Harmful and potentially harmful constituents in e-cigarettes
|
|
|
- Cory Holland
- 6 years ago
- Views:
Transcription
1 Harmful and potentially harmful constituents in e-cigarettes Prof. Riccardo Polosa Institute of Internal Medicine Centre for the Prevention and Cure of Tabagism University of Catania - ITALY Global Forum on Nicotine June 2014 Warsaw
2 Conflict of interest Riccardo Polosa I am full Professor of Internal Medicine and I am supported by the University of Catania, Italy. I undertake research and consultancy for pharma companies that develop and manufacture smoking cessation medications (i.e. Pfizer, GlaxoSmithKline and Novartis) as well as for E-cig and E-liquid companies. I served a consultancy role for the Global Health Alliance for treatment of tobacco dependence, and LIAF (the Italian Anti Smoking League).
3 No tobacco, no combustion e-cigarette facts Tobacco, and combustion Vaporisation of nicotine-containing solvents
4 Nicotine facts Nicotine is a neurostimulant (NOT a poison) Nicotine IS NOT the reason for smoking-related disease Officially IS NOT a carcinogen (IARC) DOES NOT cause lung disease Has minimal effect in CVD Even in e-cigarettes, it is NOT nicotine but other chemicals that may be problematic
5 Nicotine containing products risk estimates 100 E-cig 4 DJ Nutt, LD Phillips, D Balfour, HV Curran, M Dockrell, J Foulds, K Fagerstrom, K Letlape, A Milton, R Polosa, J Ramsey, D Sweanor. Estimating the harms of nicotine-containing products using the MCDA approach. Eur J Addiction 2014
6 Tobacco harm reduction (THR), the substitution of low-risk nicotine containing products (e.g. e-cigarettes) for cigarette smoking, may offer huge public health benefits. Vaping is an alternative to smoking. e-cigarettes should be marketed for smokers only.
7 Harm reduction categories risk estimates 100 How low is the low-risk level for e-cigarettes compared to tobacco cigarettes? Is vaporisation of e-liquids generating harmful products? E-cig 4 DJ Nutt, LD Phillips, D Balfour, HV Curran, M Dockrell, J Foulds, K Fagerstrom, K Letlape, A Milton, R Polosa, J Ramsey, D Sweanor. Estimating the harms of nicotine-containing products using the MCDA approach. Eur J Addiction 2014
8 Exhaled CO in ECIG users eco Stable free radicals Reactive oxydative species 7 ppm R. Polosa et al. BMC Public Health 2011
9 Harmful and potentially harmful constituents Nicotine Main ingredients (PG/VG) Flavorings Impurities-other
10 Nicotine toxicity in e-cigs Nicotine concentration is NOT associated with cytotoxicity Farsalinos et al, Int J Environm Res Public Health 2013
11 Harmful and potentially harmful constituents Nicotine Main ingredients (PG/VG) Flavorings Impurities-other
12 Main ingredients (PG/VG) Animal studies showed that PG is safe for inhalation (Robertson et al, J Pharmacol Exp Ther 1947) Theatrical fog exposure in actors causes irritation but no long-term health implications (Varughese et al, Am J Ind Med 2005; American Chemistry Council, 2003) Theatrical fog is not USP-grade PG, added oils to increase fog thickness Glycerol inhalation caused mild changes in the upper respiratory tract in rats (Renne et al, Inhal Toxicol 1992) PG/VG added to tobacco does not elevate toxicity, but tobacco cigarette is already highly toxic
13 Main ingredients (PG/VG) Base liquid = 50% PG and 50% VG NO CYTOTOXICITY Farsalinos et al, Int J Environm Res Public Health 2013 Farsalinos et al, Int J Environm Res Public
14 Main ingredients (PG/VG) e-liquid and lipoid pneumonia?
15 Oil red O staining of alveolar macrophages recovered by BAL showing their cytoplasm full of large rounded lipid vacuoles
16
17 Secondary school chemistry Glycerin is an ALCOHOL, not a lipid!!!
18 Hua M, et al. Health-related effects reported by e-cigarette users in online forums. Journal of medical Internet research 2013 Hypersensitivity response to components in the vapor (e.g. PG) may occur in predisposed individuals. Farsalinos K, et al. Characteristics, Perceived Side Effects and Benefits of E-Cigarette Use: A Worldwide Survey of More than 19,000 Consumers. Int J Environ Res Public Health 2014
19 RESPIRATORY AEs AFTER E-CIG USE (N = 1173) Dual users Single users (N = 1062) Farsalinos K, et al. Characteristics, Perceived Side Effects and Benefits of E-Cigarette Use: A Worldwide Survey of More than 19,000 Consumers. Int J Environ Res Public Health 2014
20 Harmful and potentially harmful constituents Nicotine Main ingredients (PG/VG) Flavorings Impurities-other
21 Toxicological studies Untreated cells E-cigarette vapor treated cells Cigarette smoke treated cells
22 Flavourings: coffee cytotoxicity Coffee flavor Romagna, Farsalinos et al, Inhal Toxicol 2013
23 Flavourings: cinnamon cytotoxicity Behar et al, Toxicol in Vitro 2013
24 Flavourings: cinnamon cytotoxicity Approved cinnamaldehyde dose up to 4 x 10-2 M (400 times higher) (EPA, 2000) Cinnamon toxicity (?) Behar et al, Toxicol in Vitro 2013
25 Flavourings: cinnamon cytotoxicity Research should represent realistic use: - Experiments on liquids - Possible use of concentrated flavors - No use of an e-cigarette device - Using in-house methodology - Tests on embryo stem cells Approved cinnamaldehyde dose up to 4 x 10-2 M (400 times higher) (EPA, 2000) Cinnamon toxicity (?) Behar et al, Toxicol in Vitro 2013
26 Flavourings: diacetyl and acetyl propionyl E-cigarette liquids are available in a variety of flavorings In most cases, they are safe for ingestion (but safety not assessed for inhalation) Diacetyl (DA) and acetyl propionyl (AP) are used for their buttery taste in a variety of food preparations; they are safe (and approved) for food use They can be harmful when inhaled (they cause development of obliterative bronchiolitis) Is there any DA and/or AP in sweet-flavored EC liquids? 159 e-liquids purchased from 36 manufacturers/retailers; tested for the presence of DA and AP by HPLC. DA and AP were found in 74.2% of the samples (more samples containing DA) Farsalinos KE, et al. Evaluation of electronic cigarette liquids and vapour for the presence of selected inhalation toxins. Poster presentation at GFN Warsaw.
