Genetically distinct Glossina fuscipes fuscipes populations in the Lake Kyoga region of Uganda and its relevance for Human Africa trypanosomiasis

Size: px
Start display at page:

Download "Genetically distinct Glossina fuscipes fuscipes populations in the Lake Kyoga region of Uganda and its relevance for Human Africa trypanosomiasis"

Transcription

1 Genetically distinct Glossina fuscipes fuscipes populations in the Lake Kyoga region of Uganda and its relevance for Human Africa trypanosomiasis Richard Echodu, Mark Sistrom, Chaz Hyseni, John Enyaru, Loyce Okedi, Serap Aksoy, Adalgisa Caccone 32 nd ISCTRC Conference 11 th September 2013, Khartoum, Sudan

2 Trypanosomiasis control No vaccine against trypanosomes Treatment is costly and sometimes ineffective Treatment of infected humans and animals Vector control best option for control Various techniques have been successful but not useful for areawide application

3 Introduction Ecological and genetic data are important in understanding population dynamics, thus help determine the appropriate scale at which control can be effective (Ouma et al. Solano et al. Beadell et al.2010, Echodu et al. 2011, Hyseni et al etc) Insights into the patterns of dispersion Identifying barriers to gene flow Predicting fly movements Assessing re-invasion risks from neighboring sites Define the spatial extent, temporal stability, and size of the population targeted for control.

4 Epidemiology of HAT & Glossina fuscipes fuscipes distribution in Uganda T. b. gambiense Source: Maina, 2010 Trypanosoma brucei rhodesiense

5 Beadell et al. (2010) PLOS Neglected Diseases

6 Specific objective Determine the level of differentiation and gene flow of G. f. fuscipes between and within the Lake Kyoga region.

7 Tsetse collections

8 Methods We visited a total of 49 sites, 23 of which yielded a total of 2918 tsetse flies with an average of 127 per site. Microsatellites genotyping 1221 tsetse flies (collected /2010) from 23 sites 18 microsatellite loci Mitochondrial DNA 489 flies (collected /2010). 570bp COI

9 Phylogenetic relationships A total of 57 haplotypes, including 15 new ones

10 Measures of genetic differentiation

11 Population Structure of Glossina fuscipes fuscipes

12 Exploring migration patterns along latitudinal or longitudinal directions KZ KK KB Uganda AR MF O KR G MS MY KF JN SS KA Y NA KT OC PD AM IGG KL BV OT MK PT BU T B Lake Victoria BKD BK BN T OK B ND North-South Transact Microsatellite mtdna cluster Total Number No. from No. from No. mixed Code cluster of migrant Northern Southern zone Total East-West Transact Code Microsatellite cluster mtdna cluster Total Number of migrant No. from Northern No. from Southern No. mixed zone Total

13 Implications for Gff vector control and future directions Hyseni et al. 2012

14 Effective population size (Ne) of the different population. NEESTIMATOR 1.3 (Peel et al. 2004). Momentum Based Temporal, Waples 1989, Bayesian approach TM3, Berthier et al. (2002), iterations & a NeMAX of Population N0. of generation Microsatellite data Mitochondria data MBT 95% CI TM3 95% CI MBT 95% CI BU infinity ,000 inf. (113.8-inf.) ( ,000) OK infinity infinity ,000 inf. (1.9-inf.) (0-20,000) BN infinity ,000 inf. (9.4-inf.) (0-20,000) MK infinity ,000 inf. (0.6-inf.) (0-20,000) MS infinity ,000 inf. (2.7-inf.) (0-20,000) JN 0-13 infinity infinity , (0.5-inf.) 91.5 ( ) UGT/OT , (6.4-inf.) (0-20,000)

15 Temporal variation in genetic diversity

16 Conclusions We identified three main genetic clusters with northern, Southern and western distributions in concordance with previous studies of Beadell et al. (2009). We find a narrow contact zone between northern and southern genetic clusters with migration between clusters. New admixture areas Karuma, Kafu, Namutumba besides MS, JN and BN All admixed sampling localities are along the path of major rivers; the Mpologoma River, the Kafu River, and the Nile River that drain into and out of Lake Kyoga. Large estimates of effective population size are indicative of the temporal stability of G. f. fuscipes populations.

17 Implications for Gff vector control This study highlights the importance of on-going monitoring of Gff in Uganda to provide quantitative information on population densities and dispersal rates to inform efficient control strategies into the future. Geographically close sampling sites exchange migrants more frequently than geographically distant sites Local scales control are unlikely to produce long-lasting results due to re-invasion from adjacent areas, and that in the absence of continued control.

18 Acknowledgements National Institute of Allergy and Infectious Diseases (NIAID) grant RO1AI068932, Fogarty International Center awards D43TW and R03TW008755

Identification of Trypanosoma brucei rhodesiense in wild Tsetse flies in Nkhotakota Wild Life Reserve by PCR

Identification of Trypanosoma brucei rhodesiense in wild Tsetse flies in Nkhotakota Wild Life Reserve by PCR Identification of Trypanosoma brucei rhodesiense in wild Tsetse flies in Nkhotakota Wild Life Reserve by PCR 32 nd International Scientific Council for Trypanosomiasis Research and Control (ISCTRC), September

More information

Investment in new knowledge and tools for control of Glossina: Current status and future perspectives

Investment in new knowledge and tools for control of Glossina: Current status and future perspectives Investment in new knowledge and tools for control of Glossina: Current status and future perspectives Mike Lehane Liverpool School of Tropical Medicine Total Papers Published 44 new papers published with

More information

THE ROLE OF LIVESTOCK IN THE EPIDEMIOLOGY OF SLEEPING SICKNESS IN TANZANIA

THE ROLE OF LIVESTOCK IN THE EPIDEMIOLOGY OF SLEEPING SICKNESS IN TANZANIA THE ROLE OF LIVESTOCK IN THE EPIDEMIOLOGY OF SLEEPING SICKNESS IN TANZANIA Imna Malele, Hamisi Nyingilili, Eugen Lyaruu, Winston Kitwika Tsetse & Trypanosomiasis Research Institute Majani Mapana, Off Korogwe

