Interpretation of Arterial Blood Gases. Prof. Dr. W. Vincken Head Respiratory Division Academisch Ziekenhuis Vrije Universiteit Brussel (AZ VUB)
|
|
- Laurel Long
- 6 years ago
- Views:
Transcription
1 Interpretation of Arterial Blood Gases Prof. Dr. W. Vincken Head Respiratory Division Academisch Ziekenhuis Vrije Universiteit Brussel (AZ VUB)
2 Before interpretation of ABG Make/Take note of Correct puncture and transport F I O 2 : room air (0.21) or under O 2 Body posture : sitting or supine At rest or during exercise
3 Arterial Blood Gases Measurement of oxygenation P a O 2 S a O 2 P A-a O 2 Measurement of alveolar ventilation and acid-base status P a CO 2 ph [HCO 3- ] Base Excess (BE)
4 Normal Arterial Blood Gases Measurement of oxygenation P a O mmhg* S a O 2 97 % P A-a O 2 <10 mmhg * P a O 2 = 105 (age/3)
5 Normal Arterial Blood Gases Measurement of alveolar ventilation and acid-base status P a CO 2 ph 7.4 [HCO 3- ] 40 mmhg 24 meq/l Base Excess (BE) 0 meq/l
6 Abnormal Arterial Blood Gases Hyperoxemia : high P a O 2 No pathophysiological substrate (except mild hyperoxemia in extreme alveolar hyperventilation) Usually indicates sampling error (air in blood sample) or high F I O 2 (oxygen administration)
7 Abnormal Arterial Blood Gases Hypoxemia : low P a O 2 Desaturation : low S a O 2
8
9 Hypoxemia : causes? Alveolo-arterial O 2 gradient P A-a O 2 = P A O 2 P a O 2 P a O 2 = P A O 2 P A-a O 2
10 Hypoxemia : causes? Alveolar gas equation P A O 2 = P I O 2 [P A CO 2 / R] P A O 2 = [(P b - P H 2O) x F I O 2 ] [P A CO 2 / R] P A O 2 P I O 2 = partial pressure of oxygen in alveolar air = partial pressure of oxygen in inspired air P A CO 2 = partial pressure of carbon dioxide in alveolar air R = respiratory exchange ratio = VCO 2 /VO 2 = barometric pressure P b P H 2O F I O 2 = partial pressure of water vapour in inspired air = fractional concentration of oxygen in inspired air
11 Hypoxemia : causes? Alveolo-arterial O 2 gradient P A-a O 2 (mmhg) = P A O 2 - P a O 2 P A O 2 is calculated using the alveolar gas equation P A O 2 = P I O 2 [P A CO 2 / R] P A O 2 = [(P b - P H 2O) x F I O 2 ] [P a CO 2 / 0.8] P A O 2 = [(760-47) x 0.21] [P a CO 2 x 1.25] P A O 2 = 149 [P a CO 2 x 1.25] P a O 2 and P a CO 2 are measured (ABG) Normal P A-a O 2 < 5 10 mmhg (up to 20 mmhg in elderly)
12 Hypoxemia : 3 main causes P A O 2 = [(P b - P H 2O) x F I O 2 ] [P A CO 2 / R] P A-a O 2 = P A O 2 P a O 2 P a O 2 = P A O 2 P A-a O 2 (1) Reduced P A O 2 (2) Increased P A-a O 2 (3) Reduced P v O 2
13 Hypoxemia : causes (1) P A O 2 = [(P b - P H 2O) x F I O 2 ] [P A CO 2 / R] P a O 2 = P A O 2 P A-a O 2 Reduced P A O 2 (and normal P A-a O 2 ) Reduced P b : high altitude Reduced F I O 2 : inhalation of hypoxic gas mixtures Increased P A CO 2 > hypercapnia
14 Hypoxemia : causes (2) P A O 2 = [(P b - P H 2O ) x F I O 2 ] [P A CO 2 / R] P a O 2 = P A O 2 P A-a O 2 Increased P A-a O 2 = Failure of the lung as a gas exchanger = Oxygenation failure or Type I Respiratory Failure = Intrapulmonary mechanism/cause of hypoxemia Ventilation/perfusion mismatch Diffusion disturbance Right>Left shunt
15 Hypoxemia : causes (2) Oxygenation Failure Ventilation/Perfusion mismatch Obstructive lung diseases (COPD, asthma, ) Parenchymal lung disease (pneumonia, atelectasis, ILD, ) Vascular lung disease
16
17
18 Hypoxemia : causes (2) Oxygenation Failure Ventilation/Perfusion mismatch Diffusion limitation (on exercise) Interstitial lung diseases Emphysema
19
20 Hypoxemia : causes (2) Oxygenation Failure Ventilation/Perfusion mismatch Diffusion limitation Anatomic R>L shunt Intracardiac (ASD, VSD, ) Intrapulmonary (A-V malformations, fistulas)
21 Hypoxemia : causes (3) Decreased P V O 2 Reduced cardiac output (Q T ) Increased (tissue) oxygen extraction Increased (tissue) oxygen consumption (VO 2 )
22 Hypoxemia : consequences Desaturation central cyanosis Chemoreceptor stimulation Central respiratory drive Output respiratory muscles V E and WOB : dyspnea V A and hypocapnia & respiratory alkalosis
23 Hypoxemia : consequences Tissue hypoxia organ disfunction: CNS, CV, kidneys anaerobic metabolism lactic acidosis Pulmonary vasoconstriction Pulmonary hypertension Cor pulmonale & right heart failure Increased renal erythropoetin production Secondary polycythemia
24 Abnormal Arterial Blood Gases Hypercapnia : high P a CO 2 Respiratory acidosis : low ph
25 Abnormal Arterial Blood Gases Hypercapnia : high P a CO 2 Respiratory acidosis : low ph Hypocapnia : low P a CO 2 Respiratory alkalosis : high ph
26 Henderson-Hasselbalch equation ph = pk + log [HCO 3- ] / 0.03 x PCO 2 Hypercapnia leads to decreased ph, i.e. Respiratory acidosis Hypocapnia leads to increased ph, i.e. Respiratory alkalosis
27 Hypercapnia : 3 main causes P a CO 2 = VCO 2 / V A VCO 2 = CO 2 production V A = alveolar ventilation (1) Increased VCO 2 (2) Reduced V A (3) Severe V/Q mismatching
28 Hypercapnia : causes (1) P a CO 2 = VCO 2 / V A VCO 2 = CO 2 production V A = alveolar ventilation Increased VCO 2 Exercise with extreme effort Fever and other hypermetabolic states
29 Hypercapnia : causes (2) P a CO 2 = VCO 2 / V A VCO 2 = CO 2 production V A = alveolar ventilation Reduced V A : alveolar hypoventilation Failure of the respiratory system as an air pump Ventilatory Failure or Type II Respiratory failure Any hypoxemia is secondary to hypercapnia, i.e., the P A-a O 2 is normal Extrapulmonary mechanism/cause of hypoxemia
