Fighting the Opioid Epidemic with Prevention vs. Treatment Introduction to Genetic Addiction RiskScore (GARS)
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1 Fighting the Opioid Epidemic with Prevention vs. Treatment Introduction to Genetic Addiction RiskScore (GARS) Justin Jones, CEO Geneus Health Marjorie C. Gondré-Lewis, Professor Howard University November 28, 2018
2 Disclaimer The information contained in this presentation is for informational and educational purposes only, and is not intended to provide medical advice. Nothing herein is intended to diagnose, treat, prevent or cure any illness or medical condition. Where appropriate, names have been changed to protect an individual s identity and privacy.
3 Agenda State of the Industry GARS overview Program Outcomes Opioid Management NIH GARS Review
4 IMPACT IN U.S. The Opioid Crisis has been declared a National Public Health Emergency by the current administration No area of the United States is exempt from this epidemic we all know a friend, family member, or loved one devastated by opioids, - CDC Principal Deputy Director Anne Schuchat The Council of Economic Advisers estimated the Opioid Epidemic costs the U.S. $500 Billion annually
5 DEVASTATING EFFECTS OF ADDICTION
6
7 Backed by over 30 years of research from Dr. Kenneth Blum, Geneus Health has created the: GARS Test Genetic Addiction Risk Score
8 REWARD DEFICIENCY SYNDROME GARS results are a tool designed to help identify potential genetic predisposition for addictive, impulsive and compulsive behaviors. This collection of harmful and challenging behaviors is encompassed by the term Reward Deficiency Syndrome (RDS) created by Dr. Blum
9 Over 110,000,000 people in the U.S. have a genetic variant that would put them at risk for Reward Deficiency Syndrome. 67% 33% 33% US Population Reward Deficiency
10 GARS GENETIC PANEL
11 GARS BEHAVIOR COVERAGE
12 GARS TEST
13 The GARS test is being in COLLABORATION with: Howard University Western University University of Buffalo National Human Genome Center National Institute of Health Received FIRST patent issued for a genetic test in U.S. Patent# US10,072,289 PEER REVIEWED and SUPPORTED by more than 550 clinical publications GARS test has been researched and VALIDATED both in the U.S. and Internationally
14 TREATMENT OPTIONS CONCURRENT Personalized addiction treatment PREVENTATIVE Risk stratification for more appropriate prescribing
15 Case Studies GARS Identifies Opioid Addiction Risk in Chronic Pain Patients NIH Trial
16 Case Study GARS used to Identify Risk for Chronic Opioid Use Disorder (OUD) among Patients attending a Pain Clinic. Pain Study Demographics Patients (N) Ethnic Group % 35 Caucasian 49%; Hispanic 31%; Unknown 20% Average Pre- Treatment Pain Score (10 most intense) X = 6 Average Morphine equivalent (MME) X =68mg/d range ( mg/day) Male %(n) 40 (14) Female 60 (21) Age X = 56 X = 60 Age Range X = 45mg/day Morphine X = 102 mg/ equivalent (MME) day Range MME mg/ day mg/day Trial conducted at *Consultants in Pain Medicine
17 Case Study Pain Patients (N=35) Chronic Opioids for at least 12 months
18 NIH Trial Drs. Marjorie C. Gondré-Lewis and Kenneth Blum are the recipients of NIH/R41MD012318, National Institute of Minority Health and Health Disparities. The aim of the grant is to use GARS to identify highly convergent candidate gene SNPS associated with Reward Deficiency Syndrome (RDS) in under-served populations with substance use disorder.
19 NIH Trial Cohort: African Americans attending Howard University Suboxone Program and a private DC drug treatment center. N = 100 RDS free controls N = 40 Neuronutrient therapy will be provided to the Experimental group for six months. Outcome will be measured using pre and post psychological and behavioral assessments and urine tox screens.
20 Subjects from NIH Grant Cohort Drug Risk Alcohol Risk Low Risk 0% Low Risk 30% High Risk 100% High Risk Low Risk High Risk 70% High Risk Low Risk
21 Panel Discussion Marjorie C. Gondré-Lewis, Ph.D. Professor and Interim Chair Department of Anatomy
22 Closing THANK YOU Questions? Justin Jones, CEO Geneus Health 5726 W. Hausman, suite 112 San Antonio, TX (210)
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