More information

Trypanosomiasis. By Ahmed Faris Alila Ahmed Laith Al-Nuaimi Ahmed Mohammed Al-juboory Ahmed Naaif Talib Ahmed Nadhem Al-Obeidy Osama Ahmed Al-Obeidy

Trypanosomiasis. By Ahmed Faris Alila Ahmed Laith Al-Nuaimi Ahmed Mohammed Al-juboory Ahmed Naaif Talib Ahmed Nadhem Al-Obeidy Osama Ahmed Al-Obeidy Trypanosomiasis By Ahmed Faris Alila Ahmed Laith Al-Nuaimi Ahmed Mohammed Al-juboory Ahmed Naaif Talib Ahmed Nadhem Al-Obeidy Osama Ahmed Al-Obeidy Ahmed Faris Alila Trypanosomiasis Kingdom: Protisata

More information

Trypanosomiasis. Introduction. Epidemiology. Global Epidemiology. Trypanosomiasis Risk in UK Travellers

Trypanosomiasis. Introduction. Epidemiology. Global Epidemiology. Trypanosomiasis Risk in UK Travellers Trypanosomiasis Introduction Epidemiology Risk for travellers Transmission Signs and symptoms Treatment Prevention References Reading list Links Introduction Trypanosomiasis is caused by parasitic protozoa

More information

اعداد رغداحمد رغد جمال الدين

اعداد رغداحمد رغد جمال الدين اعداد رغداحمد رغد جمال الدين Trypanosoma Causes Trypanosomiasis West African Trypanosomiasis T.brucei gambiense Sleeping sickness East African Trypanosomiasis T.brucei rhodesiense American Trypanosomiasis

More information

ISOTHERMAL AMPLIFICATION IN MOLECULAR DIAGNOSIS OF SLEEPING SICKNESS

ISOTHERMAL AMPLIFICATION IN MOLECULAR DIAGNOSIS OF SLEEPING SICKNESS Molecular Diagnostics Symposium 2014 Zurich, 27 February 2014 ISOTHERMAL AMPLIFICATION IN MOLECULAR DIAGNOSIS OF SLEEPING SICKNESS Stijn Deborggraeve Parasite Diagnostics Unit, Institute of Tropical Medicine

More information

Kinetoplastids Handout

Kinetoplastids Handout Kinetoplastids Handout 1 Kinetoplastids widespread group of flagellated protozoa parasitize virtually all animal groups as well as plants and insects 3 distinct kinetoplastid species cause human disease

More information

African trypanosomiasis or Sleeping sickness. A bio-mathematical study of the disease

African trypanosomiasis or Sleeping sickness. A bio-mathematical study of the disease African trypanosomiasis or Sleeping sickness A bio-mathematical study of the disease YASMINE SAMIA 008 African trypanosomiasis or Sleeping sickness A bio-mathematical study of the disease African trypanosomiasis,

More information

Temporal and spatial epidemiology of sleeping sickness and use of geographical information system (GIS) in Kenya

Temporal and spatial epidemiology of sleeping sickness and use of geographical information system (GIS) in Kenya J Vector Borne Dis 46, March 2009, pp. 18 25 Research Articles Temporal and spatial epidemiology of sleeping sickness and use of geographical information system (GIS) in Kenya Jane Jemeli Rutto & Julia

More information

Trypanosomiasis WRAIR- GEIS 'Operational Clinical Infectious Disease' Course

Trypanosomiasis WRAIR- GEIS 'Operational Clinical Infectious Disease' Course Trypanosomiasis WRAIR- GEIS 'Operational Clinical Infectious Disease' Course UNCLASSIFIED Disclaimer The views expressed in this presentation are those of the speaker and do not reflect the official policy

More information

African Trypanosomiasis Detection Using Dempster-Shafer Theory Andino Maseleno, 2 Md. Mahmud Hasan

African Trypanosomiasis Detection Using Dempster-Shafer Theory Andino Maseleno, 2 Md. Mahmud Hasan African Trypanosomiasis Detection Using Dempster-Shafer Theory 1 Andino Maseleno, 2 Md. Mahmud Hasan 1 Department of Computer Science, Faculty of Science, Universiti Brunei Darussalam 2 Jalan Tungku Link,

More information

Phylogeography and Taxonomy of Trypanosoma brucei

Phylogeography and Taxonomy of Trypanosoma brucei Oliver Balmer 1,2,3 *., Jon S. Beadell 2,4., Wendy Gibson 5, Adalgisa Caccone 2,4 1 Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland,

More information

KINETOPLASTIDS. Kinetoplast. Nucleus

KINETOPLASTIDS. Kinetoplast. Nucleus KINETOPLASTIDS Kinetoplast Nucleus widespread parasites animals (fish humans) insects plants monophyletic group related to euglenoids unifying feature = kinetoplast Giemsa staining structure KINETOPLAST

More information

fighting the epidemic

fighting the epidemic news issue a t r i - a n n u a l ne w s l e t t e r f r om I n d u s t r i K a p i ta l 1 7 autumn 2 0 0 6 SLEEPING SICKNESS IN UGANDA fighting the epidemic Gustavson on PE 4 Minimax s global ambitions

More information

CV and Bibliography KEY POINTS

CV and Bibliography KEY POINTS CV and Bibliography KEY POINTS 1. Name Serap Aksoy, Ph.D., MA 2. Education, Career, Board Certifications B.A. Vassar College, Poughkeepsie, NY 1978 M.A. Honorary, Yale University, New Haven, CT 2002 Ph.D.

