NIDA Director s Report to the National Advisory Councils of NIDA, NIAAA, & NCI February 4, Nora D. Volkow, M.D., Director

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1 NIDA Director s Report to the National Advisory Councils of NIDA, NIAAA, & NCI February 4, 2015 Nora D. Volkow, M.D., Director

2 $ (in thousands) NIDA Program Level in Appropriated Dollars and Constant 1998 Dollars 1,200,000 1,000,000 Budget Authority Appropriation in 1998 Dollars 800, , , , Budget is for AIDS research

3 No. of Applications vs. Awards NIDA Applications, Awards & Success Rates Applications Awards Success Rate () Fiscal Year

of Cigarettes, Marijuana and Alcohol 60 50 40

93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08

4 Percentage of U.S. 12 th Grade Students Reporting Past Month Use of Cigarettes, Marijuana and Alcohol Alcohol Marijuana Cigarettes SOURCE: University of Michigan, 2014 Monitoring the Future Study.

5 Status of Marijuana Laws in the US

6 Numbers in Millions Daily Use (Percent) Perceived Risk (Percent) National Survey on Drug Use and Health (NSDUH) Regular Marijuana Use, Persons Aged 12 or Older: Marijuana on 20 or More Days in Past Month Marijuana on 300 or More Days in Past Year Source: National Survey on Drug Use and Health, SAMHSA Monitoring the Future (MTF) 12th Graders Reporting Regular Marijuana Use vs. Perceived Risk of Regular Marijuana Use Perceived Risk Daily Use Source: The Monitoring the Future study, the University of Michigan

7 Subcortical Structures Differences Between Regular Marijuana Users and Nonusers Weiland B J et al. J. Neurosci. 2015;35:

Volume (mm 3 ) Effects of Prenatal Nicotine Exposure on Brain

Left Right 2 4 6 8 10 12 14 16 18 20 Age(years) 2 4 6 8 10 12 14 16

017 (post-hoc interaction: left: p=0.17; right: p=0.

8 Volume (mm 3 ) Effects of Prenatal Nicotine Exposure on Brain Development in Boys and Girls Volume (mm 3 ) Left and Right Pallidum Left Right Age(years) Age(years) Subcortical PC: NIC*Gender interaction p=0.017 (post-hoc interaction: left: p=0.17; right: p=0.68) NIC exposed females had smaller GP than controls, males show no difference Chang et al, PING CONSORTIUM

9 Adolescent Brain Cognitive Development National Longitudinal Study NIDA, NIAAA, NCI, NICHD, NIMHD, ORWH, OBSSR, NIMH, NINDS, NEI Ten year longitudinal study of 10,000 children from age 10 to 20 years to assess effects of drugs on individual brain development trajectories

Adolescent Brain & Cognitive Development (ABCD) National Longitudinal Study Expert panel workshop developed recommendations on best large-scale designs and measures to assess developmental effects of

10 Adolescent Brain & Cognitive Development (ABCD) National Longitudinal Study Expert panel workshop developed recommendations on best large-scale designs and measures to assess developmental effects of substance exposure (beginning prior to exposure) during childhood through adolescence (in human subjects) May 27-28, 2014 RFI solicited input on proposed study design/measures June-August 2014 Revised design based on input from RFI and satellite symposium at SfN November 17, 2014 Notices of Intent to Publish: FOA January 2015 Updates at: NIDA NIAAA NCI NICHD NIMHD ORWH NIMH NINDS OBSSR NEI

11 Prospective cohort study of ~10,000 youth beginning ~ ages 9-10 Substance use, Cognition, Emotion, Mental Health, Physical health, Executive Function, General Intelligence, Environment, Biospecimens: Genetics, Epigenetics Time

12 Notice of Intent to Publish a Funding Opportunity Announcement for A Longitudinal Study of Adolescent Brain and Cognitive Development (ABCD) Research Sites (U01) Notice Number: NOT-DA Key Dates Release Date: November 26, 2014 Estimated Publication Date of Announcement: January 2015 First Estimated Application Due Date: April 2015 Earliest Estimated Award Date: September 2015 Earliest Estimated Start Date: September 2015 Related Announcements NOT-DA NOT-DA Issued by National Institute on Drug Abuse (NIDA) National Cancer Institute (NCI) National Institute on Alcohol Abuse and Alcoholism (NIAAA) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Low High Relevant to advancing of knowledge NIDA Strategic Plan 2010-2015 Basic Epi, Prevention Services (HIV)

practical issues (Current 55) Use-inspired basic research to address important practical questions (Current 10) L

immediate application Chalmers et al, Lancet 2014, 383, 9912, 11-17 How to increase value and reduce waste when

13 Low High Relevant to advancing of knowledge NIDA Strategic Plan Basic Epi, Prevention Services (HIV) Treatment (HIV) RM&S IRP CTN N Bohr *30 Budget HIV/AIDS Pure basic research without consideration of relevance to practical issues (Current 55) Use-inspired basic research to address important practical questions (Current 10) L Pasteur Waste Pure applied research to address important practical questions (35) T Edison Low High Relevant to immediate application Chalmers et al, Lancet 2014, 383, 9912, How to increase value and reduce waste when research priorities are set D E Stokes. Pasteur's quadrant basic science and technological innovation. Brookings Institution Press, Washington, DC (1997)

14 NIDA Strategic Plan Current/Future Issues Leveraging new technologies Developing standards, infrastructure, and tools to support Big Data Integration with BRAIN Initiative Responding to changes in SUD landscape (i.e., marijuana policies, healthcare reform, E-cigarettes as drug delivery devices) Accelerate translation research (i.e., medications, devices) Training for next generation of scientists Input from multiple sources - NIDA staff, NIDA Advisory Council, Researchers,Practitioners, Constituent organizations, Consumer groups, Other Stakeholders Key Mechanisms: - Request for Information (RFI)/Public Comment - Bold Goals Challenge Prizes - Priority Area/Cross - Cutting Work Groups Publication: Fall 2015

15 Updating NIDA Strategic Plan RFI released Dec 10 for feedback on draft priorities: Understanding basic science of drug use, addiction, vulnerability, and recovery Supporting development of new and better interventions and treatments Increasing the public health impact of NIDA research Enhancing the national research infrastructure Comment period closed January 30 th (more than 200 comments) Next steps: Priority Area Workgroups with internal and external experts: Big Data Gene x Environment x Development interactions Complex patients (multiple comorbidities) and phenotyping Health disparities Division strategic plans Timeline RFI Review By March 6, 2015 Priority Area Workgroups Feb-July Division Strategic Plans Drafts By February 6, 2015 Draft Strategic Plan to Council May 2015 Final Strategic Plan Fall 2015

Director s Report to the National Advisory Council on Drug Abuse

Director s Report to the National Advisory Council on Drug Abuse September 5, 2018 Nora D. Volkow, M.D., Director National Institute on Drug Abuse @NIDAnews NIDA Office of Diversity & Health Disparities