27 E-cigarette liquids are available in a variety of flavorings In most cases, they are safe for ingestion (but safety not assessed for inhalation) Diacetyl (DA) and acetyl propionyl (AP) are used for their buttery taste in a variety of food preparations; they are safe (and approved) for food use They can be harmful when inhaled (they cause development of obliterative bronchiolitis) Is there any DA and/or AP in sweet-flavored EC liquids? 159 e-liquids purchased from 36 manufacturers/retailers; tested for the presence of DA and AP by HPLC. DA and AP were found in 74.2% of the samples (more samples containing DA) Farsalinos KE, et al. Evaluation of electronic cigarette liquids and vapour for the presence of selected inhalation toxins. Poster presentation at GFN Warsaw.
28 Estimated daily exposure to diacetyl (DA) and acetyl propionyl (AP) (assuming an average daily EC liquid consumption of 3ml) National Institute for Occupational Safety and Health NIOSH-defined safety limits for AP NIOSH-defined safety limits for DA Farsalinos KE, et al. Evaluation of electronic cigarette liquids and vapour for the presence of selected inhalation toxins. Poster presentation at GFN Warsaw.
29 Correlation between expected and measured concentrations of diacetyl (DA) and acetyl propionyl (AP) in vapour Farsalinos KE, et al. Evaluation of electronic cigarette liquids and vapour for the presence of selected inhalation toxins. Poster presentation at GFN Warsaw.
30 Fujioka K et al. Environ Toxicol 2006 Range mg/cig
31 Estimated daily exposure to diacetyl (DA) and acetyl propionyl (AP) (assuming an average daily EC liquid consumption of 3ml) Main stream cigarette smoke (~ 400 mg/ ONE cigarette) NIOSH-defined safety limits for AP NIOSH-defined safety limits for DA Farsalinos KE, et al. Evaluation of electronic cigarette liquids and vapour for the presence of selected inhalation toxins. Poster presentation at GFN Warsaw.
32 Harmful and potentially harmful constituents Nicotine Main ingredients (PG/VG) Flavorings Impurities-other
33 Heavy Metals Goniewicz ML, et al. Levels of selected carcinogens and toxicants in vapour from e-cigarettes. Tob Control 2013 Compound blank e-cigs (150 puffs) inhalator (1 cartridge) Metals (mg) Cd (ND-0.17) 0.03 Ni ( ) 0.19 Pb ( ) 0.04
34 Heavy Metals Goniewicz ML, et al. Levels of selected carcinogens and toxicants in vapour from e-cigarettes. Tob Control 2013 Compound blank e-cigs (150 puffs) inhalator (1 cartridge vs 16 cartridges) Metals (mg) Cd (ND-0.17) 0.03 vs 0.48 Ni ( ) 0.19 vs 3.00 Pb ( ) 0.04 vs 0.64
35 Heavy Metals
36 Heavy Metals US Pharmacopoeia, 2013
![Levels of tobacco-specific nitrosamines in electronic and conventional cigarettes Based on information from Laugesen [2009], Cahn and Siegel [2011] and Kim and Shin [2013].](/docs-images/76/72981985/images/37-0.jpg "TSNAs are major carcinogens in tobacco cigarettes! Farsalinos K, Polosa R. Safety evaluation and risk assessment of ecigs as tobacco cigarette substitutes: a systematic review.")
37 Levels of tobacco-specific nitrosamines in electronic and conventional cigarettes Based on information from Laugesen [2009], Cahn and Siegel [2011] and Kim and Shin [2013]. TSNAs are major carcinogens in tobacco cigarettes! Farsalinos K, Polosa R. Safety evaluation and risk assessment of ecigs as tobacco cigarette substitutes: a systematic review. Ther Adv Drug Saf 2014
38 Thermal degradation: aldehydes production Goniewicz ML, et al. Levels of selected carcinogens and toxicants in vapour from e-cigarettes. Tob Control 2013 Counts ME, et al. Regul Toxicol Pharmacol 2005
39 Thermal degradation: aldehydes production Range mg/cig Fujioka K et al. Environ Toxicol 2006 Range mg/cig Range mg/cig
40 Thermal degradation: aldehydes production Goniewicz ML, et al. Levels of selected carcinogens and toxicants in vapour from e-cigarettes. Tob Control Counts ME, et al. Regul Toxicol Pharmacol 2005 Fujioka K et al. Environ Toxicol 2006 Toxic substances do exist, but levels far lower compared to tobacco cigarettes!