More information

Curriculum Vitae : Mohamed Musa Mohamed-Ahmed Date & Place of Birth : , Sennar Nationality : Sudanese

Curriculum Vitae : Mohamed Musa Mohamed-Ahmed Date & Place of Birth : , Sennar Nationality : Sudanese Curriculum Vitae Name : Mohamed Musa Mohamed-Ahmed Date & Place of Birth : 1.1.1949, Sennar Nationality : Sudanese Religion : Moslem Marital Status : Married with Five Children Academic Qualification:

More information

Protozoa from tissues. Leishmania spp. Naegleria fowleri Toxoplasma gondii Trichomonas vaginalis Trypanosoma spp.

Protozoa from tissues. Leishmania spp. Naegleria fowleri Toxoplasma gondii Trichomonas vaginalis Trypanosoma spp. Protozoa from tissues Leishmania spp. Naegleria fowleri Toxoplasma gondii Trichomonas vaginalis Trypanosoma spp. Leishmaniasis Leishmania infantum, Leishmania donovani, in macrophages of man. Female sandflies:

More information

CREATION OF SUSTAINABLE TSETSE FREE AREAS IN THE NORTH-WEST AND NORTH-EAST GEOPOLITICAL ZONES OF NIGERIA.

CREATION OF SUSTAINABLE TSETSE FREE AREAS IN THE NORTH-WEST AND NORTH-EAST GEOPOLITICAL ZONES OF NIGERIA. CREATION OF SUSTAINABLE TSETSE FREE AREAS IN THE NORTH-WEST AND NORTH-EAST GEOPOLITICAL ZONES OF NIGERIA. BY Dede, P.M.; Enwezor, F.N. and Mamman M. PATTEC-Nigeria, Nigerian Institute for Trypanosomiasis

More information

Bovine Trypanosomosis in three districts of East Gojjam Zone bordering the Blue Nile River in Ethiopia

Bovine Trypanosomosis in three districts of East Gojjam Zone bordering the Blue Nile River in Ethiopia Original Article Bovine Trypanosomosis in three districts of East Gojjam Zone bordering the Blue Nile River in Ethiopia Adane Mihret, 1,2 Gezahagne Mamo, 3 1 Addis Ababa University, Faculty of Medicine,

More information

WRAIR- GEIS 'Operational Clinical Infectious Disease' Course

WRAIR- GEIS 'Operational Clinical Infectious Disease' Course Trypanosomiasis WRAIR- GEIS 'Operational Clinical Infectious Disease' Course The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or

More information

PARASITOLOGY CASE HISTORY #4 (BLOOD PARASITES) (Lynne S. Garcia)

PARASITOLOGY CASE HISTORY #4 (BLOOD PARASITES) (Lynne S. Garcia) PARASITOLOGY CASE HISTORY #4 (BLOOD PARASITES) (Lynne S. Garcia) A 52-year old male presented after complaining of a week of fever and headaches. Other symptoms included malaise and lack of appetite, and

More information

Climate change and vector-borne diseases of livestock in the tropics. Peter Van den Bossche

Climate change and vector-borne diseases of livestock in the tropics. Peter Van den Bossche Climate change and vector-borne diseases of livestock in the tropics Peter Van den Bossche Climate change & animal health Climate change in Africa: Temperature Rainfall Variability Climate change & animal

More information

Lords of the Fly: Sleeping Sickness Control in British East Africa, (review)

Lords of the Fly: Sleeping Sickness Control in British East Africa, (review) Lords of the Fly: Sleeping Sickness Control in British East Africa, 1900-1960 (review) Pascal James Imperato African Studies Review, Volume 48, Number 1, April 2005, pp. 166-169 (Review) Published by Cambridge

More information

A RECENT OUTBREAK OF NEUROLOGICAL DISEASE IN THE EQUID POPULATION OF THE CENTRAL RIVER DISTRICT OF THE GAMBIA

A RECENT OUTBREAK OF NEUROLOGICAL DISEASE IN THE EQUID POPULATION OF THE CENTRAL RIVER DISTRICT OF THE GAMBIA A RECENT OUTBREAK OF NEUROLOGICAL DISEASE IN THE EQUID POPULATION OF THE CENTRAL RIVER DISTRICT OF THE GAMBIA Laura Peachey BVSc BSc MRCVS The Royal Veterinary College Clinical problem Cases of neurological

More information

HAEMOFLAGELLATES. Dr. Anuluck Junkum Department of Parasitology Faculty of Medicine

HAEMOFLAGELLATES. Dr. Anuluck Junkum Department of Parasitology Faculty of Medicine HAEMOFLAGELLATES Dr. Anuluck Junkum Department of Parasitology Faculty of Medicine Objective Can describe the morphology, life cycle, pathology, diagnosis and prevention of Leishmania spp. and Trypanosoma

More information

The development of new diagnostic tools for sleeping sickness

The development of new diagnostic tools for sleeping sickness The development of new diagnostic tools for sleeping sickness P. Büscher Institute of Tropical Medicine, Antwerp WHO CC for Research and Training on Human African Trypanosomiasis Diagnosis 1 1 Distribution

More information

A Global Overview of the Chikungunya Virus Problem

A Global Overview of the Chikungunya Virus Problem A Global Overview of the Chikungunya Virus Problem Ann M. Powers, Ph.D. Division of Vector-Borne Infectious Diseases Centers for Disease Control and Prevention Chikungunya Virus Family Togaviridae,, genus

More information

Malawi Medical Journal 29 (1): March 2017

Malawi Medical Journal 29 (1): March 2017 Molecular identification of T. b. rhodesiense in tsetse flies 11 Original Research Polymerase chain reaction identification of Trypanosoma brucei rhodesiense in wild tsetse flies from Nkhotakota Wildlife

More information

DIVISION B DISEASE DETECTIVES

DIVISION B DISEASE DETECTIVES Total Score Rank School Name: Team Number: Student Name(s) (1): (2): DIVISION B DISEASE DETECTIVES National Science Olympiad University of Illinois Urbana-Champaign, Illinois May 22, 2010 Developed by

More information

NTDs: update on the progress. Department of Control of Neglected Tropical Diseases

