Can aspirin slow cognitive decline and the onset of dementia? The ASPREE study. Mark Nelson on behalf of ASPREE Investigators
|
|
|
- Lester Baker
- 5 years ago
- Views:
Transcription
1 Can aspirin slow cognitive decline and the onset of dementia? The ASPREE study. Mark Nelson on behalf of ASPREE Investigators
2 ASPREE Randomized, double-blind, placebo-controlled trial for extending healthy active life in the elderly (70+ years, 65+ years US minorities). 19,000 subjects randomised to daily 100 mg enteric-coated aspirin or placebo and followed for 5 years. 16,000 in Australian general practice, 3,000 in USA community (mainly minorities of African- American and Hispanic).
3 ASPREE is the largest trial ever conducted in Australia Proposed 16,000 Australian participants ( US = 19,000) Currently 10,997 Australian participants ( US = 12,744) ANBP2 6,083 Australian participants FIELD 6,051 Australian participants (+ 2,351 NZ + 1,393 Finland = 9,795) LIPID 5,958 Australian participants (+ 3,056 NZ = 9,014)
4 Million dollar sponsors (NHFA) Bayer Healthcare NHMRC NIH (NIA) Victorian state government CSIRO NCI 4
5 Screening and monitoring methods for the detection of cognitive decline and incident dementia
6 Cognitive Measurements 3MS Modified Mini-Mental State Examination Cognition and memory CES-D Center for Epidemiologic Studies - Depression Assessment of depression SDMT Symbol-Digit Modalities Test Language-independent cognition HVLT-R Hopkins Verbal Learning Test Verbal learning and memory (recognition and recall) COWAT Controlled Oral Word Association Verbal processing ability and verbal fluency
7 Dementia Assessment Regular cognitive function tests in ASPREE subjects 3MS, Hopkins VLT, SDMT, COWAT, CES-D 3MS < 78 or drop of 10 points 3MS > 78 Continue in study ASPREE Neuropsychologist : Additional cognitive tests & IADL testing (>6 weeks) (ADAS-COG, Color Trails, visual agnosia, CAM + ADCS-ADL with surrogate) + Medication records Order labs & CT/MRI Adjudication Committee (DSM-IV criteria) Dementia positive Dementia negative Continue in study PRIMARY ENDPOINT MCI (SECONDARY ENDPOINT) Continue in study
8 Alzheimers Dementia Assessment Probable AD vs probable non-ad (using McKhann et al criteria) Current ASPREE dementia assessment process addresses the 4 main criteria to separate probable AD from probably non-ad: A. Insidious onset (non-ad) B. Worsening (standardised evidence of decline with 3MS and other tests) C. Cognitive deficits (amnestic presentation (ADAS-cog & HVLT), learning & recall, language (ADAS-cog & COWAT), visuospatial (Lurian figs & pentagon in 3MS), executive dysfunction (Color trails & 3MS) D. Exclusions (dementia assessment, CT scan, patient records, labs, neuropsychologist detection of parkinsonism).
9 Baseline characteristics the first 10,000 participants Characteristics All Australia US Men Women 8465 (85) Men Women 1540 (15) Men Women N (%) 4241 (42) 5759 (58) 3737 (44) 4723 (56) 504 (33) 1036 (67) Age (years) 75.3 (4.5) 75.6 (4.6) 75.5 (4.4) 75.8 (4.4) 73.9 (4.9) 74.7 (5.4) Cognition 3MS* scores 92.9 (4.8) 94.1 (4.5) 92.9 (4.7) 94.1 (4.4) 93.2 (5.3) 94.3 (4.9) N (%) 293 (7) 246 (4) 251 (7) 187 (4) 42 (8) 59 (6) N (%) 599 (14) 614 (10) 538 (14) 504 (11) 61 (12) 110 (11) N (%) 1454 (34) 1700 (30) 1300 (35) 1448 (31) 154 (31) 252 (24) 95 N (%) 1895 (45) 3199 (56) 1648 (44) 2584 (55) 247 (49) 615 (59) Lifestyle factors N (%) Live alone 865 (20) 2506 (44) 756 (20) 2034 (43) 109 (22) 472 (46) Residential care 11 (0.3) 37 (1) 9 (0.2) 25 (0.6) 2 (0.4) 12 (1)
10 SUB STUDIES ASPREE Healthy Ageing Biobank ENVIS ion SNORE ASA ALSOP
11 ASPREE Healthy Ageing Biobank To study factors in the blood and urine that may contribute to health or disease in older Australians. Collect biospecimens (10,000 volunteers) before the onset of disease and store until future testing of novel predictors of disease or health.
