CHAPTER FOUR: MARKET SIZE AND GROWTH SLEEP MEDICATIONS MARKET PRESCRIPTION... 40
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1 CHAPTER ONE: INTRODUCTION... 1 STUDY GOALS AND OBJECTIVES... 1 REASONS FOR STUDY... 1 SCOPE OF STUDY... 1 METHODOLOGY AND INFORMATION SOURCES... 2 ANALYST CREDENTIALS... 2 RELATED BCC REPORTS... 2 BCC ONLINE SERVICES... 3 DISCLAIMER... 3 CHAPTER TWO: EXECUTIVE SUMMARY... 4 EXECUTIVE SUMMARY... 4 EXECUTIVE SUMMARY (CONTINUED)... 5 EXECUTIVE SUMMARY (CONTINUED)... 6 SUMMARY TABLE A TOTAL WORLDWIDE MARKET FOR SLEEP AIDS BY PRODUCT TYPE, THROUGH 2014 ($ MILLIONS)... 7 SUMMARY TABLE B WORLWIDE MARKET FOR SLEEP AIDS: TECHNOLOGIES AND MARKETS BY REGION, (%)... 8 SUMMARY FIGURE PERCENT OF TOTAL WORLWIDE MARKET FOR SLEEP AIDS: TECHNOLOGIES AND MARKETS BY REGION, 2014 (%)... 8 CHAPTER THREE: INDUSTRY OVERVIEW... 9 PHYSIOLOGY OF SLEEP... 9 STAGES OF SLEEP... 9 NREM Sleep Stage Stage Stage Stage REM Sleep SLEEP CYCLE BIOLOGICAL CLOCK FACTORS AFFECTING SLEEP COMFORT LEVEL ANXIETY AND STRESS CULTURAL NORMS DRUGS/MEDICATIONS ENVIRONMENT HORMONES LIFESPAN CONSIDERATIONS Lifespan Considerations (Continued) LIFESTYLE NUTRITION/DIET... 16
2 ALTERATION IN SLEEP PATTERNS INSOMNIA Psychological Insomnia Idiopathic Insomnia Sleep-State Misinterpretation NARCOLEPSY/HYPERSOMNIA SLEEP APNEA AND SNORING PARASOMNIA SLEEP DEPRIVATION DEMOGRAPHICS TABLE 1 WORLD POPULATION BY SELECTED GEOGRAPHICAL REGION, (MILLIONS) TABLE 2 ESTIMATED WORLD POPULATION BY AGE AND GEOGRAPHICAL REGION, 2008 (MILLIONS) TABLE 2 (CONTINUED) TABLE 3 PERCENTAGE OF WORLWIDE POPULATION OVER 65 BY YEAR AND REGION, (%) FIGURE 1 PERCENTAGE OF WORLDWIDE POPULATION OVER 65 BY YEAR AND REGION, (%) PREVALENCE OF SLEEP APNEA TABLE 4 PREVALENCE OF SLEEP APNEA WORLDWIDE BY REGION AND COUNTRY, TABLE 4 (CONTINUED) TABLE4 (CONTINUED) TABLE 4 (CONTINUED) OTHER SLEEP DISORDER STATISTICS TABLE 5 U.S. OTHER SLEEP DISORDER STATISTICS NARCOLEPSY RESTLESS LEG SYNDROME SUBSTANCE ABUSE AND SLEEP DISORDERS ALTERNATIVE SNORING AIDS ALTERNATIVE SNORING AIDS (CONTINUED) REIMBURSEMENT SLEEP AND THE ELDERLY DROWSY DRIVING HOME TESTING HOME TESTING (CONTINUED) OTHER SLEEP PRODUCTS OBESITY AND SLEEP PROBLEMS INNOVATIVE COST-SAVING PROGRAMS INNOVATIVE COST-SAVING PROGRAMS (CONTINUED) CHAPTER FOUR: MARKET SIZE AND GROWTH SLEEP MEDICATIONS MARKET PRESCRIPTION... 40
3 Benzodiazepines ProSom Dalmane Doral Restoril Halcion Nonbenzodiazepines Lunesta Ambien Sonata Melatonin Receptor Agonists Rozerem Narcolepsy Treatment Provigil Restless Leg Syndrome ReQuip Mirapex Neupro TABLE 6 GLOBAL SELECTED MARKETED PRESCRIPTION SLEEP AIDS, 2008 ($ MILLIONS) TABLE 6 (CONTINUED) OTC Medications Medications (Continued) TABLE 7 GLOBAL SELECTED MARKETED OTC SLEEP AIDS, 2008 ($ MILLIONS) Natural Remedies Herbs Melatonin Tryptophan, L-tryptophan New Over-the-Counter Sleep Aids New Over-the- (Continued) SLEEP MEDICATION MARKET SIZE AND FORECAST TABLE 8 GLOBAL MARKET FOR SLEEP AID MEDICATIONS AT MANUFACTURERS SALES LEVELS, THROUGH 2014 ($ MILLIONS) FIGURE 2 GLOBAL MARKET FOR SLEEP AID MEDICATIONS AT MANUFACTURERS SALES LEVELS, THROUGH 2014 ($ MILLIONS) TABLE 9 GLOBAL MARKET FOR PRESCRIPTION SLEEP AID MEDICATIONS BY TYPE AT MANUFACTURERS SALES LEVELS, THROUGH 2014 ($ MILLIONS)... 55