NTDs: update on the progress. Department of Control of Neglected Tropical Diseases NTDs: update on the progress Department of Control of Neglected Tropical Diseases WHO Department of control of Neglected Tropical Diseases Two main groups of diseases: IDM (Innovative and Intensified Diseases

More information

Morphological forms of hemoflagellates

Morphological forms of hemoflagellates Parasitology Lecture: 1 Hemoflagellates (blood and tissue flagellates) *Classification: - Sub-kingdom: Protozoa -Phylum: Sarcomastigophora -Sub-phylum: Mastigiphora -Class: Zoomastigophora د. رائد *Flagellates

More information

DOWNLOAD OR READ : SKIN DISEASES OF PARASITIC ORIGIN PDF EBOOK EPUB MOBI

DOWNLOAD OR READ : SKIN DISEASES OF PARASITIC ORIGIN PDF EBOOK EPUB MOBI DOWNLOAD OR READ : SKIN DISEASES OF PARASITIC ORIGIN PDF EBOOK EPUB MOBI Page 1 Page 2 skin diseases of parasitic origin skin diseases of parasitic pdf skin diseases of parasitic origin Condition: Description.

More information

Laboratory diagnosis of Blood and tissue flagellates

Laboratory diagnosis of Blood and tissue flagellates Laboratory diagnosis of Blood and tissue flagellates (Leishmania and trypanosma) Sarah Alharbi Clinical Laboratory department Collage of Applied Medical Sciences King Saud University Leishmania and trypanosma:

More information

CHAPTER 5. Population genetic structure and cladistic analysis of Trypanosoma brucei isolates

CHAPTER 5. Population genetic structure and cladistic analysis of Trypanosoma brucei isolates CHAPTER 5 Population genetic structure and cladistic analysis of Trypanosoma brucei isolates Eddy Chukwura Agbo 1, Peter-Henning Clausen 2, Philippe Büscher 3, Phelix A.O. Majiwa 4, Eric Claassen 5, and

More information

Luminescent Multiplex Viability Assay for T.b. gambiense

Luminescent Multiplex Viability Assay for T.b. gambiense Luminescent Multiplex Viability Assay for T.b. gambiense Van Reet N., Pyana P., Rogé S., Claes F. and Büscher, P. Institute of Tropical Medicine Antwerp 32nd ISCTRC conference 8th 12th September 2013 Introduction

More information

TDR/DDR/98.1 WHO, GENEVA, 14 JULY 1998 CONCLUSIONS AND RECOMMENDATIONS RELAPSING PATIENTS. The 14-day regimen is highly effective.

TDR/DDR/98.1 WHO, GENEVA, 14 JULY 1998 CONCLUSIONS AND RECOMMENDATIONS RELAPSING PATIENTS. The 14-day regimen is highly effective. TDR/DDR/98.1 REPORT ON A MEETING OF THE PRODUCT DEVELOPMENT TEAM FOR AFRICAN TRYPANOSOMIASIS CHEMOTHERAPY TO REVIEW THE COMPARATIVE STUDY OF 14-DAY VERSUS 7-DAY TREATMENT OF LATE STAGE T.B. GAMBIENSE AFRICAN

More information

Evolutionary Applications

Evolutionary Applications Evolutionary Applications Evolutionary Applications ISSN 1752-4571 ORIGINAL ARTICLE Whole genome sequencing shows sleeping sickness relapse is due to parasite regrowth and not reinfection Joshua B. Richardson,

More information

Edinburgh Research Explorer

Edinburgh Research Explorer Edinburgh Research Explorer Sodalis glossinidius prevalence and trypanosome presence in tsetse from Luambe National Park, Zambia Citation for published version: Dennis, JW, Durkin, SM, Horsley Downie,

More information

BIO Parasitology Spring 2009

BIO Parasitology Spring 2009 BIO 475 - Parasitology Spring 2009 Stephen M. Shuster Northern Arizona University http://www4.nau.edu/isopod Lecture 5 Discovery of the Disease In 1924 the Kala-Azar Commission noted that the distribution

More information

Reviewer 2: NIFURTIMOX+EFLORNITHINE(N+E)

Reviewer 2: NIFURTIMOX+EFLORNITHINE(N+E) Reviewer 2: NIFURTIMOX+EFLORNITHINE(N+E) 1. The multicenter clinical trial of N+E combination therapy for second-stage sleeping sickness presented on behalf of G. Priotto and the NECT Study Team offers

More information

Stage determination in sleeping sickness: comparison of two cell counting and two parasite detection techniques

Stage determination in sleeping sickness: comparison of two cell counting and two parasite detection techniques Tropical Medicine and International Health doi:1.1111/tmi.11 volume 1 no pp 77 7 june 13 Stage determination in sleeping sickness: comparison of two cell counting and two parasite detection techniques

More information

Effects of age-at-diagnosis and duration of diabetes on GADA and IA-2A positivity

Effects of age-at-diagnosis and duration of diabetes on GADA and IA-2A positivity Effects of age-at-diagnosis and duration of diabetes on GADA and IA-2A positivity Duration of diabetes was inversely correlated with age-at-diagnosis (ρ=-0.13). However, as backward stepwise regression

More information

Control Options for Human Sleeping Sickness in Relation to the Animal Reservoir of Disease 1

Control Options for Human Sleeping Sickness in Relation to the Animal Reservoir of Disease 1 Chapter 8 Control Options for Human Sleeping Sickness in Relation to the Animal Reservoir of Disease 1 S.C. Welburn 2, K. Picozzi 2, M. Kaare 3, E.M. Fèvre 2, P.G. Coleman 4 and T. Mlengeya 5 Sleeping

More information

Optimizing Population Screening for Infectious Diseases

Optimizing Population Screening for Infectious Diseases Optimizing Population Screening for Infectious Diseases Harwin de Vries MSc., Prof. Albert Wagelmans, Prof. Joris van de Klundert June 7 th, 2017 De Vries, Wagelmans, Van de Klundert Optimizing Population

