Standard Melatonin Intake and Circadian Rhythms of Elite Athletes after a Transmeridian Flight
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1 M Nomura, S Kida, J Yamashita The Journal et al. of International Medical Research Endovascular 2000; 28: Embolization of Unruptured Vertebral Dissection Standard Melatonin Intake and Circadian Rhythms of Elite Athletes after a Transmeridian Flight R MANFREDINI 1, F MANFREDINI 2 AND F CONCONI 2 1 First Internal Medicine Section, Department of Clinical and Experimental Medicine, and 2 Centre for Biomedical Studies for Sports, University of Ferrara, Italy Many transmeridian travellers, including top athletes, regularly take melatonin to reduce negative jet lag symptoms. Standard (rather than individually tailored) doses are often used. We examined the effects of a standard dose of melatonin on the body temperature rhythms of 12 elite biathletes (eight men and four women) after an eastward transmeridian flight to an international competition. The different effects on body temperature rhythms in men versus women underscore the need for personalized dosing schedules to avoid potential undesirable consequences. KEY WORDS: MELATONIN; DESYNCHRONIZATION; JET LAG; CIRCADIAN RHYTHM; CHRONOBIOLOGY; ATHLETIC PERFORMANCE INTRODUCTION Compared with only a few years ago when worldwide athletics competitions were limited to the Olympic Games, World Championships and a few other top events, today s competitive athletes may take part in a growing series of sponsored international competitions. As a direct consequence, however, athletes frequently need to travel long distances by air to attend such international competitions, and their periods of travelling may extend over several months. It is known that rapid air travel across several time zones exposes the traveller to a shift in the internal biological clock and to a transient desynchronization of their rhythms, jet lag, which lasts until rhythms adjust to the new environmental conditions. 1 The usual symptoms of jet lag 182
2 include: sleep disorders; difficulties with concentrating; disorientation; depression; irritability; distorted estimation of time, space and distance; lightheadedness; loss of appetite; and gastrointestinal disturbances. 2 In transmeridian travellers, exogenous melatonin seems to have some beneficial effects on the symptoms of jet lag, although the optimal dose and timing of ingestion have yet to be determined. 3 Many frequent transmeridian travellers, including athletes, take melatonin in an attempt to avoid the symptoms of jet lag. The aim of this study was to evaluate whether taking standard doses of melatonin is likely to be effective in reaching rhythm resynchronization following transmeridian travel. Body temperature was chosen as an indicator of endogenous biological clock function; it is often used as a marker of circadian rhythms because of its ease of measurement and because it is largely endogenously controlled. 4 SUBJECTS AND METHODS We studied the effect of a standard melatonin dose on body temperature rhythm in 12 elite athletes of the Italian National Biathlon Team (eight men, mean age 25.9 years; four women, mean age 22.5 years), who agreed to participate and gave their written consent to the study protocol. The oral body temperatures of biathletes were measured with a digital thermometer eight times daily (at 07.00, 09.00, 12.00, 14.00, 16.00, 18.00, 20.00, 22.00), both during the last full training day before departure (A) and after an 8-h eastward transmeridian flight to Japan (across eight time zones) for an international competition (B C). The flight schedule was: departure from Milan, Italy at local time, arrival in Tokyo, Japan at local time; the scheduled duration of air travel was h. On arrival, the athletes started an oral regime of melatonin once daily, at local time. The dosage was 5 mg for men (0.070 ± mg/kg) and 3 mg (0.056 ± mg/kg) for women. Body temperature was measured on the first (B) and last (sixth, C) full day in Japan, both of which were free of competitions. Athletes were asked to fill in a daily questionnaire reporting subjective impressions of quality of sleep (scored from 1 = poor to 5 = excellent ) and the presence or absence of undesired effects. Chronobiological analysis to determine circadian rhythms was done by single cosinor and partial Fourier series, using the Chronolab software on an Apple Macintosh computer. 5 The program calculates the mean of the best fit sine function (Midline Estimating Statistic of Rhythm or MESOR, the rhythm-adjusted mean over the timeperiod analysed), the amplitude (half the distance between the absolute maximum and minimum of the sine function), and the acrophase of each single harmonic (time of peak of sine function). 6 RESULTS The main results are summarized in Table 1. The men who had a delayed body temperature acrophase in Italy (peak time A: local time) did not show a significant change after the flight (peak time B: local time), and melatonin apparently advanced the time of the peak body temperature to the afternoon (peak time C: local time). On the other hand, women, who had their peak in the afternoon in Italy (peak time A: local time), showed an 8-h shift of body temperature after the flight (peak time B: local time), and melatonin had no resynchronizing effect (peak time C: local time). 183
