Advances in Environmental Biology
|
|
- Donald Sullivan
- 6 years ago
- Views:
Transcription
1 Advances in Environmental Biology, 9() November 15, Pages: AENSI Journals Advances in Environmental Biology ISSN EISSN Journal home page: Effects of Active Smoking on Renal Function Djabali Nacira, Berrezig Wiem, Ghai Djamila Department of biology, Faculty of sciences, El-Tarf University, El Tarf, 3, Algeria A R T I C L E I N F O Article history: Received September 15 Accepted 15 November 15 Available online November 15 Keywords: Active Smoking, Cigarette, Kidney, renal failure. A B S T R A C T This work focuses on studying the effects of active smoking on the kidney function. The experiment took place at the hemodialysis service and the biochemistry laboratory. The distribution of smokers and nonsmokers among dialysis patients has been established from the data mentioned in the service registry. In the second part of the work, we studied the variations of the different parameters indicative of renal functioning (biochemical and haematological) between smokers and nonsmokers who have no cardiovascular disease or diabetes. The results obtained show: Increased rate of smokers compared with nonsmokers dialysis. Increased levels of urea, creatinine, uric acid and decrease in blood albumin levels in smokers compared to nonsmokers. Decreased number of red blood cells, hemoglobin, with an increase in platelet count and erythrocyte sedimentation rate in smokers. 15 AENSI Publisher All rights reserved. To Cite This Article: Djabali Nacira, Berrezig Wiem, Ghai Djamila., Effects of Active Smoking on Renal Function. Adv. Environ. Biol., 9(), , 15 INTRODUCTION Smoking is a medical term designating acute or chronic intoxication caused by tobacco consumption; it is sometimes specified active smoking as opposed to passive smoking which qualifies the involuntary inhalation of tobacco smoke contained in the surrounding air, or inhalation deposits secondarily in air suspension. Furthermore dependence, smoking is responsible for many diseases such as cancer and cardiovascular disease, either active or passive. Smoking is the leading cause of preventable death in the world, making it a major health issue []. Smoking has been identified as an important factor in the progression of various renal diseases. Recently it has been shown that smoking harms renal hemodynamics and protein excretion in the absence of kidney disease [11]. Smoking increases the risk of progression of renal insufficiency in patients with primary renal disease. The deleterious effects of smoking were also discussed in dialysis and renal transplant. It seems that cessation smoking slows the progression of kidney disease in smokers. It therefore seemed interesting to note that in addition to well-known vascular and pulmonary disease, kidney also pays a price, sometimes high, smoking []. An interaction between smoking and kidney damage had already been established. It was only in 1997 that the nephrologists rediscovering tobacco as a risk factor for renal impairment [7]. This work aims to highlight the impact of active smoking on some parameters indicating the good renal functions. In the first place, we will discuss the distribution of smokers and nonsmokers dialysis; in the second place, we will study the changes in biochemical and hematological parameters between smokers and nonsmokers. MATERIALS AND METHODS Experimental Principle: The experiment took place at the Laboratory of Biochemistry and hemodialysis service. At the hemodialysis service we studied the distribution of smokers and nonsmokers amongst dialysis patients from the data described in the register of service. In the laboratory of biochemistry, the study included a cohort of men aged between -5 years divided into groups: A control group: non-smoking men. Corresponding Author: Djabali Nacira, Department of biology, Faculty of sciences, El-Tarf University, El Tarf, 3, Algeria Tel: ; naciradjabali@yahoo.fr
2 19 Djabali Nacira et al, 15 Advances in Environmental Biology, 9() November 15, Pages: A treatment group: male smokers who consume a pack of cigarettes a day for a period of 7 to 1 years. These people came to the laboratory to make an assessment, some were voluntary. We have chosen non-hypertensive and non-diabetic people. A survey sheet was prepared which reads: age, the first consumer age for smoking and number of cigarettes consumed per day. The blood collection is done in anticoagulant tubes. The work is based on the study of changes in biochemical parameters of different indicators kidney alterations (urea, creatinine, albumin, uric acid), as well as changes in hematological factors (the number of red blood cells, hemoglobin, speed sedimentation and platelet number) between smokers and nonsmokers. Statistical Study: The results are given as mean ± standard deviation (X ± SD) and schematically represented as histograms. As for the data statistical processing test, we chose the analysis of variance with a single criteria followed by Newman-Keuls test using Sigma Stat software. Results: Distribution of smokers and nonsmokers dialysis: The rate of smokers in the dialysis service is higher (p <.5) than that of non-smokers (Figure 1). Study of biochemical parameters: - Blood urea: urea is the major form of nitrogen metabolism. There is a significant increase (p<.5) of urea in smokers compared to non smokers (Figure ). - Blood creatinine level: creatinine is a metabolic product of creatine, primarily eliminated by the kidneys and excreted in the urine. Its level reflects the functional state of the kidneys. The creatinine level is higher (p <.1) in the group of smokers compared to non-smokers (Figure 3). - Blood uric acid: uric acid is the metabolism product of nucleic acids of the dead cells when uric acid in the blood increases, especially in overweight people, it can cause kidney disease. Uric acid in the smoking group marks a very highly significant (p <.1) and this compared to those nonsmokers (Figure ). - Blood albumin: albumin is a small protein found in the blood, which is not eliminated in the urine when the kidneys are functioning normally. If albumin pass into the urine (albuminuria) is that kidney function is impaired. have lower albumin levels (p <.5) than that of nonsmokers (Figure 5). Study of haematological parameters: - Red blood cells (RBC): we noticed a non-significant (p>.5) in the number of red blood cells in smokers compared with non-smokers (Figure ). - Hemoglobin (Hb): in the same way, hemoglobin decreased insignificantly (p>.5) in the group of smokers compared to non-smokers (Figure 7). - Sedimentation Rate: a highly significant (p <.1) of the sedimentation rate in smokers (Figure ). - Platelets: smokers have a higher number of platelets than non-smokers, this difference was significant p <.5 (Figure 9). 7 5 Rate (%) 3 1 Fig. 1: Mean Changes (X ± SD) of the rate of dialysis groups. Discussion: The number of smokers in the hemodialysis service is higher than that of non-smokers, this result us to say that tobacco is a risk factor renal failure. Cigarette smoking alters kidney function in holy people (non-diabetic, non-hypertensive or renal failure), smoking increases microalbuminuria in proportion to the number of cigarettes smoked, suggesting an impairment of the endothelium which can lead to accelerated decline renal function.