30 Hypercapnia : causes (2) Ventilatory Failure P a CO 2 = VCO 2 / V A VCO 2 = CO 2 production V A = alveolar ventilation Reduced V A : alveolar hypoventilation Reduced respiratory drive (central controller) Dysfunction of respiratory neuromuscular apparatus Chest wall disorders including severe obesity Severe Upper Airway Obstruction
31 Hypercapnia : causes (2) Ventilatory Failure Reduced respiratory drive (central controller) CNS disorders Drug (illicit or not) overdose Metabolic disorders Obesity-hypoventilation syndrome (Pickwick syndrome) Central alveolar hypoventilation
32 Hypercapnia : causes (2) Ventilatory Failure Dysfunction of respiratory neuromuscular apparatus Motor neurons (ALS, Poliomyelitis, ) Peripheral nerves (Guillain-Barré, Phrenic neuropathy, ) Myoneural junction (Myastenia, drugs, ) Muscle (Myopathy, metabolic disorders, malnutrition, ) Chest wall disorders including severe obesity Severe asphyxiating Upper Airway Obstruction
33 Hypercapnia : causes (3) Severe V/Q mismatch Severely reduced efficiency of the lung as a gas exchanger O 2 uptake hypoxemia CO 2 elimination hypercapnia stimulation of chemoreceptors Central respiratory drive and V A WOB: dyspnea P a CO 2 decreases towards but does not reach normal less complete correction of P a O 2 (poorly ventilated shunt-like regions keep bypassing venous blood)
34 Hypercapnia : consequences Hypoxemia with normal P A-a O 2 Respiratory acidosis : reduced ph If persistent : HCO 3- retention by the kidneys Increased [HCO 3- ] and positive BE Low ph will increase to almost normal (but not above 7.4) Compensatory metabolic alkalosis Acutely, HCO 3- = 0.1 x P a CO 2 Chronically, HCO 3- = 0.35 x P a CO 2
35 Clinical signs of hypercapnia CNS: cerebral vasodilatation Increased cerebral Q Intracranial hypertension Papilledema, headache Lethargy, confusion progressing to coma carbonarcosis Peripheral vasodilatation Full bounding pulses with Warm, cherry-red skin
36 Abnormal Arterial Blood Gases Hypocapnia : low P a CO 2 Respiratory alkalosis : high ph
37 Hypocapnia : 1 main mechanism P a CO 2 = VCO 2 / V A VCO 2 = CO 2 production V A = alveolar ventilation (1) Increased V A
38 Hypocapnia ~ alveolar hyperventilation : causes Stimulation of chemoreceptors Hypoxemia Metabolic acidosis Pulmonary J-receptor stimulation Tissue hypoxia Anemia, CO-, Sulf- or MetHb Hypotension, shock, sepsis Fever, thyrotoxicosis, strenuous exercise Psychogenic : hyperventilation syndrome
39 Hypocapnia : consequences Respiratory alkalosis : increased ph If persistent : HCO 3- excretion by the kidneys reduced [HCO 3- ] and negative BE (= base deficit) Elevated ph will decrease to almost normal (but not below 7.4) Compensatory metabolic acidosis Acutely, HCO 3- = 0.2 x P a CO 2 Chronically, HCO 3- = 0.5 x P a CO 2
40 Abnormal Arterial Blood Gases Acidosis : low ph Respiratory Metabolic Alkalosis : high ph Respiratory Metabolic
41 Metabolic acidosis Reduced HCO 3-, hence reduced ph and negative BE (base deficit), due to Acid [H + ] accumulation (and buffering by HCO 3- ) Renal failure Diabetes mellitus : ketoacidosis Tissue hypoxia/hypoperfusion (shock) : lactic acidosis Intoxications : ASA, antifreeze, methanol, paraldehyde Loss of HCO 3 - diarrhea
42 Metabolic acidosis If persistent, the increase in [H + ] leads to : Chemoreceptor stimulation Increased central respiratory drive Increased V E and V A : hyperventilation Hypocapnia The low ph rises towards normal (not exceeding 7.4) compensatory respiratory alkalosis P a CO 2 = 1 à 1.3 x HCO - 3
43 Metabolic alkalosis Increased HCO 3-, hence increased ph and positive BE, due to HCO 3- accumulation Excessive ingestion of alkali Drug intake : diuretics, corticosteroids Cushing syndrome Hypokalemia Loss of acid Loss of gastric acid : prolonged vomiting, nasogastric suction Via kidneys
44 Metabolic alkalosis If persistent, the reduction in [H + ] leads to : Reduced chemoreceptor stimulation Reduced central respiratory drive Reduced V E and V A : hypoventilation Hypercapnia The increased ph will decrease towards normal (but not below 7.4) compensatory respiratory acidosis P a CO 2 = 0.6 x HCO 3 -
45 Arterial Blood Gases : main use Note sampling conditions Careful sampling and handling Detection of Respiratory Failure Detection of Acid-Base disturbances
46 Interpretation of ABG Oxygenation Look at P a O 2 and S a O 2 Calculate P A-a O 2 Alveolar ventilation Look at P a CO 2 Acid-Base status Look at ph, HCO 3- and BE
47 Classification of Respiratory Failure Type I Type II Acute Chronic Hypoxemia with increased P A-a O 2 Hypocapnia Respiratory alkalosis Hypoxemia Hypocapnia Compensated respiratory alkalosis Due to HCO 3- excretion and metabolic acidosis Hypoxemia with normal P A-a O 2 Hypercapnia Respiratory acidosis Hypoxemia Hypercapnia Compensated respiratory acidosis Due to HCO 3- retention and metabolic alkalosis
48 Classification of Respiratory Failure Type I Type II Acute Chronic P a O 2 P A-a O 2 P a CO 2 ph P a O 2 P A-a O 2 P a CO 2 ph HCO 3 - BE Low High Low High Low High Low High normal Low negative Low Normal High Low Low Normal High Low normal High positive
