2011 Society of Behavioral Sleep Medicine 1
|
|
|
- Alaina Mathews
- 5 years ago
- Views:
Transcription
1 Challenges in Measuring and Shifting the Central Circadian Clock in Humans Helen J Burgess, Ph.D. Professor, Department of Behavioral Sciences Director, Biological Rhythms Research Laboratory Rush University Medical Center Outline Measuring the central clock: questionnaires wrist actigraphy core body temperature melatonin Phase shifting the central clock: exogenous melatonin bright light The Central Circadian System Emens & Burgess, Sleep Med Clin Society of Behavioral Sleep Medicine 1
2 Morningness-Eveningness (Owl-Lark) Questionnaire Horne and Ostberg, Int J Chronobiol Munich ChronoType Questionnaire Roenneberg et al., J Biol Rhythms 2003 Questionnaires ~4 h range in DLMO around each chronotype score so do not use to time circadian treatments Owl Lark Questionnaire: MEQ score Benefits of Munich: Shorter Can estimate social jetlag Munich ChronoType questionnaire: MSFsc score Kantermann, Sung & Burgess, 2015 Journal of Biological Rhythms 2011 Society of Behavioral Sleep Medicine 2
3 Actigraphy More movement = wake Less movement = sleep Two commonly used circadian phase markers temperature (deg C) Tmin raw temperature (deg C) fitted temperature (deg C) salivary melatonin (pg/ml) melato onin (pg/ml) DLMO DLMOff :00 19:00 21:00 23:00 1:00 3:00 5:00 7:00 9:00 11:00 13:00 15:00 17:00 time Pills that are swallowed to monitor temperature have not been hugely successful Society of Behavioral Sleep Medicine 3
4 6-sulphatoxymelatonin (urinary melatonin metabolite) 2008 No NSAIDs for 72 h prior (replace with acetaminophen) No beta-blockers No caffeine or alcohol for 24 h prior Dim light! Concerns: - Sampling rate low (e.g. every 2 h) - Compliance to dim light outside of the lab Most useful for: -Field studies -Unclear on patient s circadian timing DLMO = Dim light melatonin onset temperature (deg C) Tmin raw temperature (deg C) fitted temperature (deg C) salivary melatonin (pg/ml) melato onin (pg/ml) DLMO DLMOff :00 19:00 21:00 23:00 1:00 3:00 5:00 7:00 9:00 11:00 13:00 15:00 17:00 time Put picture of front door In the lab 2011 Society of Behavioral Sleep Medicine 4
5 Melatonin in Plasma 2008 Benefits: - Stronger signal (melatonin 3x higher) Concerns: -In lab only -Some folks don t want an IV -Clogged IV lines, lost data -Assay more expensive Lab DLMOs versus Home DLMOs Healthy controls r=0.91, p<0.001 DSWPD r=0.93, p<0.001 Using in R01 and R34 currently Needs development for clinical practice. Burgess et al. SLEEP Burgess et al. J Sleep Res Society of Behavioral Sleep Medicine 5
6 Shifting the Central Circadian Clock The Central Circadian System iprgcs blue light Period ~24.2 h Emens & Burgess, Sleep Med Clin 2015 The Central Circadian Clock >70% humans have an endogenous circadian period >24 hours Most of us have a natural tendency to drift later Burgess & Eastman, JBR, Society of Behavioral Sleep Medicine 6
7 Two uses: 1. Soporific (3mg) 2. Phase shifting (0.5mg) Melatonin Phase Response Curve (0.5 mg) ase Shift (h) y Advance Ph Delay Advance 3 AFTERNOON 2 5 h before usual bedtime Burgess et al., Delay MORNING -3 Usual waking time Time Relative to Baseline DLMO (h) Average Clock Time (h) Contraindications for Melatonin FDA: dietary supplement driving, operating heavy machinery seeking to become pregnant, pregnant, nursing children except non-24 h disorder, neurodevelopmental disorders asthma blood thinners epilepsy impairs glucose tolerance? interactions with other medications 2011 Society of Behavioral Sleep Medicine 7
8 Melatonin purity? USP Verified Program for Dietary Supplements (nonprofit, voluntary testing) Rugby Melatonin Receptor Agonists Sleep Med Clinics Agomelatine melatonin agonist & serotonin antagonist for depression Tasimelteon for non-24 sleep wake disorder (free running) Ramelteon for insomnia Circadian for insomnia To date, melatonin appears to phase shift as effectively as melatonin agonists 2011 Society of Behavioral Sleep Medicine 8