41 Thermal degradation: aldehydes production Solvent and power levels interaction Different puffing regime depending on equipment Kosmider L, et al. Carbonyl compounds in e-cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine Tob Res 2014
42 NJOY Electronic Cigarettes: Chemicals Below Limit of Detection or Limit of Quantification Tobacco-specific nitrosamines NNN NNK Carbonyls Acrolein Crotonaldehyde Metals Cadmium Volatile Organic Compounds Benzene Acrylonitrile 1,3-butadiene Poly-aromatic amines 4-aminobiphenyl Poly-aromatic hydrocarbons 2-aminonaphthalene Formaldehyde: Detected at 2.5% of level in cigarettes Acetaldehyde: Detected at <0.1% of level in cigarettes Rabinowitz JD, Leischow SJ. Electronic cigarettes that product nicotine aerosols substantially devoid of known toxic impurities. Presented at the annual meeting of the Society for Research on Nicotine and Tobacco, February 5-8, 2014.
43 VUSE Electronic Cigarettes: Chemicals Below Limit of Detection or Limit of Quantification Tobacco-specific nitrosamines NNN NNK NAT NAB Carbonyls Formaldehyde Acetaldehyde Acrolein Acetone Metals Arsenic Cadmium Chromium Lead Nickel Volatile Organic Compounds Benzene Acrylonitrile Propylene oxide Toluene Vinyl chloride Poly-aromatic amines 4-aminobiphenyl Poly-aromatic hydrocarbons Benzo(a)pyrene Benzo(a)anthracene Naphthalene Flourene Theophilus EH, et al. VUSE electronic cigarette aerosol characterization (poster). R.J. Reynolds Tobacco Company. Presented at the Annual Meeting of the Society of Toxicology, March 24-27, 2014.
44 Relative Risk Scale Risk
45 Relative Risk Scale PAHs NO x CO 2 CO NO 2 PM 10 PM 2.5 Benzene No uncertainty! Even in their current state, e-cigarettes are significantly less harmful compared to tobacco cigarettes Risk
46 Harmful and potentially harmful constituents handprint Synthetic chemical flavourings Pharma grade (nicotine, solvents) Temperature regulation Safer atomizer materials (wick, coil, plastics) Customer Safety GMP standards
Safety/risk assessment of electronic cigarettes
Safety/risk assessment of electronic cigarettes Dr Konstantinos Farsalinos Researcher, Onassis Cardiac Surgery Center, Greece Researcher, University Hospital Gathuisberg, Belgium E-cigarette facts New
RISK FROM E-VAPOUR PRODUCTS FOR USERS AND BYSTANDERS
RISK FROM E-VAPOUR PRODUCTS FOR USERS AND BYSTANDERS Dr Konstantinos Farsalinos Researcher Onassis Cardiac Surgery Center, Greece University of Patras, Greece COI Past 36 months 1 study funded by non-profit
David S. Goya, DO, MBA, FCCP, FACP Kaiser Permanente Medical center Santa Clara, California
* * David S. Goya, DO, MBA, FCCP, FACP Kaiser Permanente Medical center Santa Clara, California None Electric Cigarette was patented in 1965 by Herbert Gilbert First introduced into the marketplace in
Evaluation of the Potential for Second-hand Exposure to E-cigarette Aerosol in an Office Environment
Evaluation of the Potential for Second-hand Exposure to E-cigarette Aerosol in an Office Environment Edward A. Robinson, Robert D. Leverette, and Manoj Misra Lorillard Tobacco Company 68 th TSRC Charlottesville,
E-Cigarette Update: Secondhand Vapour
E-Cigarette Update: Secondhand Vapour Toxicity and Health Effects The popularity of e-cigarettes continues to increase, with more Canadians than ever using them indoors and out. The scientific evidence
Dual Use: If Electronic Cigarettes are so good, why are there so few exclusive users?. Jonathan Foulds, PhD
Dual Use: If Electronic Cigarettes are so good, why are there so few exclusive users?. Jonathan Foulds, PhD jfoulds@psu.edu Penn State College of Medicine, Department of Public Health Science May 8, 2017
E-Cigarettes: Current Perspective
E-Cigarettes: Current Perspective Aruni Bhatnagar, Ph.D. Professor of Medicine University of Louisville Louisville, KY Electronic Cigarettes E-cigarettes are electronic nicotine delivery systems (ENDS),
Cardiovascular effects of nicotine vs. cigarette smoke
Cardiovascular effects of nicotine vs. cigarette smoke Dr Konstantinos Farsalinos Researcher Onassis Cardiac Surgery Center, Greece University of Patras, Greece National School of Public Health, Athens-Greece
VAPING: What you need to know
VAPING: What you need to know Stephen Rohan - High School Principal Dan Szolek - Middle School Principal Corporal Brian Hartman- Beaver Township Police Amie Widrig - Public Health Nurse Mahoning County
Abstract and Introduction. Page 1 of 24.
Page 1 of 24 Safety Evaluation and Risk Assessment of Electronic Cigarettes as Tobacco Cigarette Substitutes: A Systematic Review Konstantinos E. Farsalinos, MD, Riccardo Polosa, PhD Ther Adv in Drug Safe.
