North Savo District Hospital, Iisalmi (Finland) Resident in Neurology, Dept. of Neurology. Kuopio University Hospital, Kuopio (Finland)

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1 Curriculum vitae PERSONAL INFORMATION Maija Pihlajamaki WORK EXPERIENCE August 1997 January 1998 Intern, Internal Medicine North Savo District Hospital, Iisalmi (Finland) February 1998 October 2004 Research training fellow Dept. of Neuroscience and Neurology, University of Kuopio, Kuopio (Finland) August 1999 November 2009 Resident in Neurology, Dept. of Neurology Kuopio University Hospital, Kuopio (Finland) November 2004 May 2005 General practitioner, Public Health and General Practice Siilinjärvi Health Center, Siilinjärvi (Finland) October 2004 August 2011 Postdoctoral researcher, Dept. of Neuroscience and Neurology August 2005 July 2008 Postdoctoral researcher Dept. of Neurology, BWH, and Athinoula A. Martinos Center for Biomedical Imaging, MGH, Harvard Medical School, Boston, MA (United States) October 2009 August 2011 Clinical teacher in Neurology University of Eastern Finland, Kuopio (Finland) December 2009 August 2011 Specialist in Neurology Kuopio University Hospital, Kuopio (Finland) August 2011 Present Senior Medical Officer Finnish Medicines Agency FIMEA, Kuopio (Finland) Clinical Medicine / Central Nervous System / Neurology and Pain, Regulatory Affairs; CNSWP standing observer since November October 2011 Present Observer Member of the EMA Central Nervous System Working Party Finnish Medicines Agency FIMEA, Kuopio (Finland) December 2014 Present Alternate member of the EMA Paediatric Committee Finnish Medicines Agency FIMEA, Kuopio (Finland) EDUCATION AND TRAINING August 1989 July 1990 Studies in Physics 15/8/17 European Union, Page 1 / 6

2 August 1990 July 1996 Medical studies August 1992 July 1993 Medical studies University of Saarbrucken, Homburg (Germany) July 1996 Present MD October 2004 Present PhD Title of the thesis: "Functional MRI Studies on Human Declarative Memory" August 2005 July 2008 Postdoctoral reseacher Harvard Medical School, Boston, MA (United States) November 2009 Present Diploma in Neurology Specialist in Neurology July 2010 Present Docent (Adjunct Professor) in Cognitive Neuroscience University of Eastern Finland, Kuopio (Finland) ADDITIONAL INFORMATION Expertise Clinical assessor for CNS medicinal products including neurological, psychiatric and pain products. Clinical assessment of central, decentralized, mutual recognition and national procedure applications and scientific advice on CNS products since Evaluation of mainly CNS paediatric investigation plans since Participation in activities of the CNS WP since 2011 and PDCO since Publications ARTICLES IN REFEREED SCIENTIFIC JOURNALS: Geroldi C, Pihlajamäki M, Laakso MP, DeCarli C, Beltramello A, Bianchetti A, Soininen H, Trabucchi M, Frisoni GB. APOE-e4 is associated with less frontal and more medial temporal lobe atrophy in AD. Neurology 53: , Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Laakso M, Partanen K, Soininen H, Aronen HJ. Verbal fluency activates the left medial temporal lobe: a functional magnetic resonance imaging study. Ann Neurol 47: , Pihlajamäki M, Tanila H, Hänninen T, Könönen M, Mikkonen M, Jalkanen V, Partanen K, Aronen HJ, Soininen H. Associative encoding activates the perirhinal cortex: an fmri study. Hippocampus 13: 67 80, Könönen M, Pääkkönen A, Pihlajamäki M, Sipilä P, Partanen K, Karjalainen PA, Aronen HJ. Visual processing of coherent rotation versus incoherent motion: An fmri study. Perception 32: , Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Hämäläinen A, Soininen H, Aronen HJ. Visual presentation of novel objects and new spatial arrangements of objects differentially activates the medial temporal lobe subareas in humans. Eur J Neurosci 19: , Pihlajamäki M, Tanila H, Könönen M, Hänninen T, Aronen HJ, Soininen H. Distinct and overlapping fmri activation networks for processing of novel identities and locations of objects. Eur J Neurosci 22: , /8/17 European Union, Page 2 / 6