12 Provide high quality data & biospecimens for applied health sciences & epidemiology for many years to come Future case control studies Identification of new predictive biomarkers Better targeting of existing prevention strategies Unique database to guide health and social policy in older Australians
13 BIOBUS
14 ENVIS ion Aspirin for the prevention of cognitive decline in the Elderly: a Neuro Vascular Imaging Study Neuro imaging sub study of ASPREE NHMRC funded 300 in Melbourne, 300 in Canberra Brain MRI, retinal VI at baseline and 3 yr Anatomical correlates and explanation for aspirin benefit on cognitive decline
15 SNORE ASA A Study of Neurocognitive Outcomes, Radiological and retinal Effects of Aspirin in Sleep Apnoea NHMRC funded ( ) 3300 Apnealink + additional neurocognition tests + sleep questionnaire 365 neuro imaging in Melbourne (brain MRI + RVI)
16 ALSOP ASPREE Longitudinal Study of Older Persons Questionnaires focussed on Medical Social Health Health Services Cohort study Framingham / Rotterdam Epidemiology factors influencing health and disease outcomes
17
DEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER
OVERCOMING THE CHALLENGES OF MANAGING CHRONIC DISEASES IN PERSONS WITH DEMENTIA DEMENTIA, THE BRAIN AND HOW IT WORKS AND WHY YOU MATTER LEARNING OBJECTIVES Be familiar with the diagnostic criteria for
CSF Aβ1-42 predicts cognitive impairment in de novo PD patients
CSF Aβ1-42 predicts cognitive impairment in de novo PD patients Mark Terrelonge MPH *1, Karen Marder MD MPH 1, Daniel Weintraub MD 2, Roy Alcalay MD MS 1 1 Columbia University Department of Neurology 2
DISCLOSURES. Objectives. THE EPIDEMIC of 21 st Century. Clinical Assessment of Cognition: New & Emerging Tools for Diagnosing Dementia NONE TO REPORT
Clinical Assessment of Cognition: New & Emerging Tools for Diagnosing Dementia DISCLOSURES NONE TO REPORT Freddi Segal Gidan, PA, PhD USC Keck School of Medicine Rancho/USC California Alzheimers Disease
David A Scott Lis Evered. Department of Anaesthesia and Acute Pain Medicine St Vincent s Hospital, Melbourne University of Melbourne
David A Scott Lis Evered Department of Anaesthesia and Acute Pain Medicine St Vincent s Hospital, Melbourne University of Melbourne This talk will include live polling so please be sure to have the meeting
Cognitive Screening in Risk Assessment. Geoffrey Tremont, Ph.D. Rhode Island Hospital & Alpert Medical School of Brown University.
Cognitive Screening in Risk Assessment Geoffrey Tremont, Ph.D. Rhode Island Hospital & Alpert Medical School of Brown University Outline of Talk Definition of Dementia and MCI Incidence and Prevalence
CHAPTER 5 NEUROPSYCHOLOGICAL PROFILE OF ALZHEIMER S DISEASE
CHAPTER 5 NEUROPSYCHOLOGICAL PROFILE OF ALZHEIMER S DISEASE 5.1 GENERAL BACKGROUND Neuropsychological assessment plays a crucial role in the assessment of cognitive decline in older age. In India, there
Neuropsychological Evaluation of
Neuropsychological Evaluation of Alzheimer s Disease Joanne M. Hamilton, Ph.D. Shiley-Marcos Alzheimer s Disease Research Center Department of Neurosciences University of California, San Diego Establish
PPMI Cognitive-Behavioral Working Group. Daniel Weintraub, MD
PPMI Cognitive-Behavioral Working Group Daniel Weintraub, MD PPMI Annual Meeting - May 6-7, 2014 Membership Daniel Weintraub WG Chair Tanya Simuni Steering Committee Shirley Lasch IND Chris Coffey, Chelsea
Korean-VCI Harmonization Standardization- Neuropsychology Protocol (K-VCIHS-NP)
