The NorPen Register Project
|
|
- George Craig
- 6 years ago
- Views:
Transcription
1 The NorPen Register Project, Professor Karolinska Institutet Department of Medicine Solna Clinical Epidemiology Unit, T2 Karolinska University Hospital Stockholm, Sweden 20 februari
2 NorPen was established 2008 The member organizations are research groups and authorities from all five Nordic countries working with pharmacoepidemiology 20 februari
3 Nordic countries and pharmacoepidemiological studies Population of almost 25 million people Homogeneous Genetically Socioeconomically National Health Registers Public health care system (almost free of charge) Reimbursement of medicines for the whole population Personal Identification Numbers (PINs) 20 februari
4 NorPEN members The pharmacoepidemiology research group, Nordic School of Public Health, Sweden Department of Clinical Epidemiology, Aarhus University, Denmark Institute of Public Health, University of Southern Denmark, Denmark Research group of USE OF ANTIDEPRESSANTS IN FINLAND, National Institutet for Health and Welfare, Finland The research group on Drug and Pregnancy (DAP), National Institutet for health and Welfare, Finland The Kuopio Research Centre of Geriatric Care (Cerho), University of Kuopio, Finland The Medicine group of the Social Insurance Institute, Finland University of Iceland, Iceland Department of pharmacoepidemiology, Norwegian Institute of Public Health, Norway Centre for Pharmacoepidemiology (CPE), Karolinska Institutet, Sweden Centre for Epidemiology, The National Board of Health and Welfare, Sweden 20 februari
5 Overall aim The overall aim of NorPen is to create a strong environment for this novel and worldunique possibility to cary out population based and cross-country comparative research in pharmacoepidemiology, thereby promoting safer and more efficient medicines and medicine use in a public health perspective. 20 februari
6 Specific aims To document, facilitate and promote Nordic pharmacoepidemiological research initiatives To increase quality of research and methodological development within pharmacoepidemiology in the Nordic countries To create an interactive forum for PhD-students and supervisors within several pharmacoepidemiological research areas 20 februari
7 Steering group Max Petzold, SE Mette Nørgaard, DK Morten Andersen, DK Jana Martikainen, FI Sirpa Hartikainen, FI Magnús Jóhansson, IS Kari Furu, NO Pinelopi Lundquist, SE Helle Kieler, SE NorPen Organisation Collaborators Database holders Authorities ENCePP Reference group Professor, Karolinska Institutet, Sweden; Professor Jesper Hallas, University of Southern Denmark; Professor Bert Leufkens, Utrecht University, the Netherlands; Professor Henrik Toft Sørensen, Aarhus University, Denmark Forum Supervisors and PhD students 20 februari
8 Nordic National Health Registries Cancers Registers Medical Birth Registers Cause of Death Registers Patient Registers Prescribed Drug Registers 20 februari
9 Nordic National Health Registries NO Cancer Registers DK FI IS SE Medical Birth Registers NO 1967 IS DK SE FI Cause of Death Registers DK 1943 NO 1951 SE 1961 FI 1969 IS februari
10 Nordic National Health Registries FI DK SE Patient Registers FI DK IS NO SE Prescribed Drug Registers februari
11 Register quality Reporting is compulsory Standardized information obtained from Physicians, midwives, pharmacies Forwarded to register holders Electronically or in a paper form Reporting rate depends on Type of disease Patients age Residential area 20 februari
12 Register quality All registers are upp-dated regularly 99 % of all cancers have been verified by pathological examinations Registers are routinely checked Current vs previous data Cancer Register vs Cause of Death Register Medical Birth Register vs Patient Register Possible to complete and correct data 20 februari
13 High validity in the Nordic databases Barlow L et al. The completeness of the Swedish Cancer Register: a sample survey for year 1998, Acta Oncol. 2009;48(1):27-33 Stensballe LG et al. Diagnosis coding in The Danish National Patient Registry for respiratory syncytial virus infections, Scand J Infect Dis. 2005;37(10): Cnattingius S et al. A quality study of a Medical Birth Registry, Scand J Soc Med Jun;18(2):143-8 Haukka J et al. High concordance between self-reported medication and official Prescription Database information. Eur J Clin Pharmacol Nov;63(11): februari
14 Nordic register collaborations ANCR - The Association of the Nordic Cancer Registries (NORDCAN) NOMESCO - Nordic Medico-Statistical Committee NOMBIR - Association for Nordic Medical Birth Registers lreproductionsummary.htm NorPEN - The Nordic Pharmacoepidemiological Network 20 februari
15 NorPEN Research documentation Annual reviews of published studies, research groups, centers working with the Nordic registers on dispensed medicines Voluntary pre-registration of register based studies within the Nordic countries Overview of organisation and content of the Nordic national registers Process to obtain permission to access the register data Identify obstacles to register based research Web-based system for publishing of basic information februari
16 Prioritised research areas Rare exposures and rare events Prescribing quality indicators Reproductive health Medicine use in children Mental health 20 februari
