KAJARIN Pure Reflections of Nature

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KAJARIN Pure Reflections of Nature FAQS - General Guidelines What is the dosage of the active ingredients in Kajarin products? 4 Balance has approximately 28.

1 KAJARIN Pure Reflections of Nature FAQS - General Guidelines What is the dosage of the active ingredients in Kajarin products? 4 Balance has approximately 28.9mg of Progesterone per pump 4 Balance Plus has approximately 32mg of progesterone, and 1mg of a biest containing.75mg of Estriol and.25mg of Estradiol per pump 4 Comfort has approximately 1.4mg of Estriol per pump 4 Male has approximately 12.1mg of Progesterone and 30.3mg of Chrysin per pump How do I know how much I need and how often? 4 Balance When used for premenopausal woman: Days of her cycle, or as directed by your practitioner. 4 Balance When used for postmenopausal woman: Days 1-21 and then take 7 days off, or as directed by your practitioner. 4Balance Plus When used for postmenopausal women: Days 1-21 and then take 7 days off, or as directed by your practitioner. 4Comfort When used for vaginal dryness/vaginal atrophy: Every day for 1-2 weeks, then down to once every 2 days then once every 3 days or as directed by your practitioner. 4Male When used for men experiencing symptoms of Andropause: Use every day, or as directed by your practitioner. Why is there a warning label for the State of California on the bottles? The state of California has over 700 ingredients that they have deemed as possible cancer risks, based on a variety of studies. It is a requirement to have this warning on anything that may be sold in the state of California, so we are complying with their state law. Please see our list of articles, there is more in depth information listed there.

2 Here is a resource that may be useful for understanding Prop 65 and progesterone: How long does the cream take to absorb into my skin? You will see it absorbed topically within a few minutes. It will become fully absorbed after 30 minutes, and you would then be able to swim, or bathe. Can I purchase from Kajarin if I am not a business or a practitioner? Kajarin does not sell directly to consumers, but if you would like to send Kajarin your information they can direct you to the nearest location carrying their products. Patients and Consumers Bioidentical hormones are essential and effective supplements. By mimicking the body s own hormones in molecular structure, they also encourage natural and optimal hormone balance without the unwanted side effects of synthetic hormone supplementation. As the body ages, the adrenal glands, ovaries (in women) and testes (in men) no longer produce optimal amounts of hormone. Your practitioner will select the right bioidentical hormones to either bring your body back into balance or to help boost levels once your body reduces production. The sex hormones, estrogens, progesterone, testosterone and DHEA, are designed to be in continuous dance with each other, rising and falling and balancing and counterbalancing in sequence. When one hormone becomes too dominant, symptoms occur. As overall levels decline due to aging or stress, we can lose our vital energy and develop additional symptoms. Utilizing bioidentical hormone supplementation re-establishes harmony and overall sense of balance, flow and well being. It is important to respect the powerful impact of hormones and supplementation, Over-dosing bioidentical hormones can also lead to unwanted side effects and symptoms. Always follow the direction you receive from your health-care practitioner.

3 Topical Cream Application Topical application of steroid hormones is the preferred method of administration due to excellent absorption and ability to bypass the liver, and therefore smaller dosages are required. Consequently there are an increasing number of prescriptions written for topical hormones every year. One issue that comes up frequently at the lab is a patient's exposure to topical hormones being used by a loved one or household member. While this doesn't cause significant concern with some hormones such as progesterone, which has a relatively wide therapeutic window and has beneficial value with men as well as women, it can be a noteworthy problem with creams and gels that contain estrogens or testosterone. It is imperative that patients who are using topical hormones of any kind are aware these can be transferred to their spouse or even to their children, so proper precautions should be taken. A recent case study of female twins shed some much needed attention to this matter. One of the twins was born with clitoromegaly and elevated testosterone levels. The second twin also began to develop clitoromegaly and had climbing testosterone levels during the first 24 months of life. Only after extensive testing and intervention had been attempted did the treatment team become aware of the fact that the twins' father was using Androgel, a prescription topical testosterone gel. He had inadvertently been exposing his wife and daughters to high levels of testosterone pre and postnatally. When this connection was made and the girls were protected from this exogenous exposure, their testosterone levels began to decline and eventually reached normal levels. Spousal exposure can surprise patients as well as their physicians, who are often unaware of this common and known side effect of transdermal hormones. In addition to this case study with the twin girls, there have been many studies on the virilization of children as a result of a parent's topical testosterone use. It is crucial that patients using topical hormones of any kind are educated on the possibility of exposure. Transference to family members can be reduced and even eliminated by applying the creams/gels to areas that aren't as likely to come in contact with others, such as behind the knees. Additionally, transference may be reduced by thoroughly washing hands after applying transdermal hormones, advising family members not to share towels, and avoiding intimate contact for 20 minutes after application. References 1. Patel A, Rivkees SA. "Prenatal Virilization Associated with Paternal Testosterone Gel Therapy" Int J Pediatr Endocrinol C. Brachet, J. Vermeulen, and C. Heinrichs, "Children's virilization and the use of a testosterone gel by their fathers,"european Journal of Pediatrics, vol. 164, no. 10, pp. 646-

