Compounding Options for Female and Male Patients
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1 Compounding Options for Female and Male Patients Bruce Biundo, RPh and Andrea Branvold, RPh 2016 Las Vegas Hormone Replacement Therapy Symposium Las Vegas, NV February 11 13, 2016
2 Men s Health: Treating Low Testosterone and Sexual Dysfunction in Males Bruce Biundo, RPh, FACA Treating Low Testosterone in Males You have the patient s lab values. You have the patient s symptoms. Now what? PCCA Men s Health Documents Male Hypogonadism Treatment Packet (98474): Includes All Documents Below Hypogonadism Diagnosis and Laboratory Values Hypogonadism / Andropause Male Hormone Screening HPA LH/FSH Diagram Treatment Options for Male Hypogonadism Male Hypogonadism Treatment Algorithm Hypogonadism Dosing Chart + References Topical Testosterone Patient Information All Rights Reserved. 1
3 Hormonal Mechanism Treatment Algorithm - PCCA Document All Rights Reserved. 2
4 Terms Definition: Hypogonadism Primary hypogonadism testicular failure Clear need for testosterone supplementation Terms Definition: Hypogonadism Secondary hypogonadism Several options that boost LH and testosterone Choosing the Right Treatment for the Patient Treatment choice All Rights Reserved. 3
5 Diagnosis Roadmap: Ways to Increase and / or Maintain Testosterone Levels Roadmap: Ways to Increase and / or Maintain Testosterone Levels All Rights Reserved. 4
6 Lifestyle Changes Simplest and soundest basis for hormonal health Roadmap: Ways to Increase and / or Maintain Testosterone Levels Reduce Estrogen Levels Estrogen plays a role in hypogonadism: 1. As a primary mediator of the hypothalamus / pituitary axis All Rights Reserved. 5
7 Reduce Estrogen Levels 2. Role in the level of Sex Hormone Binding Globulin (SHBG) Reducing Estrogen Levels Aromatase inhibitors Natural products: Zinc Vitamin C Chrysin Anastrozole Formulas All Rights Reserved. 6
8 Important to Remember Too low estradiol levels Roadmap: Ways to Increase and / or Maintain Testosterone Levels Terms Definition: Hypogonadism Secondary Hypogonadism Several options that boost LH and testosterone All Rights Reserved. 7
9 HCG Formulas HCG All Rights Reserved. 8
10 Increase Testicular Output of Testosterone Increase Testicular Output of Testosterone Clomiphene Formulas All Rights Reserved. 9
11 Clomiphene Terms Definition: Hypogonadism Primary hypogonadism testicular failure Clear need for testosterone supplementation Roadmap: Ways to Increase and / or Maintain Testosterone Levels All Rights Reserved. 10
12 Testosterone Supplementation Treatment of choice for many Baseline lab values needed prior to supplementation What dose / dosage form do I begin with? Testosterone Dosing Options: Subcutaneous Sex Med Sep 17;3(4): doi: /sm2.80. ecollection Pharmacokinetic Profile of Subcutaneous Testosterone Enanthate Delivered via a Novel, Prefilled Single Use Autoinjector: A Phase II Study. Kaminetsky J 1,Jaffe JS 2,SwerdloffRS 3. Testosterone Dosing Options: Intramuscular All Rights Reserved. 11
13 Parenteral: Intramuscular Testosterone Dosing Options Sublingual or Buccal Best given 3 to 4 times a day Absorption is higher than topical However, metabolism is rapid Daily compliance essential for maximum benefit Useful to enhance sexual function in men already on supplementation All Rights Reserved. 12
14 SL / Buccal Testosterone Formulas Testosterone Topical Topical Testosterone Formulas All Rights Reserved. 13
15 Delivery System / Base Implantable Pellets Oral Dosing All Rights Reserved. 14
16 Drugs that Affect Sexual Function PCCA Document #97720 Orgasmic Dysfunction: Yohimbine Decreased Libido and Anorgasmia: Oxytocin All Rights Reserved. 15
17 Premature Ejaculation: Tramadol Premature Ejaculation: Tramadol Low Sperm Production: Mast Cell Blockers All Rights Reserved. 16
18 Erectile Dysfunction: Triple-Mix Injections Erectile Dysfunction: Triple-Mix Injections Dosing ranges: Erectile Dysfunction: Triple-Mix Injections All Rights Reserved. 17