49 Thank you for listening Hope you enjoyed it, or at least learned something Prof. Dr. W. Vincken Head Respiratory Division AZ VUB
50 Interpretation of ABG Oxygenation reduced P a O 2 and S a O 2 60/88% = hypoxemia and arterial desaturation
51 Interpretation of ABG Alveolar ventilation Increased P a CO 2 = hypercapnia 60 Acid-Base status Look at ph, HCO 3- and BE
52 Interpretation of ABG Alveolar ventilation Increased P a CO 2 = hypercapnia 60 Acid-Base status Reduced ph = acidosis 7.20 Normal HCO 3- and BE 24/0 = acute respiratory acidosis
53 Interpretation of ABG Alveolar ventilation Increased P a CO 2 = hypercapnia 60 Acid-Base status Minimally reduced ph = acidosis 7.36 Increased HCO 3- and BE 32/+8 = chronic respiratory acidosis with compensatory metabolic alkalosis
54 Interpretation of ABG Alveolar ventilation Reduced P a CO 2 = hypocapnia 30 Acid-Base status Look at ph, HCO 3- and BE
55 Interpretation of ABG Alveolar ventilation Reduced P a CO 2 = hypocapnia 30 Acid-Base status Increased ph = alkalosis 7.50 Normal HCO 3- and BE 24/0 = acute respiratory alkalosis
56 Interpretation of ABG Alveolar ventilation Reduced P a CO 2 = hypocapnia 30 Acid-Base status Minimally increased ph = alkalosis 7.42 Reduced HCO 3- and BE 20/-4 = acute respiratory alkalosis with compensatory metabolic acidosis
57 Interpretation of ABG Alveolar ventilation Normal P a CO 2 = normocapnia 40
58 Interpretation of ABG Alveolar ventilation Normal P a CO 2 = normocapnia 40 Acid-Base status Look at ph, HCO 3- and BE
59 Interpretation of ABG Alveolar ventilation Normal P a CO 2 = normocapnia 40 Acid-Base status Reduced ph = acidosis 7.27 Look at HCO 3- and BE
60 Interpretation of ABG Alveolar ventilation Normal P a CO 2 = normocapnia 40 Acid-Base status Reduced ph = acidosis 7.27 Reduced HCO 3- and BE 16/-7 = acute metabolic acidosis
61 Interpretation of ABG Alveolar ventilation Reduced P a CO 2 = hypocapnia 30 Acid-Base status Minimally reduced ph = acidosis 7.37 Reduced HCO 3- and BE 16/-7 = chronic metabolic acidosis with compensatory respiratory alkalosis
62 Interpretation of ABG Alveolar ventilation Normal P a CO 2 = normocapnia 40
63 Interpretation of ABG Alveolar ventilation Normal P a CO 2 = normocapnia 40 Acid-Base status Look at ph, HCO 3- and BE
64 Interpretation of ABG Alveolar ventilation Normal P a CO 2 = normocapnia 40 Acid-Base status Increased ph = alkalosis 7.50 Look at HCO 3- and BE
65 Interpretation of ABG Alveolar ventilation Normal P a CO 2 = normocapnia 40 Acid-Base status Increased ph = alkalosis 7.50 Increased HCO 3- and BE 32/+8 = acute metabolic alkalosis
66 Interpretation of ABG Alveolar ventilation Increased P a CO 2 = hypercapnia 50 Acid-Base status Minimally increased ph = alkalosis 7.43 Increased HCO 3- and BE 32/+8 = chronic metabolic alkalosis with compensatory respiratory acidosis
67 Classification of Respiratory Failure According to type of onset/duration Acute Respiratory Failure Chronic Respiratory Failure Acute on Chronic Respiratory Failure
68 Definition of Respiratory Failure Abnormal Arterial Blood Gases Hypoxemia with P a O 2 < 60 mmhg without or with Hypercapnia with P a CO 2 > 50 mmhg Without ABGs No Diagnosis of RF
69 Classification of Respiratory Failure According to type of ABG abnormality Respiratory Failure Type I Hypoxemia without hypercapnia Respiratory Failure Type II Hypoxemia with hypercapnia
70 Classification of Respiratory Failure According to type of ABG abnormality Type I RF ~ Oxygenation Failure Failure of the lung as a gas exchanger (O 2 and CO 2 ) Type II RF ~ Ventilatory Failure Failure of the respiratory system as an air pump Mixed Failure
71 Oxygenation Failure Reduced P a O 2 (hypoxemia) Increased P A-a O 2 Reduced P a CO 2 (hypocapnia) Increased ph (respiratory alkalosis) If persistent: compensatory metabolic acidosis (renal bicarbonate excretion)
72 Oxygenation Failure Abnormal Chest X-Ray Diffuse pulmonary diseases Localised pulmonary diseases Normal Chest X-Ray Anatomic R>L shunts Asthma (except for hyperinflation) Pulmonary embolism/vascular disease
73 Ventilatory Failure Increased P a CO 2 (hypercapnia) Reduced ph (respiratory acidosis) Reduced P a O 2 (pro rata hypoxemia) Normal P A-a O 2 If persistent: compensatory metabolic alkalosis (renal bicarbonate retention) Acutely, HCO 3- = 0.1 x P a CO 2 Chronically, HCO 3- = 0.35 x P a CO 2
74
75
Interpretation of Arterial Blood Gases (ABG)
Interpretation of Arterial Blood Gases (ABG) Prof. Dr. W. Vincken Head Respiratory Division Universitair Ziekenhuis Brussel (UZ Brussel) Vrije Universiteit Brussel (VUB) 29-3-2015 W Vincken - UZ Brussel
More informationCarbon Dioxide Transport. Carbon Dioxide. Carbon Dioxide Transport. Carbon Dioxide Transport - Plasma. Hydrolysis of Water
Module H: Carbon Dioxide Transport Beachey Ch 9 & 10 Egan pp. 244-246, 281-284 Carbon Dioxide Transport At the end of today s session you will be able to : Describe the relationship free hydrogen ions
More informationPhysiological Causes of Abnormal ABG s
Physiological Causes of Abnormal ABG s Major Student Performance Objective 1 1. The student will be able to discuss causes for various types of blood gas results. 2. They will also be required to discuss
