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1 New Jersey enter for Teaching and Learning Slide 1 / 47 Progressive Science Initiative This material is made freely available at and is intended for the non-commercial use of students and teachers. These materials may not be used for any commercial purpose without the written permission of the owners. NJTL maintains its website for the convenience of teachers who wish to make their work available to other teachers, participate in a virtual professional learning community, and/or provide access to course materials to parents, students and others. lick to go to website: Slide 2 / 47 Mendelian Genetics & Inheritance Patterns Multiple hoice Review 1 Jean-aptiste Lamarck introduced a theory about inheritance in the early 1800s. Which of the following accurately describes his Theory of cquired haracteristics? Slide 3 / 47 Offspring traits are the result of the blending of trait the parents. Offspring traits are the result of parent individuals modifying their traits due to use or non-use. Traits are acquired from genes, and arise only from mother not from the father. Traits are acquired from grandparents and skip the generation altogether.

2 1 Jean-aptiste Lamarck introduced a theory about inheritance in the early 1800s. Which of the following accurately describes his Theory of cquired haracteristics? Slide 3 (nswer) / 47 Offspring traits are the result of the blending of trait the parents. Offspring traits are the result of parent individuals modifying their traits due to use or non-use. Traits are acquired from genes, [This object and is a pull arise tab] only from mother not from the father. nswer Traits are acquired from grandparents and skip the generation altogether. 2 Gregor Mendel was a critical contributor to our understanding of inheritance today. In his experiments he tracked seven visual traits of pea plants and ensured that they produced offspring identical to themselves. What are the terms that we used to identify two separate factors? Slide 4 / 47 genotype; true breeding genotype; cross breeding phenotype; true breeding phenotype; cross breeding 2 Gregor Mendel was a critical contributor to our understanding of inheritance today. In his experiments he tracked seven visual traits of pea plants and ensured that they produced offspring identical to themselves. What are the terms that we used to identify two separate factors? nswer genotype; true breeding genotype; cross breeding phenotype; true breeding phenotype; cross breeding Slide 4 (nswer) / 47

3 3 Mendel crossed two plants, called the P generation. The offspring of this cross are known as hybrids. What are hybrids? Slide 5 / 47 The result of crossing two true breeding plants; the contain two genes, one of each allele. The result of a hybrid cross; they contain two genes each trait, both carrying the recessive allele. The result of a hybrid cross; they contain two genes each trait, both carrying the dominant allele. The result of crossing two true breeding plants; the contain two genes of identical alleles. 3 Mendel crossed two plants, called the P generation. The offspring of this cross are known as hybrids. What are hybrids? Slide 5 (nswer) / 47 The result of crossing two true breeding plants; the contain two genes, one of each allele. The result of a hybrid cross; they contain two genes each trait, both carrying the recessive allele. The result of a hybrid cross; they contain two genes each trait, both carrying the dominant allele. nswer The result of crossing two true breeding plants; the contain two genes of identical alleles. 4 Mendel observed patterns of inheritance for all of the traits he tested. The F1 generation all had a phenotype identical to one of the parents in the P generation. What results did he find for the F2 phenotypes? Slide 6 / 47 ½ had the phenotype of one P generation plant; ½ h phenotype of the F1 parents. ¼ had the phenotype of the F1 generation and ¾ ha phenotype of one of the P generation parents. ¾ had the phenotype of the F1 generation and ¼ ha phenotype of one of the P generation parents. The results were not repeatable and identical for the generation, only for the F1 generation.