9 Light Phase Response Curve Phase Shift (h) Delay Advance Symbol for DLMO Delay (move later) NIGHT Reduced sensitivity S L E E P Advance (move earlier) MORNING Hours Before and After the DLMO ~ 3500 lux for 2 h Contraindications for Bright Light Existing eye disease May induce migraines (33% of sufferers) Taking phototoxic medications May induce mania (1% of winter depressives) No adverse events in our clinical trials 2011 Society of Behavioral Sleep Medicine 9
10 Re-timer Luminette 2 Phase shifting during sleep? Cole et al continuous light Figueiro & Rea 2012 flashes Zeitzer et al flashes ~1-2% of light can pass through eyelids, can do without major sleep disruption 2011 Society of Behavioral Sleep Medicine 10
11 Acknowledgments Faculty John Burns, PhD Dingcai Cao, PhD Stephanie Crowley, PhD Charmane Eastman, PhD Jonathan Emens, PhD Ali Keshavarzian, PhD Kristen Knutson, PhD Leon Lack, PhD Jason Ong, PhD Garth Swanson, PhD Alyson Zalta, PhD Research Assistants Catherine Keefner Athanathios Kondilis Muneer Rizvydeen Zerbrina Valdespino-Hayden Lab Manager Thomas Molina Biostatisticians Louis Fogg, PhD Rajan Kumar, PhD Current NIH funding AA021762, AT Society of Behavioral Sleep Medicine 11
Index. sleep.theclinics.com. Note: Page numbers of article titles are in boldface type.
Note: Page numbers of article titles are in boldface type. A Accidents, at work, effect of shift work disorder on, 263 264 Acetylcholine, in circadian rhythms, 100 105 Acrophase, definition of, 301 Actigraphy,
The Diagnosis and Treatment of Circadian Rhythm Disorders
Adelaide Institute for Sleep Health, Repatriation General Hospital, Daw Park, SA The Diagnosis and Treatment of Circadian Rhythm Disorders Professor Leon Lack School of Psychology, Flinders University
Delayed sleep-wake phase disorder and shift work
Delayed sleep-wake phase disorder and shift work James K. Wyatt, Ph.D., D. ABSM, FAASM Director, Section of Sleep Disorders and Sleep-Wake Research Rush University Medical Center Associate Professor of
Circadian Rhythms in Children and Adolescents
Circadian Rhythms in Children and Adolescents Sarah Morsbach Honaker, Ph.D., CBSM Assistant Professor of Pediatrics IU School of Medicine Society for Behavioral Sleep Medicine Practice and Consultation
Dr Alex Bartle. Medical Director Sleep Well Clinic Christchurch
Dr Alex Bartle Medical Director Sleep Well Clinic Christchurch 11:00-11:55 WS #113: Circadian Sleep Disorders 12:05-13:00 WS #125: Circadian Sleep Disorders (Repeated) Overview The Structure of Sleep
Conflicted clocks: social jetlag, entrainment and the role of chronotype Zerbini, Giulia
University of Groningen Conflicted clocks: social jetlag, entrainment and the role of chronotype Zerbini, Giulia IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if
Hetlioz (tasimelteon)
Hetlioz (tasimelteon) Policy Number: 5.01.687 Last Review: 01/2019 Origination: 01/2019 Next Review: 01/2020 Policy Blue Cross and Blue Shield of Kansas City (Blue KC) will provide coverage for Hetlioz
TREATMENT OF DSPD and SHIFT WORK DISORDER
TREATMENT OF DSPD and SHIFT WORK DISORDER James K. Wyatt, Ph.D., D. ABSM, C.BSM, FAASM Director, Section of Sleep Disorders and Sleep-Wake Research Rush University Medical Center Associate Professor of
Conflicted clocks: social jetlag, entrainment and the role of chronotype Zerbini, Giulia
University of Groningen Conflicted clocks: social jetlag, entrainment and the role of chronotype Zerbini, Giulia IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if
A three pulse phase response curve to three milligrams of melatonin in humans
J Physiol 86.2 (28) pp 639 647 639 A three pulse phase response curve to three milligrams of melatonin in humans Helen J. Burgess 1,VictoriaL.Revell 2 and Charmane I. Eastman 1 1 Biological Rhythms Research
Circadian Rhythm Disturbances: What Happens When Your Biological Clock Is In The Wrong Time Zone