More informationAcids, Bases, and Salts
Acid / Base Balance Objectives Define an acid, a base, and the measure of ph. Discuss acid/base balance, the effects of acidosis or alkalosis on the body, and the mechanisms in place to maintain balance
More information/ABG. It covers acid-base disturbance, respiratory failure, and a small summary for some other derangements. Causes of disturbance
/ABG This page focuses on providing some possible causes for the various disturbances that may be seen on an ABG. Although not an exhaustive list, it attempts to outline the main headings for possible
More informationArterial Blood Gases. Dr Mark Young Mater Health Services
Arterial Blood Gases Dr Mark Young Mater Health Services Why do them? Quick results Bedside test Range of important information Oxygenation Effectiveness of gas exchange Control of ventilation Acid base
More informationArterial Blood Gas Analysis
Arterial Blood Gas Analysis L Lester www.3bv.org Bones, Brains & Blood Vessels Drawn from radial or femoral arteries. Invasive procedure Caution must be taken with patient on anticoagulants ph: 7.35-7.45
More informationBlood Gases, ph, Acid- Base Balance
Blood Gases, ph, Acid- Base Balance Blood Gases Acid-Base Physiology Clinical Acid-Base Disturbances Blood Gases Respiratory Gas Exchange Chemical Control of Respiration Dyshemoglobins Oxygen Transport
More informationUNIT VI: ACID BASE IMBALANCE
UNIT VI: ACID BASE IMBALANCE 1 Objectives: Review the physiological mechanism responsible to regulate acid base balance in the body i.e.: Buffers (phosphate, hemoglobin, carbonate) Renal mechanism Respiratory
More informationRespiratory Failure. Causes of Acute Respiratory Failure (ARF): a- Intrapulmonary:
Respiratory failure exists whenever the exchange of O 2 for CO 2 in the lungs cannot keep up with the rate of O 2 consumption & CO 2 production in the cells of the body. This results in a fall in arterial
More informationAcid-Base Imbalance-2 Lecture 9 (12/4/2015) Yanal A. Shafagoj MD. PhD
AcidBase Imbalance2 Lecture 9 (12/4/2015) Yanal A. Shafagoj MD. PhD Introduction Disturbance in acidbase balance are common clinical problem that range in severity from mild to life threatening, the acute
More informationOutline. ABG Interpretation: A Respirologist s approach. Acid-Base Disturbances. What use is an ABG? Acid-Base Disturbances. Alveolar Ventilation
Outline ABG Interpretation: A Respirologist s approach Dr. Shane Shapera Division of Respirology University Health Network October 2014 A quick review of acidbase physiology The 8 steps to ABG interpretation
More informationArterial Blood Gases Interpretation Definition Values respiratory metabolic
Arterial Blood Gases Interpretation Definition A blood gas test measures the amount of oxygen and carbon dioxide in the blood. It is also useful in determining the ph level of the blood. The test is commonly
More informationBasic facts repetition Regulation of A-B balance. Pathophysiology of clinically important disorders
In The name of God Acid base balance Basic facts repetition Regulation of A-B balance Pathophysiology of clinically important disorders Acid-Base Balance Physiology - The ph of ECF is tightly regulated
More informationPICU Resident Self-Study Tutorial Interpreting Blood Gases
Christopher Carroll, MD INTRODUCTION Blood gases give us a huge amount of information regarding the patient s physiologic condition and are the best method available to assess a patient s oxygenation and
More informationOXYGENATION AND ACID- BASE EVALUATION. Chapter 1
OXYGENATION AND ACID- BASE EVALUATION Chapter 1 MECHANICAL VENTILATION Used when patients are unable to sustain the level of ventilation necessary to maintain the gas exchange functions Artificial support
More informationWanchai Wongkornrat Cardiovascular Thoracic Surgery Siriraj Hospital Mahidol University
Wanchai Wongkornrat Cardiovascular Thoracic Surgery Siriraj Hospital Mahidol University Assess adequacy of ventilation and oxygenation Aids in establishing a diagnosis and severity of respiratory failure
More informationFluid and Electrolytes P A R T 4
Fluid and Electrolytes P A R T 4 Mechanisms that control acid-base homeostasis Acids and bases continually enter and leave body Hydrogen ions also result from metabolic activity Acids Hydrogen ion donors
More informationAcid Base Balance by: Susan Mberenga RN, BSN, MSN
Acid Base Balance by: Susan Mberenga RN, BSN, MSN Acid Base Balance Refers to hydrogen ions as measured by ph Normal range: 7.35-7.45 Acidosis/acidemia: ph is less than 7.35 Alkalosis/alkalemia: ph is
More information1. What is the acid-base disturbance in this patient?
/ABG QUIZ QUIZ 1. What is the acid-base disturbance in this patient? Presenting complaint: pneumonia 1 point Uncompensated metabolic alkalosis Partially compensated respiratory alkalosis Mixed alkalosis
More information3. Which of the following would be inconsistent with respiratory alkalosis? A. ph = 7.57 B. PaCO = 30 mm Hg C. ph = 7.63 D.
Pilbeam: Mechanical Ventilation, 4 th Edition Test Bank Chapter 1: Oxygenation and Acid-Base Evaluation MULTIPLE CHOICE 1. The diffusion of carbon dioxide across the alveolar capillary membrane is. A.
More informationRespiratory Pathophysiology Cases Linda Costanzo Ph.D.