4 647, E. Cohen, O. M. Navarro, E. Reynolds, R. P. Schwartz, and P. Venkataramani, "Index of suspicion," Pediatrics in Review, vol. 28, pp , G. J. Kunz, K. O. Klein, R. D. Clemons, M. E. Gottschalk, and K. L. Jones, "Virilization of young children after topical androgen use by their parents," Pediatrics, vol. 114, no. 1, pp , Y. M. Yu, N. Punyasavatsu, D. Elder, and A. J. D'Ercole, "Sexual development in a two-yearold boy induced by topical exposure to testosterone," Pediatrics, vol. 104, no. 2, p. e23, E. L. Rhoden and A. Morgentaler, "Risks of testosteronereplacement therapy and recommendations for monitoring," New England Journal of Medicine, vol. 350, no. 5, pp , 2004 Progesterone and Heart Health Although heart disease is sometimes thought of as a man s disease, cardiovascular disease is the #1 cause of death for women; in 2006, 315,930 women died from it. Nine out of ten heart disease patients have at least one risk factor. Several medical conditions and lifestyle choices can put women at a higher risk for heart disease, including: High cholesterol Cigarette smoking High blood pressure Overweight and obesity Diabetes Physical inactivity Poor diet Alcohol use However, the importance of hormone balance should not be overlooked. It is rare that a premenopausal woman dies of a heart attack, though the incidence of cardiac mortality among older women eventually matches or exceeds that of males. It was once thought that the difference was due to a lack of estrogen after menopause. Estrogen can, after all, improve a woman s lipid profile, and has the cardiovascular benefit of relaxing the blood vessels which can protect against heart attack. However, when estrogen levels are too high its protective value in heart disease is reversed as the risk of blood clots and fluid imbalances rises. It is known that progesterone deficiency down-regulates estrogen receptors and sufficient progesterone upregulates estrogen receptors, resulting in more estrogen action without changing the amount of estrogen already present. Progesterone seems to be the key player.

5 We know that progesterone levels after menopause are almost zero. Estrogen, on the other hand, falls only 40-60% with menopause. According to John Lee, MD, lipid profiles improve when progesterone is supplemented. Progesterone increases the burning of fats for energy and, in addition, has anti-inflammatory effects, both cardio protective actions. Progesterone protects against blood clots due to excess estrogen. Progesterone protects the integrity and function of cell membranes, whereas estrogen allows an influx of sodium and water while allowing loss of potassium and magnesium. Several studies have illustrated the importance of progesterone in protecting heart health. Bioidentical progesterone has been shown to inhibit arterial smooth muscle cell proliferation, both in type II diabetics and in otherwise healthy individuals. Coronary hyperreactivity (vasospasm) in rhesus monkeys was shown to be prevented by subphysiological doses of progesterone. An additional study examined exercise-induced myocardial ischemia in patients taking estrogen/medroxyprogesterone acetate versus estrogen/bioidentical progesterone. The combined estrogen/progesterone supplementation increased exercise time to myocardial ischemia as compared to estrogen/mpa. Supplementing with bioidentical hormones, rather than conjugated equine estrogens and synthetic progestins, is essential, as also illustrated by the Women s Health Initiative. Their findings suggest that Estrogen + Progestin does not protect the heart and may even increase the risk of coronary heart disease (CHD). Overall, there was a 24% higher risk of CHD among women in the E+P study compared to women taking placebo. The women in the WHI were taking one tablet containing conjugated equine estrogens (0.625 mg) and medroxyprogesterone acetate (2.5 mg) each day (Prempro). Optimizing the progesterone/estradiol ratio can go a long way in improving cardiovascular health, so remember to include a complete hormone analysis with all of your cardiovascular patients. - Brennan J, et al. "Progesterone inhibit human infragenicular arterial smooth muscle cell proliferation induced by high glucose and insulin concentrations." J Vasc Surg : Giuseppe MC, et al. "Natural Progesterone but not Medroxyprogesterone Acetate Enhances the beneficial Effect of Estrogen on Exercise-Induced Myocardial Ischemia in Postmenopausal Women." J Am Coll Cardio : Hermsmeyer RK et al. "Prevention of Coronary Hyperreactivity in Preatherogenic Menopausal

6 Rhesus Monkeys by Transdermal Progesterone." Arterioscler Thromb Vasc Biol : Lee, John R. MD. What Your Doctor May Not Tell You About Menopause. Warner Books Chapter Rossouw JE, et al. "Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial." JAMA Jul 17;288(3): Wen-Sen L, et al. "Progesterone inhibits arterial smooth muscle cell proliferation." Nature Medicine (9): (Referenced 4/5/2010)

Therapeutic Cohort Results

Therapeutic Cohort Results Patient: JANE DOE DOB: December 31, 1968 Sex: F MRN: Order Number: Completed: February 26, 2016 Received: February 26, 2016 Collected: February 26, 2016 One Day Hormone Check - Salivary Profile Therapeutic