17 Meetings and workshops 1. March , Gothenburg, Sweden Research using prescription medicine registers Open invitation to Nordic researchers within the area 2. October , Oslo, Norway Reproductive health, medicine use in pregnancy Method workshop, Medicine exposure during pregnancy 3. March , Kuopio, Finland Mental health and psychotropic medicine use Method workshop, Record linkage with registers in psychiatry 4. October 2010, Reykjavík, Iceland Medicine use in children Method workshop, Exposure status and duration in children, multi-generation studies 5. March 2011, Odense, Denmark Measuring quality of prescribing in chronic diseases and in the elderly Method workshop, Advanced methods for analysis of medicine use pattern in databases 6. October 2012, Stockholm, Sweden Monitoring safety Methods workshop, Advanced methods for confounder control 20 februari
18 Nordic collaborative study on SSRIs during pregnancy Miia Artama, FI Anders Engeland, NO Örjan Ericsson, SE Kari Furu, NO Mika Gissler, FI Bengt Haglund, SE Helle Kieler, SE Rikke Beck Nielsen, DK Mette Nørgaard, DK Olof Stephansson, SE Unnur A. Valdimarsdóttir, IS Helga Zoëga, IS Helle Kieler 20 februari
19 Background 20 februari
20 20 februari
21 Logistics 20 februari
22 Data sources FI DK Prescribed Drug Register Medical Birth Register Cause of Death Register Abortion Register Patient Register IS NO Psychiatry Register Malformation Register SE 20 februari
23 National collaborator A Karolinska Institutet National collaborator B Birth file Synchronizing data files Birth file Maternal disease file Maternal Medicines file Statistics Denmark Maternal disease file Maternal Medicines file Infant Outcome file Adding Danish prescription data Infant Outcome file Infant Death file Abortion file Analyses Infant Death file Abortion file 20 februari
24 SE FI NO DK IS Source Comments Source Comments Source Comments Source Comments Source Comments LMP (marked whether derived from true LMP or ultrasound) MBR ultrasound MBR TRUE MBR MBR MBR Cannot MBR/MR*/ give day of Birth date (yyyymmdd) MBR AR MBR birth? MBR MBR Mat weight in early pregnancy (kg) MBR MBR from 2004 NA NA NA Mat height (cm) MBR MBR from 2004 NA NA NA Mat age at delivery/termination of pregnancy (completed years) MBR Parity (number of pregnancies leading to a birth) MBR MBR/MR*/ AR MBR MBR MBR MBR/MR*/ AR MBR MBR MBR Smoking early pregnancy if available (Y/N) MBR MBR MBR For parts MBR NA Smoking late pregnancy if available (Y/N) MBR MBR MBR For parts NA NA Family (cohabiting/singel/other) MBR MBR MBR MBR MBR Education (1-4) SCB MBR soc.eco NA SDK NA ultrasound and LMP 20 februari
25 Additional challenges 20 februari
26 SSRIs and PPHN ICD-10 codes for outcome of interest DK NO SE FI IS PFC (PPHN & PDA) P29.3 P29.3 P29.3 P29.3 P29.3 PPHN P29.3A P29.3BP29.31 PPH I27.0 I27.0 I27.0 I februari
27 Approvals 20 februari
28 External approvals SE DK FI IS NO Regional Ethical Review Board Danish Data Protection Agency National Board of Health National Institute for Health and Welfare Social Insurance Institution of Finland Statistics Finland National Bioethics Committee Data Protection Authority in Iceland Norwegian Data Inspectorate 20 februari
29 Internal approvals Research agreements between Karolinska Institutet and National Institute for Health and Welfare, Finland University of Iceland 20 februari
30 Can we combine Nordic data? 20 februari
31 Most common SSRIs Denmark Norway Sweden N06AB03 N06AB04 N06AB06 N06AB06 N06AB10 N06AB04 Denmark 63,0 21,6 46,2 Norway 29,3 52,0 44,0 Sweden 55,1 31,3 65,4 N06AB03 Fluoxetin N06AB04 Citalopram N06AB06 Sertralin N06AB10 Escitalopram 20 februari
32 SSRI use by county in Sweden Females years Patients/1000 inhabitants februari
33 Maternal age Finland Iceland Norway Sweden N % N % N % N % Smoking No Yes missing Gestational age w w w SSRI No Yes Prev psych No Yes Total februari
34 Collaborative compared to national study Pros: Better statistical power Higher generalisability Cons: More effort Longer time Barriers: Approvals Data access Facilitators: NorPEN Individual researchers Encouragement and support from outside 20 februari
35 What could we have done better? Define roles from start National PIs responsibilities/opportunities Permissions Data access and cleaning Keep up speed in their country Regular meetings between national PIs Pinpoint Collaboration 20 februari
36 Selective Serotonin Reuptake Inhibitors During Pregnancy and Risk of Stillbirth and Infant Mortality Stephansson O, Kieler H, Haglund B, Artama M, Engeland A, Furu K, Gissler M, Nørgaard M, Beck Nielsen R, Zoega H, Valdimarsdóttír JAMA. 2013;309(1):48-54 Risks of adverse pregnancy and birth outcomes in women treated or not treated with mood stabilisers for bipolar disorder: population based cohort study Bodén R, Lundgren M, Brandt L, Reutfors J, Andersen M, Kieler H BMJ. 2013;345:e7085 doi: /bmj 20 februari
37 Pharmacoepidemiol Drug Saf Jul;22(7): doi: /pds.357. Epub 2013 May 23 The Nordic prescription databases as a resource for pharmacoepidemiological research a literature review. Wettermark B, Zoëga H, Furu K, Korhonen M, Hallas J, Nørgaard M, Almarsdottir A, Andersen M, Andersson Sundell K, Bergman U, Helin-Salmivaara A, Hoffmann M, Kieler H, Martikainen J, Mortensen M, Petzold M, Wallach-Kildemoes H, Wallin C, Sørensen H. Centre for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Division of Clinical Pharmacology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden 20 februari
38 Good pharmacoepi studies We must collaborate 20 februari
39 NorPEN The Nordic Pharmacoepidemiological Network for knowledge exchange, research and research training 20 februari
40 Nordic countries and pharmacoepidemiological studies Population of 24 million people Homogeneous Genetically Socioeconomically National health registries Public health care system (almost free of charge) Reimbursement of medicines for the whole population Personal Identification Numbers (PINs) 20 februari