3 193 Djabali Nacira et al, 15 Advances in Environmental Biology, 9() November 15, Pages: ,9,,7, Urea (g/l),5,,3,,1 Fig. : Mean Changes (X ± SD) of urea between the groups Creatinin (mg/l) Fig. 3: Mean Changes (X ± SD) creatinine level between the groups. 7 5 uric acid (mg/l) 3 1 Fig. : Mean Change (X ± SD) of uric acid levels between the groups. Albumin (g/l) Fig. 5: Mean Change (X ± SD) of albumin levels between the groups. 5 RBC (x1/mm3) 3 1 Fig. : Mean Change (X ± SD) number of red blood cells between the groups.
4 19 Djabali Nacira et al, 15 Advances in Environmental Biology, 9() November 15, Pages: Hb (g/dl) Fig. 7: Mean Change (X ± SD) hemoglobin levels between the groups Sedimentation (mm/h) Fig. : Mean Change (X ± SD) sedimentation rate between the groups. 5 platelets 3 (13/mm3) 1 Fig. 9: Mean Change (X ± SD) number of platelets between the groups. Other studies have shown that patients with hypertension, diabetics and patients with kidney disease are at increased risk of worsening renal function than non-smokers (Klungsoysr et al. ). A prospective study of 3 5 people for over years shows a relative risk of renal failure.5% in smokers and tobacco-attributable risk of 31% [1]. Our results show that smokers have elevated levels of urea, creatinine, uric acid with decreased albumin levels. These factors are accompanied by the decrease in the number of red blood cells, the hemoglobin with an increased erythrocyte sedimentation rate and the number of thrombocytes. In general, these disturbances may be due to lesions of the renal parenchyma which can be induced by the effect of nicotine which is responsible for cell proliferation processes and synthesis of extracellular matrix promoting interstitial fibrosis, for the heavy metals as cadmium and lead in the smoke that accumulates in the kidney and favor tubular damage, or free radical CO [7]. Increasing the level of urea, creatinine and uric acid gives an idea about the disruption of the glomerular filtration process and the decrease in albumin leads to nephrotic syndrome and glomerulonephritis. Cigarette smokers have a risk of hyperuricaemia univariate two times higher than in non-smokers. A significant association between smoking cigarettes and high levels of uric acid has been well demonstrated in the work of Alderman. Other studies confirm this significant relationship between smoking and hyperuricemia []. Whether active or passive, smoking operates as a major risk factor for arterial and independent members and cardio - vascular diseases [1]. Another study noted 7.% of patients with hyperuricemia are smokers. The decrease in the number of red blood cells and hemoglobin is due to the decrease in erythropoietin, most smokers have a risk of anemia due to moderate to severe renal impairment.
5 195 Djabali Nacira et al, 15 Advances in Environmental Biology, 9() November 15, Pages: Excessive tobacco can be result in polycythemia because this situation created a real oxy-carbon poisoning, so there was an extra oxygen demand and production of red blood cells increases to cope. We can observe in some heavy smokers a real polycythemia. The decrease in hemoglobin causes a more rapid sedimentation of red blood cells, tobacco causes chronic renal failure is a common cause of elevated sedimentation rate. Conclusion: Tobacco is a kidney triggering factor and also the progression to a more advanced stage. Toxic harmful effects of cigarettes come mainly from tobacco components; nicotine is against indications for kidney. Accumulated by people with kidney failure, this substance should be excreted in the urine. The deleterious effects of nicotine could therefore explain the increased cardiovascular risks in these smokers. This study clearly showed that renal function is threatened by the danger of smoking. The disturbances in smokers are due to the harmful effects of tobacco on the glomerular and tubular functioning. REFERENCES [1] Alderman, M.H.,. Uric acid and cardiovascular risk. Curr opin Pharmacol, : [] Daff, B.M., S.C. Sarr, 3. Enquête Mondiale sur la Santé. [3] Klungsoysr, O., J.F. Nygard, T. Sorensen and I. Sandanger,. Cigarette smoking and incidence of first depressive episode: An 11-year population-based follow-up study. Am J Epidemiol, 13: 1-3. [] Orth, S.R.,. Smoking and the kidney. J Am Soc Nephrol., 13: [5] Orth, S.R., E. Ritz,. Adverse effect of smoking on renal function in the general population: are men at higher risk?. Am J Kidney Dis., :. [] Orth, S.R., E. Ritz and R.W. Schrier, The renal risks of smoking. Kidney Int., 51: [7] Orth, S.R., T. Schroeder, E. Ritz and P. Ferrari, 5. Effects of smoking on renal function in patients with type 1 and type diabetes mellitus. Nephrol Dial Transplant, : [] Polidori, M.C., P. Mecocci, W. Stahl and H. Sies, 3. Cigarette smoking cessation encreases plasma levels of several antioxidant micronutrients and improves resistance towards. Br J Nutr., 9(1): [9] Tomita, M., S. Mizumo and H. Yamanaka,. Does hyperuricemia affect mortality? A prospective cohort study of japanese male workers. J Epidemiol, 1(): 3-9. [1] Warmoth, L., M.M. Regalado, J. Simoni, R.B. Harrist and D.E. Wesson, 5. Cigarette smoking enhances increased urine albumin excretion as a risk factor for glomerular filtration rate decline in primary hypertension. Am J Med Sci., 33: [11] Youssef, H., P. Olivier, V. Bruno and B. Michel, 9. Tabagisme et rein. Rev Med Suisse, 5: 57-. [1] Zanetti, H., 199. Smoking and attitudes to a non-smoking policy among hospital staff. J Hum Hypertens, 11: 57-.
