Anshul A Pandya, Ph.D.

Transcription

1 Anshul A Pandya, Ph.D. Assistant Professor of Biosciences College of Rural and Community Development, University of Alaska Fairbanks PO Box 186 Kotzebue, AK Tel: (907) aapandya@alaska.edu University Education: Ph.D. Biochemistry and Molecular Biology (Neuroscience option) University of Alaska Fairbanks (UAF) Thesis: Pharmacology of a novel class of allosteric modulators for the alpha4 beta2 sub-type of neuronal nicotinic acetylcholine receptors. Advisor: Dr. Marvin Schulte Pg. Dip Post graduate diploma Biomedical Sciences, University of Wolverhampton, UK B. Pharm Bachelors of Pharmacy, R.D. College of Pharmacy, University of Pune, India Research and Academic Positions: 1/2013 Present: Assistant Professor of Biosciences, UAF, Kotzebue, AK 8/ /2012: Post-Doctoral Fellow Laboratory of Neurobiology in the National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC Research: Electrophysiological and behavioral investigation of allosteric modulators for neuronal nicotinic receptors Supervisor: Dr. J.L. Yakel 5/2009 7/2009: Adjunct Faculty, Rural Alaska Honors Institute, UAF, Fairbanks, AK 8/2004 5/2009: Graduate student, department of Chemistry & Biochemistry, UAF, Fairbanks, AK Affiliate Status: 4/2013 Present: Affiliate faculty, IDeA Network of Biomedical Research Excellence (Alaska INBRE) 2/203 Present: Affiliate faculty, Department of Chemistry & Biochemistry, College of Natural Science & Mathematics, UAF Teaching Experience: Courses developed or proposed: 1. BIOL F194 - Neuropharmacology of Addiction (approved, to be taught every fall semester) 3cr 2. Phytochemistry at 300 level (proposed for Fall-2015) 3cr 3. CHEM F394 - Medicinal Chemistry (approved, to be taught every spring semester) 3cr Anshul Pandya, Ph.D. Page 1

2 Courses taught: Fall 2014: (Distance delivery) Human Anatomy and Physiology - I (BIOL F213X) 4cr Neuropharmacology of Addiction (BIOL 194) 3cr Fall 2014: (In-class) Beginnings in Microbiology (BIOL F240) 4cr Spring 2014: (Distance delivery) - Basic General Chemistry (CHEM F103X) 4cr Science of Nutrition (HLTH 203) 3cr Spring 2014: (In-class) Human Anatomy and Physiology - II (BIOL F214X) 4cr Fall 2013: (In-class) Human Anatomy and Physiology - I (BIOL F213X) 4cr Chemistry in Complex Systems (CHEM F100X) 4cr Academic Service: 1. Executive organizer of the 7 th annual Western Alaska Interdisciplinary Science Conference and Forum (WAISC) in April-2014 in Kotzebue Alternate committee member for the Institutional Animal Care and Use Committee (IACUC) of UAF Research Focus: 1. Elucidation of the structure and function of neuronal nicotinic acetylcholine receptors 2. Developing nicotinic ligands for treating neurodevelopmental and neurodegenerative diseases 3. Behavioral actions of nicotinic ligands in animal models Publications: Under Review: Dineley KT, Pandya AA, Yakel JL. Nicotinic ACh Receptors as Targets in Neurodegenerative Disease, Neurodevelopmental Disorders, and Pain. Submitted to: Trends in Pharmacological Sciences In Preparation: Lewis JN, Pandya AA. Consumption of market-based diet rather than subsistence diet is a bigger correlate of weight status among the residents of northwest Alaska. Refereed Publications: 1) Pandya AA, Yakel JL. Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies. Biochemical Pharmacology May 31. doi: pii: S (13) /j.bcp (Invited Review). 2) Pandya AA, Yakel J. Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT1a receptor antagonist. Neuropharmacology Jan 12. pii: S (13) doi: /j.neuropharm Anshul Pandya, Ph.D. Page 2

3 3) German N, Kim JS, Jain A, Dukat M, Pandya A, Ma Y, Weltzin M, Schulte MK, Glennon RA. Deconstruction of the α4β2 nicotinic acetylcholine receptor positive allosteric modulator Desformylflustrabromine. J Med Chem Oct 27; 54(20): ) Pandya A, Yakel JL. Allosteric modulators of the α4β2 subtype of neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology Oct 15; 82(8): (Invited Review). 5) Pandya, A, Yakel, J. L. Allosteric Modulator Desformylflustrabromine Relieves the Inhibition of alpha2beta2 and alpha4beta2 Nicotinic Acetylcholine Receptors by beta-amyloid (1-42) Peptide. J Mol Neurosci Sep;45(1): ) Brams M, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, Tsetlin V, Smit AB, lens C. A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors. PLoS Biol Mar; 9(3):e Epub 2011 Mar 29. (Co-First Author). 7) Kim JS, Pandya A, Weltzin M, Schulte MK, Glennon RA. Synthesis of Desformylflustrabromine and its re-evaluation as an α4β2 nach receptor modulator. Bioorg Med Chem Lett Sep 1; 17 (17): (Co-First Author). Grants Writing Experience: Applied for K99/R00 career transition grant with the National Institutes of Health (June 2012) Pharmacy Work Experience: 6/2003 7/2004: Pharmacy technician, Staveley Chemist, Wolverhampton, UK 10/2002 5/2003: Pharmacy technician, Boots Pharmacy, Telford, Shropshire, UK 2/2002 7/2002: Pharmacist, Leelavati Hospital & Research Centre, Bombay, India 9/2000 1/2002: Pharmacist, Sahil Medical Store, Bombay, India 9/1999 8/2000: Graduate Apprentice, tablet production dept., Fulford Ltd., subsidy of Schering Plough, USA Workshop and Training Attended: 1. Online Science Education Symposium in March (University of Alaska Anchorage, AK) 2. Grant writing workshop in May (NIEHS, Durham, NC) 3. Training in teaching online courses in April (NIEHS, Durham, NC) 4. Chiphegen Protein Chip Assay technology training in July (Freemont, CA) Memberships in Professional Societies: 1. Society for Neuroscience. (2005 Present) 2. Society for the Advancement of Hispanics/Chicanos and Native Americans in Science (2011 Present) Anshul Pandya, Ph.D. Page 3