Korean-VCI Harmonization Standardization- Neuropsychology Protocol (K-VCIHS-NP) Yeonwook Kang, Ph.D. Department of Psychology, Hallym University Department of Neurology, Hallym University Sacred Heart
Dementia. Aetiology, pathophysiology and the role of neuropsychological testing. Dr Sheng Ling Low Geriatrician
Dementia Aetiology, pathophysiology and the role of neuropsychological testing Dr Sheng Ling Low Geriatrician Topics to cover Why is dementia important What is dementia Differentiate between dementia,
SUPPLEMENTAL MATERIAL
SUPPLEMENTAL MATERIAL Cognitive impairment evaluated with Vascular Cognitive Impairment Harmonization Standards in a multicenter prospective stroke cohort in Korea Supplemental Methods Participants From
Why Cognition Matters: Impact of Cognitive Impairment on Safety and Independent Living Skills
Why Cognition Matters: Impact of Cognitive Impairment on Safety and Independent Living Skills Presented by: Dr. William Mansbach CEO & Founder Mansbach Health Tools, LLC www.thebcat.com Highlights on Prevalence
Mentis Cura November
Mentis Cura November 29 2012 www.mentiscura.com New Facts on Alzheimer s Death rank nr. 2-5 in western countries Fastest growing disease in: Cost Incedence Death rate People with Alzheimer s 2012 36 million
Mild Cognitive Impairment (MCI)
October 19, 2018 Mild Cognitive Impairment (MCI) Yonas E. Geda, MD, MSc Professor of Neurology and Psychiatry Consultant, Departments of Psychiatry & Psychology, and Neurology Mayo Clinic College of Medicine
Dementia and Alzheimer s disease
Since 1960 Medicine Korat โรงพยาบาลมหาราชนครราชส มา Dementia and Alzheimer s disease Concise Reviews PAWUT MEKAWICHAI MD DEPARTMENT of MEDICINE MAHARAT NAKHON RATCHASIMA HOSPITAL 1 Prevalence Increase
Supplementary online data
THELANCETNEUROLOGY-D-07-00083 Supplementary online data MRI assessments MRI at each site included a volumetric spoiled gradient echo (T1-weighted) sequence with slice partition thickness of 1 5 mm or less
Evaluation and Treatment of Dementia
Evaluation and Treatment of Dementia Jeffrey M. Burns, MD Edward H. Hashinger Professor of Neurology Co-Director, KU Alzheimer s Disease Center Director, Clinical and Translational Science Unit Disclosures
The Association Between Comorbidities and Neurocognitive Impairment in Aging Veterans with HIV
The Association Between Comorbidities and Neurocognitive Impairment in Aging Veterans with HIV Arianna Perra, P syd, Moira Dux, PhD Terry Lee- Wilk, PhD HIV and HCV in the VA VA is the largest provider
HOW TO PREVENT COGNITIVE DECLINE.AT MCI STAGE?
EAMA CORE CURRICULUM HOW TO PREVENT COGNITIVE DECLINE.AT MCI STAGE? Sofia Duque Orthogeriatric Unit São Francisco Xavier Hospital Occidental Lisbon Hospital Center University Geriatric Unit, Faculty of
Improving diagnosis of Alzheimer s disease and lewy body dementia. Brain TLC October 2018
Improving diagnosis of Alzheimer s disease and lewy body dementia Brain TLC October 2018 Plan for this discussion: Introduction to AD and LBD Why do we need to improve diagnosis? What progress has been
DEMENTIA? 45 Million. What is. WHAT IS DEMENTIA Dementia is a disturbance in a group of mental processes including: 70% Dementia is not a disease
What is PRESENTS DEMENTIA? WHAT IS DEMENTIA Dementia is a disturbance in a group of mental processes including: Memory Reasoning Planning Learning Attention Language Perception Behavior AS OF 2013 There
The LIFE Study. Marco Pahor, MD University of Florida Institute on Aging.