UK E-Cigarette Summit Relative risks of cancer posed by combustible and vapourising forms of nicotine delivery: Evidence from chemical exposures
UK E-Cigarette Summit 2017 Relative risks of cancer posed by combustible and vapourising forms of nicotine delivery: Evidence from chemical exposures Ed Stephens University of St Andrews Scope of presentation
What is combustion and why is the absence of combustion important for heat not burn products
What is combustion and why is the absence of combustion important for heat not burn products Global Forum on Nicotine 2017 June 16 th 2017 Thomas Mc Grath PhD PMI R&D, Philip Morris Products S.A., Quai
Electronic cigarettes: Human Friend or Foe
Review Article Int. J. Curr. Res. Med. Sci. (2016). 2(12): 21-26 International Journal of Current Research in Medical Sciences ISSN: 2454-5716 www.ijcrims.com Volume 2, Issue 12-2016 Electronic cigarettes:
Applicant Name: GD Sigelei Electroinc Tech Co., Ltd B7 Building, No.1 District, Xicheng Science and Technology Park, Hengli Town, Dongguan, China
Date: Jan.17, 2018 Applicant Name: GD Sigelei Electroinc Tech Co., Ltd Applicant Add.: B7 Building, No.1 District, Xicheng Science and Technology Park, Hengli Town, Dongguan, China Test sample(s) was(were)
Vapes, Ecigs, Mods, Juuls. Chris Harnish Mercer Island Youth & Family Services
Vapes, Ecigs, Mods, Juuls Chris Harnish Mercer Island Youth & Family Services Current Alcohol Use Percent of students who report having drunk a glass, can or bottle of alcohol in the past 30 days Mercer
ENDS and Vaping. FCD Prevention Works Spring-Summer 2018
ENDS and Vaping FCD Prevention Works Spring-Summer 2018 1 FCD Prevention Works Prevention is a climate, not a program Nonprofit Over 40 years of school-based substance abuse prevention Over 2.5 million
Electronic Cigarettes
Electronic Cigarettes Jon O. Ebbert, M.D. Professor of Medicine Mayo Clinic Email: ebbert.jon@mayo.edu 2012 MFMER 3136985-1 Ecigarette ad 2012 MFMER 3136985-2 Goals & Objectives Understand the mechanics
Stop the Vape. Maria Hines RN, MSN. Denise Kneubuhler RN, MSN
Stop the Vape Maria Hines RN, MSN Denise Kneubuhler RN, MSN https://78.media.tumblr.com/3a5eee652f16d0327cf3f4d8 8a63706c/tumblr_nzpw68ossS1rc7zl1o1_500.gif Objectives Increase awareness and knowledge
RE: Docket No. FDA-2014-N , Electronic Cigarettes and the Public Health
VIA ELECTRONIC SUBMISSION June 30, 2015 Division of Dockets Management (HFA-305) Food and Drug Administration 5630 Fishers Lane, Rm. 1061 Rockville, MD 20852 RE: Docket No. FDA-2014-N-1936-0001, Electronic
E-Cigarettes: Everything You Should Know
E-Cigarettes: Everything You Should Know Phillip S. Gardiner, Dr. P. H. Co-Chair African American Tobacco Control Leadership Council (AATCLC ) and UC Smoke and Tobacco Free Fellowships Program Officer,
Might Smoking Rates go up in Flames? Dr John Schoonbee, Chief Medical Officer, Swiss Re
Might Smoking Rates go up in Flames? Dr John Schoonbee, Chief Medical Officer, Swiss Re 2 Agenda Smoking is still a problem Stopping is hard Electronic cigarettes Reduced Risk tobacco products Males >15yr
E-cigarettes: Evidence, perceptions and misconceptions. Martin Dockrell, Tobacco Control Programme Lead
E-cigarettes: Evidence, perceptions and misconceptions Martin Dockrell, Tobacco Control Programme Lead Smoking causes the greatest number of preventable deaths Are EC less tightly regulated in the UK than
ELECTRONIC CIGARETTES WHAT S THE BOTTOM LINE?
ELECTRONIC CIGARETTES WHAT S THE BOTTOM LINE? E-cigarettes have the potential to benefit adult smokers who are not pregnant if used as a complete substitute for regular cigarettes and other smoked tobacco
E-cigarettes vs. Conventional Cigarettes and their Health Effects on the Environment. Elizabeth Do 5/01/15 GCH 360
E-cigarettes vs. Conventional Cigarettes and their Health Effects on the Environment Elizabeth Do 5/01/15 GCH 360 Introduction The rate of smoking has been declining in the United States, but the new discovery
Electronic Cigarettes in the Indoor Environment
Publications 10-21-2016 Electronic Cigarettes in the Indoor Environment Cheri Marcham Embry-Riddle Aeronautical University, march617@erau.edu Follow this and additional works at: http://commons.erau.edu/publication
The electronic cigarette (personal nicotine vaporizer)
The electronic cigarette (personal nicotine vaporizer) Murray Laugesen Health New Zealand Ltd nicotine and tobacco product researchers www.healthnz.co.nz Christchurch, New Zealand (c) www.healthnz.co.nz
Air Quality assessment during indoor use of the Tobacco Heating System 2.2
Air Quality assessment during indoor use of the Tobacco Heating System 2.2 THS 2.2. is commercialized under the IQOS brand name Dr Catherine Goujon Ginglinger - Philip Morris International Research & Development,
Air Quality assessment during indoor use of the Tobacco Heating System 2.2
Air Quality assessment during indoor use of the Tobacco Heating System 2.2 THS 2.2. is commercialized under the IQOS brand name Maya Mitova, Catherine Goujon Ginglinger, Michel Rotach, Serge Maeder Philip
Tobacco Blend Style. Dinah Winter, Martin Coleman, Nigel Warren
Tobacco Blend Style Dinah Winter, Martin Coleman, Nigel Warren Tobacco Blends 100% lamina tobaccos: Virginia Burley (uncased) 50:50 Virginia/Burley Mix Oriental Examined: Blend component differences Relationships
Because PMI application did not report the full range of HPHCs in IQOS aerosol,
