Drug Safety in Ambulatory Care
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1 Drug Safety in Ambulatory Care Where is the Patient? Changing Prescription Medication Use Instructions Roundtable on Health Literacy October 12, 2007 Daniel Budnitz MD, MPH, CDR USPHS Division of Healthcare Quality Promotion Coordinating Center for Infectious Diseases TM
2 Outline Use the public health approach to describe the ambulatory drug safety problem Highlight the key role of patients in ambulatory drug safety Review considerations for patient-centered drug safety measures
3 Disclaimer The findings and conclusions in this presentation have not been formally disseminated by the Centers for Disease Control and Prevention and should not be construed to represent any agency determination or policy.
4 If you don t know where you re going, any road will get you there The Cheshire Cat Alice in Wonderland Lewis Carroll
5 The Public Health Approach Evaluate Impact Design Intervention Identify Risk Factors Describe the Problem
6 The Adverse Drug Event (ADE) Definition Harm (injury) from medication use Excludes: Abuse Self-harm (suicide attempts) Illicit substances
7 Estimated Annual Impact of Ambulatory ADEs Deaths Hospitalizations Emergency visits Office visits Patient reported effects 25% ambulatory patients? Ganhdi, T.J. et al. NEJM 2003;348:
8 Estimated Annual Impact of Ambulatory ADEs Deaths Hospitalizations Emergency visits Office visits > 3.6 million 14.3 per 1,000 US population Patient reported effects 25% ambulatory patients? Zhan, C. et al. Jt Comm J Qual Patient Saf 2005;7:372-8.
9 Estimated Annual Impact of Ambulatory ADEs Deaths Hospitalizations Emergency visits Office visits >700,000 > 3.6 million 2.4 per 1,000 US population Patient reported effects 25% ambulatory patients? Budnitz, D. S. et al. JAMA 2006;296:
10 Estimated Annual Impact of Ambulatory ADEs Deaths Hospitalizations >117,000 Emergency visits >700,000 Office visits > 3.6 million Patient reported effects 25% ambulatory patients? Budnitz, D. S. et al. JAMA 2006;296:
11 Estimated Annual Impact of Ambulatory ADEs Deaths? Hospitalizations >117,000 Emergency visits >700,000 Office visits > 3.6 million Patient reported effects 25% ambulatory patients?
12 The Public Health Approach Applied to Ambulatory ADEs Describe the Problem -Ambulatory ADEs harm many people -Range of severity
13 The Public Health Approach Identify Risk Factors Describe the Problem
14 Emergency Visits for ADEs by Patient Age, , Estimated Budnitz, D. S. et al. JAMA 2006;296:
15 Number of Cases and Annual Estimate of Individuals with Adverse Drug Events Treated in Emergency Departments by Event Type--United States, Budnitz, D. S. et al. JAMA 2006;296:
16 Number of Cases and Annual Estimate of Individuals with Adverse Drug Events Treated in Emergency Departments by Event Type--United States, Over half of hospitalizations from unintended overdoses or supra-therapeutic drug levels Budnitz, D. S. et al. JAMA 2006;296:
17 Number of Cases and Annual Estimate of Drugs Most Commonly Implicated in Adverse Events Treated in Emergency Departments--United States, Budnitz, D. S. et al. JAMA 2006;296:
18 The Public Health Approach Applied to Ambulatory ADEs Identify Risk Factors -Older adults, children -Unintended dosing problems -Common medications Describe the Problem -Ambulatory ADEs impact many people -Range of severity
19 The Public Health Approach Interventions in Hospitals -Medication errors -Systems change -Computerization Design Intervention Identify Risk Factors Identify the Problem
20 Medication Errors All Errors Preventable events that may lead to inappropriate medication use or patient harm
21 Medication Errors and Adverse Drug Events All Errors ADEs Healthy Patient Harm Injured Patient
22 Contribution of Patient Errors? Patient Errors? All Errors ADEs Healthy Patient Harm Injured Patient
23 Drug Management by Setting Hospital Ambulatory Who prescribes? Who administers? Who stores? Who monitors? Support systems? Basis for safety interventions? Professionals Professionals Professionals Professionals Extensive Systems engineering Industrial quality control
24 Drug Management by Setting Who prescribes? Who administers? Who stores? Who monitors? Support systems? Basis for safety interventions? Hospital Professionals Professionals Professionals Professionals Extensive Systems engineering Industrial quality control Ambulatory Physicians & Laypersons Laypersons Laypersons Laypersons & Physicians Minimal (Medication Label) Population-based Injury Prevention
25 To eliminate an injury, one need only find a controllable necessary condition and control that condition Leon S. Robertson Injury Epidemiology: Research and Control Strategies 2nd ed. New York, NY: Oxford University Press; 1998
26 Techniques of Population-based Injury Prevention A. Identify plausible interventions Haddon s phase-factor matrix B. Consider 3 types of strategies Education, Engineering, Enforcement C. Consider 2 types of approaches Active vs. Passive
27 A. Identify Plausible Interventions Phase-Factor Matrix Phase Factor Host (Patient) Agent (Drug) Environment Pre-event Event Post-event
28 Preventing Adverse Events from Warfarin Budnitz D.S. and Layde P.L. Pharmacoepidemiol Drug Saf 2007;16:160-5
29 Consider Implementation Strategies Education Engineering Enforcement Needlestick Safety and Prevention Act, 2000
30 Insert Part 2
31 C. Consider Preferred Approach Active Passive
32 The Public Health Approach Evaluate Impact Design Intervention Identify Risk & Protective Factors Identify the Problem
33 Summary Drug safety for ambulatory patients is an important public health problem Patients play the central role in ambulatory drug safety Opportunity for patient-centered ambulatory drug safety measures
34 Acknowledgements Division of Healthcare Quality Promotion, CDC Daniel Pollock Kelly Weidenbach Nadine Shehab Chesley Richards Office of Drug Safety, FDA Gerald Dalpan Judy Staffa Anne Trontell (previously) Paul Seligman (previously) National Center for Injury Prevention & Control, CDC Lee Annest Scott Kegler US Consumer Product Safety Commission Tom Schroeder Joel Freidman Cathleen Irish Terri Nelson TM
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