Identifying and evaluating patterns of prescription opioid use and associated risks in Ontario, Canada Gomes, T.
|
|
- Brook Carpenter
- 5 years ago
- Views:
Transcription
1 UvA-DARE (Digital Academic Repository) Identifying and evaluating patterns of prescription opioid use and associated risks in Ontario, Canada Gomes, T. Link to publication Citation for published version (APA): Gomes, T. (2017). Identifying and evaluating patterns of prescription opioid use and associated risks in Ontario, Canada. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam ( Download date: 15 Apr 2019
2 I-2 Chapter 2: Overall study methods 27
3 Overview This chapter summarizes key data sources and study methods used throughout the studies described in Parts II, III and IV of this thesis. This includes considerations related to the populations studied, databases used, and general methods implemented. Data Sources IMS BROGAN GEOGRAPHIC PRESCRIPTION MONITOR (IMS BROGAN) The analyses reported in Chapters 8 and 9 used the IMS Brogan Geographic Prescription Monitor database which provides aggregated estimates of both publicly and privately funded prescriptions for long-acting oxycodone dispensed in Canada over the relevant study periods. This database captures data from a representative sample of 5700 retail pharmacies across Canada, which is projected to estimate monthly dispensing estimates by geographic area at the levels of product formulation and strength. In these estimates several factors are taken into account, including the number of pharmacies in a given region, the distance between IMS-captured and uncaptured pharmacies, and the size of the pharmacies. IMS Brogan continuously monitors data received from retail pharmacies to ensure they meet standards set for quality control, and that the resulting product-level volume estimates are representative of all pharmacies in Canada. For Chapters 8 and 9, this database was used to determine the volume of long-acting oxycodone dispensed in regions close to the United States-Canada border. INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES (ICES) The Institute for Clinical Evaluative Sciences (ICES) is a not-for-profit research institute in Ontario, Canada that houses a large, linked repository of health databases that are accessible to the research community ( The remaining studies reported here leverage these administrative databases to conduct population-based observational studies among residents of Ontario. Two key databases that are used regularly in these analyses are: Ontario Drug Benefit (ODB) Database The Ontario Drug Benefit (ODB) database captures all prescription medications dispensed at retail pharmacies in Ontario and reimbursed by the Ontario Public Drug Programs (OPDP). The eligible population for OPDP includes people with low socio-economic status, receipt of disability support or home care services, high drug costs compared to income, residence in a long-term care facility, or age 65 years. This database captures detailed drug information, patient identifiers, quantity 28
4 dispensed and days supply for all such reimbursed prescriptions and is linked to other health databases housed at ICES. Therefore, these data were used to identify individuals in receipt of publicly-funded opioid prescriptions throughout our studies. I-2 Opioid-Related Death Database All deaths that are sudden and unexpected or unnatural are investigated by the Office of the Chief Coroner of Ontario (OCCO) to ascertain cause and manner of death. All charts for deaths that involved opioids (either alone or in combination with alcohol) between 1991 and 2013 were abstracted from the OCCO to capture key information relating to cause of death, results of post-mortem toxicology, manner of death, and patient demographics and identifiers. Opioid-related deaths were defined by the coroner as those deaths in which postmortem toxicologic analyses revealed opioid concentrations sufficiently high to cause death, or if a combination of drugs (including at least one opioid at clinically significant levels) contributed to death. Deaths were not defined as opioid-related if another drug was present on the toxicologic analysis at concentrations sufficient to cause death. This database has been regularly updated