Respiratory Pathophysiology Cases Linda Costanzo Ph.D. I. Case of Pulmonary Fibrosis Susan was diagnosed 3 years ago with diffuse interstitial pulmonary fibrosis. She tries to continue normal activities,
More informationControl of Ventilation [2]
Control of Ventilation [2] สรช ย ศร ส มะ พบ., Ph.D. ภาคว ชาสร รว ทยา คณะแพทยศาสตร ศ ร ราชพยาบาล มหาว ทยาล ยมห ดล Describe the effects of alterations in chemical stimuli, their mechanisms and response to
More informationCauses and Consequences of Respiratory Centre Depression and Hypoventilation
Causes and Consequences of Respiratory Centre Depression and Hypoventilation Lou Irving Director Respiratory and Sleep Medicine, RMH louis.irving@mh.org.au Capacity of the Respiratory System At rest During
More informationRESPIRATORY SYSTEM and ACID BASE
RESPIRATORY SYSTEM and ACID BASE Arif HM Marsaban Rudyanto Sedono Department of Anesthesiology and Intensive Therapy Faculty of medicine University of Indonesia Dr Cipto Mangunkusumo General Hospital Jakarta
More informationAcid-Base Tutorial 2/10/2014. Overview. Physiology (2) Physiology (1)
Overview Acid-Base Tutorial Nicola Barlow Physiology Buffering systems Control mechanisms Laboratory assessment of acid-base Disorders of H + ion homeostasis Respiratory acidosis Metabolic acidosis Respiratory
More informationIdentification and Treatment of the Patient with Sleep Related Hypoventilation
Identification and Treatment of the Patient with Sleep Related Hypoventilation Hillary Loomis-King, MD Pulmonary and Critical Care of NW MI Munson Sleep Disorders Center X Conflict of Interest Disclosures
More informationThere are number of parameters which are measured: ph Oxygen (O 2 ) Carbon Dioxide (CO 2 ) Bicarbonate (HCO 3 -) AaDO 2 O 2 Content O 2 Saturation
Arterial Blood Gases (ABG) A blood gas is exactly that...it measures the dissolved gases in your bloodstream. This provides one of the best measurements of what is known as the acid-base balance. The body
More informationARTERIAL BLOOD GASES PART 1 BACK TO BASICS SSR OLIVIA ELSWORTH SEPT 2017
ARTERIAL BLOOD GASES PART 1 BACK TO BASICS SSR OLIVIA ELSWORTH SEPT 2017 WHAT INFORMATION DOES AN ABG GIVE US? ph = measure of hydrogen ion concentration (acidity or alkalinity) PaCO2 = partial pressure
More informationAre you ready to have fun?
Arterial Blood Gas INTERPRETATION By Nena Bonuel, MSN, RN, CCRN, CNS, ACNS-BC Nurse Specialist, Center for Professional Excellence Are you ready to have fun? 1. Yes! 2. I rather go shopping 3. I still
More information1. When a patient fails to ventilate or oxygenate adequately, the problem is caused by pathophysiological factors such as hyperventilation.
Chapter 1: Principles of Mechanical Ventilation TRUE/FALSE 1. When a patient fails to ventilate or oxygenate adequately, the problem is caused by pathophysiological factors such as hyperventilation. F
More informationAcid/Base Disorders 2015
Objectives - 2 1. Identify acid/base disorders 2. Discuss etiologies for 1 0 acid/base disorders (will not include mixed disorders) 3. Interpret acid/base disorders by interpreting arterial blood gas &
More informationBUFFERING OF HYDROGEN LOAD
BUFFERING OF HYDROGEN LOAD 1. Extracellular space minutes 2. Intracellular space minutes to hours 3. Respiratory compensation 6 to 12 hours 4. Renal compensation hours, up to 2-3 days RENAL HYDROGEN SECRETION
More informationAcute respiratory failure
Rita Williams, NP-C, PA PeaceHealth Medical Group Pulmonary & Critical Care Acute respiratory failure Ventilation/perfusion mismatching Most common cause of hypoxemia Normal is 1:1 ratio or 1 Ventilation
More informationChronic Obstructive Pulmonary Disease
136 PHYSIOLOGY CASES AND PROBLEMS Case 24 Chronic Obstructive Pulmonary Disease Bernice Betweiler is a 73-year-old retired seamstress who has never been married. She worked in the alterations department
More informationRespiratory Physiology Part II. Bio 219 Napa Valley College Dr. Adam Ross
Respiratory Physiology Part II Bio 219 Napa Valley College Dr. Adam Ross Gas exchange Gas exchange in the lungs (to capillaries) occurs by diffusion across respiratory membrane due to differences in partial
More informationDisorders of Acid-Base
Disorders of Acid-Base Balance Bởi: OpenStaxCollege Normal arterial blood ph is restricted to a very narrow range of 7.35 to 7.45. A person who has a blood ph below 7.35 is considered to be in acidosis
More informationInterpretation of the Arterial Blood Gas
Interpretation of the Arterial Blood Gas Self-Learning Packet This self-learning packet is approved for 2 contact hours for the following professionals: 1. Registered Nurse 2. Licensed Practical Nurse
More informationANATOMY & PHYSIOLOGY - CLUTCH CH ACID-BASE BALANCE-- CONTROLLING BLOOD PH
!! www.clutchprep.com ANATOMY & PHYSIOLOGY - CLUTCH CONCEPT: INTRO. TO DISTURBING AND MAINTAINING BLOOD ph Physiological Sources of Acid (and Base): Acids are molecules/substances that H+ to a solution.
More informationUNIT 9 INVESTIGATION OF ACID-BASE DISTURBANCES
UNIT 9 INVESTIGATION OF ACIDBASE DISTURBANCES LEARNING OBJECTIVES At the end of this chapter, students must be able to: 1. Describe the main parametres that define the acidbase equilibrium 2. Identify
More informationDr. Suzana Voiculescu
Dr. Suzana Voiculescu AB balance parameters Extracellular ph (plasmatic ph)= 7.35-7.45 < 7.35= acidosis >7.45= alkalosis Kassirer-Bleich equation [H+] = 24 PCO2/ [HCO3-] predicts that the ratio of dissolved
More informationAcid Base Balance. Professor Dr. Raid M. H. Al-Salih. Clinical Chemistry Professor Dr. Raid M. H. Al-Salih
Acid Base Balance 1 HYDROGEN ION CONCENTRATION and CONCEPT OF ph Blood hydrogen ion concentration (abbreviated [H + ]) is maintained within tight limits in health, with the normal concentration being between
More informationLecture Notes. Chapter 2: Introduction to Respiratory Failure
Lecture Notes Chapter 2: Introduction to Respiratory Failure Objectives Define respiratory failure, ventilatory failure, and oxygenation failure List the causes of respiratory failure Describe the effects
More informationRenal Physiology. April, J. Mohan, PhD. Lecturer, Physiology Unit, Faculty of Medical Sciences, U.W.I., St Augustine.