41 NorPEN Document, facilitate and promote Nordic pharmacoepidemiological research initiatives Increase quality of research and methodological development Create an interactive forum for PhD-students and supervisors Assist researchers - Initiating and designing new studies - Improving quality - Avoiding common pitfalls and duplication of efforts 20 februari
42 NorPEN Research documentation Annual reviews of published studies, research groups, centers working with the Nordic registers on dispensed medicines Voluntary pre-registration of register based studies within the Nordic countries Overview of organisation and content of the Nordic national registers Process to obtain permission to access the register data Identify obstacles to register based research Web-based system for publishing of basic information - Contracted/Sponsored Nordic research 20 februari
43 NorPEN 20 februari
Self-reported data on medicine use in the Norwegian Mother and Child cohort study compared to data from the Norwegian Prescription Database
Norsk Epidemiologi 2014; 24 (1-2): 209-216 209 Self-reported data on medicine use in the Norwegian Mother and Child cohort study compared to data from the Norwegian Prescription Database Svetlana Skurtveit
More informationExamples of Nordic collaborations: benefits and challenges
Examples of Nordic collaborations: benefits and challenges There are numerous well working ongoing Nordic research collaborations, and some Nordic organizations that have a long track record of systematic
More informationParental antibiotics and childhood asthma : a population-based study. Örtqvist, A.K.; Lundholma, C.; Fang, F.; Fall, T.; Almqvist, C.
This is an author produced version of a paper accepted by Journal of Allergy and Clinical Immunology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal
More informationCancer and pharmacoepidemiology in Finland. Information sources and research possibilities
Cancer and pharmacoepidemiology in Finland Information sources and research possibilities What I will talk about Register-based data sources available in Finland Register linkage method Available background
More informationSwedish Initiative for Research on Microdata in the Social And Medical Sciences. What is SIMSAM? Anna Holmström
Swedish Initiative for Research on Microdata in the Social And Medical Sciences What is SIMSAM? Anna Holmström Ph.D., SIMSAM Network Coordinator Dept. of Clinical Neuroscience Insurance Medicine Karolinska
More informationOUTCOMES OF INFANTS EXPOSED TO MULTIPLE ANTIDEPRESSANTS DURING PREGNANCY: RESULTS OF A COHORT STUDY
OUTCOMES OF INFANTS EXPOSED TO MULTIPLE ANTIDEPRESSANTS DURING PREGNANCY: RESULTS OF A COHORT STUDY A Einarson 1, J Choi 1, G Koren 1,2, TR Einarson 1,2 1 The Motherisk Program, The Hospital for Sick Children,
More informationUse of selective serotonin reuptake inhibitors and lifestyle among women of childbearing age: a Danish cross-sectional study For peer review only
BMJ Open Use of selective serotonin reuptake inhibitors and lifestyle among women of childbearing age: a Danish cross-sectional study Journal: BMJ Open Manuscript ID: bmjopen-0-000 Article Type: Research
More informationAntidepressants. Professor Ian Jones May /WalesMentalHealth
Antidepressants Professor Ian Jones May 2017 www.ncmh.info @ncmh_wales /WalesMentalHealth 029 2074 4392 info@ncmh.info We identified 19 740 pregnancies exposed to an antidepressant at some point during
More informationMaterials and Methods
Basic & Clinical Pharmacology & Toxicology Doi: 10.1111/bcpt.12724 Utilization of Stimulants and Atomoxetine for Attention-Deficit/ Hyperactivity Disorder among 5.4 Million Children Using Population-Based
More informationSupplementary Online Content
Supplementary Online Content Mølgaard-Nielsen D, Hviid A. Newer-generation antiepileptic drugs and the risk of major birth defects. JAMA. 2011;305(19):1996-2002. emethods. Birth defects and potential confounders
More informationARTICLE. Neonate Characteristics After Maternal Use of Antidepressants in Late Pregnancy. 1-8 HAVE BEEN PUBlished
Neonate Characteristics After Maternal Use of Antidepressants in Late Pregnancy Bengt Källén, MD, PhD ARTICLE Background: Exposure to antidepressants during the third trimester of pregnancy has been associated
More informationUse of international databases national perspective. Mika Gissler National Institute for Health and Welfare, Finland Karolinska Institutet, Sweden
Use of international databases national perspective Mika Gissler National Institute for Health and Welfare, Finland Karolinska Institutet, Sweden In the beginning There were many actors with quite a little
More informationChallenges in design and analysis of large register-based epidemiological studies
FMS/DSBS autumn meeting 2014 Challenges in design and analysis of large register-based epidemiological studies Caroline Weibull & Anna Johansson Department of Medical Epidemiology and Biostatistics (MEB)
More informationData Resource Profile: The Nordic Obesity Surgery Cohort (NordOSCo)
International Journal of Epidemiology, 2017, 1367 1367g doi: 10.1093/ije/dyx199 Advance Access Publication Date: 10 October 2017 Data Resource Profile Data Resource Profile Data Resource Profile: The Nordic
More informationRepeated dispensing of codeine is associated with high consumption of benzodiazepines
Norsk Epidemiologi 2008; 18 (2): 185-190 185 Repeated dispensing of codeine is associated with high consumption of benzodiazepines Liliana C. Bachs 1, Jørgen G. Bramness 2, Anders Engeland 2,3 and Svetlana