over the past 7 years with new data as it becomes available using consistent abstraction tools and methods, and has been linked to the data warehouse at ICES for research purposes. Study Population Because ICES only collects prescription data for Ontarians eligible for public drug benefits, studies relying on linked prescribing data (Chapters 5, 6, 7, 10, and 11) are limited to the OPDP population represented in the ODB database. As described above, this generally represents a group of individuals of lower socioeconomic status, those requiring disability support, and those aged 65 or older. In contrast, studies using IMS Brogan data (Chapters 8 and 9) and those using the Coroners Opioid-Related Death Database (Chapters 3, 4) do not have such restrictions and are representative of the general population. Converting Opioid Dose Several studies reported here rely on the conversion of oral and transdermal opioid doses into milligrams of morphine equivalents (MME). Approximate conversion ratios reported in the Canadian guidelines 1 were used in these calculations as described in Table 2.1 below. These conversion ratios are aligned with those reported in several other international sources. 2 29
5 Table 2.1: Morphine equivalents for oral opioid analgesics* Opioid Ratio (opioid to morphine) Morphine 1:1 Codeine 1:0.15 Oxycodone 1:1.5 Hydromorphone 1:5 Meperidine 1:0.1 Transdermal fentanyl 25 µg/h 1:97 50 µg/h 1: µg/h 1: µg/h 1:382 *Adapted from Canadian guideline for safe and effective use of opioids for chronic non-cancer pain 1 Disease Risk Score A disease risk score was used in the nested case-control studies reported in Chapters 5, 6, and 7 to minimize differences in patient characteristics between cases and controls. This index was derived using a multivariate regression model to generate predicted probabilities of becoming a case for all individuals in the nest, adjusting for a number of potential confounders, as outlined in Table 2.2 below. 3 Controls were then matched to cases on this risk score within ±0.2 standard deviations. 30
6 Table 2.2: Components of Disease Risk Score used to Match Cases to Controls on past comorbidities Variable ICD9 Diagnosis Code ICD10 Diagnosis Code OHIP Diagnosis Code I-2 Demographic Characteristics (measured on index date) Age Age on index date Sex Patient sex Estimated residential income quintile Residence in a long-term care facility Rurality of Principal Residence Neighbourhood Income Quintile based on location of residence on index date (1=lowest, 5=highest) Based on Long-Term Care flag on most recent Ontario Drug Benefit database prescription in past 1 year Rural community defined as community with 10,000 residents Medical disorders (measured by presence in 3 years prior to index date) Acute myocardial infarction 410 I21 410, 413 Alcohol abuse V113, 291, 303.0, 303.9, 305.0, 357.5, 425.5, 535.3, 571.0, 571.1, 571.3, 790.3, F10, G31.2, G62.1, G72.1, I42.6, I70.0, K29.2, K70.1, K70.4, K70.9, K86.0, R78.0, T51.0, X65, Y15, Y91, Z50.1, Z71.4, Z86.40 Atherosclerotic disease 414.0, 440 I251, I Chronic lung disease 490.0, 491, 492.0, 494.0, , 303 J40-J44, J47 491, 492, 494, 496 Dementia 290, 331.0, 331.1, 331.2, 797 Diabetes mellitus F00, F01, F02.0, F02.1, F03, F05.1, G30, G31.0, G31.1, R54 290, 331, 797 Defined as diagnosis date in Ontario Diabetes Database that precedes the index date Dyslipidemia , E78.0-E78.6, E78.9, E88.1, H Gastrointestinal hemorrhage 531.0, 531.2, 531.4, 531.6, 532.0, 532.2, 532.4, 532.6, 533.0, 533.2, 533.4, 533.6, 534.0, 534.2, 534.4, 534.6, 578.0, 578.1, K25.0, K25.2, K25.4, K25.6, K26.0, K26.2, K26.4, K26.6, K27.0, K27.2, K27.4, K27.6, K28.0, K28.2, K28.4, K28.6, K92.0, K92.1, K92.2 Glaucoma 365 H40, H Gout 274 M Heart failure 428 I
7 Hypothyroidism 244.1, 244.3, 244.8, E01.8, E02, E03.2, E03.3, E03.5, E03.8, E03.9, E89.0 Injury other than poisoning 8XX, S* T00-T Osteoarthritis 715 M15.0-M15.2, M15.4, M16-M19, M89.41-M89.43, M89.45-M89.46, M89.48 Other coronary heart disease 411.0, 412.0, 413.0, 414.0, 414.8, I20, I24.0, I24.8, I24.9, I25.1, I25.2, I25.5, I25.6, I25.8, I25.9 Parkinson s disease G20, G21.1, G21.2, 332 G21.3, G21.8, G21.9, G22 Pneumonia J10-J Poisoning or drug toxicity T36-T Rheumatoid arthritis , M05, M06, M08.0, 714 M08.2-M08.4, M08.8, M08.9, M09, M12.0 Seizure disorder 780.3, 345 R56.0, R56.8, G40, 345 G41 Sepsis 038 A40, A41 Stroke I60, I61, I62, I63, I64, G45 Urinary incontinence N39.3, N39.4, R32 Psychiatric disorders (measured by presence in 3 years prior to index date) Affective disorder 296 F30, F31, F32.2, F32.3, F32.8, F33, F34.8, F34.9, F38, F Anxiety or sleep disorders 300 F32.0, F34.1, F40-F42, F44, F45.0-F45.2, F48, F68.0, F
