Clinician s Manual on Restless Legs Syndrome
|
|
- Georgia Marsh
- 5 years ago
- Views:
Transcription
1 Clinician s Manual on Restless Legs Syndrome
2
3 Mark J. Buchfuhrer Clinician s Manual on Restless Legs Syndrome Second Edition
4 Mark J. Buchfuhrer PIH Health Hospital - Downey Downey, CA USA ISBN ISBN (ebook) DOI / Library of Congress Control Number: Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Adis imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
5 To my wife, Dr Laurie Buchfuhrer, who has supported me and my work on RLS for the past three decades which has facilitated the development of my skills and expertise treating RLS patients and performing research and publishing in the field of RLS. I also thank her for very helpful efforts and insights aiding me with editing this manual. To Dr Wayne Henning, my coauthor of the first edition of this publication who has been missed by the RLS community since his untimely death. He was one of my original mentors, and as a teacher and clinician, he was a major influence in advancing the knowledge and awareness of RLS at a time when RLS was a little-known disease with limited therapeutic options.
6
7 Preface For many years perhaps many centuries restless legs syndrome (RLS) has been something of a stealthy sensorimotor disorder. The current RLS Foundation ( had its origin as a small newsletter group brought together by the National Organization for Rare Disorders. However, RLS was not and is not rare. In fact, it is relatively common and, in some settings, more than 10 % of adults can merit a diagnosis of RLS. In the last years, a series of studies within different populations in the primary care setting have shown that RLS can present in every medical setting. RLS can be seen by internists, family doctors, pediatricians, sleep specialists, rheumatologists, endocrinologists, gynecologists, obstetricians, nephrologists, neurologists, and sleep specialists, to name just a few. Thus, the intention of this clinician s manual is to provide a short, accessible introduction to understanding and managing RLS that is useful to all medical professionals. First, what is a sensorimotor disorder? Such a condition involves abnormalities of both sensation and movement. Indeed, RLS is a condition of both abnormal sensation and excessive movement. The primary symptom of RLS is an urge or need to move one s legs or other affected body parts (technically an akathisia) that typically occurs at first in the evening or at night when a person tries to rest or relax. This urge or need to move is often so compelling that RLS sufferers may have to walk, shake their legs, ride a bicycle, massage their legs, or stretch to alleviate their discomfort. It is usually associated with unpleasant or uncomfortable sensations. Patients with RLS may also suffer from involuntary movements at rest, known as periodic limb movement (PLM), that vii
8 viii Preface can occur both when awake and asleep. Due to this abnormal movement, patients with RLS are often seen by movement disorder specialists. Because their symptoms usually occur in the evening and at night, patients may have sleep difficulties, such as trouble falling asleep, disrupted sleep, and the daytime consequences of inadequate sleep. Sleep problems are a most prominent complaint and a common reason why patients with RLS request medical attention. As a result, physicians specializing in sleep medicine (i.e., neurologists, pulmonologists, psychiatrists) were the first to become familiar with RLS. Second, where did the term restless legs syndrome originate? Legs refers to the initial site of the disorder, but, in severely affected individuals, similar symptoms can be experienced in the arms and, less frequently, in other parts of the body; however, in almost every patient, the legs are first and most severely involved. Because the term is so evocative, although criticized as insufficiently serious, RLS has proven to be useful in increasing awareness of the condition. A few years ago, RLS received an additional name: Willis-Ekbom Disease (WED), named after Sir Thomas Willis who first described the disease in 1685 and Karl Ekbom who rediscovered the disease and named it restless legs syndrome in Although both names are currently being used, most patients and clinicians use the more common and descriptive term, RLS. Mark J. Buchfuhrer Downey, CA, USA