Prevalence of anemia and cardiovascular diseases in chronic kidney disease patients: a single tertiary care centre study
International Journal of Advances in Medicine Sathyan S et al. Int J Adv Med. 2017 Feb;4(1):247-251 http://www.ijmedicine.com pissn 2349-3925 eissn 2349-3933 Original Research Article DOI: http://dx.doi.org/10.18203/2349-3933.ijam20170120
More informationEffect of Smoking Cigarette in Albumin Creatinine Ratio in Khartoum State
EUROPEAN ACADEMIC RESEARCH Vol. IV, Issue 7/ October 2016 ISSN 2286-4822 www.euacademic.org Impact Factor: 3.4546 (UIF) DRJI Value: 5.9 (B+) Effect of Smoking Cigarette in Albumin Creatinine Ratio in Khartoum
More informationLab Values Explained. working at full strength. Other possible causes of an elevated BUN include dehydration and heart failure.
Patient Education Lab Values Explained Common Tests to Help Diagnose Kidney Disease Lab work, urine samples and other tests may be given as you undergo diagnosis and treatment for renal failure. The test
More informationIrish Practice Nurses Association Annual Conference Tullamore Court Hotel OCTOBER 6 th 2012
Irish Practice Nurses Association Annual Conference Tullamore Court Hotel OCTOBER 6 th 2012 Susan McKenna Renal Clinical Nurse Specialist Cavan General Hospital Renal patient population ACUTE RENAL FAILURE
More informationKidneys and Homeostasis
16 The Urinary System The Urinary System OUTLINE: Eliminating Waste Components of the Urinary System Kidneys and Homeostasis Urination Urinary Tract Infections Eliminating Waste Excretion Elimination of
More informationQuality ID #119 (NQF 0062): Diabetes: Medical Attention for Nephropathy National Quality Strategy Domain: Effective Clinical Care
Quality ID #119 (NQF 0062): Diabetes: Medical Attention for Nephropathy National Quality Strategy Domain: Effective Clinical Care 2018 OPTIONS F INDIVIDUAL MEASURES: REGISTRY ONLY MEASURE TYPE: Process
More informationSTUDY ON MICROALBUMINURIA AND OXIDATIVESTRESS IN DIABETICS. B. Suneel, R.R.Aparna, D.Balakrishna, B.Sowjanya and M.Audisesha Reddy.
Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 STUDY ON MICROALBUMINURIA AND OXIDATIVESTRESS IN DIABETICS * B. Suneel, R.R.Aparna, D.Balakrishna, B.Sowjanya and M.Audisesha Reddy. * Department of Biochemistry,
More informationThe Urinary System. BIOLOGY OF HUMANS Concepts, Applications, and Issues. Judith Goodenough Betty McGuire
BIOLOGY OF HUMANS Concepts, Applications, and Issues Fifth Edition Judith Goodenough Betty McGuire 16 The Urinary System Lecture Presentation Anne Gasc Hawaii Pacific University and University of Hawaii
More informationWhat Your Kidneys Do
UW MEDICINE PATIENT EDUCATION What Your Kidneys Do And what happens with kidney disease Class Goals 1. Understand what kidneys do. 2. Understand symptoms of uremia. 3. Know the common causes of kidney
More informationPatient Education Kidney Early Education Program (KEEP) Chapter 2 bjectives: Overview 1. Understand what kidneys do. 2. Understand symptoms
Patient Education (KEEP) Chapter 2 What Your Kidneys Do And what happens when they fail Objectives: 1. Understand what kidneys do. 2. Understand symptoms of uremia and some ways to treat it. 3. Know the
More informationChronic Kidney Disease. Dr Mohan B. Biyani A. Professor of Medicine University of Ottawa/Ottawa Hospital
Chronic Kidney Disease Dr Mohan B. Biyani A. Professor of Medicine University of Ottawa/Ottawa Hospital Health Seminar Series Date 12 May 2013 Objectives Normal functioning of Kidneys. Risk factors to
More informationCh17-18 Urinary System
Ch17-18 Urinary System Main Function: Filter the blood Other Functions: maintain purity and consistency of internal fluids eliminates nitrogenous wastes, toxins, and drugs from the body regulates blood
More informationChronic Kidney Disease. Basics of CKD Terms Diagnosis Management
Chronic Kidney Disease Basics of CKD Terms Diagnosis Management Review the prevalence of chronic kidney disease (CKD) Review how CKD develops Review populations at risk for CKD Review CKD diagnosis Objectives
More informationISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI CLINICAL RESEARCH CENTER ALDO E FOR CELE RARE DACCO DISEASES ALDO E CELE DACCO
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI CENTRO MARIO DI NEGRI RICERCHE INSTITUTE CLINICHE FOR PHARMACOLOGICAL PER LE MALATTIE RESEARCH RARE CLINICAL RESEARCH CENTER ALDO E FOR CELE RARE DACCO DISEASES
More informationThe Body Mass Index (BMI) of Human Age and Gender Structure as the Main Cause of Cardiovascular and Nephrotic Diseases