3 Hämäläinen A, Pihlajamäki M, Tanila H, Hänninen T, Niskanen E, Tervo S, Karjalainen PA, Vanninen RL, Soininen H. Increased fmri responses during encoding in mild cognitive impairment. Neurobiol Aging 28: , Diamond EL, Miller S, Dickerson BC, Atri A, DePeau K, Fenstermacher E, Pihlajamäki M, Celone K, Salisbury S, Gregas M, Rentz D, Sperling RA. Relationship of functional MRI activation to clinical trial memory measures in Alzheimer's disease. Neurology 69: , Joyal CC, Putkonen A, Mancini-Marie A, Hodgins S, Könönen M, Boulay L, Pihlajamäki M, Soininen H, Stip E, Tiihonen J, Aronen HJ. Violent persons with schizophrenia and comorbid disorders: a functional magnetic resonance imaging study. Schizophr Res 91: , Tapiola T, Pennanen C, Tapiola M, Tervo S, Kivipelto M, Hänninen T, Pihlajamäki M, Laakso MP, Hallikainen M, Hämäläinen A, Vanhanen M, Helkala E-L, Vanninen R, Nissinen A, Rossi R, Frisoni GB, Soininen H. MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study. Neurobiol Aging 29: 31 38, Miller SL, Celone K, DePeau K, Diamond E, Dickerson BC, Rentz D, Pihlajamäki M, Sperling RA. Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation. Proc Natl Acad Sci U S A 105: , Pihlajamäki M, DePeau KM, Blacker D, Sperling RA. Impaired medial temporal repetition suppression is related to failure of parietal deactivation in Alzheimer disease. Am J Geriatr Psychiatry 16: , Pihlajamäki M, Sperling RA: fmri: use in early Alzheimer s disease and in clinical trials. Future Neurol 3: , Jauhiainen AM, Pihlajamäki M, Tervo S, Niskanen E, Tanila H, Hänninen T, Vanninen RL, Soininen H. Discriminating accuracy of medial temporal lobe volumetry and fmri in mild cognitive impairment. Hippocampus 19: , Pihlajamäki M, Jauhiainen AM, Soininen H. Structural and functional MRI in mild cognitive impairment. Curr Alzheimer Res 6: , Pihlajamäki M, O Keefe K, Bertram L, Tanzi RE, Dickerson BC, Blacker D, Albert MS, Sperling RA. Evidence of altered posteromedial cortical fmri activity in subjects at risk for Alzheimer disease. Alzheimer Dis Assoc Disord 24: 28-36, Sperling RA, LaViolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamäki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron 63: , Pihlajamäki M, Sperling RA: Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer s disease and at-risk older individuals. Behav Neurol 21: 77 91, Julkunen V, Niskanen E, Muehlboeck S, Pihlajamäki M, Könönen M, Hallikainen M, Kivipelto M, Tervo S, Vanninen R, Evans A, Soininen H. Cortical thickness analysis to detect progressive mild cognitive impairment: A reference to Alzheimer's disease. Dement Geriatr Cogn Disord 28: , Sperling RA, Dickerson BC, Pihlajamäki M, Vannini P, Hedden T, Becker JA, Rentz DM, Buckner RL, Johnson KA. Functional alterations in memory networks in early Alzheimer s disease. Neuromolecular Med 12: 27-43, Wang L, LaViolette P, O'Keefe K, Putcha D, Bakkour A, Van Dijk KRA, Pihlajamäki M, Dickerson B, Sperling RA. Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. NeuroImage 51: , Julkunen V, Niskanen E, Herukka S-K, Pihlajamäki M, Hallikainen M, Kivipelto M, Muehlboeck S, Evans AC, Vanninen R, Soininen H. Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment and Alzheimer disease patients a longitudinal study. J Alzheimers Dis 21: , Vannini P, O Brien J, O Keefe K, Pihlajamäki M, DeLuca A, LaViolette P, Sperling RA. What goes down must come up: Role of the posteromedial cortices in encoding and retrieval. Cereb Cortex 21: 22-34, Pihlajamäki M, O Keefe K, O Brien J, Blacker D, Sperling RA. Failure of repetition suppression and memory encoding in aging and Alzheimer disease. Brain Imaging and Behavior 5: 36-44, Miettinen PS, Jauhiainen AM, Tarkka IM, Pihlajamäki M, Gröhn H, Niskanen E, Hänninen T, Vanninen R, Soininen H. Effect of cholinergic stimulation in early Alzheimer s disease functional imaging during a recognition memory task. Curr Alzheimer Res 8: , Miettinen PS, Pihlajamäki M, Jauhiainen AM, Niskanen E, Hänninen T, Vanninen R, Soininen H. Structure and function of medial temporal and posteromedial cortices in early Alzheimer s disease. Eur J Neurosci 34: , /8/17 European Union, Page 3 / 6

