Advanced Point-of-Care Bone Health Assessment HOLOGIC OSTEOPOROSIS ASSESSMENT

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1 O S T E O P O R O S I S A S S E S S M E N T Advanced Point-of-Care Bone Health Assessment HOLOGIC OSTEOPOROSIS ASSESSMENT

2 Identify Patients at Risk The evaluation of bone health has become an essential component of your patients wellness. Discovery Hologic s most advanced QDR Series bone densitometer, combines the proven clinical value of bone mineral density (BMD) measurement and vertebral fracture assessment. Hologic pioneered the integration of BMD measurement with Instant Vertebral Assessment (IVA) allowing point-of-care assessment of the two most definitive factors associated with osteoporotic fracture risk: low bone mineral density and the presence of vertebral fracture. BMD and IVA are both powered by our exclusive OnePass linear fan-beam technology improving the accuracy, speed and convenience of assessing osteoporosis. OnePass Fan-beam Acquisition OnePass vs. Rectilinear Hologic s OnePass technology achieves superior image quality and precision by eliminating the beam overlap errors and image distortion found in rectilinear systems. Superior Image Quality, Unparalleled Precision OnePassTechnology OnePass single sweep scanning enables superior image quality and unparalleled precision. Discovery s exclusive design utilizes a multi-element detector array paired with true fan-beam acquisition geometry, enabling rapid, dual-energy bone density measurements. Precise Bone Density Discovery acquires spine and hip bone density measurements with unsurpassed precision. Hologic s patented Internal Reference System provides continuous pixel-by-pixel calibration assuring precise BMD results every time. Results like these are why Hologic bone densitometers are the preferred system in 9 out of 10 clinical and pharmaceutical trials Rectilinear Fan-beam Acquisition High Definition Instant Vertebral Assessment (IVA-HD ) Vertebral Fracture Assessment, recognized as the standard in evaluating fracture risk, is now easier and better than ever. IVA-HD allows you to identify spine fractures with a rapid, low dose, single energy image in seconds. See specifications data sheet for availability of features on specific Discovery models.

3 Imagine the possibilities Discovery raises both the clinical and technological standards of bone densitometry with features that include: Express Exam TM Routine scan protocols can be automated for customized, effortless analysis and workflow. Image Repositioning Allows image centering without moving the patient. OneTime Auto Analysis Delivers hip and AP spine scans almost instantly and with no operator intervention by automatically identifying the region of interest. Tech Tips Graphical positioning aids demonstrate correct patient alignment and scan start position, making it easier than ever for technologists to position patients correctly the first time, and every time. QDR Reporting Image, scan analysis, and reference curves are combined in a concise, single-page report. Choose from several preformatted templates. Practice Management Tools Take full advantage of Discovery s practicebuilding potential. The Practice Development Guide provides a complete suite of marketing and patient education tools to help maximize your return on investment. The Osteoporosis Learning Series provides in-depth osteoporosis educational materials and gives you the opportunity to obtain up to 16 CME credits. HOLOGIC OSTEOPOROSIS ASSESSMENT

4 Imaging Power at Your Fingertips If you knew they had fractures... IVA would benefit the subset of women who have osteopenia, but whose fracture history is unknown. If you knew they had fractures, you would certainly be more aggressive in your treatment. Susan L Greenspan, M.D. Director, Osteoporosis Prevention and Treatment Division of Endocrinology, Metabolism and Geriatrics Associate Director, General Clinical Research Center, University of Pittsburgh Medical Center Professor of Medicine, University of Pittsburgh School of Medicine IVA Leads the Way in Vertebral Fracture Assessment Vertebral fractures are far more common than one might imagine. Up to one quarter of Caucasian women over age 50 have at least one fracture, 75% of which are not clinically apparent. Studies have proven that the presence of one or more vertebral fractures dramatically increases the risk of future fracture. Published studies using IVA demonstrate that up to 30% of patients needing treatment are missed using BMD results alone. These patients, many of whom have moderately decreased BMD but have already suffered a fracture, are at particularly high risk. Our new High Definition Instant Vertebral Assessment (IVA-HD) identifies fractures with a low dose single energy image, while doubling the resolution of previously available techniques. IVA-HD dramatically improves sensitivity in detecting vertebral fractures. The Image Pro digital image-processing software improves visualization of vertebral fractures and endplates, allowing clinicians to more accurately identify fractures. Simplify IVA Interpretation with CADfx CADfx computer-aided fracture assessment tool, another Hologic exclusive, quantifies and displays the degree of vertebral compression to help confirm the existence and severity of vertebral deformities. Clear, crisp images for superior prediction of fracture risk Hologic 15 seconds Competitor 3 minutes