Circadian Rhythm Disturbances: What Happens When Your Biological Clock Is In The Wrong Time Zone Steven A. Thau MD Chief, Pulmonary, Sleep Department. Phelps Hospital, Northwell Health Internal Clock Examples
Report. Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle
Current Biology 23, 554 558, August 9, 203 ª203 Elsevier Ltd All rights reserved http://dx.doi.org/0.06/j.cub.203.06.039 Entrainment of the Human Circadian Clock to the -Dark Cycle Report Kenneth P. Wright,
A BIVARIATE MATHEMATICAL MODEL FOR THE EFFECT OF MELATONIN PRODUCTION ON SAMPLINGS
A BIVARIATE MATHEMATICAL MODEL FOR THE EFFECT OF MELATONIN PRODUCTION ON SAMPLINGS Dr. S. Lakshmi 1 and Akanksha A. Desai 2 International Journal of Latest Trends in Engineering and Technology Vol.(7)Issue(4),
MORNINGNESS-EVENINGNESS QUESTIONNAIRE Self-Assessment Version (MEQ-SA) 1. Name: Date:
MORNINGNESS-EVENINGNESS QUESTIONNAIRE Self-Assessment Version (MEQ-SA) 1 Name: Date: For each question, please select the answer that best describes you by circling the point value that best indicates
Self-described ethnicity in the Brazilian 2010 census. Estrada Real The Royal Road
2018/09/22 Detailed phenotyping of sleep and circadian rhythms in a Brazilian community Malcolm von Schantz University of Surrey University of São Paulo www.ifitweremyhome.com Parallels between South Africa
DEGREE (if applicable)
OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) NAME: Eastman, Charmane I. BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors.
Defining and determining the properties of the human sleep homeostat Zavada, Andrei
University of Groningen Defining and determining the properties of the human sleep homeostat Zavada, Andrei IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish
MORNINGNESS-EVENINGNES05S QUESTIONNAIRE Self-Assessment Version (MEQ-SA) 1. Name: Date:
MORNINGNESS-EVENINGNES05S QUESTIONNAIRE Self-Assessment Version (MEQ-SA) 1 Name: Date: For each question, please select the answer that best describes you by circling the point value that best indicates
Human chronobiology, daily routines, and shift work in the Philippines
Occupational Health Nurses Association of the Philippines 48th National Annual Convention & 67th Foundation Anniversary 07 September 2017, Manila Hotel Human chronobiology, daily routines, and shift work
EVALUATION AND MANAGEMENT OF THE CIRCADIAN RHYTHM SLEEP-WAKE DISORDERS
EVALUATION AND MANAGEMENT OF THE CIRCADIAN RHYTHM SLEEP-WAKE DISORDERS James K. Wyatt, Ph.D., D. ABSM, FAASM, C.BSM Director, Section of Sleep Disorders and Sleep/Wake Research, Associate Professor Department
September 26 28, 2013 Westin Tampa Harbour Island. Co-sponsored by
September 26 28, 2013 Westin Tampa Harbour Island Co-sponsored by Insights Into Non-24-Hour Disorder Thomas Roth, PhD Wayne State University Detroit, MI University of Michigan School of Medicine Ann Arbor,
NIH Public Access Author Manuscript Curr Biol. Author manuscript; available in PMC 2014 August 19.
NIH Public Access Author Manuscript Published in final edited form as: Curr Biol. 2013 August 19; 23(16): 1554 1558. doi:10.1016/j.cub.2013.06.039. Entrainment of the Human Circadian Clock to the Natural
The Use of Bright Light in the Treatment of Insomnia
Chapter e39 The Use of Bright Light in the Treatment of Insomnia Leon Lack and Helen Wright Department of Psychology, Flinders University, Adelaide, South Australia PROTOCOL NAME The use of bright light
Sleep and Smith-Magenis Syndrome
Sleep and Smith-Magenis Syndrome Beth Malow, MD, MS Professor of Neurology and Pediatrics Burry Chair in Cognitive Childhood Development Director, Vanderbilt Sleep Disorders Division and Vanderbilt Sleep
Third Department of Psychiatry and Sleep Disorders Center, Institute of Psychiatry and Neurology in Warsaw
Psychiatr. Pol. 2017; 51(5): 793 814 PL ISSN 0033-2674 (PRINT), ISSN 2391-5854 (ONLINE) www.psychiatriapolska.pl DOI: https://doi.org/10.12740/pp/onlinefirst/66810 Treatment guidelines for Circadian Rhythm
z z z What s my story?
