Opioid Abuse and Prescribing. Dr. Mitchell Mutter Director of Special Projects
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1 Opioid Abuse and Prescribing Dr. Mitchell Mutter Director of Special Projects Auburn University February 22, 2019
2 Disclosure Statement of Financial Interest I, Mitchell Mutter, DO NOT have a financial interest/arrangement or affiliation with one or more organizations that could be perceived as a real or apparent conflict of interest in the context of the subject of this presentation.
3 CDC Conversion Mobile App
4 Key Findings in 2018 Source: CSMD 2018 Legislative Report
5 September 2017
6 Do all Healthcare Providers have to Register? If you provide direct care and prescribe controlled substances to patients in Tennessee for more than 15 days per year or you are a dispenser in practice providing direct care to patients in Tennessee for more than 15 days per year, you are required to register with the CSMD.
7 Number of Registrants of the CSMD, Number of Registrants of the CSMD, * Year Registrants Change (%) , , , , , , , , , *VA registrants were included in 2013 and forward as they were allowed to register.
8 Ratio of Number of Prescriptions to Number of Request in the CSMD, * Ratio of Number of Prescriptions to Number of Requests Ratio of Number of Prescriptions to Number of Requests in the CSMD, * Year * Data include all prescriptions reported to CSMD. From 2015 forward vendor included all roles, all report types and also data request from other states
9 Training User None of these Patients
10 Clinical Risk Indicators (high risk patients) on CSMD Reports Y = 4 Practitioners in last 90 days Y Y R R R = 4 Pharmacies in last 90 days 90 but < 120 Active Cumulative Morphine Equivalents per day 5 Practitioners in last 90 days 5 Pharmacies in last 90 days 120 Active Cumulative Morphine Equivalents per day
11 New Feature on Patient Report as of 2/2018
12 Clinical Risk Indicators (female high risk patients) on CSMD Reports Female and child bearing age (15-45 of age) years Please remember that narcotic prescriptions for women of child bearing age could result in Neonatal Abstinence Syndrome (NAS) should pregnancy occur; please discuss with your patient methods to prevent unintended pregnancy.
13 Considerations When Reading CSMD Report Payment Type Identifying Number Private Pay 01 Medicaid 02 Medicare 03 Commercial Ins. 04 Military Inst. and VA 05 Workers Comp 06 Indian Nations 07 Other 99
14 Practitioner Self Lookup with Option to Include APRN / PA
15 Clinical Risk Notifications on Prescriber Home Page in CSMD 67% of respondents received a Clinical Risk Notification 70% felt the information was useful How did the information increase awareness (could choose more than one response) 92% more aware of patients going to multiple prescriber 60% more aware of patients going to multiple dispensers 65% more aware of patients receiving highest dose of opioids Source: 2018 CSMD Prescriber and Dispenser Survey
16 The number of potential doctor/pharmacy shoppers declined 85% between 2011 and % 5/5/90
17 After viewing information found in the CSMD, I changed the treatment plan for a patient After viewing information found in the CSMD, I refused to fill a prescription as written 6% Prescibers 6% Dispensers 5% 3% 24% 32% 20% 49% 32% ~ 64% of Prescribers have changed their treatment plan Strongly Agree Somewhat Agree Neutral / No Opinion Somewhat Disagree Strongly Disagree 24% ~ 73% of Dispensers refused to fill a prescription as written Source: 2018 CSMD Prescriber and Dispenser Survey
18 Has checking the CSMD changed your practice of referring patients for Substance Use Disorder (SUD) treatment The CSMD has changed my practice of communicating with the prescriber regarding a patient whom I believe needs referred for Substance Use Disorder(SUD) treatment Prescribers Dispensers 60.00% 55.30% 40% 50.00% 35% 33% 34% 40.00% 30% 30.00% 22.60% 25% 23% 20.00% 21.50% 20% 15% 10.00% 0.00% I am more likely to refer for substance abuse I am more likely to do a Screening, Brief Intervention, and Referral to Treatment (SBIRT) screening I have not changed the way I refer patients 0.60% I am less likely to refer patients 10% 5% 0% Strongly Agree Somewhat Agree Neutral / No Opinion 5% 5% Somewhat Disagree Strongly Disagree 44% of prescribers are more likely to refer patients for substance use disorder treatment. 56% of dispensers are more likely to communicate with the prescriber regarding potential patient referral to substance use disorder treatment. Source: 2018 CSMD Prescriber and Dispenser Survey