More information

Disease Transmission Methods

Disease Transmission Methods Disease Transmission Methods In epidemiology, transmission simply means any method by which an infectious agent is spread from one host to another. Knowing the type of pathogen often, but not always, identifies

More information

Focus Specific Clinical Profiles in Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense

Focus Specific Clinical Profiles in Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense Focus Specific Clinical Profiles in Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense Lorna M. MacLean 1 *, Martin Odiit 2, John E. Chisi 3, Peter G. E. Kennedy 4, Jeremy M. Sternberg

More information

DIVISION C DISEASE DETECTIVES

DIVISION C DISEASE DETECTIVES Total Score Rank School Name: Team Number: Student Name(s) (1): (2): DIVISION C DISEASE DETECTIVES National Science Olympiad University of Illinois Urbana-Champaign, Illinois May 22, 2010 Developed by

More information

Blood Smears Only 6 October Sample Preparation and Quality Control 15B-K

Blood Smears Only 6 October Sample Preparation and Quality Control 15B-K NEW YORK STATE Parasitology Proficiency Testing Program Blood Smears Only 6 October 5 The purpose of the New York State Proficiency Testing Program in the category of Parasitology - Blood Smears Only is

More information

Planned Vaccine Trials to Follow-up on RV 144. Merlin Robb, MD Deputy Director for Clinical Research MHRP

Planned Vaccine Trials to Follow-up on RV 144. Merlin Robb, MD Deputy Director for Clinical Research MHRP Planned Vaccine Trials to Follow-up on RV 144 Merlin Robb, MD Deputy Director for Clinical Research MHRP Planned studies are mutually reinforcing and will amplify public health impact and regional relevance

More information

Cattle movements and trypanosomes: restocking efforts and the spread of Trypanosoma brucei rhodesiense sleeping sickness in post-conflict Uganda

Cattle movements and trypanosomes: restocking efforts and the spread of Trypanosoma brucei rhodesiense sleeping sickness in post-conflict Uganda Selby et al. Parasites & Vectors 2013, 6:281 RESEARCH Open Access Cattle movements and trypanosomes: restocking efforts and the spread of Trypanosoma brucei rhodesiense sleeping sickness in post-conflict

More information

1974 Bachelor of Science (BSc.), Zoology, Botany and Chemistry (Nairobi)

1974 Bachelor of Science (BSc.), Zoology, Botany and Chemistry (Nairobi) 1 Dr. Jedida A. Kongoro P.O Box 4742-00100 GPO Nairobi Kenya. 254-733-572863 (Cell-phone) E-mail: jkongoro@hotmail.com ACADEMIC QUALIFICATIONS 1998 Doctor of Philosophy (PhD), Biochemistry/Physiology (Kenyatta

More information

Ten Years of Tryps and Tsetses. Lucille Blumberg & John Frean National Institute for Communicable Diseases

Ten Years of Tryps and Tsetses. Lucille Blumberg & John Frean National Institute for Communicable Diseases Ten Years of Tryps and Tsetses Lucille Blumberg & John Frean National Institute for Communicable Diseases Source: Simarro et al. PLoS Negl Trop Dis 2011; 5: e1007 Country of acquisition Number of cases

More information

HAT. Platform EDITORIAL CONTENT P. 2 P. 2 P. 3 P. 3 P. 4 P. 4 P. 5 P. 5 P. 6 P. 6 TRAINING WORKSHOP FOR MEMBERS OF THE STEERING COMMITTEE MEETING

HAT. Platform EDITORIAL CONTENT P. 2 P. 2 P. 3 P. 3 P. 4 P. 4 P. 5 P. 5 P. 6 P. 6 TRAINING WORKSHOP FOR MEMBERS OF THE STEERING COMMITTEE MEETING HAT Platform EDITORIAL Dr Augustin Kadima Ebeja HAT Platform Coordinator We are proud to present our design for a bilingual logo that will help underscore our efforts to conduct clinical trials against

More information

Better Training for Safer Food BTSF

Better Training for Safer Food BTSF Better Training for Safer Food BTSF Importation of vector-borne infectious diseases Tanguy Marcotty Institute of Tropical Medicine Importation routes Trade Infected live animals (e.g. H5N1 avian influenza)

More information

Modelling the control of tsetse and African trypanosomiasis through application of insecticides on cattle in Southeastern Uganda

Modelling the control of tsetse and African trypanosomiasis through application of insecticides on cattle in Southeastern Uganda Modelling the control of tsetse and African trypanosomiasis through application of insecticides on cattle in Southeastern Uganda Supervisor: Prof. John Hargrove Co-supervisors: Prof. Joseph Y.T. Mugisha

More information

African sleeping sickness ( 非洲睡眠病 )

African sleeping sickness ( 非洲睡眠病 ) African sleeping sickness ( 非洲睡眠病 ) caused by Trypanosoma brucei complex 50 million people in 34 countries are at risk 25,000 cases are reported annually Trypanosoma brucei complex T. brucei gambiense

More information

Epidemiology of tsetse flies and trypanosomes with a case study in Ethiopia 1

Epidemiology of tsetse flies and trypanosomes with a case study in Ethiopia 1 Reports - Rapports afrika focus Volume 29, Nr. 2, 2016 pp. 109-116 Epidemiology of tsetse flies and trypanosomes with a case study in Ethiopia 1 Reta Duguma Abdi Department of Animal Science, Institute

More information

West Nile Virus Surveillance in mosquito vectors (Culex pipiens)

West Nile Virus Surveillance in mosquito vectors (Culex pipiens) West Nile Virus Surveillance in mosquito vectors (Culex pipiens) Dragana Despot, Ivan Aleksić, Nebojša Tačević & Branislav Pešić Institute for Biocides and Medical Ecology, Belgrade, Serbia The virus West

More information

In vitro Parasite count and EC 50 in trypanosome cultures incubated with some selected iron chelators