3 TABLE 1 Circadian rhythm of body temperature in elite biathletes before and after a flight from Italy to Japan. The athletes took melatonin orally once daily (5 mg for men; 3 mg for women) during their stay in Japan B C A Japan (arrival) Japan (departure) Italy first day sixth day P-value Acrophase (local time) < 0.05 Body temperature ( C) MESOR ± SE 35.5 ± ± ± 0.1 Amplitude ± SE 0.38 ± ± ± 0.1 Men Women Acrophase (local time) < 0.05 Body temperature ( C) MESOR ± SE 35.5 ± ± ± 0.1 Amplitude ± SE 0.16 ± ± ± 0.1 Acrophase, time of peak sine function; MESOR, rhythm-adjusted mean over the time-period analysed; amplitude, half the distance between the absolute maximum and minimum of the sine function. No significant variations were present for MESOR and amplitude. No undesired side-effects or sleep disturbances were reported, whereas the self-evaluated quality of sleep ranked from normal to excellent. DISCUSSION The main finding of this study is that a standardized melatonin administration had different effects on the computed body temperature rhythms of athletes. The extreme paucity of studies in the literature probably derives from the difficulty in obtaining data from elite athletes engaged in their usual activity, and their willingness to comply or to participate as controls, and the difficulties of devising chronobiological protocols with a reasonably limited number of daily measurements. It is known that body temperature, in humans, shows a well defined circadian pattern characterized by an afternoon peak. 4 In the male athletes studied, who had their own delayed body temperature acrophase, melatonin apparently induced an advance-phase effect towards the physiological afternoon peak. The female athletes did not show such a delayed effect, and the melatonin dosage used apparently was not effective in resynchronizing the 8-h shift following the transcontinental flight. Although considerations such as environmental influences, temperature, meteorological conditions and scheduled time of events make generalization difficult, most components of sports performance exhibit a circadian rhythm with a peak in the late afternoon/early evening, 7 rendering athletic performance most efficient at this time of 184
4 day. Taking circadian rhythms into consideration can be beneficial in tasks involving endurance, mental function, physical strength and others. Selecting the best circadian time can result in as much as a 10% increase in athletic performance. 8 A 10% decrease in peak performance is roughly equivalent to the change in performance after less than 3 h of sleep, after drinking the Italian legal limit of alcohol (80 mg/dl), or after taking barbiturates. 8 Jet lag may cause a shift in the optimal circadian peak window for performance, although the question of the relationship between athletic performance and rapid transmeridian air travel is controversial and still debated. Some previous studies have concluded that athletic performance is impaired by transmeridian air travel 9 12 but a recent review by Youngstedt and O Connor 13 concluded that the scientific evidence supporting such an assumption is neither consistent nor compelling, and further rigorous research is needed. Anecdotal reports, however, indicate that many elite athletes and other transmeridian travellers usually consume melatonin preparations. In consideration of this, a recent position statement for members of the British Olympic Association 14 suggested caution in the use of melatonin because of potential debilitating effects in athletes. The present results show that the generic intake of melatonin at standardized times and dosages, although in the presence of a good sleep and in the absence of undesired side-effects, may have widely differing effects on biological rhythms, and the resynchronizing effect is not always fully obtained. It should be considered, however, that inter-individual and intra-group variations may also result from the use of different drug dosages in relation to body weight, and possibly different endocrinological patterns, and these factors deserve further research. At this time we can only recommend a degree of caution in selecting melatonin doses for self administration. The determination of individual circadian rhythms and correspondingly tailored melatonin administration, scheduled by specialists, could avoid potential disappointing consequences and have beneficial effects for competing athletes and other international travellers. ACKNOWLEDGEMENT This study was supported by a scientific and educational grant (60%) from the University of Ferrara. REFERENCES 1 Manfredini R, Manfredini F, Fersini C, et al: Circadian rhythms, athletic performance, and jet lag. Br J Sports Med 1998; 32: Graeber RC: Alterations in performance following rapid transmeridian flight. In: Rhythmic Aspects of Behaviour (Brown FM, Graeber RC, eds). Hillsdale: Lawrence Erlbaum Associates, 1982; pp Brzezinski A: Melatonin in humans. N Engl J Med 1997; 336: Reilly T, Atkinson G, Waterhouse J (eds): Physiological rhythms at rest. In: Biological Rhythms and Exercise. Oxford: Oxford University Press, 1997; pp Mojòn A, Fernàndez JR, Hermida RC. Chronolab: an interactive software package for chronobiologic time series 185
5 analysis written for the Macintosh computer. Chronobiol Int 1992; 9: Halberg F, Carandente F, Cornelissen G, et al: Glossary of chronobiology. Chronobiologia 1977; 4 (Suppl 1): Atkinson G, Reilly T: Circadian variation in sports performance. Sports Med 1996; 21: Winget CM, Soliman MRI, Holley DC, et al: Chronobiology of physical performance and sports medicine. In: Biologic Rhythms in Clinical and Laboratory Medicine (Touitou Y, Haus E, eds). Berlin and Heidelberg: Springer Verlag, 1992; pp Rietveld WJ: Circadian rhythms: physical performance as function of the time of day. Int J Sports Med 1984; 5: Shepard RJ: Sleep, biorhythms and human performance. Sports Med 1984; 1: Winget CM, DeRoshia CW, Holley DC: Circadian rhythms and athletic performance. Med Sci Sports Exerc 1985; 17: Reilly T: Human circadian rhythms and exercise. Crit Rev Biomed Eng 1990; 18: Youngstedt SD, O Connor PJ: The influence of air travel on athletic performance. Sports Med 1999; 28: Reilly T, Maughan R, Budgett R: Melatonin: a position statement of the British Olympic Association. Br J Sports Med 1998; 32: R Manfredini, F Manfredini and F Conconi Standard Melatonin Intake and Circadian Rhythms of Elite Athletes after a Transmeridian Flight The Journal of International Medical Research 2000; 28: Received for publication 6 April 2000 Accepted 12 April 2000 Copyright 2000 Cambridge Medical Publications Address for correspondence DR R MANFREDINI First Internal Medicine Section, Department of Clinical and Experimental Medicine, University of Ferrara, via Savonarola 9, I Italy. r.manfredini@unife.it 186
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