What s my story? High school Enjoyed science = med school! Well how did I get here? Bachelors - Penn State Majored in Premed + Psychology Met Jim Smith (from Florida State University) Masters - Psychobiology
Sweet Dreams: The Relationship between Sleep Health and Your Weight
Sweet Dreams: The Relationship between Sleep Health and Your Weight Jason C. Ong, PhD Associate Professor Department of Neurology Center for Circadian and Sleep Medicine Northwestern University Feinberg
Circadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag
CIRCADIAN RHYTHM SLEEP DISORDERS Circadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag Disorders An American Academy of Sleep Medicine Review Robert L Sack, MD 1 ; Dennis Auckley,
Why Do We Sleep At Night?
4 Why Do We Sleep At Night? Now that you know what actually happens across the sleep period, let s look at what determines when we sleep. There are two biological determiners of sleep, sleep pressure and
Light treatment for sleep disorders: consensus report. IV. Sleep phase and duration disturbances.
J Biol Rhythms 1995 Jun;10(2):135-47 Related Articles, Books, LinkOut Light treatment for sleep disorders: consensus report. IV. Sleep phase and duration disturbances. Terman M, Lewy AJ, Dijk DJ, Boulos
Circadian phase delay using the newly developed re-timer portable light device
DOI 10.1007/s41105-015-0034-6 ORIGINAL ARTICLE Circadian phase delay using the newly developed re-timer portable light device Nicole Lovato 1 Leon Lack 2 Received: 24 July 2015 / Accepted: 4 October 2015
SUPPLEMENTARY INFORMATION
SUPPLEMENTARY INFORMATION METHODS Participants. All participants were mentally and physically healthy. The average (± SD) body mass index was 21.4 ± 2.7 kg/m 2 in women and 22.8 ± 2.4 kg/m 2 in men (p=0.18).
Defining and determining the properties of the human sleep homeostat Zavada, Andrei
University of Groningen Defining and determining the properties of the human sleep homeostat Zavada, Andrei IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish
7/23/2018. Nobel Prize Outline. Results of Insufficient or Poorly Timed Sleep
Nobel Prize 2017 Sleep, Circadian Rhythm and the Impact of Insufficient and Poorly Timed Sleep Awarded to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their discoveries of molecular mechanisms
The Journal of Physiology Neuroscience
J Physiol 592.1 (2014) pp 189 202 189 The Journal of Physiology Neuroscience Phase-shifting response to light in older adults Seong Jae Kim 1, Susan Benloucif 1,2, Kathryn Jean Reid 1, Sandra Weintraub
Overview of the Biology of Sleep and Circadian Rhythms
Overview of the Biology of Sleep and Circadian Rhythms Daniel J. Buysse, MD UPMC Professor of Sleep Medicine Professor of Psychiatry and Clinical and Translational Science University of Pittsburgh School
Greg Atkinson 1 and Andrew Thompson 2
Døgnrytme og svømning ydeevne Greg Atkinson 1 and Andrew Thompson 2 1 Health and Social Care Institute, Teesside University 2 Research Institute for Sport and Exercise Sciences, Liverpool John Moores University
Controlled Patterns of Daytime Light Exposure Improve Circadian Adjustment in Simulated Night Work
Controlled Patterns of Daytime Light Exposure Improve Circadian Adjustment in Simulated Night Work Marie Dumont, *,,1 Hélène Blais, * Joanie Roy, * and Jean Paquet * * Chronobiology Laboratory, Sacré-Cœur
Short Nights Reduce Light-Induced Circadian Phase Delays in Humans
1 95 RAPID PUBLICATION 75 Short Nights Reduce Light-Induced Circadian Phase Delays in Humans 25 Helen J. Burgess, PhD; Charmane I. Eastman, PhD 5 Biological Rhythms Research Laboratory, Department of Behavioral
ORIGINAL CONTRIBUTION. Familial Advanced Sleep Phase Syndrome
ORIGIAL COTRIBUTIO Familial Advanced Sleep Phase Syndrome Kathryn J. Reid, PhD; Anne-Marie Chang, BS, BA; Margarita L. Dubocovich, PhD; Fred W. Turek, PhD; Joseph S. Takahashi, PhD; Phyllis C. Zee, MD,
Overview. Introduction. Circadian Rhythm Sleep Disorders. Relationships to Narcolepsy Circadian Sleep Disorders Network
1 Introduction Overview Circadian Rhythm Sleep Disorders Definitions DSPS Non-24 Treatment and Issues Relationships to Narcolepsy Circadian Sleep Disorders Network 2 Circadian Rhythms 24 hours 10 minutes
Taking the Obesity and Diabetes Risk out of Light at Night
Taking the Obesity and Diabetes Risk out of Light at Night Martin Moore-Ede, M.D., Ph.D. CIRCADIAN Light 1980 Discovery: Location of the Human Circadian Clock 2001 Discovery: Blue Light regulates Circadian