9 Contents 1 Epidemiology of Restless Legs Syndrome References Clinical Presentation of Restless Legs Syndrome References Establishing a Diagnosis of Restless Legs Syndrome Diagnostic Interview and Clinical Assessment Differential Diagnosis References Comorbidities of Restless Legs Syndrome and Periodic Limb Movement Disorder References Management of Restless Legs Syndrome Introduction Lifestyle Adjustments Medications That Worsen Restless Legs Syndrome Iron Replacement Therapy Vibration Pad Pharmacologic Treatment Problems with the Long-Term Therapy Treatment of Special Populations Summary of Treatment References ix
10
11 Author Biography Mark J. Buchfuhrer, MD, is a consulting assistant professor at Stanford University School of Medicine, Stanford, CA, where he teaches the sleep fellows in the Restless Legs Syndrome (RLS)/Sleep Medicine Clinic. He is also in private practice in Downey, CA, USA, in the fields of pulmonary and sleep medicine. Dr Buchfuhrer graduated with a BSc from McGill University, Canada, before attending medical school at the University of Ottawa. He completed his internship and residency training in internal medicine at the University of Toronto in 1980, followed by fellowship training in pulmonary medicine at Harbor University of California Los Angeles Medical Center in Torrance, California, in Dr Buchfuhrer has authored and contributed to many publications on RLS, including clinical books for physicians and a book for patients with RLS. He has been involved in several professional RLS organizations and manages an RLS website ( org). He is the medical director of SleepMed Sleep Disorders Center in Cypress, California, and the Good Samaritan Hospital Sleep Disorders Center in Los Angeles, California. xi
Practical Case Studies in Hypertension Management. Series editor Giuliano Tocci Rome, Italy
Practical Case Studies in Hypertension Management Series editor Giuliano Tocci Rome, Italy The aim of the book series Practical Case Studies in Hypertension Management is to provide physicians who treat
More informationHandbook of Insulin Therapies
Handbook of Insulin Therapies Winston Crasto Janet Jarvis Melanie J. Davies Handbook of Insulin Therapies Winston Crasto George Eliot Hospital NHS Trust, Nuneaton United Kingdom Janet Jarvis Leicester
More informationPractical Case Studies in Hypertension Management. Series editor: Giuliano Tocci Rome Italy
Practical Case Studies in Hypertension Management Series editor: Giuliano Tocci Rome Italy The aim of the book series Practical Case Studies in Hypertension Management is to provide physicians who treat
More informationIn Clinical Practice
In Clinical Practice Taking a practical approach to clinical medicine, this series of smaller reference books is designed for the trainee physician, primary care physician, nurse practitioner and other
More informationDifferential Diagnosis of Movement Disorders in Clinical Practice
Differential Diagnosis of Movement Disorders in Clinical Practice Abdul Qayyum Rana Peter Hedera Differential Diagnosis of Movement Disorders in Clinical Practice Abdul Qayyum Rana Parkinson's Clinic
More informationLouise Grech Alan Lau Editors. Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis. From Hospital to Community
Louise Grech Alan Lau Editors Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis From Hospital to Community Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis Louise Grech
More informationMeasures of Positive Psychology
Measures of Positive Psychology Kamlesh Singh Mohita Junnarkar Jasleen Kaur Measures of Positive Psychology Development and Validation 123 Kamlesh Singh Department of Humanities and Social Sciences Indian
More informationThe Cleveland Clinic Manual of Dynamic Endocrine Testing