The LIFE Study Marco Pahor, MD University of Florida Institute on Aging www.aging.ufl.edu Marco Pahor, MD - Funding disclosure NIH Claude Pepper Older Americans Independence Center P30AG028740 The LIFE
Ian McKeith MD, F Med Sci, Professor of Old Age Psychiatry, Newcastle University
Ian McKeith MD, F Med Sci, Professor of Old Age Psychiatry, Newcastle University Design of trials in DLB and PDD What has been learnt from previous trials in these indications and other dementias? Overview
On cognitive performance as endpoint in clinical trials Ben Schmand
On cognitive performance as endpoint in clinical trials Ben Schmand Department of Neurology, Academic Medical Center Department of Psychology, University of Amsterdam The Netherlands What are the best
THE ROLE OF ACTIVITIES OF DAILY LIVING IN THE MCI SYNDROME
PERNECZKY 15/06/06 14:35 Page 1 THE ROLE OF ACTIVITIES OF DAILY LIVING IN THE MCI SYNDROME R. PERNECZKY, A. KURZ Department of Psychiatry and Psychotherapy, Technical University of Munich, Germany. Correspondence
Comments to this discussion are invited on the Alzforum Webinar page. Who Should Use the New Diagnostic Guidelines? The Debate Continues
Comments to this discussion are invited on the Alzforum Webinar page. Who Should Use the New Diagnostic s? The Debate Continues Ever since new criteria came out for a research diagnosis of prodromal/preclinical
Regulatory Challenges across Dementia Subtypes European View
Regulatory Challenges across Dementia Subtypes European View Population definition including Early disease at risk Endpoints in POC studies Endpoints in pivotal trials 1 Disclaimer No CoI The opinions
Outline. Minority Issues in Aging Research. The Role of Research in the Clinical Setting. Why Participate in Research
Outline Minority Issues in Aging Research Mary Sano, Ph.D Mount Sinai School of Medicine Bronx Veterans Medical Research Center 130 West Kingsbridge Rd Bronx NY, 10468 Phone: 718 741-4228; Fax: 718 562-9120
Lambros Messinis PhD. Neuropsychology Section, Department of Neurology, University of Patras Medical School
Lambros Messinis PhD Neuropsychology Section, Department of Neurology, University of Patras Medical School Type 2 Diabetes Mellitus is a modern day epidemic Age is a significant predictor of diabetes Males
Exploration of a weighed cognitive composite score for measuring decline in amnestic MCI
Exploration of a weighed cognitive composite score for measuring decline in amnestic MCI Sarah Monsell NACC biostatistician smonsell@uw.edu October 6, 2012 Background Neuropsychological batteries used
Acronyms and Abbreviations
Acronyms and Abbreviations 3MS Modified Mini-Mental State Examination AA Arachidonic acid AACD Aging-associated cognitive decline AAMI Age-associated memory impairment ABI Ankle-brachial index ACE Angiotensin
ORIGINAL ARTICLE Neuroscience INTRODUCTION MATERIALS AND METHODS
ORIGINAL ARTICLE Neuroscience DOI: 10.46/jkms.2010.25.7.1071 J Korean Med Sci 2010; 25: 1071-1076 Seoul Neuropsychological Screening Battery-Dementia Version (SNSB-D): A Useful Tool for Assessing and Monitoring
The Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing an example of Australian research on Alzheimer s disease
The Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing an example of Australian research on Alzheimer s disease AIBL: Two site collaborative study Study is conducted at two sites: Perth
RESEARCH AND PRACTICE IN ALZHEIMER S DISEASE VOL 10 EADC OVERVIEW B. VELLAS & E. REYNISH
EADC BRUNO VELLAS 14/01/05 10:14 Page 1 EADC OVERVIEW B. VELLAS & E. REYNISH (Toulouse, France, EU) Bruno Vellas: The European Alzheimer's Disease Consortium is a European funded network of centres of
NIH Alzheimer s Disease Centers Panel Recommendations
NIH Alzheimer s Disease Centers Panel Recommendations In June, 2017 NIA engaged leading experts from academia, industry and non-profit foundations, working in Alzheimer s and other complex diseases, in
WHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient
DEMENTIA WHAT IS DEMENTIA? An acquired syndrome of decline in memory and other cognitive functions sufficient to affect daily life in an alert patient Progressive and disabling Not an inherent aspect of
Department of Psychology, Sungkyunkwan University, Seoul, Korea
Print ISSN 1738-1495 / On-line ISSN 2384-0757 Dement Neurocogn Disord 2015;14(4):137-142 / http://dx.doi.org/10.12779/dnd.2015.14.4.137 ORIGINAL ARTICLE DND Constructing a Composite Score for the Seoul
ALZHEIMER S DISEASE OVERVIEW. Jeffrey Cummings, MD, ScD Cleveland Clinic Lou Ruvo Center for Brain Health
ALZHEIMER S DISEASE OVERVIEW Jeffrey Cummings, MD, ScD Cleveland Clinic Lou Ruvo Center for Brain Health Prevalence AD: DEMOGRAPHY AND CLINICAL FEATURES Risk and protective factors Clinical features and
Evaluations & CE Credits
Evaluations & CE Credits Nursing Contact Hours, CME, CHES and Social Work credits are available. Please visit www.phlive.org to fill out your evaluation and complete the post-test. 1 Clinical and Ethical
Dementia. Assessing Brain Damage. Mental Status Examination
Dementia Assessing Brain Damage Mental status examination Information about current behavior and thought including orientation to reality, memory, and ability to follow instructions Neuropsychological
Plenary Session 2 Psychometric Assessment. Ralph H B Benedict, PhD, ABPP-CN Professor of Neurology and Psychiatry SUNY Buffalo
Plenary Session 2 Psychometric Assessment Ralph H B Benedict, PhD, ABPP-CN Professor of Neurology and Psychiatry SUNY Buffalo Reliability Validity Group Discrimination, Sensitivity Validity Association
Diagnosis and Treatment of Alzhiemer s Disease
Diagnosis and Treatment of Alzhiemer s Disease Roy Yaari, MD, MAS Director, Memory Disorders Clinic, Banner Alzheimer s Institute 602-839-6900 Outline Introduction Alzheimer s disease (AD)Guidelines -revised
AD Prevention Trials: An Industry Perspective
AD Prevention Trials: An Industry Perspective Robert A. Lasser, MD, MBA Global Development Lead, Product Development Group Medical Director, Neurodegenerative Disorders F. Hoffmann - La Roche Ltd Regulatory
Outcome measures in neuroscience clinical trials
Neuroscience TM Outcome measures in neuroscience clinical trials Jang-Ho Cha, Head, Translational Medicine Neuroscience Novartis Institute for BioMedical Research February 2017 Outline What is our problem?