Renal Physiology April, 2011 J. Mohan, PhD. Lecturer, Physiology Unit, Faculty of Medical Sciences, U.W.I., St Augustine. Office : Room 105, Physiology Unit. References: Koeppen B.E. & Stanton B.A. (2010).
More informationa. Describe the physiological consequences of intermittent positive pressure ventilation and positive end-expiratory pressure.
B. 10 Applied Respiratory Physiology a. Describe the physiological consequences of intermittent positive pressure ventilation and positive end-expiratory pressure. Intermittent positive pressure ventilation
More informationBiochemistry of acid-base disorders. Alice Skoumalová
Biochemistry of acid-base disorders Alice Skoumalová Main topics of the lecture: Measurement of acid-base dysbalance Classification of the acid-base disorders 4 basic acid-base disorders and their compensaiton
More information3/17/2017. Acid-Base Disturbances. Goal. Eric Magaña, M.D. Presbyterian Medical Center Department of Pulmonary and Critical Care Medicine
Acid-Base Disturbances Eric Magaña, M.D. Presbyterian Medical Center Department of Pulmonary and Critical Care Medicine Goal Provide an approach to determine complex acid-base disorders Discuss the approach
More informationSIMPLY Arterial Blood Gases Interpretation. Week 4 Dr William Dooley
SIMPLY Arterial Blood Gases Interpretation Week 4 Dr William Dooley Plan Structure for interpretation 5-step approach Works for majority of cases Case scenarios Some common concerns A-a gradient BE Anion
More informationOxygen and ABG. Dr Will Dooley
Oxygen and ABG G Dr Will Dooley Oxygen and ABGs Simply in 10 cases Recap of: ABG interpretation Oxygen management Some common concerns A-a gradient Base Excess Anion Gap COPD patients CPAP/BiPAP First
More informationmore than 50% of adults weigh more than 20% above optimum
In the US: more than 50% of adults weigh more than 20% above optimum >30 kg m -2 obesity >40 kg m -2 morbid obesity BMI = weight(kg) / height(m 2 ) Pounds X 2.2 Inches divided by 39, squared From 2000
More informationAcid and Base Balance
Acid and Base Balance 1 2 The Body and ph Homeostasis of ph is tightly controlled Extracellular fluid = 7.4 Blood = 7.35 7.45 < 7.35: Acidosis (acidemia) > 7.45: Alkalosis (alkalemia) < 6.8 or > 8.0: death
More information9/14/2017. Acid-Base Disturbances. Goal. Provide an approach to determine complex acid-base disorders
Acid-Base Disturbances NCNP October 10, 2017 Eric Magaña, M.D. Presbyterian Medical Center Department of Pulmonary and Critical Care Medicine Goal Provide an approach to determine complex acid-base disorders
More informationDr. Sinan Butrus F.I.C.M.S. Clinical Standards & Guidelines. Kurdistan Board For Medical Specialties
Guidelines For the Management of Respiratory Acidosis By Dr. Sinan Butrus F.I.C.M.S Clinical Standards & Guidelines Kurdistan Board For Medical Specialties Respiratory acidosis is an acid-base balance
More informationAcid-base balance is one of the most important of the body s homeostatic mechanisms Acid-base balance refers to regulation of hydrogen ion (H + )
Acid-base balance is one of the most important of the body s homeostatic mechanisms Acid-base balance refers to regulation of hydrogen ion (H + ) concentration in body fluids Precise regulation of ph at
More informationThe Respiratory System
Elaine N. Marieb Katja Hoehn Human Anatomy & Physiology SEVENTH EDITION C H A P T E R PowerPoint Lecture Slides prepared by Vince Austin, Bluegrass Technical and Community College 22P A R T B The Respiratory
More informationThere are many buffers in the kidney, but the main one is the phosphate buffer.
9 Yanal Obada Zalat Renal Control of AcidBase Balance The kidneys play three major roles in the maintenance of normal acidbase balance: 1excretion of H+ (fixed _non volatile H+) 2Reabsorption of filtrated
More informationArterial Blood Gas Interpretation: The Basics
http://www.medicine-on-line.com ABG Basics: Page 1/10 Arterial Blood Gas Interpretation: The Basics Author: David C Chung MD, FRCPC Affiliation: The Chinese University of Hong Kong Sampling of arterial
More informationDisorders of Acid-Base Balance
OpenStax-CNX module: m46413 1 Disorders of Acid-Base Balance OpenStax College This work is produced by OpenStax-CNX and licensed under the Creative Commons Attribution License 3.0 By the end of this section,
More informationAcid-Base Balance Dr. Gary Mumaugh
Acid-Base Balance Dr. Gary Mumaugh Introduction Acid-base balance is one of the most important of the body s homeostatic mechanisms Acid-base balance refers to regulation of hydrogen ion (H + ) concentration
More informationExercise Stress Testing: Cardiovascular or Respiratory Limitation?
Exercise Stress Testing: Cardiovascular or Respiratory Limitation? Marshall B. Dunning III, Ph.D., M.S. Professor of Medicine & Physiology Medical College of Wisconsin What is exercise? Physical activity
More informationDr. Suzana Voiculescu Discipline of Physiology and Fundamental Neurosciences Carol Davila Univ. of Medicine and Pharmacy
Dr. Suzana Voiculescu Discipline of Physiology and Fundamental Neurosciences Carol Davila Univ. of Medicine and Pharmacy AB balance parameters Extracellular ph (plasmatic ph)= 7.35-7.45 < 7.35= acidosis
More informationD fini n tion: p = = -log [H+] ph=7 me m an s 10-7 Mol M H+ + (100 nmol m /l); ) p ; H=8 me m an s 10-8 Mol M H+ + (10 (10 n nmol m /l) Nor
Definition: ph regulation ph = -log [H + ] ph=7 means 10-7 Mol H + (100 nmol/l); ph=8 means 10 Normal plasma value: 7.35-7.45; 7.45; (H Acidosis: ph7.45 Intracellular ph = 7.1-7.3
More informationInter Inter Pretation of Acid Base Disturbance in Critically ill Patients. By :-: Dr. Vinay Bhomia M.D.