Dr. Colin M Shapiro. Professor, Department of Psychiatry and Opthalmology. University of Toronto Director, Sleep and Alertness Clinic
Dr. Colin M Shapiro MBBCh, PhD, MRC Psych. FRCP(C) Professor, Department of Psychiatry and Opthalmology University of Toronto Director, Sleep and Alertness Clinic Youthdale Child & Adolescent Sleep Centre
Phase advancing the human circadian clock with blue-enriched polychromatic light
Sleep Medicine (9) 87 94 Original Article Phase advancing the human circadian clock with blue-enriched polychromatic light Mark R. Smith a,b, Victoria L. Revell c, Charmane I. Eastman a,b, * a Biological
Short Blue Light Pulses (30 Min) in the Morning Support a Sleep-Advancing Protocol in a Home Setting
657462JBRXXX10.1177/0748730416657462Journal of Biological RhythmsGeerdink et al. / Short Blue Light Pulses in the Morning research-article2016 Short Blue Light Pulses (30 Min) in the Morning Support a
Conflicted clocks: social jetlag, entrainment and the role of chronotype Zerbini, Giulia
University of Groningen Conflicted clocks: social jetlag, entrainment and the role of chronotype Zerbini, Giulia IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if
Glasgow, 1055 Great Western Road, Glasgow G12 0XH, UK
Title and running title: Conscientiousness predicts diurnal preference Alexandra L. Hogben* 1 Jason Ellis* 2 Simon N. Archer 1 Malcolm von Schantz 1 * These authors contributed equally to this work 1 Surrey
Module 1 Workbook And Sleep Challenge.
Module 1 Workbook And 10 10 Sleep Challenge. INTRODUCTION. Congratulations for completing module 1. I hope you have learned why a strong circadian rhythm is important, and what you can do to dial in your
LIGHT Feeling healthy,
Performance Anti jet lag Sleep Energy LIGHT Feeling healthy, energized and fit. Chrono Eyewear BV Saal van Zwanenbergweg 11 5026 RM Tilburg The Netherlands info@propeaq.com Propeaq light therapy glasses
Bio-Rhythms. Biorhythms. Presented by: Dr. Magdy Akladios 1. What is a Biorhythm. Biorhythms Theory. SENG/ INDH 5334: Human Factors Engineering
SENG/ INDH 5334: Human Factors Engineering Bio-Rhythms By: Magdy Akladios, PhD, PE, CSP, CPE, CSHM 1 What is a Biorhythm A biorhythm is a hypothetical cyclic pattern of alterations in physiology, emotions,
10 Tips for better Sleep. Cheat Sheet
10 Tips for better Sleep Cheat Sheet Sleep is the one and only time in the 24 hour day that our body has the ability to heal itself. So when I hear people saying that they have no need for sleep, or that
HOW CIRCADIAN RHYTHM CONTROLS YOUR ENERGY, HEALTH, AND BODY COMPOSITION AND HOW TO OPTIMIZE IT
HOW CIRCADIAN RHYTHM CONTROLS YOUR ENERGY, HEALTH, AND BODY COMPOSITION AND HOW TO OPTIMIZE IT Circadian biology has a massive influence on metabolic health and energy levels. Disrupted circadian rhythm
Sleep in Athlete. March 29, 2015
Sleep in Athlete March 29, 2015 Iris A. Perez, M.D. Assistant Professor of Clinical Pediatrics Keck School of Medicine of USC Division of Pediatric Pulmonology and Sleep Medicine Children s Hospital Los
Sleep, the clock and mental health. Dr Kate Porcheret Sleep and Circadian Neuroscience Institute University of Oxford
Sleep, the clock and mental health Dr Kate Porcheret Sleep and Circadian Neuroscience Institute University of Oxford Sleep is fundamental We spend 1/3 of our lives asleep Source: Bureau of Labor Statistics,
The effects of sleep and light at night on melatonin in adolescents
HORMONES 2015, 14(3):399-409 Research paper The effects of sleep and light at night on melatonin in adolescents Caleb Hersh, 1 Julia Sisti, 2 Vincent Richiutti, 3 Eva Schernhammer 2,4,5 1 The College of
Melatonin and Human Chronobiology
Melatonin and Human Chronobiology A.J. LEWY Department of Psychiatry, Oregon Health & Science University, Portland, Oregon 97239-3098 With the development of accurate and sensitive assays for measuring
University of Groningen
University of Groningen Comparison of the Munich Chronotype Questionnaire with the Horne-Östberg s Morningness- Eveningness Score Zavada, Andrei; Gordijn, Marijke C.M.; Beersma, Domien G.M.; Daan, Serge;
Oxford Handbooks Online
Oxford Handbooks Online Circadian Rhythm Disorders I: Phase-Advanced & Phase-Delayed Syndromes Leon C. Lack and Helen R. Wright The Oxford Handbook of Sleep and Sleep Disorders Edited by Colin A. Espie
DO MAJORING SUBJECTS AFFECT THE MORNINGNESS- EVENINGNESS PREFERENCE BY STUDENTS?
