Cost-Effectiveness of Fractional Flow Reserve
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1 Cost-Effectiveness of Fractional Flow Reserve William F. Fearon, MD Associate Professor of Medicine Director, Interventional Cardiology Stanford University Medical Center
2 Cost-Effectiveness of FFR What impact does measuring FFR have on patient outcomes and costs?
3 Incremental Cost Cost-Effectiveness Plane Dominated Technology Trade-Off Technology Trade-Off Technology Dominant Technology Incremental Effectiveness Courtesy of Uwe Siebert, MD
4 Perspectives: New Yorker s View of the World Interventionalist vs. Hospital vs. Health Care System
5 Is FFR Cost Effective? Computer Modeling Evaluate and compare the cost implications of three strategies for intermediate lesions: obtain a nuclear stress imaging study (NUC Strategy) stent all patients with intermediate lesions (STENT Strategy) measure FFR at the time of angiography to help guide the decision for PCI (FFR Strategy) Am Heart J 2003;145:
6 Decision Tree: FFR 0.75 Medical Therapy FFR FFR<0.75 Immediate PCI No Ischemia Medical Therapy Intermediate Lesion Nuclear Stress Imaging Ischemia Return to Cath Lab for PCI Stent Immediate PCI in all patients
7 FFR is Cost Effective Total Cost QALYs* Cost / QALY Gained NUC Strategy $13, FFR Strategy $11, Difference $1, $808,000 STENT Strategy $15, FFR Strategy $11, Difference $3, FFR Dominates
8 IS FFR Cost-Effective? Clinical Validation: Single Vessel CAD 70 Patients UA/NSTEMI Intermediate single vessel lesion randomized Nuclear stress imaging + - FFR 0.75 <0.75 PCI Discharge Home PCI Endpoints: clinical outcome, duration/cost of hospitalization Leesar, et al. JACC 2003;41:
9 Is FFR Cost-Effective? FFR Resulted in Shorter Hospital Stay Leesar, et al. JACC 2003;41:
10 Is FFR Cost-Effective? FFR resulted in lower costs Leesar, et al. JACC 2003;41:
11 Is FFR Cost-Effective? FFR guidance resulted in similar clinical outcomes Leesar, et al. JACC 2003;41:
12 FAME Study: One Year Outcomes % 20 Angio-Guided FFR-Guided ~30% ~40% ~35% ~30% ~35% Death MI Repeat Revasc Death/MI p=0.04 MACE p=0.02 Tonino, et al. New Engl J Med 2009;360:
13 FAME: Economic Evaluation Methods Economic evaluation in the context of the US health care system Calculated the incremental cost effectiveness ratio (ICER) Net incremental costs of each strategy divided by net incremental health outcomes Resource consumption Health related quality of life (EQ-5D) One year time horizon Societal perspective, using direct costs Circulation 2010;122:
14 FAME: Economic Evaluation Overall Health Outcomes and Costs Circulation 2010;122:
15 FAME: Economic Evaluation Bootstrap Analysis Circulation 2010;122:
16 FAME: Economic Evaluation Sensitivity Analysis Circulation 2010;122:
17 FAME: Economic Evaluation Limitations Short time horizon Missing quality of life values and relatively large time intervals Did not account for indirect costs Results apply to US health care system Majority of patients were enrolled outside of the US
18 Cost-Effectiveness of FFR FFR-guided PCI is a dominant strategy when compared to angiography-guided PCI in patients with multivessel CAD. What about the cost-effectiveness of FFRguided PCI in comparison with best medical therapy in patients with stable CAD?
19 FAME 2 Stable CAD patients scheduled for 1, 2 or 3 vessel DES-PCI N = 1220 Randomized Trial FFR in all target lesions Registry At least 1 stenosis with FFR 0.80 (n=888) When all FFR > 0.80 (n=332) Randomization 1:1 PCI + MT 73% MT 27% MT 50% randomly assigned to FU Primary Endpoint: Death, MI or Urgent Revascularization at 2 Yr
20 Primary Endpoint: Death, MI, Urgent Revasc Cumulative incidence (%) 30 No. at risk MT PCI+MT Registry 0 PCI+MT vs. MT: HR 0.32 ( ); p<0.001 PCI+MT vs. Registry: HR 1.29 ( ); p=0.61 MT vs. Registry: HR 4.32 ( ); p< Months after randomization De Bruyne, et al. New Engl J Med 2012;367:
21 FAME 2: Cost-Effectiveness Change in Costs over Time Updated from TCT 2012 Late Breaking Trial
22 FAME 2: Cost-Effectiveness Change in Quality of Life Treatment Arm Baseline 1 Month Difference FFR-Guided PCI Medical Therapy
23 FAME 2: Cost-Effectiveness Assuming the difference in QALY between PCI and Medical Therapy would gradually narrow and disappear over three years Three Year Projection $2,883 / QALY = $36,000 / QALY
24 FAME 2: Cost-Effectiveness Sensitivity Analyses Variable $ / QALY DES + $400 44,000 DES - $400 29,000 No pressure wire in MT arm 44,000 Benefit of PCI lasts 2 years 54,000 Benefit of PCI lasts 4 years 27,000 Non-urgent PCI in MT arm = $0 55,000
25 FAME 2: Cost Effectiveness Bootstrap Simulation 80% are less than $50,000 / QALY
26 FAME 2: Cost Effectiveness Cost Acceptability Curve
27 Cost-Effectiveness of FFR Conclusion Although measuring FFR does add cost to a procedure, because it improves patient outcomes in all settings and avoids unnecessary PCI in some, FFR is a costeffective technique in almost all scenarios.
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