The Manual of Dynamic Endocrine Testing Ahmet Bahadir Ergin A. Laurence Kennedy Manjula K. Gupta Amir H. Hamrahian The Manual of Dynamic Endocrine Testing Ahmet Bahadir Ergin Department of Endocrinology,
More informationSpringerBriefs in Applied Sciences and Technology
SpringerBriefs in Applied Sciences and Technology Computational Intelligence Series Editor Janusz Kacprzyk, Systems Research Institute, Polish Academy of Sciences, Warsaw, Poland SpringerBriefs in Computational
More informationSPRINGER BRIEFS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. Gerhard Bauer Joseph S. Anderson. Gene Therapy for HIV From Inception to a Possible Cure
SPRINGER BRIEFS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY Gerhard Bauer Joseph S. Anderson Gene Therapy for HIV From Inception to a Possible Cure 123 SpringerBriefs in Biochemistry and Molecular Biology For
More informationWound Management in Urgent Care
Wound Management in Urgent Care Brittany Busse Wound Management in Urgent Care Brittany Busse, MD Med 7 Urgent Care Folsom, CA, USA ISBN 978-3-319-27426-3 DOI 10.1007/978-3-319-27428-7 ISBN 978-3-319-27428-7
More informationCognitive, Conative and Behavioral Neurology
Cognitive, Conative and Behavioral Neurology Michael Hoffmann Cognitive, Conative and Behavioral Neurology An Evolutionary Perspective Michael Hoffmann MD, PhD Professor of Neurology Orlando VA Medical
More informationMedical and Surgical Complications of Sickle Cell Anemia
Medical and Surgical Complications of Sickle Cell Anemia Ahmed Al-Salem Medical and Surgical Complications of Sickle Cell Anemia Ahmed Al-Salem Department of Surgery Dar A lalafia Medical Company Qatif
More informationSpringerBriefs in Criminology
SpringerBriefs in Criminology Policing Series editor M.R. Haberfeld City University of New York John Jay College of Criminal Justice New York, NY, USA More information about this series at http://www.springer.com/series/11179
More informationDesmond P. Kidd. Neuro-Ophthalmology. Illustrated Case Studies
Neuro-Ophthalmology Desmond P. Kidd Neuro-Ophthalmology Illustrated Case Studies Desmond P. Kidd Department of Clinical Neurosciences Royal Free Hospital London UK ISBN 978-1-4471-2409-2 DOI 10.1007/978-1-4471-2410-8
More informationSami Shousha Editor. Breast Pathology. Problematic Issues
Breast Pathology Editor Breast Pathology Problematic Issues Editor Charing Cross Hospital Imperial College Healthcare NHS Trust & Imperial College London United Kingdom ISBN 978-3-319-28653-2 ISBN 978-3-319-28655-6
More informationSocial Control of Sex Offenders
Social Control of Sex Offenders D. Richard Laws Social Control of Sex Offenders A Cultural History D. Richard Laws Pacific Behavioural Assessment Victoria, British Columbia, Canada ISBN 978-1-137-39125-4
More informationErin Lawson Mark S. Wallace Editors. Fibromyalgia. Clinical Guidelines and Treatments
Fibromyalgia Erin Lawson Mark S. Wallace Editors Fibromyalgia Clinical Guidelines and Treatments Editors Erin Lawson, MD Voluntary Faculty Department of Anesthesiology Center for Pain Medicine University
More informationDonald E. Wesson. Editor. Metabolic Acidosis. A Guide to Clinical Assessment and Management
Metabolic Acidosis Donald E. Wesson Editor Metabolic Acidosis A Guide to Clinical Assessment and Management Editor Donald E. Wesson, MD, MBA Baylor Scott and White Health Department of Internal Medicine
More informationAbnormal Female Puberty
Abnormal Female Puberty Heather L. Appelbaum Editor Abnormal Female Puberty A Clinical Casebook Editor Heather L. Appelbaum, MD Department of Obstetrics and Gynecology Hofstra Northwell School of Medicine
More informationTherapeutic rtms in Neurology
Therapeutic rtms in Neurology Thomas Platz Editor Therapeutic rtms in Neurology Principles, Evidence, and Practice Recommendations Editor Thomas Platz BDH-Klinik Greifswald Ernst-Moritz-Arndt Universität
More informationUrinary Tract Infection
Urinary Tract Infection Abhay Rané Ranan Dasgupta Editors Urinary Tract Infection Clinical Perspectives on Urinary Tract Infection Editors Abhay Rané, MS, FRCS, FRCS (Urol) Department of Urology Surrey