5 Effortless Reporting At the touch of a button Hologic leads the industry in providing reporting solutions for bone densitometry that streamline your workflow. Our Report Writer software produces a comprehensive electronic report that combines BMD and IVA results for enhanced assessment of fracture risk at the touch of a button. From entering patient data to physician interpretation, Discovery provides a comprehensive suite of tools to meet your reporting needs. Physician s Report Writer automatically downloads and formats key information into a customizable electronic report that includes patient biographical information, BMD, T-/Z scores, and IVA results in a concise format for better assessment of fracture risk. A Connectivity Solution for Every Clinical Setting IRIS Connectivity Solutions simplify the exchange of text data between QDR workstations and hospital information systems, connecting seamlessly to HIS/RIS systems. QDR DICOM provides the ability to send QDR bone density and IVA scans to Physicians Viewer across any established network or Picture Archiving and Communication System (PACS). QDR Mobility tablet PC mobile reporting solution allows you to generate and send reports using Physicians Viewer and Report Writer software for paperless distribution. Physician s Viewer is a stand-alone software package for remote softcopy review of BMD results and IVA scans. Together with CADfx, IVA interpretation is simplified. Physician s Viewer simplifies IVA interpretation See specifications data sheet for availability of features on specific Discovery models.

6 Clinical Applications That Meet Your High Standard of Care Dual Hip AP Spine and Proximal Femur Discovery Express BMD provides unmatched precision for lumbar spine and proximal femur studies. Dual Hip automatically moves the table and C-arm into position for a mirror image and measurement of the opposite hip allowing identification of the lowest BMD site for improved clinical assessment. Forearm Discovery produces simultaneous assessments of 1/3, mid-, and ultradistal regions. Radius and ulna can be analyzed either separately or combined. Whole Body/BMD Analysis Discovery can evaluate BMD of the entire skeleton and report on up to 10 adjustable regions of interest. Body Composition Analysis software enables evaluation of fat mass, lean mass and total mass for the entire skeleton and for individual sub-regions. Both BMD and body composition can be derived from a single whole body scan. Subregion Whole Body software places up to seven user-defined, custom regions for BMD and body composition analysis. Supine Lateral BMD Supine lateral spine BMD enables clinicians to obtain reliable, quantitative measurements of trabecular-rich vertebral bodies in the supine position. Supine lateral measurements have demonstrated superior precision over quantitative measurements in the decubitus position. Whole Body Pediatric Applications Advanced analysis algorithms automatically detect and measure very low-density bone. This combined with our Pediatric Reference Database, make Discovery the system of choice for pediatric studies. See specifications data sheet for availability of features on specific Discovery models.

7 Research Applications Prosthetic Hip The influence of metal is automatically identified and removed, providing accurate BMD measurements to effectively monitor changes in the bone structure surrounding the prosthesis. Small Animal Perform In Vivo scans of rat whole body with BMD and body composition measurements, including lean and fat tissue mass, total mass and % fat determinations. Unique, calibration phantom assures accuracy and repeatability of results. Infant Whole Body Provides bone mineral and body composition measurements for human infants ranging from 26 weeks gestational age to one year birth age, or approximately 1kg to 10 kg in weight. The measurement system uses the lowest x-ray tube currently available and exposes the patient to a very low dose (less than 2mrem). Women Caring for is a Way of Life for Us At Hologic, we take women s health issues personally. Because of our unwavering commitment to women s health, Hologic constantly seeks better solutions for the early detection of breast cancer and osteoporosis. It is the driving force behind the many technological innovations in our Lorad mammography and QDR bone densitometry systems. Our women s health technologies contribute to a greater clarity of vision that helps you see more and earlier. See where our vision for better solutions is leading us. Visit us at or call us at HOLOGIC OSTEOPOROSIS ASSESSMENT

8 The power of Hologic is the power of clear innovation and a singular focus... to challenge the boundaries of science and technology everyday to raise the standards of image quality. Our passion has led to discoveries that contribute to earlier detection, more accurate diagnoses, and better overall patient care. As we focus on the future, we are bound by our clarity of vision. A vision created solely to enhance yours. Osteoporosis Assessment DirectRay Digital Imaging Lorad Breast Cancer Detection FLUOROSCAN TM C-arm Imaging Corporate Headquarters 35 Crosby Drive, Bedford, MA USA Tel: Sales: Fax: Europe Horizon Park Leuvensesteenweg 510, BUS Zaventem, Belgium Tel: Fax: Asia Pacific Room 302, Hung Kei Building 5-8 Queen Victoria Street Central, Hong Kong Tel: Fax: B-144 US/International (04/05) Hologic All rights reserved. Printed in USA. Specifications are subject to change without prior notice. Hologic and Hologic logos, QDR, Discovery, Express BMD, Instant Vertebral Assessment, IVA, High Definition Instant Vertebral Assessment, IVA-HD, OnePass, Express BMD, Express Exam, Image Pro, CADfx, QDR Mobility, IRIS, OnePage Dx Report, Tech Tips, DXA Practice Manager, OneTime Auto Analysis, Dual Hip, A Hologic Company, are trademarks or registered trademarks of Hologic, Inc., in the United States and other countries. Windows is a registered trademark of Microsoft Corporation.

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