4 4 Mendel observed patterns of inheritance for all of the traits he tested. The F1 generation all had a phenotype identical to one of the parents in the P generation. What results did he find for the F2 phenotypes? Slide 6 (nswer) / 47 ½ had the phenotype of one P generation plant; ½ h phenotype of the F1 parents. ¼ had the phenotype of the F1 generation and ¾ ha phenotype of one of the P generation parents. ¾ had the phenotype of the [This F1 object generation is a pull tab] and ¼ ha phenotype of one of the P generation parents. nswer The results were not repeatable and identical for the generation, only for the F1 generation. 5 Which of the following statements best describes one aspect of the chromosomal theory of inheritance, posited after Mendel s time? Slide 7 / 47 hromosomes account for all of the phenotypic trai found in every organism. The hereditary factors from Mendel s experiments a actually single chromosomes. hromosomes can be found within alleles, account different phenotypic traits. The hereditary factors from Mendel s experiments a actually genes located on chromosomes. 5 Which of the following statements best describes one aspect of the chromosomal theory of inheritance, posited after Mendel s time? Slide 7 (nswer) / 47 hromosomes account for all of the phenotypic trai found in every organism. The hereditary factors from Mendel s experiments a actually single chromosomes. hromosomes can be found within alleles, account different phenotypic traits. nswer The hereditary factors from Mendel s experiments a actually genes located on chromosomes.

5 elow is a Punnett square showing a cross between two parents. Use this information to respond to the next five questions. Slide 8 / 47 P generation: x bb omplete dominance: = black rat b = white rat 6 Referring to the Punnett square above, which of the following accurately represents the phenotypic and genotypic ratios of the F1 generation? Slide 9 / 47 Phenotypic ratio 100% white, genotypic ratio 100% Genotypic ratio 100% black, phenotypic ratio 100% Phenotypic ratio 100% black, genotypic ration 100% Phenotypic ratio 50% black, 50% white, genotypic ra 100% b 6 Referring to the Punnett square above, which of the following accurately represents the phenotypic and genotypic ratios of the F1 generation? Slide 9 (nswer) / 47 Phenotypic ratio 100% white, genotypic ratio 100% Genotypic ratio 100% black, phenotypic ratio 100% Phenotypic ratio 100% black, genotypic ration 100% nswer Phenotypic ratio 50% black, 50% white, genotypic ra 100% b

6 7 Using the information in the Punnett square above, how would we refer to the parents and the offspring? Slide 10 / 47 One parent homozygous, one is heterozygous, the offspring are homozygous One parent is homozygous dominant, one parent is homozygous recessive, the offspring are heterozyg One parent is homozygous dominant, one parent is heterozygous recessive, the offspring are homozyg dominant One parent is heterozygous dominant, one is hetero recessive, the offspring are heterozygous dominant 7 Using the information in the Punnett square above, how would we refer to the parents and the offspring? Slide 10 (nswer) / 47 One parent homozygous, one is heterozygous, the offspring are homozygous One parent is homozygous dominant, one parent is homozygous recessive, the offspring are heterozyg One parent is homozygous dominant, one parent is heterozygous recessive, the [This offspring object is a pull tab] are homozyg dominant nswer One parent is heterozygous dominant, one is hetero recessive, the offspring are heterozygous dominant 8 If we were to cross the offspring in the Punnett square above (known as the F1 generation) what will be the genotypic and phenotypic ratios of the F2 generation? Slide 11 / 47 Phenotypic ratio 3:1; genotypic ratio 1:2:1 Phenotypic ratio 1:2:1, genotypic ration 3:1 Phenotypic ratio 3:1, genotypic ration 3:1 Phenotypic ratio 1:2:1, genotypic ration 1:2:1

7 8 If we were to cross the offspring in the Punnett square above (known as the F1 generation) what will be the genotypic and phenotypic ratios of the F2 generation? Slide 11 (nswer) / 47 nswer Phenotypic ratio 3:1; genotypic ratio 1:2:1 Phenotypic ratio 1:2:1, genotypic ration 3:1 Phenotypic ratio 3:1, genotypic ration 3:1 Phenotypic ratio 1:2:1, genotypic [This object is a ration pull tab] 1:2:1 9 Mendel used dihybrid crosses in an effort to uncover more information about inheritance patterns. From this he developed two laws of inheritance. Which of the following accurately described the law of segregation? Slide 12 / 47 This law states that alleles, on different chromosom be inherited independently of one another. This law states that gametes each carry only one all a trait, to be combined when fertilization occurs. This law states that gametes carry two alleles for ea to ensure adequate inheritance by offspring. This law states that alleles, on the same chromosom be inherited independently of one another. 9 Mendel used dihybrid crosses in an effort to uncover more information about inheritance patterns. From this he developed two laws of inheritance. Which of the following accurately described the law of segregation? Slide 12 (nswer) / 47 This law states that alleles, on different chromosom be inherited independently of one another. nswer This law states that gametes each carry only one all a trait, to be combined when fertilization occurs. This law states that gametes carry two alleles for ea to ensure adequate inheritance by offspring. This law states that alleles, on the same chromosom be inherited independently of one another.