A Fresh View of Cognitive Disorders in Older Adults: New Classification and Screening Strategies
A Fresh View of Cognitive Disorders in Older Adults: New Classification and Screening Strategies Lynda Mackin, PhD, AGPCNP-BC, CNS University of California San Francisco School of Nursing 1 Alzheimer s
Table e-1. MCI diagnosis criteria used by articles included in AAN MCI guideline. MCI diagnosis criteria used by included articles
Memory complaint Cognitive complaint Memory impairment Cognitively impaired Relatively preserved general cognition Intact ADL No dementia CDR 0.5 Table e-1. MCI diagnosis criteria used by articles included
Assessing and Managing the Patient with Cognitive Decline
Assessing and Managing the Patient with Cognitive Decline Center of Excellence For Alzheimer s Disease for State of NY Capital Region Alzheimer s Center of Albany Medical Center Earl A. Zimmerman, MD Professor
Recognizing Signs and Symptoms of Alzheimer's Disease in Earlier Stages Can Lead to Diagnosis
A joint publication of the Illinois Health Care Association and CE Solutions November 2015 Recognizing Signs and Symptoms of Alzheimer's Disease in Earlier Stages Can Lead to Diagnosis Early diagnosis
Drug Update. Treatments for Cognitive Impairment in the Older Adult. William Solan, M.D. Karen Sanders, Ph.D. Northwest Hospital Seattle
Drug Update Treatments for Cognitive Impairment in the Older Adult William Solan, M.D. Karen Sanders, Ph.D. Northwest Hospital Seattle Current Drug Treatments for Alzheimer s Disease Cholinesterase Inhibitors:
Section Editor Steven T DeKosky, MD, FAAN Kenneth E Schmader, MD
Prevention of dementia Author Daniel Press, MD Michael Alexander, MD Section Editor Steven T DeKosky, MD, FAAN Kenneth E Schmader, MD Deputy Editor Janet L Wilterdink, MD Last literature review version
Detecting neurocognitive impairment in HIV-infected youth: Are we focusing on the wrong factors?
Detecting neurocognitive impairment in HIV-infected youth: Are we focusing on the wrong factors? Jennifer Lewis, PsyD; Mathew Hirsch, PsyD & Susan Abramowitz, PhD NYU School of Medicine, New York, NY Friday,
3 COMMON PSYCHIATRIC DISORDERS IN OLDER ADULTS: NEW INSIGHTS
3 COMMON PSYCHIATRIC DISORDERS IN OLDER ADULTS: NEW INSIGHTS PHOVOIR/SHUTTERSTOCK Mild cognitive impairment (MCI), dementia, and depression are common in elderly patients. Three new studies focus on the
Erin Cullnan Research Assistant, University of Illinois at Chicago
Dr. Moises Gaviria Distinguished Professor of Psychiatry, University of Illinois at Chicago Director of Consultation Liaison Service, Advocate Christ Medical Center Director of the Older Adult Program,
Adaptive Design in CIAS
Adaptive Design in CIAS or If you don t know where you re going, any road will get you there Michael Sand, PhD, MPH Senior Clinical Program Leader, CNS Boehringer Ingelheim Disclosures I m an employee
Measurement and Classification of Neurocognitive Disability in HIV/AIDS Robert K. Heaton Ph.D University of California San Diego Ancient History
Measurement and Classification of Neurocognitive Disability in HIV/AIDS Robert K. Heaton Ph.D University of California San Diego Ancient History Group Means for NP and MMPI Variables N=381 Consecutive
Trail making test A 2,3. Memory Logical memory Story A delayed recall 4,5. Rey auditory verbal learning test (RAVLT) 2,6
NEUROLOGY/2016/790584 Table e-1: Neuropsychological test battery Cognitive domain Test Attention/processing speed Digit symbol-coding 1 Trail making test A 2,3 Memory Logical memory Story A delayed recall
Treatment of AD with Stabilized Oral NADH: Preliminary Findings
MS # 200 000 128 Treatment of AD with Stabilized Oral NADH: Preliminary Findings G.G. Kay, PhD, V. N. Starbuck, PhD and S. L. Cohan, MD, PhD Department of Neurology, Georgetown University School of Medicine