J. Human Ergol., 28: 49-53, 1999 Communications DO MAJORING SUBJECTS AFFECT THE MORNINGNESS- EVENINGNESS PREFERENCE BY STUDENTS? TETSUO HARADA AND MITSUAKI INOUE Laboratory of Environmental Physiology,
Start Time Survey Analysis
Start Time Survey Analysis Prepared for Simsbury Public Schools (minor additions/edits made by SPS Administration) January 2018 www.hanoverresearch.com Table of Contents Key Points from Sleep Expert Presentation:
INSOMNIA IN GERIATRICS. Presented By: Sara Kamalfar MD, Geriatrics Medicine Fellow
INSOMNIA IN GERIATRICS Presented By: Sara Kamalfar MD, Geriatrics Medicine Fellow Insomnia Insomnia is the inability to fall asleep, the inability to stay asleep, or waking up earlier than desired. To
to dusk Chris Aiken, MD Instructor, Wake Forest University Dept of Psychiatry Director, Mood Treatment Center NCPA, 2018
DAWN to dusk Chris Aiken, MD Instructor, Wake Forest University Dept of Psychiatry Director, Mood Treatment Center NCPA, 2018 Disclaimer Materials that are included in this course may include interventions
Clinical Trial Synopsis TL , NCT#
Clinical Trial Synopsis, NCT#00492011 Title of Study: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Ability of Ramelteon 1 mg, 4 mg, and 8 mg to Alleviate the Insomnia
Feasibility and Efficacy of Bright Light Therapy in Depressed Adolescent Inpatients
Original Article Feasibility and Efficacy of Bright Light Therapy in Depressed Adolescent Inpatients First Open-Label, Single-Arm, Prospective Clinical Trial Inken Kirschbaum-Lesch 1, Stephanie Gest 1,
DAWN. to dusk. Chris Aiken, MD Instructor, Wake Forest University Dept of Psychiatry Director, Mood Treatment Center. Friday, September 28, 2018
Dawn to Dusk Chris Aiken, MD DAWN to dusk Chris Aiken, MD Instructor, Wake Forest University Dept of Psychiatry Director, Mood Treatment Center NCPA, 2018 Disclaimer Materials that are included in this
The effect of circadian rhythm on the perceived tinnitus severity: A preliminary study
ORIGINAL ARTICLE DOI: 10.5935/0946-5448.20140006 International Tinnitus Journal. 2014;19(1):41-45. The effect of circadian rhythm on the perceived tinnitus severity: A preliminary study Abstract Thomas
Influence of Light at Night on Melatonin Suppression in Children. Shigekazu Higuchi, Yuki Nagafuchi, Sang-il Lee, and Tetsuo Harada
ORIGINAL Endocrine ARTICLE Research Influence of Light at Night on Melatonin Suppression in Shigekazu Higuchi, Yuki Nagafuchi, Sang-il Lee, and Tetsuo Harada Department of Human Science (S.H., Y.N., S.L.),
NIH Public Access Author Manuscript Neuro Endocrinol Lett. Author manuscript; available in PMC 2012 May 10.