8 Psychoses, agitation, and related disorders 292, 293.0, 293.8, 294, 295, 297.1, 297.3, 297.8, 297.9, 299 All other mental disorders 301, , , 304.9, , 305.9, 306.4, 306.5, 306.8, 306.9, 307, 308.3, 308.9, 309.0, 309.2, 309.8, 310.1, 310.2, 310.8, 310.9, 311.0, , 312.8, 312.9, 313.0, 313.2, 313.3, 313.8, 313.9, 314.0, 314.2, 314.8, 314.9, 315, Other Variables Suicide attempt in 3 years prior to index date Number of visits to a physician in the past 1 year prior to index date Care by a psychiatrist in 1 year prior to index date Days in hospital during 1 year prior to index date X60-X84 F02.2-F02.4, F02.8, F04, F05.0, F05.8, F05.9, F06.0-F06.6, F06.8, F06.9, F09, F11.0, F11.3-F11.9 F12.0, F12.3-F12.9 F13.0, F13.3-F13.9 F14.0, F14.3-F14.9 F15.0, F15.3-F15.9 F16.0, F16.3-F16.9 F17.0, F17.3-F17.9 F18.0, F18.3-F18.9 F19.0, F19.3-F19.9 F20-F22, F23.2, F24, F25, F53.1, F84 F06.7, F07, F11.1, F11.2 F12.1, F12.2 F13.1, F13.2 F14.1, F14.2 F15.1, F15.2 F16.1, F16.2 F17.1, F17.2 F18.1, F18.2 F19.1, F19.2 F32.9, F43, F45.3, F45.4, F45.8, F45.9, F50, F51, F52, F53.0, F54-F59, F60-F66, F68.1, F68.8, F69, F80-F83, F88-F95, F98, G , , 302, 304, 305, Count only one Ontario Health Insurance Plan claim per person per physician per day. Main Specialty in ICES Physician Database = PSYCHIATRY Sum of total length of stay of all hospitalizations discharged in prior year I-2 33
9 References 1. National Opioid Use Guideline Group. Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain. 2010; mcmaster.ca/opioid/. Accessed November 27, Nielsen S, Degenhardt L, Hoban B, Gisev N. A synthesis of oral morphine equivalents (OME) for opioid utilisation studies. Pharmacoepidemiology and drug safety. 2016;25(6): Arbogast PG, Ray WA. Use of disease risk scores in pharmacoepidemiologic studies. Stat Methods Med Res. 2009;18(1):
Supplementary Online Content
Supplementary Online Content Gomes T, Redelmeier DA, Juurlink DN, et al. Opiod dose and risk of road trauma in Canada: a populationbased study. JAMA Intern Med. Published online January 14, 2013. doi:10.1001/2013.jamainternmed.733.
More informationUvA-DARE (Digital Academic Repository) Improving aspects of palliative care for children Jagt, C.T. Link to publication
UvA-DARE (Digital Academic Repository) Improving aspects of palliative care for children Jagt, C.T. Link to publication Citation for published version (APA): Jagt, C. T. (2017). Improving aspects of palliative
More informationUvA-DARE (Digital Academic Repository) Vascular factors in dementia and apathy Eurelings, Lisa. Link to publication
UvA-DARE (Digital Academic Repository) Vascular factors in dementia and apathy Eurelings, Lisa Link to publication Citation for published version (APA): Eurelings, L. S. M. (2016). Vascular factors in
More informationGezinskenmerken: De constructie van de Vragenlijst Gezinskenmerken (VGK) Klijn, W.J.L.
UvA-DARE (Digital Academic Repository) Gezinskenmerken: De constructie van de Vragenlijst Gezinskenmerken (VGK) Klijn, W.J.L. Link to publication Citation for published version (APA): Klijn, W. J. L. (2013).
More informationUvA-DARE (Digital Academic Repository) An electronic nose in respiratory disease Dragonieri, S. Link to publication
UvA-DARE (Digital Academic Repository) An electronic nose in respiratory disease Dragonieri, S. Link to publication Citation for published version (APA): Dragonieri, S. (2012). An electronic nose in respiratory
More informationAnxiety disorders in children with autism spectrum disorders: A clinical and health care economic perspective van Steensel, F.J.A.
UvA-DARE (Digital Academic Repository) Anxiety disorders in children with autism spectrum disorders: A clinical and health care economic perspective van Steensel, F.J.A. Link to publication Citation for
More informationPrediction of toxicity in concurrent chemoradiation for non-small cell lung cancer Uijterlinde, W.I.