More informationRespiratory Medicine Series Editor: Sharon I.S. Rounds. Marc A. Judson Editor. Pulmonary Sarcoidosis A Guide for the Practicing Clinician
Respiratory Medicine Series Editor: Sharon I.S. Rounds Marc A. Judson Editor Pulmonary Sarcoidosis A Guide for the Practicing Clinician Respiratory Medicine Series Editor: Sharon I.S. Rounds For further
More informationHandbook for Venous Thromboembolism
Handbook for Venous Thromboembolism Gregory Piazza Benjamin Hohlfelder Samuel Z. Goldhaber Handbook for Venous Thromboembolism Gregory Piazza Cardiovascular Division Harvard Medical School Brigham and
More informationNeurobiological Bases of Abnormal Aggression and Violent Behaviour
Neurobiological Bases of Abnormal Aggression and Violent Behaviour . József Haller Neurobiological Bases of Abnormal Aggression and Violent Behaviour József Haller Department of Behavioral Neurobiology
More informationSurgical Techniques for Kidney Cancer
Surgical Techniques for Kidney Cancer Rakesh V. Khanna Gennady Bratslavsky Robert J. Stein Editors Surgical Techniques for Kidney Cancer 123 Editors Rakesh V. Khanna Department of Urology SUNY Upstate
More informationPharmaceutical Care Issues of Patients with Rheumatoid Arthritis
Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis Louise Grech Alan Lau Editors Pharmaceutical Care Issues of Patients with Rheumatoid Arthritis From Hospital to Community Editors Louise
More informationMusculoskeletal Health in Women
Musculoskeletal Health in Women Elinor Mody Elizabeth Matzkin Editors Musculoskeletal Health in Women Editors Elinor Mody, MD Department of Rheumatology Gretchen and Edward Fish Center for Women s Health
More informationCongenital Hip Disease in Adults
Congenital Hip Disease in Adults George Hartofilakidis George C. Babis Kalliopi Lampropoulou-Adamidou Congenital Hip Disease in Adults George Hartofilakidis, MD, FACS Orthopaedic Department Medical School
More informationSinus Headache, Migraine, and the Otolaryngologist
Sinus Headache, Migraine, and the Otolaryngologist Mark E. Mehle Editor Sinus Headache, Migraine, and the Otolaryngologist A Comprehensive Clinical Guide 123 Editor Mark E. Mehle Private Practice ENT and
More informationEsthetic and Functional Management of Diastema
Esthetic and Functional Management of Diastema Ugur Erdemir Esra Yildiz Editors Esthetic and Functional Management of Diastema A Multidisciplinary Approach Editors Ugur Erdemir Faculty of Dentistry University
More informationProgress in Social Psychiatry in Japan
Progress in Social Psychiatry in Japan Yoshibumi Nakane Progress in Social Psychiatry in Japan An Approach to Psychiatric Epidemiology Yoshibumi Nakane Department of Neuropsychiatry Nagasaki University
More informationPolymyalgia Rheumatica and Giant Cell Arteritis
Polymyalgia Rheumatica and Giant Cell Arteritis Jozef Rovenský Burkhard Leeb Viera Štvrtinová Richard Imrich Editors Polymyalgia Rheumatica and Giant Cell Arteritis Third Edition Editors Josef Rovenský
More informationIatrogenic Effects of Orthodontic Treatment
Iatrogenic Effects of Orthodontic Treatment Roberto Justus Iatrogenic Effects of Orthodontic Treatment Decision-Making in Prevention, Diagnosis, and Treatment Roberto Justus Department of Orthodontics
More informationOsteoarthritic Knee Joint Painted by Artist: Mika Katsuta (Japan)
Osteoarthritis Osteoarthritic Knee Joint Painted by Artist: Mika Katsuta (Japan) Mohit Kapoor Nizar N. Mahomed Editors Osteoarthritis Pathogenesis, Diagnosis, Available Treatments, Drug Safety, Regenerative
More informationAtlas of Lymphatic Anatomy in the Head, Neck, Chest and Limbs
Atlas of Lymphatic Anatomy in the Head, Neck, Chest and Limbs Wei-Ren Pan Atlas of Lymphatic Anatomy in the Head, Neck, Chest and Limbs Wei-Ren Pan Department of Anatomy Xuzhou Medical College Xuzhou Jiangsu
More informationRadiation Therapy for Gastrointestinal Cancers
Radiation Therapy for Gastrointestinal Cancers Theodore Hong Prajnan Das Editors Radiation Therapy for Gastrointestinal Cancers Editors Theodore Hong Massachusetts General Hospital Harvard Medical School
More informationGenetic Influences on Response to Drug Treatment for Major Psychiatric Disorders