AGED SPECIFIC ASSESSMENT TOOLS. Anna Ciotta Senior Clinical Neuropsychologist Peninsula Mental Health Services
AGED SPECIFIC ASSESSMENT TOOLS Anna Ciotta Senior Clinical Neuropsychologist Peninsula Mental Health Services Issues in assessing the Elderly Association between biological, psychological, social and cultural
FROM THE ALZHEIMER S ASSOCIATION INTERNATIONAL CONFERENCE 2018
FOR IMMEDIATE RELEASE CONTACT: Alzheimer s Association AAIC Press Office, 312-949-8710, aaicmedia@alz.org Niles Frantz, Alzheimer s Association, 312-335-5777, nfrantz@alz.org FROM THE ALZHEIMER S ASSOCIATION
Delirium assessment and management. Dr Kim Jeffs Northern Health
Delirium assessment and management Dr Kim Jeffs Northern Health What do you need to know? Epidemiology How big is the problem? Who is at risk? Assessment Tools for diagnosis Prevention Evidence base Management
Cognitive Assessment 4/29/2015. Learning Objectives To be able to:
Supporting the Desire to Age in Place: Important Considerations for the Aging Population AGENDA 8:45 9:00 AM Geriatric Principles Robert L. Kane, MD *9:00 9:55 AM Cognitive Assessments Ed Ratner, MD 10:00
Early Diagnosis of Alzheimer s Disease and MCI via Imaging and Pattern Analysis Methods. Christos Davatzikos, Ph.D.
Early Diagnosis of Alzheimer s Disease and MCI via Imaging and Pattern Analysis Methods Christos Davatzikos, Ph.D. Director, Section of Biomedical Image Analysis Professor of Radiology http://www.rad.upenn.edu/sbia
Healthy Aging 11/10/2011. Frank R. Lin, M.D. Ph.D. Maintaining Physical Mobility & Activity. Keeping Socially Engaged & Active.
& Frank R. Lin, M.D. Ph.D. Assistant Professor Johns Hopkins Department of Otolaryngology-HNS Core Faculty Johns Hopkins Center on Aging & Health 27 October 2011 & Overview Why study hearing loss? physiology
The Influence of Sleep on Cognition in Breast Cancer
The Influence of Sleep on Cognition in Breast Cancer Sonia Ancoli-Israel, PhD Professor of Psychiatry and Medicine University it of California i San Diego Fatigue by Rodin Supported by NIC CA112035, UL1RR031980
Learning objectives 6/20/2018
Cognitive impairment of patients with chronic migraine, in a neuropsychological assessment, does not depend on the use of topiramate or comorbidities Ferreira KS, MD, PhD Professor, Neurology Clinic, Medicine
SHARED CARE OF MCI/EARLY DEMENTIA
SHARED CARE OF MCI/EARLY DEMENTIA BY DR. OLUFEMI BANJO MD, DTM, DCP, DIPA&DS, DHM, M.Med.Sc, FRCP(C) GERIATRIC PSYCHIATRIST. ASSISTANT MEDICAL DIRECTOR, ADULT MENTAL HEALTH AND ADDICTION, GRAND RIVER HOSPITAL
Efficacy of a Cognitive Training Program for Individuals with Moderate Cognitive Impairment: Evaluating Cognition
Minnesota State University, Mankato Cornerstone: A Collection of Scholarly and Creative Works for Minnesota State University, Mankato All Theses, Dissertations, and Other Capstone Projects Theses, Dissertations,
Carol Manning, PhD, ABPP-CN Director, Memory Disorders Clinic University of Virginia
Carol Manning, PhD, ABPP-CN Director, Memory Disorders Clinic University of Virginia Case Study Mr. S. is a 74 year old man who has smoked for 20 years. He is overweight, has high cholesterol and high
Dementia: It s Not Always Alzheimer s
Dementia: It s Not Always Alzheimer s A Caregiver s Perspective Diane E. Vance, Ph.D. Mid-America Institute on Aging and Wellness 2017 My Background Caregiver for my husband who had Lewy Body Dementia
APPENDIX A TASK DEVELOPMENT AND NORMATIVE DATA
APPENDIX A TASK DEVELOPMENT AND NORMATIVE DATA The normative sample included 641 HIV-1 seronegative gay men drawn from the Multicenter AIDS Cohort Study (MACS). Subjects received a test battery consisting
Mental Disorders in Older Adults, by George W. Rebok, is available under a Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Generic license.