In vitro Parasite count and EC 50 in trypanosome cultures incubated with some selected iron chelators Global Advanced Research Journal of Medicine and Medical Sciences Vol. 1(1) pp. 017-026, March, 2012 Available online http://garj.org/garjmms/index.htm Copyright 2012 Global Advanced Research Journals

More information

Biological Basis for Increased Risk of Graft Loss in African American (AA)-APOL1 and Beyond

Biological Basis for Increased Risk of Graft Loss in African American (AA)-APOL1 and Beyond Biological Basis for Increased Risk of Graft Loss in African American (AA)-APOL1 and Beyond Jonah Odim, MBA, MD, PhD Chief, Clinical Transplantation Division of Allergy, Immunology, and Transplantation

More information

Post-Nargis Periodic Review I

Post-Nargis Periodic Review I Post-Nargis Periodic Review I 9 Section 2: Fi n d i n g s This section presents the findings of both the quantitative and qualitative research conducted for the first round of the Periodic Review. Information

More information

Factors Affecting the Propensity of Tsetse Flies to Enter Houses and Attack Humans Inside: Increased Risk of Sleeping Sickness in Warmer Climates

Factors Affecting the Propensity of Tsetse Flies to Enter Houses and Attack Humans Inside: Increased Risk of Sleeping Sickness in Warmer Climates Factors Affecting the Propensity of Tsetse Flies to Enter Houses and Attack Humans Inside: Increased Risk of Sleeping Sickness in Warmer Climates Glyn A. Vale 1,2 *, John W. Hargrove 2, Andrew Chamisa

More information

P PDF [Page: 1 of 8]

P PDF [Page: 1 of 8] P152603.PDF [Page: 1 of 8] P152603.PDF [Page: 2 of 8] P152603.PDF [Page: 3 of 8] Am. J. Trop. Med. Hyg., 52(3), 1995, pp. 281-286 Copyright C 1995 by The American Society of Tropical Medicine and Hygie-ne

More information

Journal Of Agriculture and Social Research (JASR) Vol. 8, No.1, 2008

Journal Of Agriculture and Social Research (JASR) Vol. 8, No.1, 2008 PREVALENCE OF TSETSE FLY AND BOVINE TRYPANOSOMOSIS IN THE BIOLOGICAL CONTROL OF TSETSE FLY PROJECT (BICOT) WITHIN LAFIA LOCAL GOVERNMENT AREA OF NASARAWA STATE, NIGERIA OLUWAFEMI, R. A, ILEMOBADE, A. A

More information

Project : Long-term epidemiology of Meningococcal Meningitis in the African belt: dynamics and impact of vaccination

Project : Long-term epidemiology of Meningococcal Meningitis in the African belt: dynamics and impact of vaccination Project : Long-term epidemiology of Meningococcal Meningitis in the African belt: dynamics and impact of vaccination Spatio-temporal dynamics (spread, persistence, periodicity), Comparative approach, impact

More information

Molecular screening of tsetse flies and cattle reveal different Trypanosoma species including T. grayi and T. theileri in northern Cameroon

Molecular screening of tsetse flies and cattle reveal different Trypanosoma species including T. grayi and T. theileri in northern Cameroon Ngomtcho et al. Parasites & Vectors (2017) 10:631 DOI 10.1186/s13071-017-2540-7 RESEARCH Molecular screening of tsetse flies and cattle reveal different Trypanosoma species including T. grayi and T. theileri

More information

Downloaded from:

Downloaded from: Palmer, JJ; Surur, EI; Checchi, F; Ahmad, F; Ackom, FK; Whitty, CJ (2014) A mixed methods study of a health worker training intervention to increase syndromic referral for gambiense human african trypanosomiasis

More information

Hybridization in the Triticum Aegilops species complex Nils Arrigo, Uni. Lausanne, CH

Hybridization in the Triticum Aegilops species complex Nils Arrigo, Uni. Lausanne, CH Hybridization in the Aegilops species complex Nils Arrigo, Uni. Lausanne, CH 1 Nils Arrigo nils.arrigo@unil.ch The Aegilops polyploid complex AABBDD A genome AABB Meimberg 2009 2 The Aegilops polyploid

More information

Partnering to tackle Neglected Tropical Diseases

Partnering to tackle Neglected Tropical Diseases Partnering to tackle Neglected Tropical Diseases 2013 IEEE Global Humanitarian Technology Conference Tala de los Santos Diagnostics Group Leader 21 October 2013 NEGLECTED TROPICAL DISEASES The most important

More information

In 1841 G. Valentin in Berne, Switzerland, saw a protozoan in the blood of a trout that moved by means of its undulating membrane; it was a

In 1841 G. Valentin in Berne, Switzerland, saw a protozoan in the blood of a trout that moved by means of its undulating membrane; it was a In 1841 G. Valentin in Berne, Switzerland, saw a protozoan in the blood of a trout that moved by means of its undulating membrane; it was a trypanosome. Two years later David Gruby in Paris discovered

More information

TRYPANOSOMA BRUCEI GAMBIENSE TRYPANOSOMIASIS IN TEREGO COUNTY, NORTHERN UGANDA, 1996: A LOT QUALITY ASSURANCE SAMPLING SURVEY

TRYPANOSOMA BRUCEI GAMBIENSE TRYPANOSOMIASIS IN TEREGO COUNTY, NORTHERN UGANDA, 1996: A LOT QUALITY ASSURANCE SAMPLING SURVEY Am. J. Trop. Med. Hyg., 70(4), 2004, pp. 390 394 Copyright 2004 by The American Society of Tropical Medicine and Hygiene TRYPANOSOMA BRUCEI GAMBIENSE TRYPANOSOMIASIS IN TEREGO COUNTY, NORTHERN UGANDA,

More information

West Nile Virus. By Frank Riusech

West Nile Virus. By Frank Riusech West Nile Virus By Frank Riusech Disease Etiology: West Nile virus(wnv), genus, flavivirus is positive- stranded RNA arbovirus (arthropod- borne), belonging to the Flaviviridae family. Included in this