Genetic Influences on Response to Drug Treatment for Major Psychiatric Disorders Janusz K. Rybakowski Alessandro Serretti Editors Genetic Influences on Response to Drug Treatment for Major Psychiatric
More informationWhite Coat Hypertension
White Coat Hypertension Giuseppe Mancia Guido Grassi Gianfranco Parati Alberto Zanchetti White Coat Hypertension An Unresolved Diagnostic and Therapeutic Problem Giuseppe Mancia Emeritus Professor University
More informationProgressive Multiple Sclerosis
Progressive Multiple Sclerosis Alastair Wilkins Editor Progressive Multiple Sclerosis Editor Alastair Wilkins, M.A., M.B., B.Chir, Ph.D., FRCP Department of Neurology Frenchay Hospital Bristol UK ISBN
More informationDeep Brain Stimulation for Neurological Disorders
Deep Brain Stimulation for Neurological Disorders Toru I t a k u ra Editor Deep Brain Stimulation for Neurological Disorders Theoretical Background and Clinical Application Editor Toru Itakura, MD, PhD
More informationLow and Lower Fertility
Low and Lower Fertility Ronald R. Rindfuss Minja Kim Choe Editors Low and Lower Fertility Variations across Developed Countries Editors Ronald R. Rindfuss Department of Sociology and Carolina Population
More informationImaging of Urinary Tract Diverticula
Imaging of Urinary Tract Diverticula Vladimir M. Builov Imaging of Urinary Tract Diverticula Vladimir M. Builov Department of X-Ray and MRI RailWay Clinical Hospital Yaroslavl Russia ISBN 978-3-319-05382-0
More informationDepression and Anxiety in Patients with Chronic Respiratory Diseases
Depression and Anxiety in Patients with Chronic Respiratory Diseases Amir Sharafkhaneh Abebaw Mengistu Yohannes Nicola Alexander Hanania Mark E. Kunik Editors Depression and Anxiety in Patients with Chronic
More informationMorbid Obesity in Adolescents
Morbid Obesity in Adolescents ThiS is a FM Blank Page Kurt Widhalm Gerhard Prager Editors Morbid Obesity in Adolescents Conservative Treatment and Surgical Approaches Editors Kurt Widhalm Department of
More informationEssentials in Ophthalmology
Essentials in Ophthalmology Series Editor Arun D. Singh, MD More information about this series at http://www.springer.com/series/5332 Kathryn Colby Editor Corneal Diseases in Children Challenges and Controversies
More informationAdvances in Experimental Medicine and Biology
Advances in Experimental Medicine and Biology Volume 938 Editorial Board IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel N.S. ABEL LAJTHA, Kline Institute for Psychiatric Research, Orangeburg,
More informationRadiology Illustrated
Radiology Illustrated For further volumes: http://www.springer.com/series/11755 In-One Kim Editor Radiology Illustrated: Pediatric Radiology Editor In-One Kim, M.D. Department of Radiology Seoul National
More informationJohn Papadopoulos David R. Schwartz Consulting Editor. Pocket Guide to Critical Care Pharmacotherapy Second Edition
John Papadopoulos David R. Schwartz Consulting Editor Pocket Guide to Critical Care Pharmacotherapy Second Edition 123 Pocket Guide to Critical Care Pharmacotherapy John Papadopoulos Author David R. Schwartz
More informationSpringerBriefs in Psychology. Series Editors Daniel David Raymond A. DiGiuseppe Kristene A. Doyle
SpringerBriefs in Psychology Series Editors Daniel David Raymond A. DiGiuseppe Kristene A. Doyle Epidemiological studies show that the prevalence of mental disorders is extremely high across the globe
More informationEvidence-Based Forensic Dentistry
Evidence-Based Forensic Dentistry Balwant Rai Jasdeep Kaur Evidence-Based Forensic Dentistry Authors Balwant Rai Earth and Life Sciences Vrije Universiteit Amsterdam and ILEWG Amsterdam The Netherlands
More informationPediatric Endodontics
Pediatric Endodontics Anna B. Fuks Benjamin Peretz Editors Pediatric Endodontics Current Concepts in Pulp Therapy for Primary and Young Permanent Teeth Editors Anna B. Fuks Department of Pediatric Dentistry
More informationInflammation and Lung Cancer
Inflammation and Lung Cancer Steven M. Dubinett Editor Inflammation and Lung Cancer 1 3 Editor Steven M. Dubinett David Geffen School of Medicine at UCLA Los Angeles California USA ISBN 978-1-4939-2723-4