Because PMI application did not report the full range of HPHCs in IQOS aerosol, characterize HPHCs in sidestream emissions, include a non-targeted analysis of chemicals in emissions, or conduct clinical
Smoking, e-cigs and reduced risk products. Dr John Schoonbee, IMS November 2017
Smoking, e-cigs and reduced risk products Dr John Schoonbee, IMS November 2017 2 The storyline smoking is bad yet many folks still smoke because quitting is very hard is it better, if one cannot quit,
West Milford Township Public Schools. Substance Abuse Policy and Regulation Review. and Vape Education for Parents. April 26, 2018
West Milford Township Public Schools Substance Abuse Policy and Regulation Review and Vape Education for Parents April 26, 2018 Important to Note Consequences for policy violation include, but are not
THE INFLUENCE OF CIGARETTE FILTER DESIGN ON THE YIELD AND COMPOSITION OF CIGARETTE SMOKE
THE INFLUENCE OF CIGARETTE FILTER DESIGN ON THE YIELD AND COMPOSITION OF CIGARETTE SMOKE Dr M J Taylor Director of Scientific Development Essentra Scientific Services CORESTA Congress Quebec 12 to 16 October
Prevent disease Protect from injury Promote healthy lifestyles
https://youtu.be/9dzs_rniak0 Prevent disease Protect from injury Promote healthy lifestyles Objectives 1. Obtain a better understanding of local policies that make a difference 2. Establish a plan of action
Electronic Nicotine Delivery Systems
Electronic Nicotine Delivery Systems Michael Burke, EdD 2013 MFMER slide- # Learning objectives At the end of the presentation the participants should be able to Describe the history and patterns of use
E-cigaretes, Dripping, and Automated Dripping Devices (ADD)
E-cigaretes, Dripping, and Automated Dripping Devices (ADD) Presented by: Paul Truman Harrell, Ph.D. Eastern Virginia Medical School Department of Pediatrics Division of Community Health and Research Research
WHO work on smokeless tobacco. Dr Vinayak Prasad, WHO HQ Ms Sarah Emami, WHO HQ
WHO work on smokeless tobacco Dr Vinayak Prasad, WHO HQ Ms Sarah Emami, WHO HQ WHO provides technical assistance to Member States on SLT policies and programs: MPOWER package ( key demand reduction measures
Electronic Cigarettes: What we know so far
Electronic Cigarettes: What we know so far Dr. Lynne Dawkins Drugs and Addictive Behaviours Research Group (DABRG), School of Psychology http://www.uel.ac.uk/psychology/research/drugs What I m going to
CATCH MY BREATH. ASHA Conference: October 12, Marcella Bianco CATCH My Breath Program Manager CATCH Global Foundation
CATCH MY BREATH ASHA Conference: October 12, 2017 Marcella Bianco CATCH My Breath Program Manager CATCH Global Foundation marcella@catch.org Valerie Phillips Athletic Coordinator/Head of PE Department
E-Vapour (EVAP) Sub-Group 2017 Report. Kitzbühel, Austria October 10, 2017
E-Vapour (EVAP) Sub-Group 2017 Report Kitzbühel, Austria October 10, 2017 History Evolution o 2014, formation of E-cigarette TF o 2016, TF activities completed; formation of E-vapor product SG 2 E-Vapour
ESPs are battery-operated devices that contain cartridges filled with liquid chemicals. The chemicals turn into a vapour that the user inhales (this
ESPs are battery-operated devices that contain cartridges filled with liquid chemicals. The chemicals turn into a vapour that the user inhales (this is called vaping). They do not contain tobacco. They
The Changing Landscape of Tobacco: E-Cigarettes, E-Hookahs and More
38th Annual Family Medicine Intensive Review Course The Changing Landscape of Tobacco: E-Cigarettes, E-Hookahs and More Debbie Rushing, LADAC, CTTS-M Associate Branch Chief Tobacco Prevention and Cessation
Health Effects of Electronic Nicotine Delivery Systems: A Systematic Review
Health Effects of Electronic Nicotine Delivery Systems: A Systematic Review ALLISON GLASSER SENIOR PROJECT MANAGER FEBRUARY 21, 2017 RAYMOND NIAURA DIRECTOR, SCIENCE AND TRAINING Disclosures Allison Glasser
New & Emerging Tobacco Products. Linda Bauld & Kamran Siddiqi
New & Emerging Tobacco Products Linda Bauld & Kamran Siddiqi Outline Electronic cigarettes Heat not burn tobacco Smokeless tobacco Waterpipes Terminology E-cigarettes are not a single product Debate about
American School of Warsaw
American School of Warsaw Parent Presentation FCD Prevention Works April 10th 2019 John Tummon Senior Prevention Specialist 1 FCD Prevention Works Prevention is a climate, not a program Private nonprofit
Electronic Cigarettes: What They Are, How They re Marketed, & How We Can Protect Our Youth
Electronic Cigarettes: What They Are, How They re Marketed, & How We Can Protect Our Youth Amy Barkley Coalition for a Tobacco- Free West Virginia Charleston, WV February 26, 2014 Big Picture Points Tobacco
SAFETY E-CIGS: CLINICAL STUDIES
SAFETY E-CIGS: CLINICAL STUDIES SAFETY ECIGS: clinical studies Source: Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: A systematic review. Ther Adv Drug
Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke;
This document is scheduled to be published in the Federal Register on 04/03/2012 and available online at http://federalregister.gov/a/2012-07727, and on FDsys.gov 4160-01-P DEPARTMENT OF HEALTH AND HUMAN
Modelling the effects of user exposure to harmful emissions across the spectrum of nicotine delivery
Global Nicotine Forum 2018 Modelling the effects of user exposure to harmful emissions across the spectrum of nicotine delivery Ed Stephens University of St Andrews Declaration: No conflicts of interest
VAPING: What s the Evidence?