Bangladesh Journal of Medical Science Vol. 12 No. 03 July 13 Original article: The Body Mass Index (BMI) of Human Age and Gender Structure as the Main Cause of Cardiovascular and Nephrotic Diseases Beadini
More informationReversal of Microalbuminuria A Causative Factor of Diabetic Nephropathy is Achieved with ACE Inhibitors than Strict Glycemic Control
ISSN 0976 3333 Available Online at www.ijpba.info International Journal of Pharmaceutical & Biological Archives 2013; 4(5): 923-928 ORIGINAL RESEARCH ARTICLE Reversal of Microalbuminuria A Causative Factor
More information>4000 mg/dl (=20000/(500/100)) >615 mmol/l (=20000/(65*0.5))
Supplemental Table 1 Thresholds to define outliers of lab values in screening test for proteinuria Type of screening test Unit Threshold for Outliers References 24 hour urine albumin mg/d >20000 experienced
More informationNon-protein nitrogenous substances (NPN)
Non-protein nitrogenous substances (NPN) A simple, inexpensive screening test a routine urinalysis is often the first test conducted if kidney problems are suspected. A small, randomly collected urine
More informationThe hypertensive kidney and its Management
The hypertensive kidney and its Management Dr H0 Chung Ping Hypertension Management Seminar 20061124 Hypertensive kidney Kidney damage asymptomatic till late stage Viscous cycle to augment renal damage
More informationUse the following diagram to answer the next question. 1. In the diagram above, pressure filtration occurs in a. W b. X c. Y d. Z
Part A: Multiple Choice Questions Value: 32 Marks Suggested time: 40 minutes Instructions: For each question select the best answer and record your choice on the Scantron card provided. Using an HB pencil,
More informationClinical Study Factors Associated with the Decline of Kidney Function Differ among egfr Strata in Subjects with Type 2 Diabetes Mellitus
International Endocrinology Volume 2012, Article ID 687867, 6 pages doi:10.1155/2012/687867 Clinical Study Factors Associated with the Decline of Kidney Function Differ among egfr Strata in Subjects with
More informationCHRONIC KIDNEY FAILURE
CHRONIC KIDNEY FAILURE Overview Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood,
More informationHIV AND CHRONIC KIDNEY DISEASE. Understanding GFR
HIV AND CHRONIC KIDNEY DISEASE Understanding GFR in PEOPLE WITH HIV contents Introduction... 4 Chronic Kidney Disease... 5 What are kidneys and what do they do?... 5 What is glomerular filtration rate
More informationNephrology - the study of the kidney. Urology - branch of medicine dealing with the male and female urinary systems and the male reproductive system
Urinary System Nephrology - the study of the kidney Urology - branch of medicine dealing with the male and female urinary systems and the male reproductive system Functions of the Urinary System 1. Regulation
More informationIntroduction. 1. Introduction
1. Introduction Chronic kidney disease (CKD) encompasses a spectrum of different pathophysiologic processes associated with abnormal kidney function, and a progressive decline in glomerular filtration
More informationThe Respiratory System
Respiration and Excretion Name Date Class The Respiratory System This section describes the parts of the respiratory system and how they work to help you breathe and speak. Use Target Reading Skills As
More informationCase Presentation Turki Al-Hussain, MD
Case Presentation Turki Al-Hussain, MD Director, Renal Pathology Chapter Saudi Society of Nephrology & Transplantation Consultant Nephropathologist & Urological Pathologist Department of Pathology & Laboratory
More informationBASELINE CHARACTERISTICS OF THE STUDY POPULATION
Study Summary DAILY ORAL SODIUM BICARBONATE PRESERVES GLOMERULAR FILTRATION RATE BY SLOWING ITS DECLINE IN EARLY HYPERTENSIVE NEPHROPATHY This was a 5-year, single-center, prospective, randomized, placebo-controlled,
More informationPreoperative Serum Bicarbonate Levels Predict Acute Kidney Iinjry after Cardiac Surgery
International Journal of ChemTech Research CODEN (USA): IJCRGG, ISSN: 0974-4290, ISSN(Online):2455-9555 Vol.11 No.06, pp 203-208, 2018 Preoperative Serum Bicarbonate Levels Predict Acute Kidney Iinjry
More informationLecture-2 Review of the previous lecture:
Lecture-2 Review of the previous lecture: -Kidney s function is to clean the blood by the removing of the waste plus adding some valuable substances -kidney failure will lead to death for many reasons,
More informationEXCRETION QUESTIONS. Use the following information to answer the next two questions.