4 FIGURE 3 GLOBAL MARKET FOR PRESCRIPTION SLEEP AID MEDICATIONS BY TYPE AT MANUFACTURERS SALES LEVELS, THROUGH 2014 ($ MILLIONS) TABLE 10 GLOBAL MARKET FOR OTC SLEEP AID MEDICATIONS BY DRUG CLASS AT MANUFACTURERS SALES LEVELS, THROUGH 2014 ($ MILLIONS) FIGURE 4 GLOBAL MARKET FOR OTC SLEEP AID MEDICATIONS BY DRUG CLASS AT MANUFACTURERS SALES LEVELS, ($ MILLIONS) United States European Union Japan Rest of World TABLE 11 GLOBAL MARKET FOR SLEEP AID MEDICATIONS BY REGION, THROUGH 2014 ($ MILLIONS) FIGURE 5 GLOBAL MARKET FOR SLEEP AID MEDICATIONS BY REGION, ($ MILLIONS) TABLE 12 GLOBAL PERCENTAGE OF MARKET FOR SLEEP AID MEDICATIONS BY REGION, (%) FIGURE 6 GLOBAL PERCENTAGE OF MARKET FOR SLEEP AID MEDICATIONS BY REGION, (%) COMPETITIVE ANALYSIS OF THE PRESCRIPTION AND OTC SLEEP AID MEDICATIONS MARKET TABLE 13 GLOBAL COMPETITIVE ANALYSIS OF PRESCRIPTION AND OTC SLEEP AIDS BY DRUG MANUFACTURER REVENUES AND MARKET SHARE, 2009 ($ MILLIONS/%) FIGURE 7 GLOBAL COMPETITIVE ANALYSIS OF PRESCRIPTION AND OTC SLEEP AIDS BY DRUG MANUFACTURER REVENUES, 2009 ($ MILLIONS) SLEEP APNEA DEVICES MARKET SLEEP APNEA Obstructive Sleep Apnea Obstructive Sleep Apnea (Continued) Obstructive Sleep Apnea (Continued) Obstructive Sleep Apnea (Continued) Obstructive Sleep Apnea (Continued) Central Apnea Central Apnea (Continued) Mixed Apnea SLEEP APNEA THERAPEUTIC EQUIPMENT Flow Generators CPAP Devices Bi-Level PAP Devices APAP Devices... 72
5 Facial Interfaces SLEEP APNEA DEVICE MARKET SIZE AND FORECAST TABLE 14 GLOBAL MARKET FOR SLEEP APNEA DEVICES, THROUGH 2014 ($ MILLIONS) United States European Union Japan Rest of World TABLE 15 GLOBAL MARKET FOR SLEEP APNEA DEVICES BY REGION, THROUGH 2014 ($ MILLIONS) FIGURE 8 GLOBAL MARKET FOR SLEEP APNEA DEVICES BY REGION, ($ MILLIONS) TABLE 16 GLOBAL MARKET FOR SLEEP APNEA DEVICES BY REGION, (%) COMPETITIVE ANALYSIS OF THE SLEEP APNEA DEVICES MARKET TABLE 17 COMPETITIVE ANALYSIS OF SLEEP APNEA DEVICE MANUFACTURERS WITH GLOBAL MARKET SHARES AND REVENUES, 2009 ($ MILLIONS/%) FIGURE 9 COMPETITIVE ANALYSIS OF SLEEP APNEA DEVICE MANUFACTURERS WITH GLOBAL MARKET SHARES, 2009 (%) SLEEP LABORATORIES MARKET BACKGROUND OF SLEEP LABORATORIES SLEEP LAB PROTOCOLS Polysomnogram Split Night Study Multiple Sleep Latency Test CPAP Titration Study SLEEP LABORATORIES MARKET SIZE AND FORECAST TABLE 18 GLOBAL MARKET FOR SLEEP LABORATORIES BY REGION, THROUGH 2014 ($ MILLIONS) FIGURE 10 GLOBAL MARKET FOR SLEEP LABORATORIES BY REGION, ($ MILLIONS) TABLE 19 GLOBAL MARKET FOR SLEEP LABORATORIES BY REGION, THROUGH 2014 (%) FIGURE 11 GLOBAL MARKET FOR SLEEP LABORATORIES BY REGION, 2014 (%) MATTRESS AND PILLOW MARKET MATTRESSES Innerspring Foam Air Beds Air Beds (Continued) PILLOWS... 86