Mental Disorders in Older Adults, by George W. Rebok, is available under a Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Generic license. 2007, The Johns Hopkins University and George W. Rebok.
Cognitive Evaluation in Primary Care. Scott T. Larson, MD Clinical Assistant Professor University of Iowa
Cognitive Evaluation in Primary Care Scott T. Larson, MD Clinical Assistant Professor University of Iowa scott-larson@uiowa.edu Objectives Understand the subtypes of dementia, and the DSM-5 categorization
NEUROPSYCHOMETRIC TESTS
NEUROPSYCHOMETRIC TESTS CAMCOG It is the Cognitive section of Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) The measure assesses orientation, language, memory, praxis, attention, abstract
21/05/2018. Today s webinar will answer. Presented by: Valorie O Keefe Consultant Psychologist
Today s webinar will answer. 1. What is the RBANS, and how is the updated version different than the original version? 2. What are the neurocognitive areas assessed by the RBANS and what scores are available?
Service Related Project. Kimberley Keegan
AN EVALUATION OF ADDENBROOKE S COGNITIVE EXAMINATION III (ACE-III) SCORES, NEUROPSYCHOLOGICAL ASSESSMENT SCORES, AND DIAGNOSIS OUTCOME WITHIN A MEMORY SERVICE. Service Related Project Kimberley Keegan
Assessment Toolkits for Lewy Body Dementia
Study : Assessment Toolkits for Lewy Body Dementia There are two toolkits, depending on whether the patient is presenting with a primary cognitive problem or with cognitive decline in the context of established
Cognitive rehabilitation: assessment. Dawn Langdon PhD
Cognitive rehabilitation: assessment Dawn Langdon PhD 1 Assessment for cognitive rehabilitation Patient context Individual Family Work Insight Mood Motivation Observation of patient performance Rehabilitation
Mild Cognitive Impairment or Mild Neurocognitive Disorder: Implications for Clinical Practice. Hypothesized Key Players in the Pathogenesis of AD
AD is a Neurodegenerative Disease as Seen in the PET Scan and is Characterized by Amyloid Plaques and Neurofibrillary Tangles Mild Cognitive Impairment or Mild Neurocognitive Disorder: Implications for
Alzheimer s disease is an
Alzheimer s Disease FACT SHEET Alzheimer s disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, and eventually even the ability to carry out the simplest
The role of memory on patients with mild cognitive impairment. Sophia Vardaki, PhD National Technical University of Athens
The role of memory on patients with mild cognitive impairment Sophia Vardaki, PhD National Technical University of Athens Athens, 26 June 2015 Objective-Presentation Structure Objective To explore the
The ABCs of Dementia Diagnosis
The ABCs of Dementia Diagnosis Dr. Robin Heinrichs, Ph.D., ABPP Board Certified Clinical Neuropsychologist Associate Professor, Psychiatry & Behavioral Sciences Director of Neuropsychology Training What
Piano playing skills in a patient with frontotemporal dementia: A longitudinal case study
International Symposium on Performance Science ISBN 978-94-90306-01-4 The Author 2009, Published by the AEC All rights reserved Piano playing skills in a patient with frontotemporal dementia: A longitudinal
Alzheimer s Disease. Clinical characteristics of late-onset Alzheimer s disease (LOAD) A/Prof David Darby
Alzheimer s Disease Clinical characteristics of late-onset Alzheimer s disease (LOAD) A/Prof David Darby Florey Institute of Neuroscience and Mental Health 28-6-2013 The burden of late-onset Alzheimer
Case Presentation. Cognition: changes with Normal Aging? Synonyms
Case Presentation 78 yr old new patient presenting for new PCP after discharge from hospital stay Discharged 3 days ago Summary : admitted with new atrial fibrillation, with history of DM, CHF. In hospital,
How to Diagnose Early (Prodromal) Lewy Body Dementia. Ian McKeith MD, FRCPsych, F Med Sci.