Inter Inter Pretation of Acid Base Disturbance in Critically ill Patients. By :-: Dr. Vinay Bhomia M.D. Normal Blood PH 7.35 to 7.45 Crucial importance to maintain homeostatic function of Body. Any Significant
More informationi-stat Alinity v Utilization Guide
istat Alinity v Utilization Guide The istat Alinity v delivers blood gas, acidbase, electrolyte, chemistry, and hematology measurements in a completely portable, handheld package. Accuracy is ensured by
More information5. What is the cause of this patient s metabolic acidosis? LACTIC ACIDOSIS SECONDARY TO ANEMIC HYPOXIA (HIGH CO LEVEL)
Self-Assessment RSPT 2350: Module F - ABG Analysis 1. You are called to the ER to do an ABG on a 40 year old female who is C/O dyspnea but seems confused and disoriented. The ABG on an FiO 2 of.21 show:
More informationPARAMEDIC RESOURCE MANUAL
ONTARIO BASE HOSPITAL GROUP PARAMEDIC RESOURCE MANUAL ACID-BASE BALANCE SECTION SIX Version 1.1 2010 Update PARAMEDIC RESOURCE MANUAL OBJECTIVES: ACID-BASE BALANCE The objectives indicate what you should
More informationFoundation in Critical Care Nursing. Airway / Respiratory / Workbook
Foundation in Critical Care Nursing Airway / Respiratory / Workbook Airway Anatomy: Please label the following: Tongue Larynx Epiglottis Pharynx Trachea Vertebrae Oesophagus Where is the ET (endotracheal)
More informationAcid Base Balance. Chapter 26 Balance. ph Imbalances. Acid Base Balance. CO 2 and ph. Carbonic Acid. Part 2. Acid/Base Balance
Acid Base Balance Chapter 26 Balance Part 2. Acid/Base Balance Precisely balances production and loss of hydrogen ions (ph) The body generates acids during normal metabolism, tends to reduce ph Kidneys:
More informationObjectives. Health care significance of ARF 9/10/15 TREATMENT OF ACUTE RESPIRATORY FAILURE OF VARIABLE CAUSES: INVASIVE VS. NON- INVASIVE VENTILATION
TREATMENT OF ACUTE RESPIRATORY FAILURE OF VARIABLE CAUSES: INVASIVE VS. NON- INVASIVE VENTILATION Louisa Chika Ikpeama, DNP, CCRN, ACNP-BC Objectives Identify health care significance of acute respiratory
More informationCASE 27. What is the response of the kidney to metabolic acidosis? What is the response of the kidney to a respiratory alkalosis?
CASE 27 A 21-year-old man with insulin-dependent diabetes presents to the emergency center with mental status changes, nausea, vomiting, abdominal pain, and rapid respirations. On examination, the patient
More informationThe equilibrium between basis and acid can be calculated and termed as the equilibrium constant = Ka. (sometimes referred as the dissociation constant
Acid base balance Dobroslav Hájek dhajek@med.muni.cz May 2004 The equilibrium between basis and acid can be calculated and termed as the equilibrium constant = Ka. (sometimes referred as the dissociation
More informationControl of Breathing
Physio # 11 Dr. Yanal Shafaqoj Done By: Lejan Al - Dof'at 13/12/13 Control of Breathing We talked previously about Oxygen extraction and CO 2 production, and how these are transfused through blood (in
More informationACID-BASE DISORDERS. Assist.Prof.Dr. Filiz BAKAR ATEŞ
ACID-BASE DISORDERS Assist.Prof.Dr. Filiz BAKAR ATEŞ Acid-Base Regulation Metabolic processes continually produce acid and, to a lesser degree, base. Hydrogen ion (H+) is especially reactive; it can attach
More informationCarbon Dioxide Transport and Acid-Base Balance
CHAPTER 7 Carbon Dioxide Transport and Acid-Base Balance Carbon Dioxide Transport Dioxide Transport In plasma: Carbamino compound (bound to protein) Bicarbonate Dissolved CO 2 CO 2 Is Converted to HCO
More informationArterial blood gas analysis
perioperativecpd.com continuing professional development Arterial blood gas analysis Article based on original by the Resuscitation Council U.K. Introduction Interpreting the analysis of an arterial blood
More informationLecture Notes. Chapter 9: Smoke Inhalation Injury and Burns
Lecture Notes Chapter 9: Smoke Inhalation Injury and Burns Objectives List the factors that influence mortality rate Describe the nature of smoke inhalation and the fire environment Recognize the pulmonary
More informationInformation Often Given to the Nurse at the Time of Admission to the Postanesthesia Care Unit
Information Often Given to the Nurse at the Time of Admission to the Postanesthesia Care Unit * Patient s name and age * Surgical procedure and type of anesthetic including drugs used * Other intraoperative
More informationIntroduction and Overview of Acute Respiratory Failure
Introduction and Overview of Acute Respiratory Failure Definition: Acute Respiratory Failure Failure to oxygenate Inadequate PaO 2 to saturate hemoglobin PaO 2 of 60 mm Hg ~ SaO 2 of 90% PaO 2 of 50 mm
More informationi-stat Alinity v Utilization Guide
istat Alinity v Utilization Guide The istat Alinity v delivers blood gas, acidbase, electrolyte, chemistry, and hematology results in a completely portable, handheld package. Accuracy is ensured by extensive
More informationBasic mechanisms disturbing lung function and gas exchange
Basic mechanisms disturbing lung function and gas exchange Blagoi Marinov, MD, PhD Pathophysiology Department, Medical University of Plovdiv Respiratory system 1 Control of breathing Structure of the lungs
More informationThe relationship between H+,PaCO₂ and HCO₃ are expressed in the equation of:
[Acid-Base Balance] [Dr. Bashir Khasawneh] [5 th February 2012] Acid-Base Basic Concepts: The relationship between H+,PaCO₂ and HCO₃ are expressed in the equation of: Which is modified from Henderson-Hasselbach
More informationi. Zone 1 = dead space ii. Zone 2 = ventilation = perfusion (ideal situation) iii. Zone 3 = shunt
Respiratory Review I. Oxygen transport a. Oxygen content of blood i. Dissolved oxygen =.003 x PaO 2, per 100 ml plasma 1. Henry s Law ii. Oxygen on hemoglobin = 1.34 ml x sat x Hgb iii. CaO 2 = Dissolved
More informationPulmonary Pearls. Medical Pearls. Case 1: Case 1 (cont.): Case 1: What is the Most Likely Diagnosis? Case 1 (cont.):
Pulmonary Pearls Christopher H. Fanta, MD Pulmonary and Critical Care Division Brigham and Women s Hospital Partners Asthma Center Harvard Medical School Medical Pearls Definition: Medical fact that is
More informationsounds are distant with inspiratory crackles. He sits on the edge of his chair, leaning forward, with both hands on his
I NTE R P R ETI N G A R T E R I A L B L O O D G A S E S : EASY AS A B C Take this step-by-step approach to demystify the parameters of oxygenation, ventilation, acid-base balance. BY WILLIAM C. PRUITT,
More informationChapter 15 Fluid and Acid-Base Balance
Chapter 15 Fluid and Acid-Base Balance by Dr. Jay M. Templin Brooks/Cole - Thomson Learning Fluid Balance Water constitutes ~60% of body weight. All cells and tissues are surrounded by an aqueous environment.
