AAIC Satellite Symposium: Buenos Aires, Argentina April 17-18, 2018 Sheraton Libertador Hotel Grand Bourg Ballroom

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1 AAIC Satellite Symposium: Buenos Aires, Argentina April 17-18, 2018 Sheraton Libertador Hotel Grand Bourg Ballroom Day 1 8:00a.m. 9:00-9:45a.m. Name Badge & Meeting Material Pick-up Begins Welcome Harry Johns, President & CEO, Alzheimer s Association Maria Carrillo, Chief Science Officer, Alzheimer s Association Remarks from A.L.M.A. Noemi Medina, Vice President, A.L.M.A Session 1: Epidemiology of AD & Dementia in Latin America Session Chair & Discussion Moderator: Ricardo Nitrini (Brazil) 9:45-10:00a.m. 10:00-10:15a.m. 10:15-10:55a.m. 10:55-11:20a.m. 11:20-11:40a.m. 11:40-12:10p.m. 12:10-12:25p.m Alzheimer s Disease International: Global Prevalence of Alzheimer s Paola Barbarino (U.K.) Latin America Epidemiology of Alzheimer s & Dementia Nilton Custodio (Peru) Moderated Discussion: Ricardo Nitrini, Brazil Nilton Custodio, Peru Daisy Acosta, Dominican Republic Ana Luisa Sosa, Mexico Gladys Maestre, U.S./Venezuela Paola Barbarino, Alzheimer s Disease International Perspective: WHO Pan American Health Organization (PAHO) Devora Kestel (U.S.) Keynote: NIA-AA Research Framework Clifford Jack (U.S.) Industry Perspective on the NIA-AA Research Framework Samantha Budd Haeberlein (U.S.)

2 12:25-1:25p.m. 1:25-2:40p.m. Rapid Fire Poster Presentations Poster Presenters Attached Moderators: Jose Abisambra & Yakeel Quiroz LUNCH & POSTER PRESENTATIONS Session 2: Imaging Biomarkers: Advances & Implementation Session Chair & Discussion Moderator: Janus Kremer (Argentina) 2:40-2:50p.m. 2:50-3:00p.m. 3:00-3:15p.m. 3:15-3:30p.m. 3:30-3:45p.m. 3:45-4:10p.m. 4:10-4:30p.m. MRI in Alzheimer s & Dementia Research Yakeel Quiroz (U.S./Colombia) MRI in Clinical Use for Alzheimer s & Dementia in Latin America Ismael Calandri (Argentina) Advances in PET Imaging: PIB, Amyloid, Tau & Emerging Modalities Victor Villemagne (Australia) Implementation of PET in Argentina Silvia Vazquez (Argentina) Implementation of PET: Multitracer Approach at CUDIM Andres Damian (Uruguay) Panel of Session 2 Speakers + Merce Boada (Spain) Session 3: Biochemical Biomarkers: Advances & Implementation Session Chair & Discussion Moderator: Gustavo Sevlever (Argentina) 4:30-4:45p.m. 4:45-5:00p.m. 5:00-5:15p.m. 5:15-5:35p.m. 5:35-6:25p.m. 6:25-6:30p.m. BioFluids in Alzheimer s: Appropriate Use Criteria for CSF Jose Luis Molinuevo (Spain) Challenges in the Development of New Biomarkers in Other BioFluids: Reality of implementation Ezequiel Surace (Argentina) Integration Across Imaging & Biochemical Platforms: FLENI Ricardo Allegri (Argentina) Panel of Session 3 Speakers Validation of the NIA-AA Research Framework Across Latin America Discussion Moderator: Maria C. Carrillo (United States) Panelists: Eric Siemers (U.S.) Clifford R. Jack (U.S.) Ricardo Allegri (Argentina) Jose Luis Molinuevo (Spain) Jalayne Arias (U.S.) Gustavo Sevlever (Argentina) Alzheimer Argentina Luis Ignacio Brusco, Alzheimer Argentina