6 Bed Pillows Orthopedic Pillows Decorative Decorative (Continued) MATTRESS AND PILLOW MARKET SIZE AND FORECAST TABLE 20 GLOBAL MARKET FOR MATTRESSES AND PILLOWS, THROUGH 2014 ($ MILLIONS) FIGURE 12 GLOBAL MARKET FOR MATTRESSES AND PILLOWS, ($ MILLIONS) TABLE 21 GLOBAL MARKET FOR MATTRESSES AND PILLOWS BY REGION, THROUGH 2014 ($ MILLIONS) FIGURE 13 GLOBAL MARKET FOR MATTRESSES AND PILLOWS BY REGION, ($ MILLIONS) TABLE 22 GLOBAL MARKET FOR MATTRESSES AND PILLOWS BY REGION, (%) FIGURE 14 GLOBAL MARKET FOR MATTRESSES AND PILLOWS BY REGION, 2014 (%) COMPETITIVE ANALYSIS OF THE MATTRESS AND PILLOW MARKET Competitive Analysis of the Mattress (Continued) TABLE 23 GLOBAL COMPETITIVE ANALYSIS OF MATTRESS AND PILLOW MANUFACTURERS WITH MARKET SHARES AND REVENUES, 2009 ($ MILLIONS/%) FIGURE 15 GLOBAL COMPETITIVE ANALYSIS OF MATTRESS AND PILLOW MANUFACTURERS REVENUES, 2009 ($ MILLIONS) CHAPTER FIVE RESEARCH AND DEVELOPMENT RECENT APPROVALS EDLUAR ZOLPIMIST AWAITING APPROVAL CILTYRI INDIPLON INTERMEZZO SILENOR SOLZIRA PHASE III ALMOREXANT NUVIGIL VEC-162 (TASIMELTEON) TABLE 24 DRUGS IN DEVELOPMENT WORLDWIDE FOR SLEEP DISORDERS, TABLE 24 (CONTINUED) NEW DEVELOPMENTS MARKET SUMMARY
7 TOTAL MARKET TABLE 25 GLOBAL MARKET FOR SLEEP AIDS: TECHNOLOGIES AND MARKETS, THROUGH 2014 ($ MILLIONS) TOTAL MARKET BY PRODUCT TYPE TABLE 26 GLOBAL MARKET FOR SLEEP AIDS BY PRODUCT TYPE, THROUGH 2014 ($ MILLIONS) FIGURE 16 GLOBAL MARKET FOR SLEEP AIDS BY PRODUCT TYPE, ($ MILLIONS) FIGURE 17 GLOBAL MARKET FOR SLEEP AIDS BY PRODUCT TYPE, 2009 (%) FIGURE 17 (CONTINUED) TOTAL MARKET BY GEOGRAPHIC REGION TABLE 27 GLOBAL MARKET FOR SLEEP AIDS: TECHNOLOGIES AND MARKETS BY REGION, THROUGH 2014 ($ MILLIONS) FIGURE 18 GLOBAL MARKET FOR SLEEP AIDS: TECHNOLOGIES AND MARKETS BY REGION, THROUGH 2014 ($ MILLIONS) TABLE 28 GLOBAL MARKET FOR SLEEP AIDS: TECHNOLOGIES AND MARKETS BY REGION, (%) FIGURE 19 GLOBAL MARKET FOR SLEEP AIDS: TECHNOLOGIES AND MARKETS BY REGION, (%) TOTAL COMPETITIVE ANALYSIS OF THE SLEEP AIDS MARKET TABLE 29 TOP COMPETITORS IN SLEEP AIDS: TECHNOLOGIES AND GLOBAL MARKETS, 2009 ($ MILLIONS/%) FIGURE 20 TOP COMPETITORS IN SLEEP AIDS: TECHNOLOGIES AND GLOBAL MARKETS, 2009 (%) INDUSTRY PARTICIPANTS BY PRODUCT TYPE TABLE 30 SELECTED SLEEP AID DISORDERS TREATMENT MANUFACTURERS BY TYPE, TABLE 30 (CONTINUED) CHAPTER SIX: COMPANY PROFILES CADWELL LABORATORIES, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY CAREFUSION CORP BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 31 COMPANY REVENUES, 2008 AND CEPHALON, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY
8 TABLE 32 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) COMPUMEDICS, LTD. AUSTRALIA BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 33 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) DEVILBISS HEALTHCARE BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY EMBLA SYSTEMS BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY FISHER & PAYKEL BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 34 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) GLAXOSMITHKLINE BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 