NIH Public Access Author Manuscript Published in final edited form as: Neuro Endocrinol Lett. 2010 ; 31(1): 92 96. Lack of short-wavelength light during the school day delays dim light melatonin onset
The Relationships between Sleep-Wake Cycle and Academic Performance in Medical Students
Biological Rhythm Research 0165-0424/01/3202-263$16.00 2001, Vol. 32, No. 2, pp. 263 270 Swets & Zeitlinger The Relationships between Sleep-Wake Cycle and Academic Performance in Medical Students Ana Ligia
Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory
J Sleep Res. (213) 22, 155 159 Circadian rhythms Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory ALPAR S. LAZAR 1 *, NAYANTARA
How to Trick Mother Nature into Letting You Fly Around or Stay Up All Night
10.1177/0748730405277233 JOURNALOF Revell, Eastman BIOLOGICALRHYTHMS / HOW TO TRICK MOTHER / August NATURE 2005 JET LAG & SHIFTWORK How to Trick Mother Nature into Letting You Fly Around or Stay Up All
Make sure you remember the Key Concepts
A2 Psychology Term 1 Module 4 Physiological Psychology Biological Rhythms, Sleep and Dreaming Area of Study: Biological Rhythms. Lesson 7 Getting you Thinking pg 403 Make sure you remember the Key Concepts
Differential effects of light wavelength in phase advancing the melatonin rhythm
J. Pineal Res. 24; 36:14 144 Copyright Ó Blackwell Munksgaard, 24 Journal of Pineal Research Differential effects of light wavelength in phase advancing the melatonin rhythm Abstract: Shorter wavelength
Relationship of chronotype to sleep pattern in a cohort of college students during work days and vacation days
Indian Journal of Experimental Biology Vol. 52, May 2014, pp. 569-574 Relationship of chronotype to sleep pattern in a cohort of college students during work days and vacation days Arjita Yadav & Sudhi
MEDICAL CHALLENGES: EFFECTS of TRAVEL FATIGUE and JET LAG
MEDICAL CHALLENGES: EFFECTS of TRAVEL FATIGUE and JET LAG Prof Christa Janse van Rensburg MBChB, MSc, MMed, MD FACSM, FFIMS Sports Medicine & SEMLI, University of Pretoria Consultant Rheumatologist, Eugene
Circadian Period and the Melatonin Rhythm in Men and Women: Predictors of Sleep during the Weekend and in the Laboratory
Circadian Period and the Melatonin Rhythm in Men and Women: Predictors of Sleep during the Weekend and in the Laboratory Running title: Circadian period and weekend sleep JOSR-12-134-R1 Alpar S Lazar*
NIH Public Access Author Manuscript Sleep Med Clin. Author manuscript; available in PMC 2010 June 1.
NIH Public Access Author Manuscript Published in final edited form as: Sleep Med Clin. 2009 June 1; 4(2): 241 255. doi:10.1016/j.jsmc.2009.02.006. How To Travel the World Without Jet lag Charmane I. Eastman,
Sleep and mental wellbeing: exploring the links
Sleep and mental wellbeing: exploring the links Like most physiological functions, the length and quality of sleep is influenced by a host of biological, environmental and lifestyle factors. Across all
3 SAMPL E REPORT S. This Assessment features three reporting options: Rhythm Adrenocortex Stress Profile Comprehensive Melatonin Profile GDX-4-225
3 SAMPL E REPORT S This Assessment features three reporting options: Rhythm Adrenocortex Stress Profile Comprehensive Melatonin Profile GDX-4-225 SAMPLE REPORT Rhythm Patient: SAMPLE PATIENT ID: Page 2
The effect of sleeping patterns on mental distress and overweight risk under shifting light conditions in north Norway.
UNIVERSITY HOSPITAL OF NORTH NORWAY, TROMSØ DEPARTMENT OF CLINICAL MEDICINE FACULTY OF HEALTH SCIENCES, UNIVERSITY OF TROMSØ The effect of sleeping patterns on mental distress and overweight risk under
Subject: Hetlioz (tasimelteon) Original Effective Date: 4/26/2016. Policy Number: MCP-273. Revision Date(s): Review Date(s): DISCLAIMER
Subject: Hetlioz (tasimelteon) Original Effective Date: 4/26/2016 Policy Number: MCP-273 Revision Date(s): Review Date(s): DISCLAIMER This Medical Policy is intended to facilitate the Utilization Management
MESA EXAM 5 ANCILLARY STUDY 113 SLEEP QUESTIONNAIRE DATA SET VARIABLE GUIDE
MESA EXAM 5 ANCILLARY STUDY 113 SLEEP QUESTIONNAIRE DATA SET VARIABLE GUIDE Data Set name : Principal Investigator : Contact Information : MESAe5_SleepQ_20140617 Susan Redline sredline1@rics.bwh.harvard.edu
A Reliability Study of The Turkish Version of The Morningness-Eveningness Questionnaire
Türk Psikiyatri Dergisi 2005; 16(1): Turkish Journal of Psychiatry A Reliability Study of The Turkish Version of The Morningness-Eveningness Questionnaire Zekine PÜNDÜK, Hakan GÜR, İlker ERCAN SUMMARY
Who s Not Sleepy at Night? Individual Factors Influencing Resistance to Drowsiness during Atypical Working Hours
Who s Not Sleepy at Night? Individual Factors Influencing Resistance to Drowsiness during Atypical Working Hours Halszka OGINSKA Department of Ergonomics, Jagiellonian University, Kraków, Poland Abstract:
Introduction. What is Shiftwork. Normal Human Rhythm. What are the Health Effects of Shiftwork? Blue Light
Shiftwork Health Effects and Solutions James Miuccio, MSc, CIH, CRSP Occupational Hygienist February 28, Introduction What is Shiftwork Normal Human Rhythm What are the Health Effects of Shiftwork? Blue
John McLachlan. Clinical Lead Pulmonary Physiology & Sleep Medicine. President Elect, WA Branch Thoracic Society of Australia & NZ
John McLachlan Respiratory & Sleep Physician @FSH Clinical Lead Pulmonary Physiology & Sleep Medicine Sleep Physician x 27 years Interest in Insomnia management President Elect, WA Branch Thoracic Society
Index. sleep.theclinics.com. Note: Page numbers of article titles are in boldface type.