More information

1. Toxoplasma gondii:

1. Toxoplasma gondii: Parasites affecting the central nervous system: 1. Toxoplasma gondii: It s a protozoa family member, more specifically a member of the apicomplexa just like plasmodium malaria. Causes toxoplasmosis Has

More information

DOWNLOAD OR READ : WEST AFRICAN HYGIENE PDF EBOOK EPUB MOBI

DOWNLOAD OR READ : WEST AFRICAN HYGIENE PDF EBOOK EPUB MOBI DOWNLOAD OR READ : WEST AFRICAN HYGIENE PDF EBOOK EPUB MOBI Page 1 Page 2 west african hygiene west african hygiene pdf west african hygiene West African Ebola virus epidemic Simplified Ebola virus epidemic

More information

Use of Molecular and Bioinformatics Tools for Developing Methods of Epidemiological Identification of Trypanosomes. By Gaber Adwik

Use of Molecular and Bioinformatics Tools for Developing Methods of Epidemiological Identification of Trypanosomes. By Gaber Adwik Use of Molecular and Bioinformatics Tools for Developing Methods of Epidemiological Identification of Trypanosomes By Gaber Adwik Submitted in fulfilment of the requirements of the degree of Doctor of

More information

On the origin of species, Really

On the origin of species, Really On the origin of species, Really Mohamed Noor Duke University Life on our planet is highly diverse but that life seems to exist in discrete clusters at multiple levels We readily recognize these clusters

More information

Abstract. Keywords: Trypanosomosis /Tsetse/ Prevalence/Density/ Sibu Sire/ Guto Gida/ Western Ethiopia. Shimelis Dagnachew 1 * and Sisay Shibeshi

Abstract. Keywords: Trypanosomosis /Tsetse/ Prevalence/Density/ Sibu Sire/ Guto Gida/ Western Ethiopia. Shimelis Dagnachew 1 * and Sisay Shibeshi Prevalence and vector distributions of bovine trypanosomosis in control (Sibu Sire) and noncontrol (Guto Gida) districts bordering upper Anger valley of East Wollega Zone, Western Ethiopia Shimelis Dagnachew

More information

Guidelines for revising ivermectin treatment boundaries within the context of onchocerciasis elimination

Guidelines for revising ivermectin treatment boundaries within the context of onchocerciasis elimination When and AFRICAN PROGRAMME FOR ONCHOCERCIASIS CONTROL World Health Organization Guidelines for revising ivermectin treatment boundaries within the context of onchocerciasis elimination AFRICAN PROGRAMME

More information

Linking migration, mobility and HIV risk among young African women: the role of transactional sex

Linking migration, mobility and HIV risk among young African women: the role of transactional sex Linking migration, mobility and HIV risk among young African women: the role of transactional sex Carol S. Camlin, PhD, MPH Dept. of Obstetrics, Gynecology & Reproductive Sciences & Center for AIDS Prevention

More information

Thank you for the opportunity to submit testimony on the Fiscal Year (FY) 2014 State

Thank you for the opportunity to submit testimony on the Fiscal Year (FY) 2014 State Drugs for Neglected Diseases initiative, North America Jennifer Katz, Policy Director March 2013 Testimony to the Subcommittee on State and Foreign Operations, Committee on Appropriations United States

More information

J. Jannin, P. Simarro, J.R. Franco Neglected Tropical Diseases

J. Jannin, P. Simarro, J.R. Franco Neglected Tropical Diseases J. Jannin, P. Simarro, J.R. Franco Neglected Tropical Diseases Decision of fighting HAT IOM Public Workshop on Causes and Consequences of Neglected Tropical Diseases -Washington DC, USA. 21-22 September

More information

11.1 Genetic Variation Within Population. KEY CONCEPT A population shares a common gene pool.

11.1 Genetic Variation Within Population. KEY CONCEPT A population shares a common gene pool. KEY CONCEPT A population shares a common gene pool. Genetic variation in a population increases the chance that some individuals will survive. Genetic variation leads to phenotypic variation. Phenotypic

More information

Patterns in Age-Seroprevalence Consistent with Acquired Immunity against Trypanosoma brucei in Serengeti Lions

Patterns in Age-Seroprevalence Consistent with Acquired Immunity against Trypanosoma brucei in Serengeti Lions Patterns in Age-Seroprevalence Consistent with Acquired Immunity against Trypanosoma brucei in Serengeti Lions Sue Welburn 1 *, Kim Picozzi 1, Paul G. Coleman 2, Craig Packer 3 1 Centre for Infectious

More information

guidelines COLLECTION OF ENTOMOLOGICAL BASELINE DATA FOR TSETSE AREA-WIDE INTEGRATED PEST MANAGEMENT PROGRAMMES FAO ANIMAL PRODUCTION AND HEALTH

guidelines COLLECTION OF ENTOMOLOGICAL BASELINE DATA FOR TSETSE AREA-WIDE INTEGRATED PEST MANAGEMENT PROGRAMMES FAO ANIMAL PRODUCTION AND HEALTH 1 ISSN 1810-0708 FAO ANIMAL PRODUCTION AND HEALTH guidelines COLLECTION OF ENTOMOLOGICAL BASELINE DATA FOR TSETSE AREA-WIDE INTEGRATED PEST MANAGEMENT PROGRAMMES 1 FAO ANIMAL PRODUCTION AND HEALTH guidelines

More information

Hybridization and Genetic Extinction. Can and do we preserve the genetic integrity of species, and if so, how?