EXCRETION QUESTIONS Use the following information to answer the next two questions. 1. Filtration occurs at the area labeled A. V B. X C. Y D. Z 2. The antidiuretic hormone (vasopressin) acts on the area
More informationThe Clinical Case for providing stop smoking support to Renal Patients
The Clinical Case for providing stop smoking support to Renal Patients Why intervene in secondary care? 1. Hospital patients are more receptive to Very Brief Advice (VBA) and an offer of support to stop
More informationEffects of smoking on renal function in patients with type 1 and type 2 diabetes mellitus
Nephrol Dial Transplant (2005) 20: 2414 2419 doi:10.1093/ndt/gfi022 Advance Access publication 26 July 2005 Original Article Effects of smoking on renal function in patients with type 1 and type 2 diabetes
More informationStudy of association of serum bicarbonate levels with mortality in chronic kidney disease
International Journal of Research in Medical Sciences Kumar S et al. Int J Res Med Sci. 2016 Nov;4(11):4852-4856 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Original Research Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20163779
More information2019 COLLECTION TYPE: MIPS CLINICAL QUALITY MEASURES (CQMS) MEASURE TYPE: Process
Quality ID #119 (NQF 0062): Diabetes: Medical Attention for Nephropathy National Quality Strategy Domain: Effective Clinical Care Meaningful Measure Area: Management of Chronic Conditions 2019 COLLECTION
More information12/7/10. Excretory System. The basic function of the excretory system is to regulate the volume and composition of body fluids by:
Excretory System The basic function of the excretory system is to regulate the volume and composition of body fluids by: o o removing wastes returning needed substances to the body for reuse Body systems
More informationObjectives. Pre-dialysis CKD: The Problem. Pre-dialysis CKD: The Problem. Objectives
The Role of the Primary Physician and the Nephrologist in the Management of Chronic Kidney Disease () By Brian Young, M.D. Assistant Clinical Professor of Medicine David Geffen School of Medicine at UCLA
More informationIntravenous Iron Does Not Affect the Rate of Decline of Residual Renal Function in Patients on Peritoneal Dialysis
Advances in Peritoneal Dialysis, Vol. 22, 2006 Hemal Shah, Ashutosh Shukla, Abirami Krishnan, Theodore Pliakogiannis, Mufazzal Ahmad, Joanne M. Bargman, Dimitrios G. Oreopoulos Intravenous Iron Does Not
More informationA study of predictive value of microalbuminuria in early outcome of non-diabetic patients of acute myocardial infarction
International Journal of Advances in Medicine Patel SR et al. Int J Adv Med. 2017 Apr;4(2):334-338 http://www.ijmedicine.com pissn 2349-3925 eissn 2349-3933 Original Research Article DOI: http://dx.doi.org/10.18203/2349-3933.ijam20170523
More informationWhat Your Kidneys Do and What Happens When They Fail
Patient Education Chapter 2 Page 1 What Your Kidneys Do and What Happens When They Fail Objectives: 1. Understand basic kidney functions. 2. Understand symptoms of uremia and some treatments used for it.
More informationStages of Chronic Kidney Disease (CKD)
Early Treatment is the Key Stages of Chronic Kidney Disease (CKD) Stage Description GFR (ml/min/1.73 m 2 ) >90 1 Kidney damage with normal or GFR 2 Mild decrease in GFR 60-89 3 Moderate decrease in GFR
More informationΟ ρόλος των τριγλυκεριδίων στην παθογένεια των μικροαγγειοπαθητικών επιπλοκών του σακχαρώδη διαβήτη
Ο ρόλος των τριγλυκεριδίων στην παθογένεια των μικροαγγειοπαθητικών επιπλοκών του σακχαρώδη διαβήτη Κωνσταντίνος Τζιόμαλος Επίκουρος Καθηγητής Παθολογίας Α Προπαιδευτική Παθολογική Κλινική, Νοσοκομείο
More informationCardiovascular Pharmacotherapy in Special Population: Cardio-Nephrology
49 th Annual Scientific Meeting The Heart Association of Thailand under the Royal Patronage of H.M. the King Cardiology on the move 24-25 March 2017 @Sheraton, HuaHin Cardiovascular Pharmacotherapy in
More informationAddressing Chronic Kidney Disease in People with Multiple Chronic Conditions
Addressing Chronic Kidney Disease in People with Multiple Chronic Conditions Andrew S Narva, MD Na/onal Kidney Disease Educa/on Program U.S. Department of Health and Human Services National Institute of
More informationEXCRETION IN HUMANS 31 JULY 2013
EXCRETION IN HUMANS 31 JULY 2013 Lesson Description In this lesson we: Discuss organs of excretion Look at the structure of the urinary system Look at the structure and functioning of the kidney Discuss
More informationAGING KIDNEY IN HIV DISEASE
AGING KIDNEY IN HIV DISEASE Michael G. Shlipak, MD, MPH Professor of Medicine, Epidemiology and Biostatistics, UCSF Chief, General Internal Medicine, San Francisco VA Medical Center Kidney, Aging and HIV
More informationUric acid and CKD. Sunil Badve Conjoint Associate Professor, UNSW Staff Specialist, St George