More informationDNBC Application Form
1 Application form for access to data and biological samples Ref. 2016-20 Project title: Applicant: Other partners taking part in the project Names and work addresses: Developmental trajectories of child
More informationANCR. PC-NORDCAN version 2.4
PC-NORDCAN version 2.4 A PC based program for presentation of regional and national cancer incidence and mortality in the Nordic countries. Present facilities Sponsored by Powered by ANCR 1 Reference Gerda
More informationThe use of prescription databases for the study of prescription drug abuse: Prescriptions of Benzodiazepines in Denmark
The use of prescription databases for the study of prescription drug abuse: hstovring@health.sdu.dk Research Unit of General Practice University of Southern Denmark Prescription Drug Abuse Conference,
More informationDNBC application form
ref. 2011-27 Project title: Applicant: Other partners taking part in the project Names and work addresses: The association of early growth with wheezing and asthma Name: Agnes Sonnenschein-van der Voort,
More informationSupplementary Online Content
Supplementary Online Content Viktorin A, Uher R, Kolevzon A, Reichenberg A, Levine SZ, Sandin S. Association of antidepressant medication use during pregnancy with intellectual disability in offspring.
More informationMental Health Series for Perinatal Prescribers. Pharmacotherapy for depression and anxiety
Mental Health Series for Perinatal Prescribers Pharmacotherapy for depression and anxiety Non-medication Treatments Psychosocial support Prenatal education, Doula support, La Leche League, Mom s groups,
More informationLinkage of birth data in Europe. Marie Delnord EPOPé INSERM
Linkage of birth data in Europe Marie Delnord EPOPé INSERM Perinatal health data sources Perinatal care is multidisciplinary : Involves midwives, obstetricians, paediatricians, and other sub-specialists.
More informationPaternal use of antidepressants and offspring outcomes in Sweden: nationwide prospective cohort study
Paternal use of antidepressants and offspring outcomes in Sweden: nationwide prospective cohort study Alexander Viktorin, 1 Stephen Z Levine, 2 Margret Altemus, 3 Abraham Reichenberg, 4,5 Sven Sandin 1,4,5
More informationUse of Selective Serotonin Reuptake Inhibitors during Pregnancy and Risk of Autism
The new england journal of medicine original article Use of Selective Serotonin Reuptake Inhibitors during Pregnancy and Risk of Autism Anders Hviid, Dr.Med.Sci., Mads Melbye, M.D., Dr.Med.Sci., and Björn
More informationWeimin YE Professor Department of Medical Epidemiology and Biostatistics Karolinska Institutet
Swedish Health Registers Weimin YE Professor Department of Medical Epidemiology and Biostatistics Karolinska Institutet Overview of Health Registers Nationwide registers National Healthcare Quality Registers
More informationCancer incidence in type 1 diabetes: A 5-country study of 9,000 cancers in type 1 diabetic individuals. Electronic Supplementary Material
Cancer incidence in type 1 diabetes: A -country study of 9, cancers in type 1 diabetic individuals Electronic Supplementary Material http://bendixcarstensen.com/dmca/t1d/t1d-ca-suppl.pdf February 216 Compiled
More informationCohort profile. Maret-Ouda, John
https://helda.helsinki.fi Cohort profile Maret-Ouda, John 2017-06 Maret-Ouda, J, Wahlin, K, Artama, M, Brusselaers, N, Farkkila, M, Lynge, E, Mattsson, F, Pukkala, E, Romundstad, P, Tryggvadottir, L, von
More informationMinutes Tissue Typers Meeting Aarhus, 21st September 2018
Minutes Tissue Typers Meeting Aarhus, 21st September 2018 Location: Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus N, relocation to C104 patiently accepted by all participants.
More information1. Family aggregation and long-term outcome of psychopathology in children and adolescents in the Danish Three Generation Study (3GS)
Aalborg CAP research programme 2016 1. Family aggregation and long-term outcome of psychopathology in children and adolescents in the Danish Three Generation Study (3GS) Objectives: Study of the aggregation
More informationWide variation in the number of different drugs prescribed by general practitioners A prescription database study
ORIGINAL PAPER Wide variation in the number of different drugs prescribed by general practitioners A prescription database study Lars Bjerrum 1,2 and Ulf Bergman 2,3 1 Research Unit of General Practice,
More informationRESEARCH. Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study
Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort study Lars Henning Pedersen, research assistant, 1 visiting scholar, 2 Tine Brink Henriksen, consultant,
More informationGestational diabetes mellitus and later cardiovascular disease: a Swedish population based case control study
DOI: 10.1111/1471-0528.12754 www.bjog.org General obstetrics Gestational diabetes mellitus and later cardiovascular disease: a Swedish population based case control study H Fadl, a A Magnuson, b IÖstlund,
More informationAssociation between preterm birth and intrauterine growth retardation and child asthma
Eur Respir J 2013; 41: 671 676 DOI: 10.1183/09031936.00041912 CopyrightßERS 2013 Association between preterm birth and intrauterine growth retardation and child asthma Bengt Källén*, Orvar Finnström #,
More informationValidity of data sources in pharmacoepidemiology
Validity of data sources in pharmacoepidemiology Jesper Hallas MD DrMedSc Dept of clinical pharmacology University of Southern Denmark, Odense jhallas@health.sdu.dk Disposition 1. Defining validity 2.