8 10 What is considered to be incomplete dominance? Slide 13 / 47 When the phenotype of the hybrid is the same as fo homozygous recessive. When the phenotype of the hybrid is the same as fo homozygous dominant. When the phenotype of the hybrid shows an in-betw phenotype of the two parents. Then the phenotype of the homozygous dominant s an in-between phenotype of the two parents. 10 What is considered to be incomplete dominance? Slide 13 (nswer) / 47 When the phenotype of the hybrid is the same as fo homozygous recessive. When the phenotype of the hybrid is the same as fo homozygous dominant. nswer When the phenotype of the hybrid shows an in-betw phenotype of the two parents. Then the phenotype of the homozygous dominant s an in-between phenotype of the two parents. Slide 14 / 47 cross occurs between a black homozygous mouse and a white homozygous mouse. They produce gray offspring. Use this scenario to respond to the next three questions:

9 11 What type of dominance is reflected in the scenario above? Slide 15 / 47 codominance incomplete dominance complete dominance blending of genes 11 What type of dominance is reflected in the scenario above? Slide 15 (nswer) / 47 codominance nswer incomplete dominance complete dominance blending of genes 12 What are the percentage probabilities for the genotype and phenotype of the offspring? Slide 16 / % black; 100% b 100% gray; 100% bb 100% white; 75% b, 25% bb 100% gray; 100% b

10 12 What are the percentage probabilities for the genotype and phenotype of the offspring? Slide 16 (nswer) / % black; 100% b nswer 100% gray; 100% bb 100% white; 75% b, 25% bb 100% gray; 100% b 13 Referring to the mouse scenario noted above, what is the percentage phenotypic probability if we cross two gray mice from the F1 generation? Slide 17 / % black 75%gray; 25% white 25% black; 50% gray; 25% white 50% black; 50% white 13 Referring to the mouse scenario noted above, what is the percentage phenotypic probability if we cross two gray mice from the F1 generation? Slide 17 (nswer) / % black nswer 75%gray; 25% white 25% black; 50% gray; 25% white 50% black; 50% white

11 14 cross occurs between a chicken with white feathers and a chicken with black feathers. This results in offspring with some black feathers and some white feathers. What type of inheritance is this? Slide 18 / 47 incomplete dominance complete dominance codominance blended dominance 14 cross occurs between a chicken with white feathers and a chicken with black feathers. This results in offspring with some black feathers and some white feathers. What type of inheritance is this? Slide 18 (nswer) / 47 incomplete dominance complete dominance codominance nswer blended dominance 15 Sickle cell disease is the result of one gene abnormality. When two recessive alleles occur, sickle cell disease is inherited. The disease results in mis-shaped hemoglobin. What type of molecule is hemoglobin? Slide 19 / 47 protein carbohydrate lipid RN

12 15 Sickle cell disease is the result of one gene abnormality. When two recessive alleles occur, sickle cell disease is inherited. The disease results in mis-shaped hemoglobin. What type of molecule is hemoglobin? protein carbohydrate lipid RN nswer Slide 19 (nswer) / Polygenic inheritance refers to which of the following conditions of inheritance? Slide 20 / 47 When one allele affects more than one trait. When multiple alleles affect one trait. When multiple alleles affect multiple traits. When one allele dominates another allele. 16 Polygenic inheritance refers to which of the following conditions of inheritance? Slide 20 (nswer) / 47 When one allele affects more than one trait. nswer When multiple alleles affect one trait. When multiple alleles affect multiple traits. When one allele dominates another allele.