How to Diagnose Early (Prodromal) Lewy Body Dementia Ian McKeith MD, FRCPsych, F Med Sci. Parkinson s Disease Lewy Body Disease Time PD Dementia Lewy Body Dementias Dementia with Lewy Bodies (DLB) Diagnostic
8/14/2018. The Evolving Concept of Alzheimer s Disease. Epochs of AD Research. Diagnostic schemes have evolved with the research
The Evolving Concept of Alzheimer s Disease David S. Geldmacher, MD, FACP Warren Family Endowed Chair in Neurology Department of Neurology UAB School of Medicine Epochs of AD Research Epoch Years Key Event
Significance A Busy Clinician's Guide to Seniors with Memory Loss
Significance A Busy Clinician's Guide to Seniors with Memory Loss Victoria Braund MD FACP CMD Division of Geriatrics. NorthShore University HealthSystem Alzheimer's disease is the sixth leading cause of
Cognitive-Motor Interference in Persons with Parkinson Disease
Cognitive-Motor Interference in Persons with Parkinson Disease Tara L. McIsaac, PhD, PT Associate Professor of Physical Therapy A.T. Still University Arizona School of Health Sciences October 11, 2014
Alzheimer s disease. The future of clinical trials: big problem, Big Data, big solution?
Alzheimer s disease The future of clinical trials: big problem, Big Data, big solution? The Problem More than 36m people with dementia Consumes 1% global GDP Serial trials failure Targets for therapy Nothing
Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial [HYVET] R. Peters
![Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial [HYVET] R. Peters](/thumbs/74/71463454.jpg "Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial [HYVET] R. Peters")
Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial [HYVET] R. Peters ClinicalTrials.gov: NCT00122811 Backgound The prevalence of dementia rises with increasing
Lung Cancer Screening: Evidence and current recommendations
Lung Cancer Screening: Evidence and current recommendations 20 th March 2018 Dr Annette McWilliams Fiona Stanley Hospital University of Western Australia WA Cancer & Palliative Care Network I have no financial
An integrated natural disease progression model of nine cognitive and biomarker endpoints in patients with Alzheimer s Disease
An integrated natural disease progression model of nine cognitive and biomarker endpoints in patients with Alzheimer s Disease Angelica Quartino 1* Dan Polhamus 2*, James Rogers 2, Jin Jin 1 212, Genentech
Patterns of Cognitive Impairment in Dementia
Patterns of Cognitive Impairment in Dementia Lindsay R. Clark, PhD Assistant professor (CHS) Department of Medicine - Division of Geriatrics & Gerontology UW-Madison School of Medicine & Public Health
2013 AAIC WW-ADNI Meeting, Boston K-ADNI Update
2013 AAIC WW-ADNI Meeting, Boston K-ADNI Update July 12th, 2013 Seong Yoon Kim, Seol Hee Han, Duk L. Na Update for K-ADNI, 2013 General Year1 Tasks Infrastructure setup for K-ADNI is under way. Database
The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing. (AUSTRALIAN ADNI) July 2013 UPDATE Imaging Christopher Rowe MD Neuroimaging stream leader June 2013 The Australian Imaging Biomarkers
PCPT and SELECT Cancer Cohorts
PCPT and SELECT Cancer Cohorts Briefly describe PCPT and SELECT trial designs Current follow-up status for each cohort SELECT Centralized Follow-up Data elements and biologic samples collected Events ascertained,
LANGUAGE AND COGNITIVE TASKS MOST PREDICTIVE OF MILD COGNITIVE IMPAIRMENT. A Thesis by Brooke Holt
LANGUAGE AND COGNITIVE TASKS MOST PREDICTIVE OF MILD COGNITIVE IMPAIRMENT A Thesis by Brooke Holt Submitted to the Graduate School at Appalachian State University in partial fulfillment of the requirements
Coconut Oil, Vitamins and Alzheimer s: What Really Works?
Program by Phone March 13, 2018 Coconut Oil, Vitamins and Alzheimer s: What Really Works? Robert L. Russell, MD Medical Director, Kindred at Home, Indianapolis, IN 1 OBJECTIVES To discuss how lifestyle
Dementia Prepared by: Joanne Leung Psychiatry Resident, University of Toronto
Dementia Prepared by: Joanne Leung Psychiatry Resident, University of Toronto Dementias are acquired neurodegenerative disorders involving a syndrome of cognitive impairment accompanied with social and
Nature, prevalence and clinical significance. Barcelona, Spain
Nature, prevalence and clinical significance Jaime Kulisevsky Barcelona, Spain 1 Non motor (neuropsychiatric) symptoms are an integral part of Parkinson s s disease (PD) Affective disorders And are associated