Note: Page numbers of article titles are in boldface type. A Actigraphy, 475, 485, 496 Adolescents, sleep disorders in, 576 578 Adults, sleep disorders in, 578 580 Advanced sleep phase disorder, 482 Age,
SLEEP AND MELATONIN SECRETION ABNORMALITIES IN CHILDREN & ADOLESCENTS WITH FASD DR. S. GORIL DR. D. ZALAI DR. C. SHAPIRO DR. L. A.
SLEEP AND MELATONIN SECRETION ABNORMALITIES IN CHILDREN & ADOLESCENTS WITH FASD DR. S. GORIL DR. D. ZALAI DR. C. SHAPIRO DR. L. A. SCOTT SLEEP Pivotal role in brain development during maturation Sleep
Healthy Sleep Tips Along the Way!
Women and Sleep What You Will Learn The Benefits and Importance of Sleep States and Stages of the Sleep Cycle Unique Physiology of Women s Sleep Common Disorders in Women that Affect Sleep Women s Role
CHAPTER. Summary, Conclusion and Recommendations
CHAPTER 5 Summary, Conclusion and Recommendations SCeep!J3efia viour aruf
Robert C. Whitaker, MD, MPH Professor of Epidemiology, Biostatistics and Pediatrics Temple University Philadelphia, PA
37 th Annual Meeting Society of Behavioral Medicine The Impact of School Start Time Change on Adolescents Sleep, Health, Safety, and School Functioning Robert C. Whitaker, MD, MPH Professor of Epidemiology,
Virtual Mentor American Medical Association Journal of Ethics November 2009, Volume 11, Number 11:
Virtual Mentor American Medical Association Journal of Ethics November 2009, Volume 11, Number 11: 876-881. CLINICAL PEARL Managing the Effects of Shift Work in Medicine Holger Link, MD, and Robert Sack,
Beyond our eyes: the non-visual impact of light
Beyond our eyes: the non-visual impact of light Christian Cajochen, PhD Centre for Chronobiology Psychiatric Hospital of the University of Basel, Switzerland Workshop Intelligent Efficient Human Centric
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution
Nonvisual effects of light. Prof. Grega Bizjak, PhD Laboratory of Lighting and Photometry Faculty of Electrical Engineering University of Ljubljana
Nonvisual effects of light Prof. Grega Bizjak, PhD Laboratory of Lighting and Photometry Faculty of Electrical Engineering University of Ljubljana Visual and nonvisual effects of light MIND VISION HEALTH
Circadian rhythm sleep-wake disorders and treatment. Debra J. SKENE. Chronobiology. University of Surrey, Guildford, UK.
Circadian rhythm sleep-wake disorders and treatment Debra J. SKENE Chronobiology University of Surrey, Guildford, UK d.skene@surrey.ac.uk ICSD3, 2014 Circadian Rhythm Sleep-Wake Disorders Extrinsic Jet
Consciousness, Stages of Sleep, & Dreams. Defined:
Consciousness, Stages of Sleep, & Dreams I. Consciousness Conscious is: Waking Consciousness Defined: Altered State of Consciousness Defined: Most of waking life Fuzzy, organized, bizarre thoughts Examples:
Sleep Putting in Place the Missing Foundation for Your Patient. Dr. Catherine Darley The Institute of Naturopathic Sleep Medicine
Sleep Putting in Place the Missing Foundation for Your Patient Dr. Catherine Darley The Institute of Naturopathic Sleep Medicine Learning Objectives: 1. Review basic sleep physiology and circadian rhythms
Teenagers: Sleep Patterns and School Performance
The National Healthy Sleep Awareness Project involves a partnership between the American Academy of Sleep Medicine, Center for Disease Control and Sleep Research Society. The long term goal of the project