13 17 group of individuals have lived for generations on an island. Their average height is 5 feet 2 inches. Eventually, ships stop by the islands bringing more fruits, vegetables and meats to their diet and more food overall. While the islanders continue to marry islanders and produce children, over generations the average height of the islander population reaches 5 feet 6 inches. What was most likely the main factor in this change? Slide 21 / 47 changes and mutations in the genes within the island population of islanders changes in nutrition that affected the phenotype, fully expressing the genotype an influx of new genes from the incoming human population the effect of medications brought by the ships stopping at the island 17 group of individuals have lived for generations on an island. Their average height is 5 feet 2 inches. Eventually, ships stop by the islands bringing more fruits, vegetables and meats to their diet and more food overall. While the islanders continue to marry islanders and produce children, over generations the average height of the islander population reaches 5 feet 6 inches. What was most likely the main factor in this change? Slide 21 (nswer) / 47 changes and mutations in the genes within the island population of islanders changes in nutrition that affected the phenotype, fully expressing the genotype an influx of new genes from the incoming human population nswer the effect of medications brought by the ships stopping at the island Slide 22 / 47 man who is a carrier for cystic fibrosis marries a woman who is a carrier for cystic fibrosis. Respond to the next three questions based upon this scenario.

14 18 What is the percentage probability that this couple will have a child with cystic fibrosis? Slide 23 / 47 50% 100% 75% 25% 18 What is the percentage probability that this couple will have a child with cystic fibrosis? Slide 23 (nswer) / 47 50% 100% 75% 25% nswer 19 What is the percentage probability that they will have a child who is a carrier? Slide 24 / 47 50% 100% 75% 25%

15 19 What is the percentage probability that they will have a child who is a carrier? Slide 24 (nswer) / 47 50% 100% 75% 25% nswer 20 The couple in the above scenario has four children. How many of their children will have cystic fibrosis? Slide 25 / 47 one two it could be none to all of their children it depends whether they are male or female 20 The couple in the above scenario has four children. How many of their children will have cystic fibrosis? Slide 25 (nswer) / 47 one two nswer it could be none to all of their children it depends whether they are male or female

16 21 Issues with inbreeding often occur with dog breeds, such as German shepherds. How can we best describe inbreeding? Slide 26 / 47 successive breeding with individuals from a variety populations successive breeding with individuals from within on population breeding between different breeds to produce new b breeding the same set of parents more than once 21 Issues with inbreeding often occur with dog breeds, such as German shepherds. How can we best describe inbreeding? Slide 26 (nswer) / 47 successive breeding with individuals from a variety populations successive breeding with individuals from within on population nswer breeding between different breeds to produce new b breeding the same set of parents more than once 22 How does inbreeding increase the probabilities of recessive disorders? Slide 27 / 47 arriers have an increased chance of reproducing together to produce a homozygous recessive condi Homozygous recessive individuals are more likely t an reproduce when based within strong families. Spontaneous mutations are increased when closely related organisms reproduce successively The probability that individuals who are homozygou recessive increase as the heterozygous conditions increase

17 22 How does inbreeding increase the probabilities of recessive disorders? Slide 27 (nswer) / 47 arriers have an increased chance of reproducing together to produce a homozygous recessive condi Homozygous recessive individuals are more likely t an reproduce when based within strong families. nswer Spontaneous mutations are increased when closely related organisms reproduce successively The probability that individuals [This object who is a pull are tab] homozygou recessive increase as the heterozygous conditions increase 23 What is true about the majority of sex-linked disorders in humans? Slide 28 / 47 Females have a high probability of inheriting sex lin disorders Males have a higher probability of inheriting sex link disorders Gender does not play a role in the probability of inh a sex linked disorder Females have a higher probability of inheriting rece sex linked disorders. 23 What is true about the majority of sex-linked disorders in humans? Slide 28 (nswer) / 47 Females have a high probability of inheriting sex lin disorders Males have a higher probability of inheriting sex link disorders nswer Gender does not play a role in the probability of inh a sex linked disorder Females have a higher probability [This object is a of pull tab] inheriting rece sex linked disorders.