Uric acid and CKD Sunil Badve Conjoint Associate Professor, UNSW Staff Specialist, St George Hospital @Badves Case Mr J, 52 Male, referred in June 2015 DM type 2 (4 years), HTN, diabetic retinopathy, diabetic
More informationThe Diabetes Kidney Disease Connection Missouri Foundation for Health February 26, 2009
The Diabetes Kidney Disease Connection Missouri Foundation for Health February 26, 2009 Teresa Northcutt, RN BSN Primaris Program Manager, Prevention - CKD MO-09-01-CKD This material was prepared by Primaris,
More informationHIHIM 409 7/26/2009. Kidney and Nephron. Fermamdo Vega, M.D. 1
Function of the Kidneys Nephrology Fernando Vega, M.D. Seattle Healing Arts Center Remove Wastes Regulate Blood Pressure Regulate Blood Volume Regulates Electrolytes Converts Vitamin D to active form Produces
More informationRenal System and Excretion
Renal System and Excretion Biology 105 Lecture 19 Chapter 16 Outline Renal System I. Functions II. Organs of the renal system III. Kidneys 1. Structure 2. Function IV. Nephron 1. Structure 2. Function
More informationAcknowledgements. National Kidney Foundation of Connecticut Mark Perazella. Co-PI Slowing the progression of chronic kidney disease to ESRD
A Practical Approach to Chronic Kidney Disease Management for the Primary Care Practioner: A web-site sponsored by the National Kidney Foundation of Connecticut Robert Reilly, M.D. Acknowledgements National
More informationAlterations of Renal and Urinary Tract Function
Alterations of Renal and Urinary Tract Function Chapter 29 Urinary Tract Obstruction Urinary tract obstruction is an interference with the flow of urine at any site along the urinary tract The obstruction
More informationDiabetes. Albumin. Analyte Information
Diabetes Albumin Analyte Information -1-2014-05-02 Albumin Introduction Albumin consists of a single polypeptide chain of 585 amino acids with molecular weight of 66.5 kda. The chain is characterized by
More informationTHE PROGNOSIS OF PATIENTS WITH CHRONIC KIDNEY DISEASE AND DIABETES MELLITUS
214 ILEX PUBLISHING HOUSE, Bucharest, Roumania http://www.jrdiabet.ro Rom J Diabetes Nutr Metab Dis. 21(3):23-212 doi: 1.2478/rjdnmd-214-25 THE PROGNOSIS OF PATIENTS WITH CHRONIC KIDNEY DISEASE AND DIABETES
More informationFamilial DDD associated with a gain-of-function mutation in complement C3.
Familial DDD associated with a gain-of-function mutation in complement C3. Santiago Rodríguez de Córdoba, Centro de investigaciones Biológicas, Madrid Valdés Cañedo F. and Vázquez- Martul E., Complejo
More informationRole of High-sensitivity C-reactive Protein as a Marker of Inflammation in Pre-dialysis Patients of Chronic Renal Failure
ORIGINAL ARTICLE JIACM 2009; 10(1 & 2): 18-22 Abstract Role of High-sensitivity C-reactive Protein as a Marker of Inflammation in Pre-dialysis Patients of Chronic Renal Failure N Nand*, HK Aggarwal**,
More informationSummary of Recommendation Statements Kidney International Supplements (2013) 3, 5 14; doi: /kisup
http://www.kidney-international.org & 2013 DIGO Summary of Recommendation Statements idney International Supplements (2013) 3, 5 14; doi:10.1038/kisup.2012.77 Chapter 1: Definition and classification of
More informationThe Egyptian Journal of Hospital Medicine (October 2017) Vol.69(1), Page
The Egyptian Journal of Hospital Medicine (October 2017) Vol.69(1), Page 1589-1594 Using Serum Beta Trace Protein to Estimate Residual Kidney Function in Hemodialysis Patients Hesham M. El-Sayed, Hussein
More informationDiabetes in Renal Patients. Contents. Understanding Diabetic Nephropathy
Diabetes in Renal Patients Contents Understanding Diabetic Nephropathy What effect does CKD have on a patient s diabetic control? Diabetic Drugs in CKD and Dialysis Patients Hyper and Hypoglycaemia in
More informationOutline Urinary System. Urinary System and Excretion. Urine. Urinary System. I. Function II. Organs of the urinary system
Outline Urinary System Urinary System and Excretion Bio105 Chapter 16 Renal will be on the Final only. I. Function II. Organs of the urinary system A. Kidneys 1. Function 2. Structure III. Disorders of
More informationBlood pressure and kidney disease
Blood pressure and High blood pressure is the second most common cause of. Your heart pumps your blood through tubes (blood vessels) called arteries and veins. When your blood moves through the blood vessels,
More informationDRUG NAME: Eculizumab Brand(s): Soliris DOSAGE FORM/ STRENGTH: 10 mg/ml (300 mg per vial)
Preamble: A confirmed diagnosis of atypical hemolytic uremic syndrome (ahus) is required for eculizumab funding. The information below is to provide clinicians with context for how a diagnosis of ahus
More informationManagement of End Stage Renal Disease-Bangladesh Perspective
Send Orders for Reprints to reprints@benthamscience.net 108 The Open Urology & Nephrology Journal, 2014, 7, 108-112 Management of End Stage Renal Disease-Bangladesh Perspective Harun Ur Rashid * Open Access
More informationDisorders of the kidney. Urine analysis. Nephrotic and nephritic syndrome.