More informationNIH Public Access Author Manuscript N Engl J Med. Author manuscript; available in PMC 2013 March 18.
NIH Public Access Author Manuscript Published in final edited form as: N Engl J Med. 2013 January 24; 368(4): 333 340. doi:10.1056/nejmoa1207210. Risk of fetal death after pandemic influenza infection
More informationDeclaration of interests. Register-based research on safety and effectiveness opportunities and challenges 08/04/2018
Register-based research on safety and effectiveness opportunities and challenges Morten Andersen Department of Drug Design And Pharmacology Declaration of interests Participate(d) in research projects
More informationFounded 1969 by the Nordic Council of Ministers
Founded 1969 by the Nordic Council of Ministers Slideshow 217 Scandiatransplant activities Slide presentation of Scandiatransplant activities 217 Presentation, purpose, awards and office Slide 3 Overall
More informationSTANCE Program: Studying social services, treatment and other interventions for Alcohol and Narcotics and resulting health outcomes Age, Gender,
STANCE Program: Studying social services, treatment and other interventions for Alcohol and Narcotics and resulting health outcomes Age, Gender, education and country of birth differences in health outcomes
More informationDanish population-based registries in cancer pharmacoepidemiology. Cancer Pharmacoepidemiology Meeting Dublin September 2013
Danish population-based registries in cancer pharmacoepidemiology Deirdre Cronin Fenton dc@dce.au.dk Cancer Pharmacoepidemiology Meeting Dublin September 2013 Frank L. Science 2003 The Danish Cohort The
More informationProgramme & Abstracts
Association of the Nordic Cancer Registries ANCR 29th - 30th August 2012 Oslo - Norway Soria Moria by Theodor Kittelsen (1881) Programme & Abstracts Soria Moria Conference hotel Voksenkollveien 60, 0790Oslo,
More informationResearch Article The Danish Model for Improvement of Diabetes Care in General Practice: Impact of Automated Collection and Feedback of Patient Data
International Family Medicine Volume 2012, Article ID 208123, 5 pages doi:10.1155/2012/208123 Research Article The Danish Model for Improvement of Diabetes Care in General Practice: Impact of Automated
More informationBirth Rate among Patients with Epilepsy: A Nationwide Population-based Cohort Study in Finland
American Journal of Epidemiology Copyright 2004 by the Johns Hopkins Bloomberg School of Public Health All rights reserved Vol. 159, No. 11 Printed in U.S.A. DOI: 10.1093/aje/kwh140 Birth Rate among Patients
More informationBMJ Open. Pharmacology and therapeutics. Maternal medicine < OBSTETRICS, Depression & mood disorders < PSYCHIATRY, EPIDEMIOLOGY
Combined use of selective serotonin reuptake inhibitor and sedatives/hypnotics during pregnancy: Risk of relatively severe congenital malformations or cardiac defects. A register study Journal: Manuscript
More informationPlanning an effective HPV vaccination launch: The key indicators for success Joakim Dillner
Planning an effective HPV vaccination launch: The key indicators for success Joakim Dillner Professor of Infectious Disease Epidemiology PI, International HPV Reference Center Director, Swedish Cervical
More informationHomogeneous Prostate Cancer Mortality in the Nordic Countries Over Four Decades
EUROPEAN UROLOGY 58 (2010) 427 432 available at www.sciencedirect.com journal homepage: www.europeanurology.com Prostate Cancer Homogeneous Prostate Cancer Mortality in the Nordic Countries Over Four Decades
More informationPEER REVIEW HISTORY ARTICLE DETAILS VERSION 1 - REVIEW. Randi Selmer Senior Researcher Norwegian Institute of Public Health Norway
PEER REVIEW HISTORY BMJ Open publishes all reviews undertaken for accepted manuscripts. Reviewers are asked to complete a checklist review form (see an example) and are provided with free text boxes to
More informationMeasuring and predicting cancer incidence, prevalence and survival in Finland
Measuring and predicting cancer incidence, prevalence and survival in Finland Timo Hakulinen and Karri Seppä Finnish Cancer Registry- the Institute for Statistical and Epidemiological Cancer Research ABSTRACT
More informationUpdate on hemoglobin and ferritin with data from the Danish Blood Donor Study
The Danish Blood Donor Study Update on hemoglobin and ferritin with data from the Danish Blood Donor Study Henrik Ullum Copenhagen University Hospital Topics Iron depletion in blood donors Clinical consequences
More informationReviewing the long-term use of selective serotonin reuptake inhibitors in patients with depression
CLINICAL AUDIT Reviewing the long-term use of selective serotonin reuptake inhibitors in patients with depression Valid to November 2022 bpac nz better medicin e Audit Focus This audit helps health professionals
More informationThe Danish Twin Registry - a National and International Research Ressource for 65 Years
The Danish Twin Registry - a National and International Research Ressource for 65 Years Alder The Danish Twin Registry (1953-) Twins born in Denmark 1870-2009 86,398 pairs included 105,000 twins alive
More informationDo morphology and stage explain the inferior lung cancer survival in Denmark?