19 Erectile Dysfunction: Natural Supplements References Document with all references available upon request Over 700 pieces of literature on Men s Health PCCA Document # Thank You Questions bbiundo@pccarx.com All Rights Reserved. 18
20 Compounding Opportunities in Women s Health Andrea Branvold, MS, RPh Why Compounding Options are Important in Women s Health Medication on backorder or unavailable Side effects of therapy; compliance Treatment failure with current therapy Combination customized prescription can target the problem with multiple mechanisms of action Why Compounding Options are Important in Women s Health Skyrocketing commercial drug prices Insurance rejections with many commercial drugs Unaffordable copays Compounds offer a variety of clinical options with unique innovative bases and dosage forms All Rights Reserved. 19
21 MucoLox : A Mucoadhesive Base Used in Women s Health MucoLox is a polysaccharide mucosal delivery system Patent pending Unique synergy between Pullulan, Tamarind Xyloglucan, Zea Mays Starch and Sodium Hyaluronate Designed to improve API contact time on mucosal surfaces. Polysaccharides are highly stable, safe, non toxic, hydrophilic and biodegradable Topical Application of Control Product Topical Application of MucoLox Pilot All Rights Reserved. 20
22 Evaluation of the Vaginal Safety and Toxicological Profile of MucoLox MucoLox exerts minimal toxicity on the vaginal mucosa following over 20 hours of exposure Document #98930 Conditions in Women s Health that May Benefit from Prolonged Contact of the Active Pharmaceutical Ingredient Genital herpes Genital warts PCOS Endometriosis Infections Vaginal dryness Vaginal itching Vulvodynia Lichen sclerosus Anal fissures Hemorrhoids Compounding Opportunities for Genital Herpes Prolonged contact of the API may provide benefit Combination therapy is often requested for pain control All Rights Reserved. 21
23 Compounding Opportunities for Genital Herpes Skyrocketing commercial drugs prices for herpes Brand name cream cost to pharmacy could be >$650 for 5 grams!!! (no generic for the cream) Brand name ointment cost to pharmacy could be almost $1200 for 30 grams Acyclovir ointment cost to pharmacy may be anywhere from $280 $650 for 30 grams (depends on contract but average may be >$400) Considerations: May be rejected by insurance Copay may make it unaffordable for patient Compounding Opportunities for Genital Herpes Compounded alternative #11413 Acyclovir 5% / Lidocaine HCl 5% / Deoxy D Glucose 2% Vaginal Gel (MucoLox ) Genital Warts #11111 Fluorouracil (5 FU) 5% Topical Gel (MucoLox / VersaBase ) #11112 Imiquimod 0.5% Vaginal Gel (MucoLox / VersaBase ) #11415 Deoxy D Glucose 0.2% / Acyclovir 5% / Imiquimod 2.5% / Tea Tree Oil 2.5% Vaginal Gel (MucoLox / VersaBase ) PCCA Document #98856 Multi Therapy Use of Topical Imiquimod & Formulas All Rights Reserved. 22
24 PCOS Metformin GI side effects when taken orally; patients are often unable to tolerate it #11542 Metformin HCl 10% Vaginal Gel (MucoLox ) #10871 Metformin HCl 10% Topical Lipoderm #98749 Transdermal Metformin Consultant's Corner by Jane Jones ( Apothagram) PCCA Document #98746 PCOS Nutritional References PCCA Document # Video on Demand: PCOS, Endometriosis, and Sleep Disorders in Menopause Endometriosis #11946 Progesterone 10% Vaginal Gel (MucoLox ) #11950 Danazol 10% Vaginal Gel (MucoLox ) PCCA Document #98746 PCOS Nutritional References PCCA Document #98833 Video on Demand: PCOS, Endometriosis, and Sleep Disorders in Menopause Pelvic Pain Various potential causes Lack of topical / vaginal commercial options Combination gels used vaginally can offer a variety of mechanisms of action #11114 Diazepam 10 mg/gm Vaginal / Rectal Gel (MucoLox / VersaBase ) (BUD Study) #11109 Ketamine HCl 0.5%/Diazepam 1%/Baclofen 2% Vaginal Gel (MucoLox / VersaBase ) #11946 Progesterone 10% Vaginal Gel (MucoLox ) All Rights Reserved. 23