3 6:30-6:40p.m. Close of Day 1 Heather M. Snyder, Alzheimer s Association 6:45-8:30p.m. RECEPTION: ALL ATTENDEES DAY 2: 8:45-9:00a.m. 9:00-9:15a.m. 9:15-9:30a.m. 9:30-10:30a.m. 10:30-11:05a.m. 11:05-11:30a.m. Overview of Day One Gustavo Sevlever (Argentina) PAMI s Strategic National Plan for Brain Health, Alzheimer s Disease and other Dementias Julian Bustin (Argentina) GBHI Overview Victor Valcour (U.S.) Rapid Fire GBHI Poster Presentations Poster Presenters Attached Moderators: Bruce Miller (U.S.) & Mary Sano (U.S.) Keynote Introduction: Mary Sano (U.S.) Keynote: Considerations of Brain Health: Risk for Dementia & Health Equity in Latin America Facundo Manes (Argentina) Session 4: Contributions to Brain Health & Dementia Risk Session Chair & Discussion Moderator: Jose Abisambra (U.S.) 11:30-11:45a.m. 11:45-12:00p.m. 12:00-12:15p.m. 12:15-12:30p.m. 12:30-12:55p.m. 12:55-2:10p.m. Literacy, Memory & Brain Connectivity Elisa de Paula Franca Resende (Brazil/USA) Non-Alzheimer s Contributions to Cognition Oscar Lopez (U.S) Vascular Contributions to Brain Health Lea Grinberg (U.S) Risk Factors in Dementia with Lewy Bodies Angel Golimstok (Argentina) Panel of Session 4 Speakers & Keynote LUNCH & POSTER PRESENTATIONS Session 5: Emerging Therapeutics & Lifestyle Interventions Session Chair & Discussion Moderator: Khalid Iqbal (U.S.) 2:10-2:25p.m. Targeting Tau as a Possible Therapy for Alzheimer s Alejandra Alonso (U.S.)

4 2:25-2:40p.m. 2:40-2:55p.m. 2:55-3:10p.m. 3:10-3:25p.m. 3:25-3:50p.m. 3:50-4:10p.m. Targeting Axonal Transport Dysfunction in Alzheimer s Tomas Falzone (Argentina) Molecular mechanisms involved in early neuronal bioenergetics dysfunction Laura Morelli (Argentina) How Exercise May Correct Memory Deficits in Models of AD Sergio Ferreira (Brazil) Typical and non-typical approaches to Therapy Development in Alzheimer s Nibaldo Inestrosa (Chile) Panel of Session 5 Speakers Session 6: Clinical Studies in Sporadic and Dominantly Inherited Alzheimer s Populations Session Chair & Discussion Moderator: Ruben Vidal (U.S.) 4:10-4:25p.m. 4:25-4:40p.m. 4:40-4:55p.m. 4:55-5:10p.m. 5:10-5:25p.m. 5:25-5:45p.m. 5:45pm. Mild Behavioral Impairment in Argentina Fernando E. Taragano (Argentina) Rare Coding Variants in Sporadic AD in South America Alfredo Ramirez (Germany/Chile) DIAN Families in Latin America Patricio Chrem Mendez (Argentina) Colombian Kindred Francisco Lopera (Colombia) Down Syndrome & Alzheimer s Disease Cynthia Lemere (U.S.) Panel of Session 6 Speakers Close of Meeting

