Material Safety Data Sheet

Transcription

1 Material Safety Data Sheet NFPA HMIS Personal Protective Equipment 0 Health Hazard Fire Hazard 0 See Section 5. Section. Chemical Product and Company Identification Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Poloxamer 407 SPECTRUM LABORATORY PRODUCTS INC S. SAN PEDRO STREET GARDENA, CA Pluronic F27; Polyethylene-polypropylene glycol; Polyoxyethylene-Polyoxypropylene Block Copolymer; Poly(Ethylene oxide-co-polypropylene oxide), Block; Block Copolymer of Ethylene Oxide and Propylene Oxide; Ethylene oxide/polypropylene oxide copolymer; Methyl-oxirane polymer with oxirane Catalog Number(s). CAS# RTECS TSCA CI# P26, P ; or TP IN CASE OF EMERGENCY CHEMTREC (24hr) Page Number: TSCA 8(b) inventory: CAS no listed as Oxirane, methyl-, polymer with oxirane; CAS no is not TSCA listed. Chemical Name Chemical Family Chemical Formula Supplier Oxirane, methyl,-polymer with oxirane, block POLYMER or (C3-H6-O.C2-H4-O)x or HO(C2H4O)a(C3H6O)b(C2H4O)aH SPECTRUM LABORATORY PRODUCTS INC S. SAN PEDRO STREET GARDENA, CA CALL (30) Section 2.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight ) Poloxamer 407, N.F or Toxicological Data on Ingredients

2 Poloxamer 407 Page Number: 2 Section 3. Hazards Identification Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Potential Chronic Health Effects CARCINOGENIC EFFECTS: MUTAGENIC EFFECTS: TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY: Repeated or prolonged exposure is not known to aggravate medical condition. Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 5 minutes. Cold water may be used. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Inhalation Serious Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion Serious Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances May be combustible at high temperature. >250 C (482 F) CLOSED CUP: >50 C (302 F). These products are carbon oxides (CO, CO2), phosphates. Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances Risks of explosion of the product in presence of mechanical impact: Risks of explosion of the product in presence of static discharge: Fire Fighting Media and Instructions Fire Hazards Explosion Hazards SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.

3 Poloxamer 407 Page Number: 3 Section 6. Accidental Release Measures Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Precautions Storage Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill Exposure Limits Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Granular solid. Coarse particle. Prill) Odor Molecular Weight ph (% soln/water) g/mole Not available Taste Color White. Boiling Point Melting Point 53 C (27.4 F - 57 C.) Critical Temperature Specific Gravity Vapor Pressure Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties See solubility in water. Solubility Soluble in cold water. Solubility in Water: deg. C.

4 Poloxamer 407 Page Number: 4 Section 0. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Non-corrosive in presence of glass. Corrosivity Polymerization Will not occur. Section. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Inhalation. Ingestion. Acute oral toxicity (LD50): 0000 mg/kg [Rat]. Acute dermal toxicity (LD50): >5000 mg/kg [Rabbit]. Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Lethal Dose/Conc 50% kill: LD50 [Mouse] - Route: Unreported; Dose: 2250 mg/kg May contain trace amounts of Ethylene oxide, and,4-dioxane which may cause cancer. May contain trace amounts of Ethylene oxide which may cause adverse reproductive effects. Acute Potential Health Effects: Skin: Not expected to cause skin irritation. May cause skin irritation in sensitive individuals. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May cause gastric disturbances. Expected low toxicity and hazard. Section 2. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Toxicity of the Products of Biodegradation the Products of Biodegradation Ecotoxicity in water (LC50): >0000 mg/l 96 hours [Fish (Zebra fish)]. >99 mg/l 96 hours [Fish (Trout)]. >. mg/l 48 hours [Daphnia (daphnia)]. >970 mg/l 72 hours [Algae (Algae.)]. Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The product itself and its products of degradation are not toxic.

5 Poloxamer 407 Page Number: 5 Section 3. Disposal Considerations Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 4. Transport Information DOT Classification Not a DOT controlled material (United States). Identification Special Provisions for Transport DOT Section 5. Other Regulatory Information and Pictograms Federal and State Regulations California Proposition 65 Warnings Other Regulations cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Ethylene oxide;,4-dioxane cause reproductive harm (female) which would require a warning under the statute: Ethylene oxide cause birth defects which would require a warning under the statute: No products were found. cause cancer which would require a warning under the statute: Ethylene oxide;,4-dioxane TSCA 8(b) inventory: CAS no listed as Oxirane, methyl-, polymer with oxirane; CAS no is not TSCA listed. California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: Ethylene oxide;,4-dioxane California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. For CAS no EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances. Canada: Listed on Canadian Domestic Substance List (DSL). China: Listed on National Inventory. Japan: Listed on National Inventory (ENCS). Korea: Listed on National Inventory (KECI). Philippines: Listed on National Inventory (PICCS). Australia: Listed on AICS. Other Classifications WHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC) This product is not classified according to the EU regulations. HMIS (U.S.A.) Health Hazard Fire Hazard Personal Protection 0 E National Fire Protection Association (U.S.A.) Health 0 Flammability Specific hazard

6 Poloxamer 407 Page Number: 6 WHMIS (Canada) DSCL (Europe) TDG (Canada) ADR (Europe) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. Section 6. Other Information MSDS Code References Other Special Considerations P3952 Validated by Sonia Owen on 7/24/2007. Verified by Sonia Owen. Printed 9/24/2007. CALL (30) Notice to Reader

7 Poloxamer 407 Page Number: 7 All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.