35 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) JOHNSON & JOHNSON BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 36 COMPANY REVENUES, 2008 AND 2009 ($ BILLIONS) KING PHARMACEUTICALS, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 37 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) MERCK & CO., INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 38 COMPANY REVENUES 2007 AND 2008 ($ MILLIONS) NATUS MEDICAL, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 39 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS)
9 NEUROCRINE BIOSCIENCES, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 40 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) NOVADEL PHARMA, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 41 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) PFIZER, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 42 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) PHILIPS RESPIRONICS, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 43 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) RESMED, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 44 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) SANOFI-AVENTIS BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 45 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) SEALY CORP BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 46 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) SELECT COMFORT CORP BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 47 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) SEPRACOR, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY
10 TABLE 48 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) SLEEPMED, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY SOMAXON PHARMACEUTICALS, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 49 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) TEMPUR-PEDIC INTERNATIONAL, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 50 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) UCB, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 51 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) VANDA PHARMACEUTICALS, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 52 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) XENOPORT, INC BRIEF HISTORY PRODUCTS COMPANY REVENUE HISTORY TABLE 53 COMPANY REVENUES, 2008 AND 2009 ($ MILLIONS) APPENDIX A SLEEP ASSOCIATIONS AMERICAN ACADEMY OF SLEEP MEDICINE AMERICAN SLEEP APNEA ASSOC AMERICAN SLEEP DISORDERS ASSOCIATIONS (ASDA) INTERNATIONAL SLEEP PRODUCTS ASSOC. (ISPA) NARCOLEPSY NETWORK, INC NATIONAL CENTER ON SLEEP DISORDERS RESEARCH (NCSDR) NATIONAL FOUNDATION FOR SLEEP AND RELATED DISORDERS IN CHILDEN (NFSRDC) NATIONAL HEART, LUNG AND BLOOD INSTITUTE (NHLBI) NATIONAL SLEEP FOUNDATION
11 SLEEP MEDICINE RESEARCH FOUNDATION, INC APPENDIX B TABLE 54 LIST OF PARTICIPATING COMPANIES TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED) TABLE 54 (CONTINUED)
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