18 Use the information and the Punnett square below to respond to the next three questions: Slide 29 / 47 Hemophilia is an X linked recessive disorder y 24 What are the chances that this couple will have a child with the hemophilia? Slide 30 / 47 75% 50% 25% 0% 24 What are the chances that this couple will have a child with the hemophilia? Slide 30 (nswer) / 47 75% 50% 25% 0% nswer

19 25 The mother undergoes amniocentesis during her pregnancy, and is told that the child she is carrying is a boy. What are the chances that her son will have hemophilia? Slide 31 / 47 75% 50% 25% 0% 25 The mother undergoes amniocentesis during her pregnancy, and is told that the child she is carrying is a boy. What are the chances that her son will have hemophilia? Slide 31 (nswer) / 47 75% 50% 25% 0% nswer 26 The mother has a second pregnancy four years later. She is told that her baby will be a girl. What are the chances that her daughter will be have hemophilia? Slide 32 / 47 75% 50% 25% 0%

20 26 The mother has a second pregnancy four years later. She is told that her baby will be a girl. What are the chances that her daughter will be have hemophilia? Slide 32 (nswer) / 47 75% 50% 25% 0% nswer 27 Which of the following is accurate about an X- linked trait? Slide 33 / 47 There is a 50% chance that a son inherits an X-linke from his father There is a 25% chance that a son inherits an X-linke from his father There is 0% chance that a son inherits an X-linked t from his father There is an 80% chance that a son inherits an X-link from his father 27 Which of the following is accurate about an X- linked trait? Slide 33 (nswer) / 47 There is a 50% chance that a son inherits an X-linke from his father There is a 25% chance that a son inherits an X-linke from his father nswer There is 0% chance that a son inherits an X-linked t from his father There is an 80% chance that a son inherits an X-link from his father

21 28 Prenatal or fetal tests can be performed that can provide information about the genetic make-up. Which of the following is based upon family history to estimate probabilities of genetic disorders? Slide 34 / 47 amniocentesis pedigrees chorionic villus sampling fetoscopy 28 Prenatal or fetal tests can be performed that can provide information about the genetic make-up. Which of the following is based upon family history to estimate probabilities of genetic disorders? Slide 34 (nswer) / 47 nswer amniocentesis pedigrees chorionic villus sampling fetoscopy Slide 35 / 47 Use the pedigree shown below to answer the next two questions: files/bio%20101/io%20101%20laboratory/pedigree%20nalysis/peigree.htm

22 29 Given the information provided in the pedigree above, what can we determine about the trait seen in the darkened circles and squares? Slide 36 / 47 The trait is autosomal dominant The trait is autosomal recessive The trait is x-linked dominant The trait is x-linked recessive 29 Given the information provided in the pedigree above, what can we determine about the trait seen in the darkened circles and squares? Slide 36 (nswer) / 47 The trait is autosomal dominant The trait is autosomal recessive nswer The trait is x-linked dominant The trait is x-linked recessive 30 What are the genotypes of the parents in level 1, in the above pedigree? Slide 37 / 47 mother is homozygous dominant, father is homozyg recessive mother is homozygous recessive, father is homozyg dominant mother is homozygous recessive, father is heterozy mother is heterozygous, father is homozygous dom

23 30 What are the genotypes of the parents in level 1, in the above pedigree? Slide 37 (nswer) / 47 mother is homozygous dominant, father is homozyg recessive mother is homozygous recessive, father is homozyg dominant nswer mother is homozygous recessive, father is heterozy mother is heterozygous, father [This object is is homozygous a pull tab] dom 31 What determines maleness in humans? Slide 38 / 47 n extra Y chromosome, resulting in YY single X chromosome, resulting in XO single Y chromosome, regardless of number of X chromosomes. single X chromosome, regardless of the presence Y chromosomes. 31 What determines maleness in humans? Slide 38 (nswer) / 47 n extra Y chromosome, resulting in YY single X chromosome, resulting in XO single Y chromosome, regardless of number of X chromosomes. nswer single X chromosome, regardless of the presence Y chromosomes.

24 32 What does the term autosomal refer to? Slide 39 / 47 The non XY chromosomes found in an organism The XY chromosomes found in an organism The dominant homozygous trait The recessive homozygous trait 32 What does the term autosomal refer to? Slide 39 (nswer) / 47 The non XY chromosomes found in an organism The XY chromosomes found in an organism nswer The dominant homozygous trait The recessive homozygous trait 33 Which of the following accurately describes the relationship between a dominant and a recessive allele? Slide 40 / 47 The dominant allele physically alters the recessive a so that it cannot be expressed The dominant allele blends with the recessive allele produce an in-between trait The dominant allele is expressed however the reces allele is unaltered. The dominant allele is more common in the species population than the recessive.