Disorders of the kidney. Urine analysis. Nephrotic and nephritic syndrome. Azotemia and Urinary Abnormalities Disturbances in urine volume oliguria, anuria, polyuria Abnormalities of urine sediment red
More informationHEALTHYSTART TRAINING MANUAL. Living well with Kidney Disease
HEALTHYSTART TRAINING MANUAL Living well with Kidney Disease KIDNEY DISEASE CAN AFFECT ANYONE! 1 HEALTHYSTART PROGRAMME HEALTHYSTART is a lifestyle management programme to assist you to remain healthy
More informationCKD FOR INTERNISTS. Dr Ahmed Hossain Associate professor Medicine Sir Salimullah Medical College
CKD FOR INTERNISTS Dr Ahmed Hossain Associate professor Medicine Sir Salimullah Medical College INTRODUCTION In 2002, the National Kidney Foundation s Kidney Disease Outcomes Quality Initiative(KDOQI)
More informationAssessment of glomerular filtration rate in healthy subjects and normoalbuminuric diabetic patients: validity of a new (MDRD) prediction equation
Nephrol Dial Transplant (2002) 17: 1909 1913 Original Article Assessment of glomerular filtration rate in healthy subjects and normoalbuminuric diabetic patients: validity of a new () prediction equation
More informationLAB TIME/DATE. 1. most numerous leukocyte. 3. also called an erythrocyte; anucleate formed element. 6. ancestral cell of platelets
ighapmlre29apg245_250 5/12/04 2:46 PM Page 245 impos03 302:bjighapmL:ighapmLrevshts:layouts: NAME Blood LAB TIME/DATE REVIEW SHEET exercise 29A Composition of Blood 1. What is the blood volume of an average-size
More informationPublished trials point to a detrimental relationship
ANEMIA, CHRONIC KIDNEY DISEASE, AND CARDIOVASCULAR DISEASE: THE CLINICAL TRIALS Steven Fishbane, MD* ABSTRACT Clinical trials have shown a strong detrimental relationship among anemia, chronic kidney disease
More information1. a)label the parts indicated above and give one function for structures Y and Z
Excretory System 1 1. Excretory System a)label the parts indicated above and give one function for structures Y and Z W- renal cortex - X- renal medulla Y- renal pelvis collecting center of urine and then
More informationA Study of substance abuse among chronic kidney disease patients having psychiatric illness undergoing haemodialysis
International Journal of Multidisciplinary and Current Research Research Article ISSN: 2321-3124 Available at: http://ijmcr.com A Study of substance among chronic kidney disease patients having psychiatric
More informationIELTS Placement Test
IELTS Placement Test Time allowed: 2 hours QUESTION PAPER DO NOT write on this paper Instructions: Please answer all questions DO NOT use a dictionary Write all answers on the separate answer sheet Section
More informationThe CARI Guidelines Caring for Australasians with Renal Impairment. ACE Inhibitor and Angiotensin II Antagonist Combination Treatment GUIDELINES
ACE Inhibitor and Angiotensin II Antagonist Combination Treatment Date written: September 2004 Final submission: September 2005 Author: Kathy Nicholls GUIDELINES No recommendations possible based on Level
More informationChapter 11 Lecture Outline
Chapter 11 Lecture Outline See separate PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright 2016 McGraw-Hill Education. Permission required for reproduction
More informationLeft ventricular hypertrophy: why does it happen?
Nephrol Dial Transplant (2003) 18 [Suppl 8]: viii2 viii6 DOI: 10.1093/ndt/gfg1083 Left ventricular hypertrophy: why does it happen? Gerard M. London Department of Nephrology and Dialysis, Manhes Hospital,
More informationOutline. Outline CHRONIC KIDNEY DISEASE UPDATE: WHAT THE GENERALIST NEEDS TO KNOW 7/23/2013. Question 1: Which of these patients has CKD?
CHRONIC KIDNEY DISEASE UPDATE: WHAT THE GENERALIST NEEDS TO KNOW MICHAEL G. SHLIPAK, MD, MPH CHIEF-GENERAL INTERNAL MEDICINE, SAN FRANCISCO VA MEDICAL CENTER PROFESSOR OF MEDICINE, EPIDEMIOLOGY AND BIOSTATISTICS,
More informationDiabetic Nephropathy
Diabetic Nephropathy Objectives: Know what Diabetic Nephropathy means. Know how common is Diabetic nephropathy in Saudi Arabia and to appreciate how bad are this complications. Know the risk factors of
More informationA&P 2 CANALE T H E U R I N A R Y S Y S T E M
A&P 2 CANALE T H E U R I N A R Y S Y S T E M URINARY SYSTEM CONTRIBUTION TO HOMEOSTASIS Regulates body water levels Excess water taken in is excreted Output varies from 2-1/2 liter/day to 1 liter/hour
More informationJournal of Chemical and Pharmaceutical Research, 2015, 7(6): Research Article
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2015, 7(6):568-572 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Early markers of renal dysfunction in Syrian beta
More informationChapter 14. Blood. Blood Volume. Blood Composition. Blood
Blood connective tissue transports vital substances maintains stability of interstitial fluid distributes heat Chapter 14 Blood Blood Cells form mostly in red bone marrow red blood cells white blood cells
More informationManagement of early chronic kidney disease
Management of early chronic kidney disease GREENLANE SUMMER GP SYMPOSIUM 2018 Jonathan Hsiao Renal and General Physician Introduction A growing public health problem in NZ and throughout the world. Unknown