VAPING: What s the Evidence? Jen Palminteri, MD Tufts University, Assistant Professor Chest Medicine Associates, Portland, ME Maine Association of Physician Assistants 29 th Annual Winter Conference February
Effect of Sugars on Selected Toxicant Yields in e-cigarettes
CORESTA Congress, 11th October 2016, Berlin Effect of Sugars on Selected Toxicant Yields in e-cigarettes Jennifer Margham 1, Kevin McAdam 1 ST 31 BERLIN 2016 1 British American Tobacco, Group R&D, Southampton,
The fitness for purpose of existing tobacco product test methods identifying the gaps
The fitness for purpose of existing tobacco product test methods identifying the gaps Wright C., Ticha J. and Mariner D. British American Tobacco, Research & Development, Southampton UK IG4, 1 th October
Aerosol Characterisation of e-cigarettes. Ross Cabot, Anna Koc, Caner U. Yurteri & John McAughey
Aerosol Characterisation of e-cigarettes Ross Cabot, Anna Koc, Caner U. Yurteri & John McAughey European Aerosol Conference, Prague 2-6 September 2013 1 Organisation Background Description History Regulation
Preventing Youth Electronic Cigarette Use: Partnering with Schools
Preventing Youth Electronic Cigarette Use: Partnering with Schools Kris Minard Montana Office of Public Instruction Tobacco Use Prevention Education Kminard@mt.gov (406) 444-0785 I work for the State of
White Paper: Electronic Cigarettes in the Indoor Environment
White Paper: Electronic Cigarettes in the Indoor Environment American Industrial Hygiene Association AIHA Board Approval Date: January 21, 2019 Sponsored by the AIHA Indoor Environmental Quality Committee
Cooperation Centre for Scientific Research Relative to Tobacco. CORESTA Guide N 22
Cooperation Centre for Scientific Research Relative to Tobacco CORESTA Guide N 22 Technical Guide for the Selection of Appropriate Intense Vaping Regimes for E-Vapour Devices February 2018 E-Vapour Sub-Group
Exploring five common claims about e-cigarette use. Lion Shahab, PhD University College
Exploring five common claims about e-cigarette use Lion Shahab, PhD University College London @LionShahab Claim 1: Renormalisation Claim 1: Renormalisation A priori predictions for impact on population
Matt S. Melvin, Karen C. Avery, Jason W. Flora, Karl A. Wagner. Altria Client Services LLC l Regulatory Sciences 12Oct2016 Final 1
Determination of 2,3-Butanedione, 2,3-Pentanedione, and Acetoin in Electronic Cigarette Formulations and Aerosols by Gas Chromatography-Mass Spectrometry Matt S. Melvin, Karen C. Avery, Jason W. Flora,
Welcome Superheros! YOUR. Winter Awareness Workshop 2017 BE A HERO IN COMMUNITY!
Welcome Superheros! BE A HERO IN YOUR COMMUNITY! Winter Awareness Workshop 2017 WHAT ARE E-CIGARETTES /VAPING DEVICES? Devices that allow users to inhale aerosol containing nicotine or other substances.
E-cigarettes and personal vapourisers: current research and policy
E-cigarettes and personal vapourisers: current research and policy Declaration of interest I have no links with any e-cigarette manufacturers I have received no funding from the tobacco or pharmaceutical
The Effect of Puff Profile and Volume on the Yields of E-Cigarettes
The Effect of Puff Profile and Volume on the Yields of E-Cigarettes Dr M J Taylor, Filtrona Technology Centre Smoke Science/Product Technology Meeting Seville, Spain, 29 September to 03 October 2013 Introduction
E-Cigarettes and Vapes
E-Cigarettes and Vapes What You Need to Know Education for Parents/Guardians Electronic Nicotine Delivery Device $3 Billion Global Industry 600 + Brands 8000+ Flavors & Liquids Less than a decade ago,
A. Incorrect! The alveolus is where gas exchange takes place. B. Correct! Surfactant is the lipid-rich material that permits lung inflation.
Toxicology - Problem Drill 13: Respiratory Toxicology No. 1 of 10 1. The lipid-rich material that decreases surface tension of the alveoli, allowing sacs to inflate properly and remain inflated during
A combination of licensed medication and professional support is four times more likely to achieve a stop in smoking behaviour.
