Trail making test A 2,3. Memory Logical memory Story A delayed recall 4,5. Rey auditory verbal learning test (RAVLT) 2,6

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1 NEUROLOGY/2016/ Table e-1: Neuropsychological test battery Cognitive domain Test Attention/processing speed Digit symbol-coding 1 Trail making test A 2,3 Memory Logical memory Story A delayed recall 4,5 Rey auditory verbal learning test (RAVLT) 2,6 RAVLT total learning, trials 1 5 RAVLT short-term delayed recall; trial 6 RAVLT short-term delayed recall; trial 7 Benton visual retention test recognition 7,8 Language Boston naming test; 30 items 9,10 Semantic fluency (animals) 2,11 Visuospatial Block design 12,13 Executive function Controlled oral word association test 2,11 Trail making test B 2,3 Note: memory tests were used to assess (single-domain) amnestic MCI, impairment in any one of the other domains would result in (single-domain) nonamnestic MCI. Combinations contribute to amnestic or nonamnestic multiple-domain MCI.

2 AERTS Supplemental Tables & Figures 2 Table e-2: MCI prevalence at biennial follow-up Wave 1 Wave 2 Wave 3 Wave 4 n % Total n % Total % Subtotal n % Total % Subtotal n % Total % Subtotal No MCI MCI amci nmci amdmci nmdmci Subtotal Dementia N/A a No data N/A Total b 661 c a individuals with dementia were excluded from the study at baseline b 14 dementia cases at wave 2 subtracted from total sample c 44 dementia cases at waves 2 and 3 subtracted from total sample MCI: Mild cognitivie impairment; amci: single-domain amnestic MCI; nmci: single-domain nonamnestic MCI; amdmci: multi-domain amnestic MCI; nmdmci: multi-domain nonamnestic MCI

3 AERTS Supplemental Tables & Figures 3 Figure e-1: Data overview Classifications of all participants per assessment wave: no MCI (green), single domain MCI (yellow), multidomain MCI (orange), dementia (red), missing or incomplete data (white). Completers only (n=508) WAVE Total sample (n=705) WAVE

4 AERTS Supplemental Tables & Figures 4 Table e-3: Participant characteristics per pattern Total Stable No MCI Stable MCI Decliners Reverters Statistics N (37.6%) 92 (13.0%) 172 (24.4%) 176 (25.0%) Age, yrs (SD) (4.59) (4.16) (4.75) (4.91) (4.27) Gender, % male Education (3.52) (3.40) (3.46) (3.48) (3.75) MMSE, adj (1.31) (1.09) (1.46) (1.26) (1.45) a Kruskal-Wallis; b Chi-square test statistic H = a p < χ 2 = 7.32 b p = 0.06 H = 4.23 a p = 0.24 H = a p < 0.001

5 AERTS Supplemental Tables & Figures 5 Table e-4: Diagnosis prior to dementia classification 2 years prior 4 years prior 6 years prior N % (95% CI) N % (95% CI) N % (95% CI) No MCI ( ) ( ) ( ) MCI ( ) ( ) ( ) amci ( ) ( ) ( ) nmci ( ) ( ) ( ) amdmci ( ) ( ) ( ) nmdmci ( ) ( ) ( ) Subsample No data Total sample 76 Amnestic MCI ( ) ( ) ( ) Non-amnestic MCI ( ) ( ) ( )

6 AERTS Supplemental Tables & Figures 6 Figure e-2: Cumulative incidence of dementia for (A) amnestic and nonamnestic or (B) single and multiple domain subtypes of MCI

7 AERTS Supplemental Tables & Figures 7 Figure e-3: The effect of reversion from (A) single- or (B) multiple-domain MCI on cumulative incidence of dementia

8 AERTS Supplemental Tables & Figures 8 Supplementary references 1. Wechsler D. Wechsler Adult Intelligence Scale - Third Edition. 3rd ed. San Antonio: The Psychological Corporation; Strauss E, Sherman EMS, Spreen O. A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. 3rd Editio. Oxford University Press; Tombaugh TN. Trail Making Test A and B: Normative data stratified by age and education. Arch Clin Neuropsychol. 2004;19: Wechsler D. Wechsler Memory Scale. 3rd ed. San Antonio: The Psychological Corporation; Grundman M, Petersen RC, Ferris SH, et al. Mild Cognitive Impairment Can Be Distinguished From Alzheimer Disease and Normal Aging for Clinical Trials. JAMA Neurol. 2004;61: Ivnik RJ, Malec JF, Smith GE, et al. Mayo s older americans normative studies: Updated AVLT norms for ages 56 to 97. Clin Neuropsychol. 1992;6: Benton AL, Sivan AB, Spreen O. Der Benton Test Manual. 7th ed. Bern: Huber; Lechevallier-Michel N, Fabrigoule C, Lafont S, Letenneur L, Dartigues J-F. Normes pour le MMSE, le test de rétention visuelle de Benton, le set test d Isaacs, le sous-test des codes de la WAIS et le test de barrage de Zazzo chez des sujets âgés de 70 ans et plus : données de la cohorte PAQUID. /data/revues/ / /1059/. Elsevier Masson; Epub Kaplan E. The Boston Naming Test. Philadelphia: Lippincott Williams Wilkins; Fastenau PS, Denburg NL, Mauer B a. Parallel short forms for the Boston Naming Test: psychometric properties and norms for older adults. J Clin Exp Neuropsychol. 1998;20: Tombaugh T, Kozak J, Rees L. Normative Data Stratified by Age and Education for Two Measures of Verbal Fluency FAS and Animal Naming. Arch Clin Neuropsychol. 1999;14: Wechsler D. WAIS-R Manual. New York: The Psychological Corporation; Ivnik RJ, Malec JF, Smith GE, et al. Mayo s older americans normative studies: WAIS-R norms for ages 56 to 97. Clin. Neuropsychol