More informationReconstructive Oral and Maxillofacial Surgery
Reconstructive Oral and Maxillofacial Surgery Carlos Navarro Vila Editor Reconstructive Oral and Maxillofacial Surgery Editor Carlos Navarro Vila Hospital General Universitario Gregorio Marañón Madrid
More informationComplications of Anorectal Surgery
Complications of Anorectal Surgery Herand Abcarian Jose Cintron Editors Complications of Anorectal Surgery Prevention and Management 123 Editors Herand Abcarian Division of Colon and Rectal Surgery University
More informationAlexander N. Sencha Elena V. Evseeva Mikhail S. Mogutov Yury N. Patrunov. Breast Ultrasound
Breast Ultrasound Alexander N. Sencha Elena V. Evseeva Mikhail S. Mogutov Yury N. Patrunov Breast Ultrasound Alexander N. Sencha Department of Ultrasound Diagnostics Yaroslavl Railway Clinic Yaroslavl
More informationHealth Issues in Women with Multiple Sclerosis
Health Issues in Women with Multiple Sclerosis Maria K. Houtchens A. Dessa Sadovnick Editors Health Issues in Women with Multiple Sclerosis Editors Maria K. Houtchens Partners MS Center Brigham and Women
More informationSpringerBriefs in Cancer Research
SpringerBriefs in Cancer Research For further volumes: http://www.springer.com/series/10786 Natalia Aptsiauri Angel Miguel Garcia-Lora Teresa Cabrera MHC Class I Antigens In Malignant Cells Immune Escape
More informationLocal Flaps in Facial Reconstruction
Local Flaps in Facial Reconstruction Velupillai Ilankovan Madan Ethunandan Tian Ee Seah Local Flaps in Facial Reconstruction A Defect Based Approach Velupillai Ilankovan Poole Hospital NHS Foundation
More informationThe Role of Bacteria in Urology
The Role of Bacteria in Urology Dirk Lange Ben Chew Editors The Role of Bacteria in Urology Editors Dirk Lange Basic Science Research The Stone Centre at Vancouver General Hospital Vancouver British Columbia
More informationAdvancing Responsible Adolescent Development
Advancing Responsible Adolescent Development Series Editor Roger J.R. Levesque For additional volumes: http://www.springer.com/series/7284 wwwwwwwwww Anna-Karin Andershed Editor Girls at Risk Swedish Longitudinal
More informationMark W.J. Strachan Brian M. Frier. Insulin Therapy. A Pocket Guide
Insulin Therapy Mark W.J. Strachan Brian M. Frier Insulin Therapy A Pocket Guide Mark W.J. Strachan, MD, FRCP (Ed) Metabolic Unit Western General Hospital Edinburgh United Kingdom Brian M. Frier, MD,
More informationCurrent Therapy and Surgery for Urogenital Tuberculosis
Current Therapy and Surgery for Urogenital Tuberculosis Ekaterina Kulchavenya Current Therapy and Surgery for Urogenital Tuberculosis Ekaterina Kulchavenya Research TB Institute Novosibirsk Medical University
More informationSpringerBriefs in Environmental Science
SpringerBriefs in Environmental Science More information about this series at http://www.springer.com/series/8868 Daniel Żarski Ákos Horváth Gergely Bernáth Sławomir Krejszeff János Radóczi Katarzyna Palińska-Żarska
More informationEmerging Concepts of Tumor Exosome Mediated Cell Cell Communication
Emerging Concepts of Tumor Exosome Mediated Cell Cell Communication Huang-Ge Zhang Editor Emerging Concepts of Tumor Exosome Mediated Cell Cell Communication 2123 Editor Huang-Ge Zhang University of Louisville
More informationPractical Issues in Geriatrics. Series Editor Stefania Maggi Aging Branch CNR-Neuroscience Institute Padova, Italy
Practical Issues in Geriatrics Series Editor Stefania Maggi Aging Branch CNR-Neuroscience Institute Padova, Italy This practically oriented series presents state of the art knowledge on the principal diseases
More informationRadiation Therapy for Extranodal Lymphomas
Radiation Therapy for Extranodal Lymphomas Keisuke Sasai Masahiko Oguchi Editors Radiation Therapy for Extranodal Lymphomas Editors Keisuke Sasai Department of Radiation Oncology Juntendo University Faculty
More informationRadiation Therapy for Skin Cancer
Radiation Therapy for Skin Cancer Armand B. Cognetta Jr. William M. Mendenhall Editors Radiation Therapy for Skin Cancer Editors Armand B. Cognetta Jr. Dermatology Associates of Tallahassee Chief, Division