Eur Respir J 1999; 13: 430±435 Printed in UK ± all rights reserved Copyright #ERS Journals Ltd 1999 European Respiratory Journal ISSN 0903-1936 Do morphology and stage explain the inferior lung cancer
More informationSupplementary appendix: Oral polio vaccination and hospital admissions with non-polio infections in Denmark: Nationwide retrospective cohort study
Supplementary appendix: Oral polio vaccination and hospital admissions with non-polio infections in Denmark: Nationwide retrospective cohort study Signe Sørup, Lone G. Stensballe, Tyra G. Krause, Peter
More informationEnriched RWE study in the Nordics a case study
Enriched RWE study in the Nordics a case study RWD conf. Helsinki, November 28, 2018 Susanne Kihlblom, MSc Pharm., Diplom.Clin.Trials Copyright 2017 IQVIA. All rights reserved. IQVIA 2017. All rights reserved.
More informationSocio-economic Consequences of Pain-Intensive Diseases in Denmark
Summary of publication from the Danish Institute for Health Services Research: Socio-economic Consequences of Pain-Intensive Diseases in Denmark Jan Christensen Lone Bilde Anders Gustavsson The Danish
More informationSCENIHR Public Hearing Luxemburg Roland Laurent Swedish Tanning Association
SCENIHR Public Hearing Luxemburg Swedish Tanning Association Member of TC 412 of EN16489 working group Type-3 Scandinavian countries are type-3 regulated Described in EN 60335-2-27 for home use by unskilled
More informationChronic liver disease can lead to cirrhosis, which is
Hepatology Communications, VOL. 2, NO. 11, 2018 Outcomes of Pregnancy in Mothers With Cirrhosis: A National Population-Based Cohort Study of 1.3 Million Pregnancies Hannes Hagström, 1,2 Jonas Höijer, 3
More informationYear 2013 Number of articles 45 Title of study. Journal. Authors (alphabetic order)
Year 2013 Number of articles 45 Title of study. Journal. Authors (alphabetic order) 1 2 The Asian Pharmacoepidemiology Network (AsPEN): promoting multi-national collaboration for pharmacoepidemiologic
More informationUpper Gastrointestinal Research (UGIR) Jesper Lagergren, professor of surgery Karolinska Institutet and King s Health Partners London
Upper Gastrointestinal Research (UGIR) Jesper Lagergren, professor of surgery Karolinska Institutet and King s Health Partners London UGIR SIMSAM funding in 2008 Creation of UGIR (Upper Gastro-Intestinal
More informationJinliang Zhu, Carsten Obel, Jørn Olsen Department of Public Health, University of Aarhus
Parental smoking during pregnancy and short- and long-term adverse outcomes in offspring: Using data from ad hoc birth cohorts and registers in Denmark Jinliang Zhu, Carsten Obel, Jørn Olsen Department
More informationManuscript ID BMJ entitled "Benzodiazepines and the Risk of Allcause Mortality in Adults: A Cohort Study"
12-Jan-2017 Dear Dr. Patorno Manuscript ID BMJ.2016.036319 entitled "Benzodiazepines and the Risk of Allcause Mortality in Adults: A Cohort Study" Thank you for sending us your paper. We sent it for external
More informationDecision making and medication risk: from signal to policy and regulation. Hubert G. Leufkens UIPS Utrecht Institute for Pharmaceutical Sciences
Decision making and medication risk: from signal to policy and regulation Hubert G. Leufkens Public health effects of medicines Direct clinical effects (e.g. analgesics and pain relief, antivirals and
More informationRisk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy a cohort linkage study
DOI: 10.1111/1471-0528.14026 www.bjog.org Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy a cohort linkage study E Garne, a A Vinkel Hansen, a J Morris,
More informationPrevalence of Hypospadias in Danish Boys: A Longitudinal Study,
european urology 55 (2009) 1022 1026 available at www.sciencedirect.com journal homepage: www.europeanurology.com Platinum Priority Pediatric Urology Editorial by Paolo Caione on pp. 1027 1029 of this
More informationStatin Use and Risk of Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Statin Use and Risk of Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders Henrik Toft Sørensen, DMSc; Anders Hammerich Riis, MSc; Timothy L. Lash, DSc; Lars Pedersen, PhD Background Use of
More informationEffect of Screening in the Nordic Cancer Control up to the Year 2017
Acta Oncologica ISSN: 0284-186X (Print) 1651-226X (Online) Journal homepage: http://www.tandfonline.com/loi/ionc20 Effect of Screening in the Nordic Cancer Control up to the Year 2017 Matti Hakama & Lora
More informationExcess mortality, causes of death and life expectancy in main groups of patients with recent onset of mental disorders in
Excess mortality, causes of death and life expectancy in main groups of patients with recent onset of mental disorders in 2000-2006 in Denmark, Finland and Sweden Saving Lives in Nordic Countries, The
More informationPASS Information. 10 mg, 18 mg, 25 mg, 40mg, 60 mg, 80 mg, 100 mg