19
20 The Opioid Crisis by the Numbers
21 Postsurgical prescriptions for opioid naïve patients and association with overdose and misuse: retrospective cohort study Rates of misuse by opioid use: 1,015,116 Opioid naïve patients had surgery 568,612 (50%) Received Opioids Misuse more than doubled within one refill 293 vs 145 in 100,000 person years Not related to dose Source: thebmj BMJ2018;360;j5790 doi /bmj.j5790
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24 Tennessee s Bordering States and Interstate Data Sharing Source: Netstate.com website:
25 Risk Proof Your Practice How many patients on greater than 120 MEDD? How many patients drive a far distance to practice site? How many patients are on combinations? Resources available in office Naloxone handouts Education on near misses Education on street drugs
26 Annual NAS Trends Source: Neonatal Abstinence Surveillance System. TN Dept. of Health
27
28 NAS Rate per 1,000 Live Births, 2017 Source: Neonatal Abstinence Surveillance System. TN Dept. of Health
29 Why do Prescribers and Dispensers Check the CSMD? Source: CSMD 2018 Legislative Report
30 Number of Prescriptions Reported to TN CSMD, * Number of Prescriptions Dispensed in TN and Reported to CSMD, * Number of Prescriptions 19,000,000 18,500,000 18,000,000 17,500,000 17,000,000 16,500,000 16,000,000 15,500,000 15,000,000 14,500,000 14,000, Year All Patients in the CSMD TN patients Excluding prescriptions reported from VA pharmacies.
31 Number of Prescriptions Dispensed Among TN Patients and Reported to the CSMD by the Class of Controlled Substances, * Number of Prescriptions Dispensed Among TN Patients and Reported to the CSMD by the Class of Controlled Substances, * Number fo Prescriptions 9,000,000 8,000,000 7,000,000 6,000,000 5,000,000 4,000,000 3,000,000 2,000,000 1,000,000 0 Class of Controlled Substance * 1) The class of controlled substances was defined based on a CDC document. If a drug was not on the document, the drug was grouped into the 'Other';
32 Number of Stimulant Prescriptions Dispensed Among TN Patients by Age Groups and Reported to the CSMD, * 500,000 Number of Stimulant Prescriptions Dispensed Among TN Patients by Age Group and Reported to the CSMD, * Number of Stimulant Prescriptions 450, , , , , , , ,000 50,000 0 < Age Group (Year) * Excluding stimulant prescriptions reported from VA pharmacies.
33 Number of Benzodiazepine Prescriptions Dispensed Among TN Patients by Age Groups and Reported to the CSMD, * Number of Benzodiazepine Prescriptions Dispensed Among TN Patients by Age Group and Reported to the CSMD, * 1,000,000 Number of Benzodiazpine Prescriptions 900, , , , , , , , ,000 0 < Age Group (Year) * Excluding the prescriptions reported from VA pharmacies.
34 MME of Opioids Reported to TN CSMD, *
35 Change in MME Dispensed Among TN Patients, *
36 MME for Long Acting Opioids Reported to the CSMD, * Amount of MME for Long Acting Drugs Dispensed in TN and Reported to the CSMD, * Year Overall patients in CSMD TN patients Change among TN patients (%) ,190,989,273 3,057,991, ,254,786,743 3,121,293, ,285,062,156 3,148,353, ,238,216,544 3,106,161, ,924,795,127 2,806,107, ,552,291,111 2,454,148, ,124,916,097 2,045,899, ,630,298,000 1,568,894, ,204,793,575 1,162,067, * 1) The classes of controlled substances were defined based on a CDC document; 2) Excluding prescriptions reported from VA pharmacies. 3) Excluding buprenorphine products.
37 MME for Short Acting Opioids Reported to the CSMD, * Amount of MME for Short Acting Drugs Dispensed in TN and Reported to the CSMD, * Year Overall patients in CSMD TN Patients Change among TN Patients (%) ,039,428,269 4,864,582, ,727,903,926 5,469,306, ,891,039,406 5,645,050, ,676,117,306 5,459,300, ,495,823,563 5,283,695, ,371,326,766 5,168,525, ,046,357,775 4,863,320, ,606,843,191 4,448,492, ,025,049,294 3,890,868, * 1) The classes of controlled substances were defined based on a CDC document; 2) Excluding prescriptions reported from VA pharmacies. 3) Excluding buprenorphine products.