PHA Position Statement E-cigarettes 30 May 2014 The Public Health Agency (PHA) considers E-cigarettes with caution at this time. E-cigarettes are not licensed nicotine replacement products. They are not
Clearing The Air about: Gretchen Hagenbuch, M.Ed. SAP Coordinator Philadelphia Region
Clearing The Air about: Gretchen Hagenbuch, M.Ed. SAP Coordinator Philadelphia Region Caron Quick Facts Nationally recognized behavioral healthcare and addiction treatment facility Addiction treatment
Robert L. Cranfield MD. November 24, 2015 ABSTRACT
Health Effects and Demographics of Electronic Cigarette Users. A Comparison of Health Events in Previous Smokers With Three or more years of Electronic Cigarette Experience. Robert L. Cranfield MD November
R. Polosa COI last 5 yrs
R. Polosa COI last 5 yrs Full tenure Professor of Internal Medicine at the University of Catania (Italy) LIAF (Italian Anti Smoking League) Scientific advisor unpaid CASAA (Consumer Advocates for Smoke-free
Schedule of Accreditation issued by United Kingdom Accreditation Service 2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK
2 Pine Trees, Chertsey Lane, Staines-upon-Thames, TW18 3HR, UK ISO/IEC 17025: 2005 Essentra Scientific Services Contact: Mr A Stutz Shaftesbury Avenue Tel: +44 (0)191 428 0100 Jarrow Fax: +44 (0)191 428
ELECTRONIC CIGARETTE EVOLUTION FROM FIRST TO FOURTH GENERATION PRODUCTS AND BEYOND
ELECTRONIC CIGARETTE EVOLUTION FROM FIRST TO FOURTH GENERATION PRODUCTS AND BEYOND Konstantinos Farsalinos, MD Onassis Cardiac Surgery Center, Greece University of Patras, Greece COI 2 (unpublished yet)
Initiation of Traditional Cigarette Smoking after E-Cigarette Use Among Tobacco-Naïve Young Adults. Brian A. Primack, MD, PhD
Initiation of Traditional Cigarette Smoking after E-Cigarette Use Among Tobacco-Naïve Young Adults Brian A. Primack, MD, PhD Co-Authors Ariel Shensa, MA Jaime E. Sidani, PhD Beth L. Hoffman, BSc Samir
It is important to split the health issues into their two distinct components-
E Cigarettes One major point to make at the outset:- It is important to split the health issues into their two distinct components- -The health of the wider public in the context of new take up of e-cigariettes
Contribution To Standards Development For Next Generation Products. Eduardo BEREA Alternative Ingredients ENDS 2018 London 4-5 June 2018
Contribution To Standards Development For Next Generation Products Eduardo BEREA Alternative Ingredients ENDS 2018 London 4-5 June 2018 2010s Disposables / Cigalikes Rechargeable Cigalike & Cartomizers
Kevin Walton, Ph.D. Chief, Clinical Research Grants Branch Division of Therapeutics and Medical Consequences NIDA. No disclosures
Kevin Walton, Ph.D. Chief, Clinical Research Grants Branch Division of Therapeutics and Medical Consequences NIDA No disclosures NIDA Organizational Chart Office of Diversity & Health Disparities Office
Electronic cigarettes
Electronic cigarettes Karen M. Wilson, MD, MPH, FAAP Associate Professor of Pediatrics Section Head, Pediatric Hospital Medicine University of Colorado School of Medicine Children s Hospital Colorado American
Contribution To Standards Development For Next Generation Products. Dr Nils ROSE
Contribution To Standards Development For Next Generation Products Dr Nils ROSE 2010s Disposables / Cigalikes Rechargeable Cigalike & Cartomizers Fixed Voltage Devices Drip Tips Open System Atomizer Single
Background. Description. Disclosure. Objectives. Types of ENDS. APNA 30th Annual Conference Session 4024: October 22, 2016.
Electronic Nicotine Delivery Systems (ENDS): Information and Discussion on Electronic Cigarettes and Vape Pens Carolyn Baird DNP, CARN-AP, FIAAN Carol Essenmacher DNP, CTTS October 22, 2016 Background
Electronic Nicotine and Non Nicotine Delivery Systems (ENDS)
Electronic Nicotine and Non Nicotine Delivery Systems (ENDS) Dr Meena Dawar Medical Health Officer 30 September 2014 1 VCH MHO Recommendations 1. Include e-cigarettes and related ENDS devices in the City
PROVINCE OF BRITISH COLUMBIA ORDER OF THE LIEUTENANT GOVERNOR IN COUNCIL
PROVINCE OF BRITISH COLUMBIA ORDER OF THE LIEUTENANT GOVERNOR IN COUNCIL Order in Council No. ' 423, Approved and Ordered APR 2 2001.01111mork Lieutenant Governor Executive Council Chambers, Victoria On
Biology Advanced Unit 5: Energy, Exercise and Coordination
Pearson Edexcel International Advanced Level Biology Advanced Unit 5: Energy, Exercise and Coordination June 2017 Scientific Article for use with Question 7 Paper Reference WBI05/01 Do not return the insert
Horace Greeley High School Parent Presentation Vaping, E-cigs and the Health of Our Youth. Richard Stumacher, MD, FCCP January 18, 2018
Horace Greeley High School Parent Presentation Vaping, E-cigs and the Health of Our Youth Richard Stumacher, MD, FCCP January 18, 2018 Vaping, E-Cigs and the Health of Our Youth Are Vaping, E-cigs healthy?