4 Könönen M, Tarkka IM, Niskanen E, Pihlajamäki M, Mervaala E, Pitkänen K, Vanninen R. Functional MRI and motor behavioral changes obtained with related to constraint-induced movement therapy in chronic stroke. Eur J Neurol 9: , Miettinen PS, Jauhiainen AM, Tarkka IM, Pihlajamäki M, Gröhn H, Niskanen E, Hänninen T, Vanninen R, Soininen H. Long-term response to cholinesterase inhibitor treatment is related to functional MRI response in Alzheimer's disease. Dement Geriatr Cogn Disord 40: , OTHER SCIENTIFIC PUBLICATIONS: - Pihlajamäki M, Sperling RA. Neuroimaging in dementia, Functional MRI. In: Kowall NW, Budson AE, editors. Alzheimer s disease and other dementias. Hoboken (NJ): Blackwell publishing, , Pihlajamäki M, Soininen H. Alzheimer s disease. In: Bartsch T, editor. The clinical neurobiology of the hippocampus. Kiel (Germany): Oxford University Press, , Projects PROJECT TITLE: Functional MRI Studies On Human Declarative Memory Role: PhD student (Supervisors: H. Soininen, H.J. Aronen, K. Partanen, H. Tanila) Grants from the following funding sources: - Research training fellow position of the Academy of Finland, Kuopio University Hospital EVO grants, North Savo Cultural Foundation, Neurology Foundation, University of Kuopio, Duodecim Society, South-Carelian Society for Physicians, 2005 PROJECT TITLE: Neural Substrates of Memory Deterioration in Mild Cognitive Impairment as Revealed by Functional Magnetic Resonance Imaging Role: Project Leader (PI: Reisa Sperling) Funding source: Academy of Finland / Post Doctoral Fellowship Funding period: 8/1/05 7/31/08 Project description: Event-related fmri at high field is used to investigate successful and failed memory processes in normal subjects and patients with mild cognitive impairment and early Alzheimer's disease. PROJECT TITLE: Functional and Molecular Imaging of Hippocampal-Cinguloparietal Memory Networks in Aging Role: PI (co-pi prof. Reisa Sperling) Funding source: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School: Advanced Multimodal Neuroimaging Training Grant Funding period: 11/27/07 7/31/08 Project description: Functional MRI and PIB-PET is used to investigate successful and failed memory processes in healthy elderly subjects. PROJECT TITLE: High-resolution fmri of the medial temporal lobe during a novel event-related paradigm in aging, mild cognitive impairment and Alzheimer s disease. Role: PI (co-pi prof. Reisa Sperling) Funding source: Harvard Center for Neurodegeneration and regeneration Funding period: 1/1/06 12/31/07 PROJECT TITLE: Multimodal 3T MR imaging of preclinical Alheimer s disease Role: PI Funding source: Kuopio University Hospital EVO funding Funding period: 1/1/11 12/31/12 Memberships SCIENTIFIC EXPERT POSITIONS 15/8/17 European Union, Page 4 / 6

5 Ad hoc reviewer for the following journals in Neuroscience, Neurology and Neuroimaging: Alzheimer s Disease and Associated Disorders, Annals of Neurology, Biological Psychiatry, Brain, Brain Research, Cerebral Cortex, Dementia and Geriatric Cognitive Disorders, European Journal of Neuroscience, Hippocampus, Human Brain Mapping, Journal of Geriatric Psychiatry and Neurology, Journal of Neurology, Neurosurgery and Psychiatry, Journal of Neuroscience, Neurobiology of Aging, Neurobiology of Learning and Memory, NeuroImage, Neurology, PNAS, Psychology and Aging Other reviewer responsibilities: Israeli Science Foundation, Ontario Mental Health Foundation, Dutch Program for Brain and Cognition Opponent of doctoral thesis: MD Marta Grau, University of Barcelona, MEMBERSHIPS IN PROFESSIONAL SOCIETIES - Federation of European Neuroscience Societies Finnish Brain Research Society Finnish Society for Physicians Finnish Medical Society (Duodecim) Finnish Society for Radiologists Finnish Neurological Association Finnish Young Physicians Society South-Carelian Society for Physicians North-Savo Society for Physicians Finnish Association of Pharmaceutical Physicians 2011 MOST IMPORTANT SCIENTIFIC ACKNOWLEDGEMENTS AND AWARDS - Young Investigators Award, Radiological Society of Finland, Young Researchers Award, Finnish Alzheimer's Research Society, Radiological Society of Finland Award, Finnish Academy of Science and Letters Award, University of Kuopio, Best Thesis of the Year 2004, South-Carelian Society for Physicians Award, Travel Fellowship for the Alzheimer s Imaging Consortium in Madrid, Spain, Travel Fellowship Award for the 10th International Conference on Alzheimer s Disease and Related Disorders in Madrid, Spain, Best Poster Award of the Alzheimer s Imaging Consortium in Madrid, Spain, Advanced Multimodal Neuroimaging Training Grant, MGH, Harvard Medical School, Martti Hämäläinen Award for Young Investigators, 2010 INTERNATIONAL ORAL PRESENTATIONS - Nordic Congress of Radiology, Helsinki, Finland, Society for Neuroscience Annual Meeting, New Orleans LA, USA, European Federation of Neurological Societies Congress, Helsinki, Finland, th International Conference on Alzheimer s Disease and Related Disorders, Madrid, Spain, Society for Neuroscience Annual Meeting, Washington DC, USA, 2008 INVITED SCIENTIFIC LECTURES - Meeting of the Finnish Society of Clinical Neurophysiology, Kuopio, Finland, Neuroimaging Seminar Series, Vrije Universiteit Medical Centre, Amsterdam, the Netherlands, Advanced Magnetic Resonance Imaging, 11th Kuopio Bio-NMR Workshop, AIV Institute, Kuopio, Finland, Seminar Series of the Cognitive Neuroscience Laboratory, MGH, Boston, USA, Neuroscience Seminar Series, UKU, Kuopio, Finland 1999, Seminar Series of Department of Clinical Radiology, KUH, Kuopio, Finland 2004, /8/17 European Union, Page 5 / 6

6 Other Relevant Information 15/8/17 European Union, Page 6 / 6