More informationEpigenetic Advancements in Cancer
Epigenetic Advancements in Cancer Manoj K. Mishra Kumar S. Bishnupuri Editors Epigenetic Advancements in Cancer Editors Manoj K. Mishra Department of Biological Sciences Alabama State University Montgomery,
More informationThe Many Faces of Social Attention
The Many Faces of Social Attention Aina Puce Bennett I. Bertenthal Editors The Many Faces of Social Attention Behavioral and Neural Measures 1 3 Editors Aina Puce Psychological and Brain Sciences Indiana
More informationManagement of Post-Stroke Complications
Management of Post-Stroke Complications Ajay Bhalla Jonathan Birns Editors Management of Post-Stroke Complications Editors Ajay Bhalla Department of Ageing and Health Guy s and St Thomas NHS Foundation
More informationCLINICAL GASTROENTEROLOGY
CLINICAL GASTROENTEROLOGY Series Editor George Y. Wu University of Connecticut Health Center, Farmington, CT, USA For further volumes: http://www.springer.com/series/7672 Elizabeth J. Carey Keith D. Lindor
More informationDiseases of the Spinal Cord
Diseases of the Spinal Cord Elke Hattingen Stefan Weidauer Matthias Setzer Johannes C. Klein Frank Vrionis Editors Diseases of the Spinal Cord Novel Imaging, Diagnosis and Treatment Editors Elke Hattingen
More informationThe Olfactory System
The Olfactory System Editor The Olfactory System From Odor Molecules to Motivational Behaviors Editor Department of Physiology The University of Tokyo Tokyo, Japan ISBN 978-4-431-54375-6 ISBN 978-4-431-54376-3
More informationCerebral Blood Flow, Metabolism, and Head Trauma
Cerebral Blood Flow, Metabolism, and Head Trauma Christian W. Kreipke Editors Jose A. Rafols Cerebral Blood Flow, Metabolism, and Head Trauma The Pathotrajectory of Traumatic Brain Injury Editors Christian
More informationJennifer Moriatis Wolf Editor. Tennis Elbow. Clinical Management
Tennis Elbow Jennifer Moriatis Wolf Editor Tennis Elbow Clinical Management 1 3 Editor Jennifer Moriatis Wolf Department of Orthopedic Surgery University of Connecticut Health Center Farmington, CT, USA
More informationChronic Pain. For other titles published in this series, go to
Chronic Pain For other titles published in this series, go to www.springer.com/series/7633 Dawn A. Marcus, M.D. Chronic Pain A Primary Care Guide to Practical Management Second Edition Dawn A. Marcus,
More informationThe Essential Guide to Lithium Treatment
The Essential Guide to Lithium Treatment Michael Bauer Michael Gitlin The Essential Guide to Lithium Treatment Michael Bauer Technische Universtät Dresden University Hospital Carl Gustav Carus Dresden
More informationBiomarkers and Mental Illness
Biomarkers and Mental Illness Paul C. Guest Biomarkers and Mental Illness It s Not All in the Mind Paul C. Guest Charlesworth House Debden, Essex, UK ISBN 978-3-319-46087-1 ISBN 978-3-319-46088-8 (ebook)
More informationAtlas of Lymph Node Anatomy
Atlas of Lymph Node Anatomy Mukesh G. Harisinghani Editor Atlas of Lymph Node Anatomy This publication was developed through an unrestricted educational grant from Siemens. Editor Mukesh G. Harisinghani
More informationPerineal Trauma at Childbirth
Perineal Trauma at Childbirth Khaled M.K. Ismail Editor Perineal Trauma at Childbirth Editor Khaled M.K. Ismail University of Birmingham Birmingham, United Kingdom ISBN 978-3-319-14859-5 DOI 10.1007/978-3-319-14860-1
More informationFrozen Section Library Series Editor Philip T. Cagle, MD Houston, Texas, USA
Frozen Section Library Series Editor Philip T. Cagle, MD Houston, Texas, USA For further volumes, go to http://www.springer.com/series/7869 Frozen Section Library: Central Nervous System Richard A. Prayson
More informationOrganization and Management of IVF Units
Organization and Management of IVF Units Steven D. Fleming Alex C. Varghese Editors Organization and Management of IVF Units A Practical Guide for the Clinician Editors Steven D. Fleming, BSc, MSc, PhD
More informationMedical Management of the Pregnant Patient