Page 1 PASS Information Title Strattera patient exposures and adherence in the United Kingdom, Germany, the Netherlands, and Sweden: 2016 Bi-annual assessment report. (B4Z-MC-B025) Version identifier 001
More informationBMJ Open. Reproductive medicine. Secondary Subject Heading: Epidemiology, Obstetrics and gynaecology, Public health
Psychiatric disorders among women and men in assisted reproductive technology (ART) treatment. The Danish National ART-Couple (DANAC) cohort: protocol for a longitudinal, national register-based cohort
More informationCompetition challenges in the pharmacy/pharmaceutical sector
Executive summary of report from the Nordic Competition authorities No. 1/2008 Competition challenges in the pharmacy/pharmaceutical sector Competition challenges in the pharmacy/pharmaceutical sector
More informationNordic Specialist Course in Palliative Medicine
Nordic Specialist Course in MODULE 1 25-29 September 2017, Trondheim, Norway A. INTRODUCTION TO PALLIATIVE MEDICINE (1/2 day) To have an understanding of palliative medicine, its characteristics, advantages,
More informationValidation of disease registration in pregnant women in the Medical Birth Registry of Norway
Acta Obstetricia et Gynecologica. 2009; 88: 10831089 ORIGINAL ARTICLE Validation of disease registration in pregnant women in the Medical Birth Registry of Norway ANDERS ENGELAND 1,2, TONE BJØRGE 2,3,
More informationAntidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study
Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study Xiaoqin Liu, 1 Esben Agerbo, 1,2,3 Katja G Ingstrup, 1 Katherine Musliner, 1,3
More informationStatin use and risk of endometrial cancer: a nationwide registry-based case control study
AOGS ORIGINAL RESEARCH ARTICLE : a nationwide registry-based case control study CECILIE D. SPERLING 1, FREIJA VERDOODT 1, SØREN FRIIS 2,3,4, CHRISTIAN DEHLENDORFF 2 & SUSANNE K. KJAER 1,5 1 Virus, Lifestyle
More informationPatterns of psychotropic medicine use in pregnancy in the United States from 2006 to 2011 among women with private insurance
Hanley and Mintzes BMC Pregnancy and Childbirth 2014, 14:242 RESEARCH ARTICLE Patterns of psychotropic medicine use in pregnancy in the United States from 2006 to 2011 among women with private insurance
More informationSeminars in contraception uit.no/semcontra
Tromsø, Norway, November 9-10, 2017 Seminars in contraception uit.no/semcontra Program Thursday 10:30 Welcome/0pening User patterns of contraception in the Nordic countries 10.40 Use of hormonal contraception
More informationPharmaco-epidemiological outcome research
Pharmaco-epidemiological outcome research Using the PHARMO-Eindhoven Cancer Registry linkage Lonneke van de Poll-Franse Professor of Cancer Epidemiology and Survivorship, Tilburg University & Head department
More informationThe 5-minute Apgar score as a predictor of childhood cancer: a population-based cohort study in five million children
Open Access Research The 5-minute Apgar score as a predictor of childhood cancer: a population-based cohort study in five million children Jiong Li, 1 Sven Cnattingus, 2 Mika Gissler, 3 Mogens Vestergaard,
More informationIncidence of total hip replacement for primary osteoarthrosis in Iceland
Acra Orthop Scand 999; 70 (3): 229-233 229 Incidence of total hip replacement for primary osteoarthrosis in Iceland 982-996 Thorvaldur Ingvarsson~2, Gunnar Hagglund2, Halldor Jonsson J6 and L Stefan Lohmander2
More informationCite this article as: BMJ, doi: /bmj (published 22 June 2004)
Cite this article as: BMJ, doi:10.1136/bmj.38133.622488.63 (published 22 June 2004) Change in suicide rates for patients with schizophrenia in Denmark, 1981-97: nested case-control study Merete Nordentoft,
More informationAntidepressant Selection in Primary Care
Antidepressant Selection in Primary Care R E B E C C A D. L E W I S, D O O O A S U M M E R C M E B R A N S O N, M O 1 5 A U G U S T 2 0 1 5 Objectives Understand the epidemiology of depression. Recognize
More informationIncreased use of antidepressants and decreasing suicide rates: a population-based study using Danish register data
Increased use of antidepressants and decreasing suicide rates: a population-based study using Danish register data A Erlangsen, 1,2 V Canudas-Romo, 3 Y Conwell 2 c Additional tables are published online
More informationPre-pregnancy body mass index and the risk of adverse outcome in type 1 diabetic pregnancies: a population-based cohort study
Open Access To cite: Persson M, Pasupathy D, Hanson U, et al. Pre-pregnancy body mass index and the risk of adverse outcome in type 1 diabetic pregnancies: a population-based cohort study. BMJ Open 2012;2:
More informationCitation for the original published paper (version of record): N.B. When citing this work, cite the original published paper.