5 Day 1, April 17, 2018 Rapid Fire Poster Presentations Moderators: Jose Abisambra, PhD (US) & Yakeel Quiroz, PhD (US) Poster Presenters: Paula Desplats, PhD University of California San Diego Cross-Talk Between DNA Methylation and Circadian Rhythms: When the Clock is Off in the Alzheimer's Brain. Karen Dorsman, BA University of California, San Francisco Characteristics of cognitively impaired Spanish-speaking individuals of Hispanic origin in the NACC database German Falasco, Eng. Centro de Imagenes Moleculares, FLENI Brain asymmetries in normal and pathological aging: A molecular imaging perspective Gonzalo A. Farias MD, PhD Department of Neurosciences, Universidad de Chile and International Center for Biomedicine (ICC). Tau in platelets as a biomarker for Alzheimer's disease and related neurodegenerative conditions Lionel M. Igaz, PhD University of Buenos Aires School of Medicine, Buenos Aires, Argentina Evaluation of behavioral phenotypes before and after transgene suppression in a conditional TDP-43 mouse model of Frontotemporal dementia /Amyotrophic lateral sclerosis. Tatiana Itzcovich, MSc FLENI A novel mutation in PSEN1 (p.t119i) in an Argentine family with early and late-onset Alzheimer's disease Renata R Kochhann, PhD Pontifical Catholic University, Sao Paulo, Brazil Self versus proxy-evaluated functionality: which has a stronger relation with white and gray integrity in patients with Alzheimer's disease? Alfredo Lorenzo, PhD INIMEC-CONICET- Universidad Nacional de Córdoba APP/Go protein G-beta-Gamma complex signaling mediates AB degeneration and cognitive impairment in rat and human models of Alzheimer's disease MB Bistue Millon, PhD ICBM, Catholic University of Cuyo / CONICET, San Juan, Argentina Role of LSD1 in inflammation and Cognition in a Transgenic Rat Model of AD-like pathology. Sebastian Moguilner, M.Sc. INECO Weighted Symbolic Dependence Dynamics (wsdd) for fmri resting-state connectivity: A multicentric validation for frontotemporal dementia

6 DAY 2, April 18, 2018 Rapid Fire GBHI Poster Presentations Moderators: Bruce Miller (U.S.) & Mary Sano (U.S.) Jalayne J. Arias, JD Memory and Aging Center, Department of Neurology, UCSF A New Model for Long-term Care Insurance and Financing Long-term Care Services and Supports Eléonore Bayen, M.D., Ph.D. Brain Health matters : create optimism and understanding around dementia and brain health at school Alissa S. Bernstein, Ph.D., MPH Mapping the Dynamics of Caregiver Burden in Alzheimer's Disease Dominic Campbell, BA Creative Aging International - Celebration as Strategy Laurent Cleret de Langavant, M.D., Ph.D. Department of Neurology, Paris Est University Statistical learning to track dementia in population-based surveys Bárbara Costa Beber, Ph.D. Speech and Language Therapy Department, UFCSPA, Brazil Investigation of the topic of dementia in the curricula of Speech and Language Therapy undergraduate programs in Brazil - Preliminary results Elissaios Karageorgiou, M.D., Ph.D. Memory and Aging Center, UCSF Cognitive Behavioral Therapy for Insomnia in Mild Cognitive Impairment Jorge J Llibre Guerra, M.D., MSc National Institute of Neurology, La Habana, Cuba Ancestry Background: Implications for Cognitive Decline and Mortality in Dementia. Rogerio Panizzutti, M.D., Ph.D Instituto de Ciências Biomedicas, Universidade Federal do Rio de Janeiro Digital cognitive training to promote brain health: implementation and engagement Elisa PF Resende, M.D. Faculty of Medicine, Universidade Federal de Minas Gerais Literacy and memory: Any amount matters and it is never too late to improve.

7 Adrià Rofes, Ph.D. Word properties of fluency tasks in three variants of Primary Progressive Aphasia Fionnuala Sweeney B.A. (Hons.) H.Dip. Ed Your Brain's Health Ioannis Tarnanas, Ph.D. Prognostic Digital Biomarkers for MCI due to AD Stelios Zygouris, MSc Medical School, Aristotle University of Thessaloniki A two-tiered cost-efficient computerized cognitive screening protocol

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