Two copies of each autosomal gene affect phenotype.
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1 UNIT 3 GENETICS LESSON #34: Chromosomes and Phenotype Objective: Explain how the chromosomes on which genes are located can affect the expression of traits. Take a moment to look at the variety of treats around you in the classroom. Hair color and texture, eye color and shape, height, and weight are all influenced by genetics.
2 Main Idea #1 Two copies of each autosomal gene affect phenotype. Gene expression is often related to whether a gene is located on an autosome or on a sex chromosome. Remember: Sex chromosomes determines an organisms sex. Recall: sexually reproducing organisms have two of each chromosome. Each pair consists of one chromosome from each of two parents. Both chromosomes have the same genes, but the chromosomes might have different alleles for those genes. *Different alleles can produce different phenotypes, such as white flowers or purple flowers.*
3 Most traits in sexually reproducing organisms, including humans, are the result of autosomal genes. Is your hair curly or straight? What about your parents hair? The genes that affect your hair texture curly hair or straight hair are autosomal genes. Many human genetic disorders are also caused by autosomal genes. The chance of a person having one of these disorders can be predicted, just as Mendel could predict the phenotypes that would appear in his pea plants. Why? Because there are two copies of each gene on autosomes one on each homologous chromosomes and each copy can influence phenotype.
4 Disorders Caused by Recessive Alleles Some human genetic disorders are caused by recessive alleles on autosomes. Two copies of the recessive allele must be present for a person to have the disorder. These disorders often appear in offspring of parents who are both heterozygotes. Each parent has one dominant, normal allele that masks the one disease-causing recessive allele. Carrier: does not show disease symptoms but can pass on the disease-causing allele to offspring. For example: Cystic Fibrosis is a severe recessive disorder that mainly affects the sweat glands and the mucus glands. A person who is homozygous for the recessive allele will have the disease. Someone who is heterozygous for the alleles will not have the disease but is a carrier.
5 Alleles that are lethal, or deadly, in a homozygous recessive individual can remain in a population s gene pool.
6 Disorders Caused by Dominant Alleles Dominant genetic disorders are far less common than recessive disorders. For example: Huntington s disease damages the nervous system and usually appears during adulthood. Because the disease is caused by a dominant allele, there is a 50% chance that a child will have it even if only one parent has one of the alleles. If both parents are heterozygous for the disease, there is a 75% chance that any of their children will inherit the disease. Because Huntington s disease strikes later in life, a person with the allele can have children before the disease appears. In that way, the allele is passed on in the population even though the disease is fatal.
7 Main Idea #2 Males and Females can differ in sex-linked traits. Sex-linked genes: genes that are located on the sex chromosome. Genes on the Y chromosome are responsible for the development of male offspring, but the X chromosome actually has more influence over phenotype. The gametes from an XY male determine the sex of the offspring. Female parent (XX) The X chromosome has many genes that affect many traits. The Y chromosome is much smaller and has many fewer genes than the X chromosome. Male parent (XY) female male female male
8 Main Idea #2 Expression of Sex-Linked Genes X & Y chromosomes have different genes, thus sex-linked genes have a a pattern of expression that is different from autosomal genes. Two copies of an autosomal gene affect a trait. Males only have one copy of each type of sex chromosome, they express all of the alleles on both chromosomes. In mammals the expression of sex-linked genes in females is also different from the way in which genes on other chromosomes are express. X Chromosome Inactivation: when one of the two X chromosomes is randomly turned off in each cell of female mammals. X chromosome inactivation results in females with an active X chromosome from the mother, and a second type with an active X chromosome from the father.
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