Medical Management of the Pregnant Patient Karen Rosene-Montella Editor Medical Management of the Pregnant Patient A Clinician s Handbook Editor Karen Rosene-Montella, MD SVP Women s Services and Clinical
More informationRadiation Therapy for Head and Neck Cancers
Radiation Therapy for Head and Neck Cancers Murat Beyzadeoglu Gokhan Ozyigit Ugur Selek Editors Radiation Therapy for Head and Neck Cancers A Case-Based Review Editors Murat Beyzadeoglu, MD Professor
More informationECG INTERPRETATION: FROM PATHOPHYSIOLOGY TO CLINICAL APPLICATION
ECG INTERPRETATION: FROM PATHOPHYSIOLOGY TO CLINICAL APPLICATION ECG INTERPRETATION: FROM PATHOPHYSIOLOGY TO CLINICAL APPLICATION by Fred Kusumoto, MD Electrophysiology and Pacing Service Division of Cardiovascular
More informationMinimally Invasive Gynecological Surgery
Minimally Invasive Gynecological Surgery O l av Is t re Editor Minimally Invasive Gynecological Surgery Editor Olav Istre, MD, PhD Fredriksberg Denmark ISBN 978-3-662-44058-2 ISBN 978-3-662-44059-9 (ebook)
More informationChildhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia Ajay Vora Editor Childhood Acute Lymphoblastic Leukemia Editor Ajay Vora Department of Paediatric Haemotology Sheffield Children's Hospital NHS Trust University of
More informationTadaaki Kirita Ken Omura Editors. Oral Cancer. Diagnosis and Therapy
Oral Cancer Tadaaki Kirita Ken Omura Editors Oral Cancer Diagnosis and Therapy Editors Tadaaki Kirita Department of Oral and Maxillofacial Surgery Nara Medical University Nara, Japan Ken Omura Oral Cancer
More informationEmergency Department Management of Obstetric Complications
Emergency Department Management of Obstetric Complications Joelle Borhart Editor Emergency Department Management of Obstetric Complications Editor Joelle Borhart MedStar Georgetown University Hospital
More informationNext Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders
Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders Lee-Jun C. Wong Editor Next Generation Sequencing Based Clinical Molecular Diagnosis of Human Genetic Disorders
More informationMorphological Aspects of Inner Ear Disease
Morphological Aspects of Inner Ear Disease Yasuya Nomura Morphological Aspects of Inner Ear Disease Yasuya Nomura President The Society for Promotion of International Oto-Rhino-Laryngology Tokyo, Japan
More informationMitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy
Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy Dhyan Chandra Editor Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy 1 3 Editor Dhyan Chandra, Associate
More informationChromosomal Translocations and Genome Rearrangements in Cancer
Chromosomal Translocations and Genome Rearrangements in Cancer Janet D. Rowley Michelle M. Le Beau Terence H. Rabbitts Editors Chromosomal Translocations and Genome Rearrangements in Cancer Editors Janet
More informationIndirect Questioning in Sample Surveys
Indirect Questioning in Sample Surveys Arijit Chaudhuri Tasos C. Christofides Indirect Questioning in Sample Surveys 123 Arijit Chaudhuri Applied Statistics Unit Indian Statistical Institute Kolkata,
More informationThe Pharmacology of Alcohol and Drugs of Abuse and Addiction
The Pharmacology of Alcohol and Drugs of Abuse and Addiction Norman S. Miller The Pharmacology of Alcohol and Drugs of Abuse and Addiction Springer-Verlag New York Berlin Heidelberg London Paris Tokyo
More informationHuman Motivation and Interpersonal Relationships
Human Motivation and Interpersonal Relationships Netta Weinstein Editor Human Motivation and Interpersonal Relationships Theory, Research, and Applications Editor Netta Weinstein Department of Psychology
More informationThe Mediterranean Diet
The Mediterranean Diet wwwwwwwwwwwwww Eric Zacharias, M.D. The Mediterranean Diet A Clinician s Guide for Patient Care Eric Zacharias, M.D. Chairman, Department of Medicine, Boulder Medical Center Assistant
More informationAbsolute Neurocritical Care Review
Absolute Neurocritical Care Review Zachary David Levy Editor Absolute Neurocritical Care Review Editor Zachary David Levy Assistant Professor of Emergency Medicine and Neurosurgery Hofstra Northwell School
More information