More informationRenal Function in Minahasanese Patients with Chronic Gout Arthritis and Tophi
ORIGINAL ARTICLE Renal Function in Minahasanese Patients with Chronic Gout Arthritis and Tophi Candra Wibowo *, AMC Karema Kaparang **, Emma Sy Moeis **, AL Kapojos ** ABSTRACT Aim: determine renal function
More information1. Urinary System, General
S T U D Y G U I D E 16 1. Urinary System, General a. Label the figure by placing the numbers of the structures in the spaces by the correct labels. 7 Aorta 6 Kidney 8 Ureter 2 Inferior vena cava 4 Renal
More informationRENAL FAILURE IN CHILDREN Dr. Mai Mohamed Elhassan Assistant Professor Jazan University
RENAL FAILURE IN CHILDREN Dr. Mai Mohamed Elhassan Assistant Professor Jazan University OBJECTIVES By the end of this lecture each student should be able to: Define acute & chronic kidney disease(ckd)
More informationNephrology. Renal Replacement in End-Stage Renal Disease Patients over 75 Years Old. ABC Fax
American Journal of Nephrology Original Article: Basic Sciences Am J Nephrol 2003;23:7 77 DOI: 0.59/000068040 Received: July 23, 2002 Accepted: October 2, 2002 Renal Replacement in End-Stage Renal Disease
More informationIncreased Risk of Renal Deterioration Associated with Low e-gfr in Type 2 Diabetes Mellitus Only in Albuminuric Subjects
ORIGINAL ARTICLE Increased Risk of Renal Deterioration Associated with Low e-gfr in Type 2 Diabetes Mellitus Only in Albuminuric Subjects Shu Meguro, Toshikatsu Shigihara, Yusuke Kabeya, Masuomi Tomita
More informationEfficacy and tolerability of oral Sucrosomial Iron in CKD patients with anemia. Ioannis Griveas, MD, PhD
Efficacy and tolerability of oral Sucrosomial Iron in CKD patients with anemia Ioannis Griveas, MD, PhD Anaemia is a state in which the quality and/or quantity of circulating red blood cells are below
More informationClinical pathological correlations in AKI
Clinical pathological correlations in AKI Dr. Rajasekara chakravarthi Director - Nephrology Star Kidney Center, Star Hospitals Renown clinical services India Introduction AKI is common entity Community
More informationApplying clinical guidelines treating and managing CKD
Applying clinical guidelines treating and managing CKD Develop patient treatment plan according to level of severity. Source: Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012
More informationRenal Disease and PK/PD. Anjay Rastogi MD PhD Division of Nephrology
Renal Disease and PK/PD Anjay Rastogi MD PhD Division of Nephrology Drugs and Kidneys Kidney is one of the major organ of drug elimination from the human body Renal disease and dialysis alters the pharmacokinetics
More information1. INSTRUCTIONS 2. DEFINITION OF HUS
CQ_IBK_aHUS_01 / version 25/11/09 European Paediatric Research Group for HUS and related disorders Case questionnaire for diarrhoea negative/vtec (STEC) negative cases acute phase 1. INSTRUCTIONS Please
More informationUrinary System. consists of the kidneys, ureters, urinary bladder and urethra
Urinary System 1 Urinary System consists of the kidneys, ureters, urinary bladder and urethra 2 Location of Kidneys The kidneys which are positioned retroperitoneally lie on either side of the vertebral
More informationUnderstanding Your Hemodialysis Access Options UNDERSTANDING WHAT IT MEANS TO HAVE PROTEIN IN YOUR URINE
Understanding Your Hemodialysis Access Options UNDERSTANDING WHAT IT MEANS TO HAVE PROTEIN IN YOUR URINE 2 AAKP: Understanding What It Means to Have Protein in Your Urine Understanding What It Means to
More information1. Disorders of glomerular filtration
RENAL DISEASES 1. Disorders of glomerular filtration 2. Nephrotic syndrome 3. Disorders of tubular transport 4. Oliguria and polyuria 5. Nephrolithiasis 6. Disturbances of renal blood flow 7. Acute renal
More informationCreatinine & egfr A Clinical Perspective. Suheir Assady MD, PhD Dept. of Nephrology & Hypertension RHCC
Creatinine & egfr A Clinical Perspective Suheir Assady MD, PhD Dept. of Nephrology & Hypertension RHCC CLINICAL CONDITIONS WHERE ASSESSMENT OF GFR IS IMPORTANT Stevens et al. J Am Soc Nephrol 20: 2305
More informationIt hurts you. It doesn t take much. It doesn t take long.
Secondhand smoke is dangerous. The Surgeon General of the United States, working with a team of leading health experts, studied how breathing secondhand tobacco smoke affects you. This booklet explains
More informationOutline Urinary System
Urinary System and Excretion Bio105 Lecture Packet 20 Chapter 16 Outline Urinary System I. Function II. Organs of the urinary system A. Kidneys 1. Function 2. Structure B. Urine formation 1. Hormonal regulation
More informationQUICK REFERENCE FOR HEALTHCARE PROVIDERS
KEY MESSAGES 1 SCREENING CRITERIA Screen: Patients with DM and/or hypertension at least yearly. Consider screening patients with: Age >65 years old Family history of stage 5 CKD or hereditary kidney disease
More informationIntroduction to Clinical Diagnosis Nephrology
Introduction to Clinical Diagnosis Nephrology I. David Weiner, M.D. C. Craig and Audrae Tisher Chair in Nephrology Professor of Medicine and Physiology and Functional Genomics University of Florida College
More information