38 Public Chapters Public Chapter 476 mandates the top 50 prescribers of controlled substances in the state be annually identified and sent a letter notifying them of their inclusion on this list and asked to respond with a justification for their prescribing patterns Public Chapter 476 adds the top 10 prescribers from all of the combined counties having populations of fewer than 50,000 this process Public Chapter 987 requires the identification of the top 20 prescribers who have unique DEA numbers of buprenorphine products in the previous calendar year, or if implemented more frequently for the relevant time period as determined by the department 38
39 MMEs Prescribed by Top 50 Prescribers and Dispensed in Source: CSMD 2018 Legislative Report
40 Prescription Drug Overdose Dashboard Scroll Down
41 Tennessee Drug Overdose Data Source:
42 Tennessee Drug Overdose Data Source: htps://
43 Age-adjusted drug overdose death rates, by state, United States, NOTES: Deaths are classified using the International Classification of Diseases, Tenth Revision. Drug-poisoning (overdose) deaths are identified using underlying cause-of-death codes X40 X44, X60 X64, X85, and Y10 Y14.. SOURCE: NCHS, National Vital Statistics System, Mortality.
44 Tennessee Overdose Deaths where patient did not have prescriptions in CSMD 60 days prior to death Source: TN Dept. of Health, Office of Informatics and Analytics
45 Opioids Present In Overdose Deaths, * Percentage of Overdose Death Opioid Fentanyl Heroin * Percentages for fentanyl and heroin are included in the opioid category and are broken out for clarity.
46 All Fentanyl Deaths by Age Distribution, Number of Deaths years years years years years years years years 85+ years
47 Scott County, Indiana Outbreak 220 U.S. counties had highest vulnerability 41 small counties located in TN 25 overlapped with more granular TN data CDC acquired HIV 2016 Source: Clinical Infectious Diseases, December 7, 2017
48 Consequences of Opioid Epidemic Tennessee in-state variability assessment for a Rapid Dissemination of HIV or HCV Infection Event utilizing data about the opioid epidemic. More granular data improved insights into county-level HIV/HCV outbreak vulnerability compared to national models. Source: Clinical Infectious Diseases, December 7, 2017
49 Risk Ranking Source: Clinical Infectious Disease, December 7, 2017
50 Public Chapter 1033 Pain Management Clinics transitions from certificate system to licensure system Medical director holds license Non-transferable Only a pain specialist is eligible to be medical director > 50% of patients being treated for pain qualifies as a pain clinic and must be registered No pharmacy Clinic can be suspended based on specific violation No new patients Monitored Went into effect on July 1, 2017
51 TN Pain Management Clinics per County, 1/29/2019 Tennessee Pain Clinics per County 124 Total Pain Clinics in Tennessee As of January, 2019 County # of clinics Knox 20 Davidson 17 Rutherford 10 Source Tennessee Department of Health
52 Public Chapter 430 Requires the development of the TN Chronic Pain Guidelines 1 st edition nd edition rd edition 2019 Annual review
53 Recommendations TN- CDC-
54 Tennessee Chronic Pain Guidelines vs. CDC Guidelines
55 Tennessee Chronic Pain Guidelines vs. CDC Guidelines
56 Tennessee Chronic Pain Guidelines vs. CDC Guidelines
57 Access to Documents 2018 CSMD Legislative Report TDH Pain Management Clinic Statutes, Rules, and Guidelines Buprenorphine Guidelines *Buprenorphine Treatment Guidelines are at the bottom of the homepage
58 Access to Documents Tennessee s In-State Vulnerability Assessment for a Rapid Dissemination of HIV or HCV Infection Event Utilizing Data about the Opioid Epidemic Tennessee Drug Overdose Dashboard Neonatal Abstinence Syndrome (NAS)
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Opioid Addiction and Prescribing Mitchell Mutter, MD Director of Special Projects Nashville, TN April 12, 2018 Disclosure Statement of Financial Interest I, Mitchell Mutter, DO NOT have a financial interest/arrangement
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