FORMs of TOBACCO. 2 nd of 3 Prep for Session 1
FORMs of TOBACCO 2 nd of 3 Prep for Session 1 FORMS of TOBACCO Cigarettes Spit tobacco (chewing tobacco, oral snuff) All forms of tobacco are harmful. Pipes Cigars Clove cigarettes Bidis Hookah (waterpipe)
Public Health Key Opinion Leaders and Scientists Response to the EC Public Consultation on Excise Duties Applied to Manufactured Tobacco CONTENTS
European Commission Directorate-General for Taxation and Customs Union Rue de Spa 3, Office 5/82 B-1049 Brussels, Belgium TAXUD-UNIT-C2@ec.europa.eu 15 th February 2017 Public Health Key Opinion Leaders
Carl D. D Ruiz 1*, Donald W. Graff 2 and Edward Robinson 3
D Ruiz et al. BMC Public Health (2016) 16:543 DOI 10.1186/s12889-016-3236-1 RESEARCH ARTICLE Open Access Reductions in biomarkers of exposure, impacts on smoking urge and assessment of product use and
Electronic cigarettes: a task force report from the European Respiratory Society
ERS OFFICIAL DOCUMENTS ERS TASK FORCE REPORT Electronic cigarettes: a task force report from the European Respiratory Society Robert Bals 1, Jeanette Boyd 2, Susanna Esposito 3, Robert Foronjy 4, Pieter
Is Vaping a Valid Strategy for Smoking Cessation? Myths and Facts Jaspreet S. Brar. MD, PhD Community Care Behavioral Health Organization
Is Vaping a Valid Strategy for Smoking Cessation? Myths and Facts Jaspreet S. Brar. MD, PhD Learning Objectives What are e-cigarettes and vapes? Myths and Facts related to vaping Vaping for harm reduction
Outline 3/7/2017. Hookah. Lula or Lulava. chillim. Narghile or Arghile. cachimba. Quylan. Shisha, Boory or Goza
Hookah and Electronic Nicotine Delivery Systems (ENDS) Presented By: Mary Martinasek, PhD, RRT, AE C, MCHES 2017 Big Sky Pulmonary Conference Outline Hookah products and research Hookah Concerns ENDS Concerns
00:08 For decades our scientists have endeavoured to reduce the risks of tobacco use and continue to do so today. 00:15
00:00 British American Tobacco 00:02 00:03 The Electronic Cigarette 00:07 00:08 For decades our scientists have endeavoured to reduce the risks of tobacco use and continue to do so today. 00:15 00:15 Our
Measuring Emissions as Part of a Regulatory Regime. Prof. Riccardo Polosa Professor of Internal Medicine and Convenor CEN TC437/WG4
Measuring Emissions as Part of a Regulatory Regime Prof. Riccardo Polosa Professor of Internal Medicine and Convenor CEN TC437/WG4 . (b) a list of all ingredients contained in, and emissions resulting
North Salem High School Parent Presentation Vaping, E-cigs and the Health of Our Youth. Richard Stumacher, MD, FCCP January 10, 2018
North Salem High School Parent Presentation Vaping, E-cigs and the Health of Our Youth Richard Stumacher, MD, FCCP January 10, 2018 Vaping, E-Cigs and the Health of Our Youth Are Vaping, E-cigs healthy?
Peering through the mist: systematic review of what the chemistry of contaminants in electronic cigarettes tells us about health risks
Burstyn BMC Public Health 2014, 14:18 http://www.biomedcentral.com/1471-2458/14/18 RESEARCH ARTICLE Open Access Peering through the mist: systematic review of what the chemistry of contaminants in electronic
No matter what form it takes, tobacco is not safe.
TOBACCO IS TARGETING YOUR KIDS IN DEVIOUS AND TASTY NEW WAYS No matter what form it takes, tobacco is not safe. DDPHTO 26822 The Ugly Truth Brochure_v3.indd 2 THE GOOD NEWS: FEWER KIDS ARE SMOKING. THE
SUPER SMOKER EXPERT REPORT FINAL REPORT
TOXICOLOGY LABORATORY GASTHUISBERG CAMPUS, O&N2 P8 922, HERESTRAAT 49 D-3000 LEUVEN CATHOLIC UNIVERSITY LEUVEN LEUVEN, 29 June 2007 SUPER SMOKER EXPERT REPORT FINAL REPORT On 28 February 2007 the following
Menthol Addition to Cigarettes Using Breakable Capsules in the Filter. Impact on the Mainstream Smoke Yields of the Health Canada List Constituents
pubs.acs.org/crt Terms of Use Menthol Addition to Cigarettes Using Breakable Capsules in the Filter. Impact on the Mainstream Smoke Yields of the Health Canada List Constituents C. Dolka,* J.-J. Piade,
EASY PUFF with cartomiser compared with other brands. Report of tests July to September 2013
36 Winchester St Lyttelton Christchurch 8082 New Zealand Ph: +64 3 3288688 Cell: 027 488 4375 Skype: murraylaugesen laugesen@healthnz.co.nz www.healthnz.co.nz 30 Sep 2013. Health NEW ZEALAND Research and
Reduced-Risk Products Science Update
Reduced-Risk Products Science Update Dr. Ian Jones, PhD JTI VP, Reduced-Risk Products Science Forward-Looking Statements This presentation contains forward-looking statements. These statements appear in
2017_ST10_JinCathy.pdf. SSPT Document not peer-reviewed by CORESTA
Investigation of TSNA Formation in Electronic Cigarette Liquids and Aerosols Xiaohong Cathy Jin, Karen C. Avery, Georgios D. Karles, William P. Gardner, Matt S. Melvin, Donna C. Smith, Willie J. Mckinney,
Low-Nitrosamine Dissolvable Tobacco Products Star Scientific, Inc. Part III Initiation and Cessation
Low-Nitrosamine Dissolvable Tobacco Products Star Scientific, Inc. Part III Initiation and Cessation Using science to reduce tobacco-related harm at every level of the population 1 Summary - Parts I &
Nicotine Reduction Workshop Role of nicotine in smoking behaviour
Nicotine Reduction Workshop Role of nicotine in smoking behaviour Derek Mariner APSTW02 11 October 2016 2016 CORESTA Congress, Berlin, Germany, 9-13 October 2016 Introduction Nicotine itself is not especially
Electronic Cigarettes, Nicotine and Policy Implications
Electronic Cigarettes, Nicotine and Policy Implications Neal L Benowitz MD University of California San Francisco The E-Cigarette Summit The Royal Society London November 17, 2016 Disclosures Dr Benowitz