More informationAcid-Base Imbalance. Shu-Yi (Emily) Wang, PhD, RN, CNS Denver School of Nursing
Acid-Base Imbalance Shu-Yi (Emily) Wang, PhD, RN, CNS gpwsy@hotmail.com Denver School of Nursing ph Ranges Compatible With Life In blood, the ph represents the relationship between the respiratory and
More informationDisclaimer. Chapter 3 Disorder of Water, Electrolyte and Acid-base Professor A. S. Alhomida. Disorder of Water and Electrolyte
Disclaimer King Saud University College of Science Department of Biochemistry The texts, tables, figures and images contained in this course presentation (BCH 376) are not my own, they can be found on:
More informationWeeks 1-3:Cardiovascular
Weeks 1-3:Cardiovascular Cardiac Output The total volume of blood ejected from the ventricles in one minute is known as the cardiac output. Heart Rate (HR) X Stroke Volume (SV) = Cardiac Output Normal
More informationCarver College of Medicine University of Iowa
October 15, 2010 Deborah J. DeWaay MD Assistant Professor of Medicine Associate Vice Chair i of Education Department of Internal Medicine Medical University of South Carolina Joel A. Gordon, MD Professor
More informationNeaam Al-Bahadili. Rana J. Rahhal. Mamoun Ahram
5 Neaam Al-Bahadili Rana J. Rahhal Mamoun Ahram In this sheet we will continue taking about Titration curve and Buffers in human body. Let s begin Titration curve of phosphate buffer: 1. There are 3 buffering
More informationCor pulmonale. Dr hamid reza javadi
1 Cor pulmonale Dr hamid reza javadi 2 Definition Cor pulmonale ;pulmonary heart disease; is defined as dilation and hypertrophy of the right ventricle (RV) in response to diseases of the pulmonary vasculature
More informationFor more information about how to cite these materials visit
Author(s): John G. Younger, M.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike 3.0 License: http://creativecommons.org/licenses/by-sa/3.0/
More informationINDICATIONS FOR RESPIRATORY ASSISTANCE A C U T E M E D I C I N E U N I T P - Y E A R M B B S 4
INDICATIONS FOR RESPIRATORY ASSISTANCE A C U T E M E D I C I N E U N I T P - Y E A R M B B S 4 RESPIRATORY FAILURE Acute respiratory failure is defined by hypoxemia with or without hypercapnia. It is one
More informationPulmonary Problems of the Neonate. Jon Palmer, VMD, DACVIM Chief, Neonatal Intensive Care Service New Bolton Center, University of Pennsylvania, USA
Pulmonary Problems of the Neonate Jon Palmer, VMD, DACVIM Chief, Neonatal Intensive Care Service New Bolton Center, University of Pennsylvania, USA Lower Respiratory Diseases Ventilation/Perfusion Abnormalities
More informationACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) Rv
ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) Rv.8.18.18 ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) SUDDEN PROGRESSIVE FORM OF ACUTE RESPIRATORY FAILURE ALVEOLAR CAPILLARY MEMBRANE BECOMES DAMAGED AND MORE
More information3. Which statement is false about anatomical dead space?
Respiratory MCQs 1. Which of these statements is correct? a. Regular bronchioles are the most distal part of the respiratory tract to contain glands. b. Larynx do contain significant amounts of smooth
More informationCritical Care Monitoring. Assessing the Adequacy of Tissue Oxygenation. Tissue Oxygenation - Step 1. Tissue Oxygenation
Critical Care Monitoring 1 Assessing the Adequacy of Tissue oxygenation is the end-product of many complex steps 2 - Step 1 Oxygen must be made available to alveoli 3 1 - Step 2 Oxygen must cross the alveolarcapillary
More informationAcute respiratory failure. Arterial blood gas assessment. finn rasmussen 2011
Acute respiratory failure Arterial blood gas assessment finn rasmussen 2011 Normal P a CO 2 = 40mmHg Normal P a O 2 = 90-95 mmhg ALVEOLAR VENTILATION Normal HCO 3- = 22-27 mmol/l H + 2 0 CO + 2 H HCO -
More informationNeaam Al-Bahadili. Rana J. Rahhal. Mamoun Ahram
5 Neaam Al-Bahadili Rana J. Rahhal Mamoun Ahram In this sheet we will continue taking about Titration curve and Buffers in human body. Let s begin Titration curve of phosphate buffer: 1. There are 3 buffering
More informationControl of Respiration
Control of Respiration Graphics are used with permission of: adam.com (http://www.adam.com/) Benjamin Cummings Publishing Co (http://www.awl.com/bc) Page 1. Introduction The basic rhythm of breathing is
More information