIGHT INTO BONE METABOLISM AND SKELETAL MASS IN POLYCYSTIC OVARY SYNDROME

INSIGHT INTO BONE METABOLISM AND SKELETAL MASS IN POLYCYSTIC OVARY SYNDROME INSIGHT INTO BONE METABOLISM AND SKELETAL MASS IN POLYCYSTIC OVARY SYNDROME *Zehra Berberoglu Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Ankara, Turkey *Correspondence

More information

OSTEOPOROSIS IN MEN is a major public health problem

OSTEOPOROSIS IN MEN is a major public health problem 0021-972X/04/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 89(12):6025 6029 Printed in U.S.A. Copyright 2004 by The Endocrine Society doi: 10.1210/jc.2004-0602 Estrogens Are Essential for

More information

Trebeculae. Step 4. compact bone. Diploë Pearson Education, Inc.

Trebeculae. Step 4. compact bone. Diploë Pearson Education, Inc. Trebeculae compact bone Step 4 Diploë Abnormalities in bone growth Fibrodysplasia ossificans progressiva (FOP) autosomal dominant, Codon 206: Arg à Hist 1 : 2, 000, 000 endothelial cells à mesenchymal

More information

Bad to the bones: treatments for breast and prostate cancer

Bad to the bones: treatments for breast and prostate cancer 12 th Annual Osteoporosis: New Insights in Research, Diagnosis, and Clinical Care 23 rd July 2015 Bad to the bones: treatments for breast and prostate cancer Richard Eastell, MD FRCP (Lond, Edin, Ireland)

More information

A KL/R / AN A K/O / P O G G

A KL/R / AN A K/O / P O G G Outline and New Treatments on the Horizon Steven R. Cummings, MD CPMC and UCSF San Francisco Coordinating Center Support from Lilly and Amgen New treatments, new mechanisms of action Cathepsin K inhibition

More information