http://www.diva-portal.org This is the published version of a paper published in European Child and Adolescent Psychiatry. Citation for the original published paper (version of record): Kleppang, A L.,
More informationEU Osteoporosis Report SWEDEN
EU Osteoporosis Report 2007-2008 SWEDEN Completed by: Kristina Åkesson, Bone & Joint Decade Eva Waern, Andreas Kindmark, Caroline Åkerhielm Swedish Rheumatism Association OVERVIEW 2001-2005 2007 Ref: Osteoporosis
More informationASTHMA, ANXIETY AND DEPRESSION IN PREGNANCY - THE IMPACT ON PREGNANCY, DELIVERY AND PERINATAL OUTCOMES
From DEPARTMENT OF MEDICAL EPIDEMIOLOGY AND BIOSTATISTICS Karolinska Institutet, Stockholm, Sweden ASTHMA, ANXIETY AND DEPRESSION IN PREGNANCY - THE IMPACT ON PREGNANCY, DELIVERY AND PERINATAL OUTCOMES
More informationOutline. Definitions. ATC Anatomical Therapeutic Chemical classification
The Anatomical Therapeutic Chemical Classification and the Defined Daily Dose: Classifying and Quantifying Drug Use Hanne Strøm Department of Pharmacoepidemiology ICPE, Chicago August 2011 : Preconference
More informationCohort Profile: The Metropolit 1953 Danish Male Birth Cohort
Published by Oxford University Press on behalf of the International Epidemiological Association International Journal of Epidemiology 2006;35:541 545 Ó The Author 2005; all rights reserved. Advance Access
More informationPost-Authorisation Safety Study of Agomelatine and the Risk of Hospitalisation for Acute Liver Injury. 22 July 2015
PASS Information Document title Post-Authorisation Safety Study of Agomelatine and the Risk of Hospitalisation for Acute Liver Injury Protocol version identifier 2.1 Date of last version of protocol EU
More informationPharmacovigilance Methods and Post-Authorisation Safety Studies
Pharmacovigilance Methods and Post-Authorisation Safety Studies Alex Dodoo Director, WHO Collaborating Centre for Advocacy and Training in Pharmacovigilance Accra, Ghana Objectives At the end of this module
More informationIs there an association between selective serotonin reuptake inhibitor use and uncomplicated peptic ulcers? A population-based case-control study
Is there an association between selective serotonin reuptake inhibitor use and uncomplicated peptic ulcers? A population-based case-control study Michael Dall Dall, Ove B. Schaffalitzky de Muckadell, Annmarie
More informationSmoking and Celiac Disease: A Population-Based Cohort Study
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 2005;3:869 874 Smoking and Celiac Disease: A Population-Based Cohort Study JONAS F. LUDVIGSSON,*, SCOTT M. MONTGOMERY,*, and ANDERS EKBOM, *Pediatric Department,
More informationPros and cons with registry-based research
Pros and cons with registry-based research Måns Rosén SBU My focus this time is on clinical studies more than on etiologic research Health data registers Cancer Register Medical Birth Register including
More informationAspects of statin prescribing in Norwegian counties with high, average and low statin. Department of Pharmacy, University of Tromsø, Tromsø, Norway
Title page Aspects of statin prescribing in Norwegian counties with high, average and low statin consumption - an individualised prescription database study Ingeborg Hartz, 1 Solveig Sakshaug, 2 Kari Furu
More informationSex differences in mortality among patients admitted with affective disorders in North Norway -
Sex differences in mortality among patients admitted with affective disorders in North Norway - a 33-year prospective register study Anne Høye a,b, Ragnar Nesvåg c,d, Ted Reichborn-Kjennerud c, Bjarne
More informationESPEN Congress Copenhagen 2016 SPREADING KNOWLEDGE AND INTEREST IN NUTRITION
ESPEN Congress Copenhagen 2016 SPREADING KNOWLEDGE AND INTEREST IN NUTRITION DIFFERENT APPROACHES TO COMMIT YOUNG PEOPLE: NORDIC NUTRITION ACADEMY, ESPEN COURSES, LLL T. Cederholm (SE) Different approaches
More informationFirst Interim Report to the European Commission DG-SANCO for: Grant Agreement No.: (790655) EAIS. December Annex 2
First Interim Report to the European Commission DG-SANCO for: Grant Agreement.:2005112 (790655) EAIS. December 2006 Annex 2 European Autism Information System (EAIS) Project: Design of a Prevalence study.
More informationMEDICATIONS PRESCRIPTION AT HOSPITAL DISCHARGE IN PATIENTS WITH VALIDATED DIAGNOSIS OF DEMENTIA. Federica Edith Pisa University Hospital Udine
MEDICATIONS PRESCRIPTION AT HOSPITAL DISCHARGE IN PATIENTS WITH VALIDATED DIAGNOSIS OF DEMENTIA Federica Edith Pisa University Hospital Udine BACKGROUND Polypharmacy and psychotropic medication use are
More informationMeasuring drug exposure: rationale and methods
Measuring drug exposure: rationale and methods Hubert G. Leufkens Declaration of interests Chairman of the Dutch Medicines Evaluation Board (MEB), since mid 2007. Professor of Pharmacoepidemiology, Utrecht
More informationNorwegian health services in comparative perspective. Terje P. Hagen Department of Health Management and Health Economics
Norwegian health services in comparative perspective Terje P. Hagen Department of Health Management and Health Economics 1) What are the values and the pitfalls of international comparisons? Values Identify
More informationAntidepressants and the risk of suicide in young persons prescription trends and toxicological analyses
Acta Psychiatr Scand 2014: 129: 296 302 All rights reserved DOI: 10.1111/acps.12160 2013 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd. ACTA PSYCHIATRICA SCANDINAVICA Antidepressants
More information