Hybridization and Genetic Extinction. Can and do we preserve the genetic integrity of species, and if so, how? Hybridization and Genetic Extinction Can and do we preserve the genetic integrity of species, and if so, how? Hybridization Hybridization: mating between different species or two genetically distinct populations

More information

Ch. 24 Speciation BIOL 221

Ch. 24 Speciation BIOL 221 Ch. 24 Speciation BIOL 221 Speciation Speciation Origin of new, is at the focal point of evolutionary theory Microevolution consists of adaptations that evolve within a population confined to one gene

More information

4/24/2013. Haemophilus influenzae Meningitis. Neisseria Meningitis. Streptococcus pneumoniae Meningitis

4/24/2013. Haemophilus influenzae Meningitis. Neisseria Meningitis. Streptococcus pneumoniae Meningitis 1 2 3 4 5 6 7 Chapter 22 Microbial Diseases of the Nervous System The Human Nervous System Meninges protect brain and spinal cord Dura mater: Outermost layer Arachnoid mater: Middle layer Subarachnoid

More information

XIII Flagellates (2005) A. Hemoflagellates (Chapter 5) 1. Classification of trypanosomes a. Phylum Euglenazoa b. Subphylum Kinetoplasta * c.

XIII Flagellates (2005) A. Hemoflagellates (Chapter 5) 1. Classification of trypanosomes a. Phylum Euglenazoa b. Subphylum Kinetoplasta * c. XIII Flagellates (2005) A. Hemoflagellates (Chapter 5) 1. Classification of trypanosomes a. Phylum Euglenazoa b. Subphylum Kinetoplasta * c. Class Trypanosomatida d. Important genera (1) Trypanosoma (2)

More information

Control and surveillance of human African trypanosomiasis

Control and surveillance of human African trypanosomiasis In the 1960s, it appeared that human African trypanosomiasis (HAT) could be effectively controlled, but by the beginning of the twenty-first century several decades of neglect had led to alarming numbers

More information

Downloaded from:

Downloaded from: Capewell, P; Cooper, A; Duffy, CW; Tait, A; Turner, CM; Gibson, W; Mehlitz, D; Macleod, A (2013) Human and Animal Trypanosomes in Cte d Ivoire Form a Single Breeding Population. PLoS One, 8 (7). e67852.

More information

SUMMARY OF THE THIRD MEETING OF THE ITFDE(II) October 18, 2002

SUMMARY OF THE THIRD MEETING OF THE ITFDE(II) October 18, 2002 SUMMARY OF THE THIRD MEETING OF THE ITFDE(II) October 18, 2002 This meeting of the International Task Force for Disease Eradication (ITFDE) was convened at The Carter Center from 9:00am to 4:00pm on October

More information

Estimating Incidence of HIV with Synthetic Cohorts and Varying Mortality in Uganda

Estimating Incidence of HIV with Synthetic Cohorts and Varying Mortality in Uganda Estimating Incidence of HIV with Synthetic Cohorts and Varying Mortality in Uganda Abstract We estimate the incidence of HIV using two cross-sectional surveys in Uganda with varying mortality rates. The

More information

Dengue Virus in Sub-tropical Northern and Central Viet Nam: Population Immunity and Climate Shape Patterns of Viral Invasion and Maintenance

Dengue Virus in Sub-tropical Northern and Central Viet Nam: Population Immunity and Climate Shape Patterns of Viral Invasion and Maintenance Dengue Virus in Sub-tropical Northern and Central Viet Nam: Population Immunity and Climate Shape Patterns of Viral Invasion and Maintenance Maia A. Rabaa 1,2, Cameron P. Simmons 2,3, Annette Fox 3,4,

More information

SECTION A NEWS CONFERENCE REPORT

SECTION A NEWS CONFERENCE REPORT 2001 Tsetse and Trypanosomiasis Information Quarterly SECTION A NEWS CONFERENCE REPORT The 26 th ISCTRC Conference was held at Ouagadougou, Burkina Faso, 1-5 October 2001. Given below is an edited summary

More information

Baba SALL 1, Momar Talla SECK2, Jérémy BOUYER3, Marc J.B. VREYSEN4

Baba SALL 1, Momar Talla SECK2, Jérémy BOUYER3, Marc J.B. VREYSEN4 Baba SALL 1, Momar Talla SECK2, Jérémy BOUYER3, Marc J.B. VREYSEN4 1 Direction des Services vétérinares/ Ministère de l Elevage et des Productions animales 2Laboratoire national de l Elevage et de Recherches

More information

CLIMATE DRIVES THE SEASONAL AND REGIONAL VARIATION IN DENGUE INCIDENCE IN THE MALDIVES

CLIMATE DRIVES THE SEASONAL AND REGIONAL VARIATION IN DENGUE INCIDENCE IN THE MALDIVES CLIMATE DRIVES THE SEASONAL AND REGIONAL VARIATION IN DENGUE INCIDENCE IN THE MALDIVES Foundation for Environment, Climate and Technology C/o Mahaweli Authority of Sri Lanka, Digana Village, Rajawella,

More information

Reid H 1, Kibona S 2, Rodney A 1, McPherson B 1, Sindato C 2, Malele I 4, Kinung hi S 3, Jennaway M 1, Changalucha J 3, Blake B 1, *Vallely A 1,3.

Reid H 1, Kibona S 2, Rodney A 1, McPherson B 1, Sindato C 2, Malele I 4, Kinung hi S 3, Jennaway M 1, Changalucha J 3, Blake B 1, *Vallely A 1,3. Assessment of the burden of human African trypanosomiasis by rapid participatory appraisal in three high-risk villages in Urambo District, Northwest Tanzania Reid H 1, Kibona S 2, Rodney A 1, McPherson

More information

FINDs programme on diagnostics for NTDs

FINDs programme on diagnostics for NTDs FINDs programme on diagnostics for NTDs JM Ndung u, A. Picado, I Cruz & S Biéler Presentation at IRD, Montpellier, France, 12March 2018 FIND who we are & what we do A not-for-profit international organization

More information

Introduction - Lumpy skin disease workshop

Introduction - Lumpy skin disease workshop 1 Introduction - Lumpy skin disease workshop Eeva Tuppurainen, DVM, MSc, PhD, MRCVS Lumpy skin disease scientific expert FAO Regional Office for Europe and Central Asia, Hungary Geographic distribution

More information