4 Mentorship: 1. Currently mentoring an undergraduate student (Jeanne Lewis) with her research project funded by Undergraduate Research & Scholarly Activity (URSA) office of UAF 2. Currently mentoring an undergraduate student (Rommel Benzon) to develop, write and apply for URSA research funding to carry out a research project 3. As a post-doctoral fellow at NIEHS, mentored 2 undergraduate students and helped them in their research projects Writing experience: Contributor for Environmental Factor a monthly NIEHS / NIH online magazine Example of writing contributed: Community service: 1. Presented a science seminar titled "Drugs that can make you smart can also make you anxious" in the spring semester of 2013 at the Chukchi campus of UAF in Kotzebue, AK 2. Conducted a science discussion titled "Science and Society" in the fall semester of 2013 at the Chukchi campus of UAF in Kotzebue, AK Volunteering and Social service: 5/2012 to 12/2012 Volunteer (mentor) for the Big Brother Big Sisters of the Triangle, NC Presentations: Invited Seminars: 1. Anshul Pandya. Career opportunities in the field of Biomedical Science and Healthcare. (May, 2014). GAALEE YA STEM Symposium. Interior Aleutian Campus, UAF, Fairbanks, AK 2. Anshul Pandya. Allosteric modulation of neuronal nicotinic acetylcholine receptors. (Feb, 2012). NIH Neuroscience weekly seminar series. Bethesda, MD Other Seminars: 1. Anshul Pandya. Allosteric modulation of neuronal nicotinic acetylcholine receptors. (June, 2011). Laboratory of Neurobiology, NIEHS, Durham, NC 2. Anshul Pandya. Pharmacology of a novel allosteric modulator for neuronal nicotinic acetylcholine receptors. (Jan, 2011). Laboratory of Neurobiology, NIEHS, Durham, NC 3. Anshul Pandya. Pharmacology of a novel allosteric modulator for neuronal nicotinic acetylcholine receptors. (May, 2009). 5 th annual University of Alaska biomedical research annual conference (UBRAC), Fairbanks, AK 4. Anshul Pandya. Allosteric modulation of neuronal nicotinic acetylcholine receptors. (March, 2009). Departmental seminar, Institute of Arctic Biology. UAF, Fairbanks AK Anshul Pandya, Ph.D. Page 4

5 5. Anshul Pandya. Interaction between the different classes of positive allosteric modulators for neuronal nicotinic acetylcholine receptors. (May, 2008). 4 th annual University of Alaska biomedical research annual conference (UBRAC), Anchorage, AK 6. Anshul Pandya. Structure Function study of the desformylflustrabromine class of positive allosteric modulators for neuronal nicotinic acetylcholine receptors. (May, 2007). 3 th annual University of Alaska biomedical research annual conference (UBRAC), Fairbanks, AK 7. Anshul Pandya. Identification of a novel class of positive allosteric modulators for neuronal nicotinic acetylcholine receptors. (May, 2006). 2 nd annual University of Alaska biomedical research annual conference (UBRAC), Anchorage, AK Posters: 1. Anshul Pandya and Jerrel Yakel. Effects of Phantasmidine on neuronal nicotinic Acetylcholine and 5- HT 3 receptors. Submitted for presentation at the 42 nd annual meeting of Society for Neuroscience. New Orleans. (Oct, 2012) 2. Anshul Pandya and Jerrel Yakel. Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT1a receptor antagonist. Submitted for presentation at the 42 nd annual meeting of Society for Neuroscience. New Orleans. (Oct, 2012) 3. Anshul Pandya and Jerrel Yakel. Desformylflustrabromine relieves the inhibition of alpha2 beta2 and alpha4 beta2 nicotinic acetylcholine receptors by beta-amyloid (1-42) Peptide. 41 st annual meeting of Society for Neuroscience. Washington DC. (Nov, 2011) 4. Anshul Pandya and Jerrel Yakel. Desformylflustrabromine relieves the inhibition of alpha2 beta2 and alpha4beta2 nicotinic acetylcholine receptors by beta-amyloid (1-42) Peptide. 2 nd Nicotinic Acetylcholine Receptors meeting (May 2011). Cambridge, UK 5. Anshul Pandya and Marvin Schulte. Interaction between the different classes of positive allosteric modulators for neuronal nicotinic acetylcholine receptors. 39 th annual meeting of Society for Neuroscience. Chicago, IL (Oct, 2009) 6. Anshul Pandya, Marvin Schulte. Structure Function study of the desformylflustrabromine class of positive allosteric modulators for neuronal nicotinic acetylcholine receptors. 38 th annual meeting of Society for Neuroscience. Washington DC. (Nov, 2008) 7. Anshul Pandya, Magen Weltzin, Marvin Schulte. Identification of a novel class of positive allosteric modulators for neuronal nicotinic acetylcholine receptors. 37 th annual meeting of Society for Neuroscience. San Diego, CA. (Nov, 2007) Anshul Pandya, Ph.D. Page 5