ÁLVARO PINTO. Servicio de Oncología Médica Hospital Universitario La Paz IdiPAZ, Madrid
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1 ACTUALIZACIÓN EN EL ABORDAJE DEL CÁNCER DE PRÓSTATA METASTÁSICO HORMONO--SENSIBLE HORMONO ÁLVARO PINTO Servicio de Oncología Médica Hospital Universitario La Paz IdiPAZ, Madrid
2 ADT + docetaxel: a new standard of care for men with mcnpc and high metastatic burden (2015) Presented By Karim Fizazi at 2017 ASCO Annual Meeting
3 LATITUDE: A phase 3, double-blind, randomized trial of androgen deprivation therapy with abiraterone acetate plus prednisone or placebos <br />in newly diagnosed high-risk metastatic hormone-naïve prostate cancer patients Presented By Karim Fizazi at 2017 ASCO Annual Meeting
4 Overall study design of LATITUDE Presented By Karim Fizazi at 2017 ASCO Annual Meeting
5 Treatment arms were well balanced Presented By Karim Fizazi at 2017 ASCO Annual Meeting
6 Statistically significant 38% risk reduction of death Presented By Karim Fizazi at 2017 ASCO Annual Meeting
7 OS benefit consistently favorable across subgroups Presented By Karim Fizazi at 2017 ASCO Annual Meeting
8 Statistically significant 53% risk reduction of radiographic progression or death Presented By Karim Fizazi at 2017 ASCO Annual Meeting
9 Statistically significant improvement in all secondary end points Presented By Karim Fizazi at 2017 ASCO Annual Meeting
10 Statistically significant 70% risk reduction of time to PSA progression Presented By Karim Fizazi at 2017 ASCO Annual Meeting
11 Statistically significant 30% risk reduction of time to pain progression Presented By Karim Fizazi at 2017 ASCO Annual Meeting
12 Statistically significant 58% risk reduction of time to subsequent <br />PC therapy Presented By Karim Fizazi at 2017 ASCO Annual Meeting
13 Summary of adverse events Presented By Karim Fizazi at 2017 ASCO Annual Meeting
14 Adverse events of special interest Presented By Karim Fizazi at 2017 ASCO Annual Meeting
15 Conclusions Presented By Karim Fizazi at 2017 ASCO Annual Meeting
16 Conclusions Presented By Karim Fizazi at 2017 ASCO Annual Meeting
17 Slide 24 Presented By Karim Fizazi at 2017 ASCO Annual Meeting
18 Slide 1 Presented By Nicholas James at 2017 ASCO Annual Meeting
19 Docetaxel & ZA comparisons: patients Presented By Nicholas James at 2017 ASCO Annual Meeting
20 Abiraterone comparison: patients Presented By Nicholas James at 2017 ASCO Annual Meeting
21 Inclusion criteria Presented By Nicholas James at 2017 ASCO Annual Meeting
22 Outcome measures Presented By Nicholas James at 2017 ASCO Annual Meeting
23 Multi-arm multi-stage (MAMS) design Presented By Nicholas James at 2017 ASCO Annual Meeting
24 Accrual Presented By Nicholas James at 2017 ASCO Annual Meeting
25 Slide 30 Presented By Nicholas James at 2017 ASCO Annual Meeting
26 Slide 38 Presented By Nicholas James at 2017 ASCO Annual Meeting
27 Slide 42 Presented By Nicholas James at 2017 ASCO Annual Meeting
28 Slide 47 Presented By Nicholas James at 2017 ASCO Annual Meeting
29 Slide 53 Presented By Nicholas James at 2017 ASCO Annual Meeting
30 Slide 63 Presented By Nicholas James at 2017 ASCO Annual Meeting
31 Slide 70 Presented By Nicholas James at 2017 ASCO Annual Meeting
32 Slide 76 Presented By Nicholas James at 2017 ASCO Annual Meeting
33 Comparing CHAARTED High Volume Patients and LATITUDE Patients Presented By Eric Small at 2017 ASCO Annual Meeting
34 Comparing LATITUDE and CHAARTED Patients Presented By Eric Small at 2017 ASCO Annual Meeting
35 Comparing LATITUDE Patients and CHAARTED High Volume Patients Presented By Eric Small at 2017 ASCO Annual Meeting
36 Comparing Overall Survival Across Studies Presented By Eric Small at 2017 ASCO Annual Meeting
37 Slide 20 Presented By Eric Small at 2017 ASCO Annual Meeting
38 Slide 22 Presented By Eric Small at 2017 ASCO Annual Meeting
39 Slide 26 Presented By Eric Small at 2017 ASCO Annual Meeting
40 Comparing Overall Survival Across Studies Presented By Eric Small at 2017 ASCO Annual Meeting
41 Take Homes from Latitude Presented By Eric Small at 2017 ASCO Annual Meeting
42 PROS & CONS ABIRATERONA DOCETAXEL Menor toxicidad Pacientes unfit para QT Elección del paciente Menor coste Menor duración de tratamiento Exceso de presión antiandrogénica? Toxicidad financiera Paciente fit para QT? Seguimiento corto Exceso de toxicidad para obtener resultados similares? No todos son fit
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48 CONCLUSIONES TENEMOS DOS ESTÁNDARES DE TRATAMIENTO? EN QUÉ BASAREMOS LA ELECCIÓN? Toxicidad Forma de presentación Coste Conveniencia (iv vs oral) Secuenciación posterior Lo que nos dejen poner
49 MUCHAS GRACIAS POR SU ATENCIÓN ÁLVARO PINTO Servicio de Oncología Médica Hospital Universitario La Paz IdiPAZ, Madrid
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