25 33 Which of the following accurately describes the relationship between a dominant and a recessive allele? Slide 40 (nswer) / 47 The dominant allele physically alters the recessive a so that it cannot be expressed The dominant allele blends with the recessive allele produce an in-between trait The dominant allele is expressed [This object is however a pull tab] the reces allele is unaltered. nswer The dominant allele is more common in the species population than the recessive. 34 What type of organisms (for the trait of flower color) are shown crossed in the image below? Slide 41 / 47 false breeding plants heterozygous plants self-breeding plants true breeding plants 34 What type of organisms (for the trait of flower color) are shown crossed in the image below? Slide 41 (nswer) / 47 false breeding plants nswer heterozygous plants self-breeding plants true breeding plants

26 35 The probability of an event, such as inheriting a recessive allele, is ½. The probability of inheriting a second recessive allele is ½. What, then, is the probability of inheriting two recessive alleles? Slide 42 / 47 1/2 1/4 1/8 1/10 35 The probability of an event, such as inheriting a recessive allele, is ½. The probability of inheriting a second recessive allele is ½. What, then, is the probability of inheriting two recessive alleles? Slide 42 (nswer) / 47 1/2 1/4 1/8 1/10 nswer 36 onsider a dihybrid cross between two rabbits Llb x Llb. What are the phenotypic ratios of the offspring? (L = long ears l = short ears; = black b = white) Slide 43 / Long lack: 4 short white 9 Long white: 3 Long lack: 3 short lack: 1 short w 9 Long lack; 3 Long white: 3 short lack: 1 short w 12 short lack: 4 Long lack

27 36 onsider a dihybrid cross between two rabbits Llb x Llb. What are the phenotypic ratios of the offspring? (L = long ears l = short ears; = black b = white) Slide 43 (nswer) / 47 nswer 12 Long lack: 4 short white 9 Long white: 3 Long lack: 3 short lack: 1 short w 9 Long lack; 3 Long white: 3 short lack: 1 short w 12 short lack: 4 Long lack 37 lood type in humans is the result of multiple alleles. lood type is also an example of which type of inheritance pattern? Slide 44 / 47 omplete dominance Incomplete dominance o-dominance X-linked inheritance 37 lood type in humans is the result of multiple alleles. lood type is also an example of which type of inheritance pattern? Slide 44 (nswer) / 47 nswer omplete dominance Incomplete dominance o-dominance X-linked inheritance

28 38 female who is O (i, i O ) mates with a male who is O (i, i O ). What possible blood types can their children inherit? Slide 45 / 47 Types,,, and O Types and O Types and Types, and O 38 female who is O (i, i O ) mates with a male who is O (i, i O ). What possible blood types can their children inherit? Slide 45 (nswer) / 47 nswer Types,,, and O Types and O Types and Types, and O 39 efore having children, a couple prepares a pedigree of their family for one particular autosomal dominant disorder. They chart all of their relatives back three generations. From this information, can they determine whether or not they will have a child with the disorder? Slide 46 / 47 It is possible, but not guaranteed. Yes, they can absolutely tell from this information No, it is not possible with this type of disorder. Yes, they can know with certainty.

29 39 efore having children, a couple prepares a pedigree of their family for one particular autosomal dominant disorder. They chart all of their relatives back three generations. From this information, can they determine whether or not they will have a child with the disorder? Slide 46 (nswer) / 47 It is possible, but not guaranteed. nswer Yes, they can absolutely tell from this information No, it is not possible with this type of disorder. Yes, they can know with certainty. 40 What is meant by the term pleiotropy? Slide 47 / 47 When a single allele affects a single phenotype When a single allele affects multiple phenotypes When multiple alleles affect multiple phenotypes When multiple alleles affect a single phenotype 40 What is meant by the term pleiotropy? Slide 47 (nswer) / 47 When a single allele affects a single phenotype nswer When a single allele affects multiple phenotypes When multiple alleles affect multiple phenotypes When multiple alleles affect a single phenotype

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