25 Pelvic Pain (cont d) Transdermal pain creams may be an option in some cases; apply externally #9874 Ketoprofen 10% / Cyclobenzaprine HCl 2% Topical Lipoderm (BUD Study) #9380 Ketoprofen 5% / Cyclobenzaprine HCl 0.5% / Lidocaine HCl 5% / Bupivacaine HCl 1% Topical Lipoderm Vaginal Infections Recurrent vaginal infections Commercial options tried first to treat the actual infection Boric acid #11368 Boric Acid 30% Vaginal Gel (MucoLox ) #11367 Boric Acid 600 mg Base MBK / MucoLox Vaginal Suppository (Pink Mold) Resistant infections Yeast (Candida glabrata, resistant C tropicalis) Flucytosine Commercial option for cream not available Per the study: #14 500mg capsules needed to make (only) 45 grams of cream * worldwide.org/assets/uploads/files/ Glabrata%20boric%20acid%205Flu%20copy%202%20 (1)(1).pdf Cost to pharmacy to purchase 500mg x 100 caps (to only use #14 per Rx) may be around $11,000 Insurance rejection or unaffordable copay #11113 Flucytosine 15% Vaginal Cream (MucoLox / VersaBase ) All Rights Reserved. 24
26 Vaginal Dryness Patients asking for alternatives Concern over hormones Non hormonal options Practitioners are aware of estriol and benefits; not commercially available Vaginal Dryness (cont d) Skyrocketing commercial drug products Conjugated estrogen: not bioidentical Estradiol vaginal cream (commercial) 42.5 gram tube cost to the pharmacy is over $250 There are no generic options Insurance rejection Vaginal Dryness (cont d) Compounded alternatives #11115 Estriol 0.05% Vaginal Gel (MucoLox / VersaBase ) #11724 Oxytocin 120 U/Gm Vaginal Gel (MucoLox / VersaBase ) #11118 Sodium Hyaluronate 5 mg/gm Compound Vaginal Gel (MucoLox / VersaBase Gel) #11119 Vitamin E 200 U/Gm Vaginal Gel (MucoLox / VersaBase ) All Rights Reserved. 25
27 Vaginal Itching There could be many reasons for itching; practitioners and patients often seek options after traditional treatments have been tried Moisturizing base may provide a benefit Multi drug therapy in a compounded base may be beneficial especially if cause is unknown Vaginal Itching (cont d) Skyrocketing drug prices Common commercial compound Rx often unavailable Crotamiton / betamethasone commercial products often unavailable to patients A 60 gram tube cost to the pharmacy is close to $500 Compounded alternatives #11887 Tranilast 1% / Betamethasone 0.05% Topical Gel (MucoLox / VersaBase ) #11575 Ketotifen 0.4% Vaginal Gel (MucoLox / VersaBase ) Vulvodynia Prolonged contact time with the mucosa and multidrug therapy may be beneficial to try help with pain #11108 Amitriptyline HCl 2% / Baclofen 2% Vaginal Gel (MucoLox ) #11109 Ketamine HCl 0.5% / Diazepam 1% / Baclofen 2% Vaginal Gel (MucoLox / VersaBase ) #11110 Gabapentin 6% Vaginal Gel (MucoLox / VersaBase ) All Rights Reserved. 26
28 Lichen Sclerosus Prolonged contact time may be helpful for delivery of active pharmaceutical ingredients #11751 Tacrolimus 0.03% Vaginal Gel (MucoLox / VersaBase ) Tacrolimus 0.1% ointment was applied twice daily for 6 weeks, then tapered over a further 6 weeks. Commercial product choices: 100 grams close to $550! #11884 Clobetasol Propionate 0.05% Vaginal Gel (MucoLox / VersaBase ) Anal Fissures There are not commercial topical options available without compounding. #11124 Nifedipine 0.2% Rectal Gel (MucoLox /VersaBase ) Nifedipine 0.2% / Lidocaine HCl 2% Rectal Gel (MucoLox ) Hemorrhoids #11954 Pramoxine HCl 1% / Zinc Oxide 12.5% / Lidocaine HCl 5% Topical Gel (MucoLox ) #11491 Lidocaine 2% / Hydrocortisone 1% Base MBK / Wax / MucoLox Suppository (Rectal Rocket) All Rights Reserved. 27
29 Female Sexual Dysfunction #11947 Testosterone 0.2% Vaginal Gel (MucoLox ) #11948 Sildenafil 1% / Testosterone 0.1% Topical Gel (MucoLox ) Female Sexual Dysfunction #11386 Dehydroepiandrosterone 13 mg/gm Vaginal Gel (MucoLox / VersaBase ) PCCA Document Treatment Options for Vaginal Atrophy: What Do the New Studies Show? by Annie DeReese (Consultant's Corner, Apothagram) See PCCA document #97920 Compounding Ideas / Formulations Marketing Sheet Female Sexual Dysfunction & Libido Thank You Questions All Rights Reserved. 28
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