UvA-DARE (Digital Academic Repository) Prediction of toxicity in concurrent chemoradiation for non-small cell lung cancer Uijterlinde, W.I. Link to publication Citation for published version (APA): Uijterlinde,
More informationClinimetrics, clinical profile and prognosis in early Parkinson s disease Post, B.
UvA-DARE (Digital Academic Repository) Clinimetrics, clinical profile and prognosis in early Parkinson s disease Post, B. Link to publication Citation for published version (APA): Post, B. (2009). Clinimetrics,
More informationCitation for published version (APA): van Munster, B. C. (2009). Pathophysiological studies in delirium : a focus on genetics.
UvA-DARE (Digital Academic Repository) Pathophysiological studies in delirium : a focus on genetics van Munster, B.C. Link to publication Citation for published version (APA): van Munster, B. C. (2009).
More informationCharacterizing scaphoid nonunion deformity using 2-D and 3-D imaging techniques ten Berg, P.W.L.
UvA-DARE (Digital Academic Repository) Characterizing scaphoid nonunion deformity using 2-D and 3-D imaging techniques ten Berg, P.W.L. Link to publication Citation for published version (APA): ten Berg,
More informationIdentifying and evaluating patterns of prescription opioid use and associated risks in Ontario, Canada Gomes, T.
UvA-DARE (Digital Academic Repository) Identifying and evaluating patterns of prescription opioid use and associated risks in Ontario, Canada Gomes, T. Link to publication Citation for published version
More informationTobacco control policies and socio-economic inequalities in smoking cessation Bosdriesz, J.R.
UvA-DARE (Digital Academic Repository) Tobacco control policies and socio-economic inequalities in smoking cessation Bosdriesz, J.R. Link to publication Citation for published version (APA): Bosdriesz,
More informationAMORE (Ablative surgery, MOulage technique brachytherapy and REconstruction) for childhood head and neck rhabdomyosarcoma Buwalda, J.
UvA-DARE (Digital Academic Repository) AMORE (Ablative surgery, MOulage technique brachytherapy and REconstruction) for childhood head and neck rhabdomyosarcoma Buwalda, J. Link to publication Citation
More informationUvA-DARE (Digital Academic Repository) The artificial pancreas Kropff, J. Link to publication
UvA-DARE (Digital Academic Repository) The artificial pancreas Kropff, J. Link to publication Citation for published version (APA): Kropff, J. (2017). The artificial pancreas: From logic to life General
More informationStudies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R.
UvA-DARE (Digital Academic Repository) Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R. Link to publication Citation for published version
More informationUvA-DARE (Digital Academic Repository) Marfan syndrome: Getting to the root of the problem Franken, Romy. Link to publication
UvA-DARE (Digital Academic Repository) Marfan syndrome: Getting to the root of the problem Franken, Romy Link to publication Citation for published version (APA): Franken, R. (2016). Marfan syndrome: Getting
More informationCitation for published version (APA): Sivapalaratnam, S. (2012). The molecular basis of early onset cardiovascular disease
UvA-DARE (Digital Academic Repository) The molecular basis of early onset cardiovascular disease Sivapalaratnam, S. Link to publication Citation for published version (APA): Sivapalaratnam, S. (2012).
More informationUvA-DARE (Digital Academic Repository) The systemic right ventricle van der Bom, T. Link to publication
UvA-DARE (Digital Academic Repository) The systemic right ventricle van der Bom, T. Link to publication Citation for published version (APA): van der Bom, T. (2014). The systemic right ventricle. General
More informationBuilding blocks for return to work after sick leave due to depression de Vries, Gabe
UvA-DARE (Digital Academic Repository) Building blocks for return to work after sick leave due to depression de Vries, Gabe Link to publication Citation for published version (APA): de Vries, G. (2016).
More informationCitation for published version (APA): van de Vijver, S. J. M. (2015). Cardiovascular disease prevention in the slums of Kenya
UvA-DARE (Digital Academic Repository) Cardiovascular disease prevention in the slums of Kenya van de Vijver, Steven Link to publication Citation for published version (APA): van de Vijver, S. J. M. (2015).
More informationCitation for published version (APA): Bartels, S. A. L. (2013). Laparoscopic colorectal surgery: beyond the short-term effects
UvA-DARE (Digital Academic Repository) Laparoscopic colorectal surgery: beyond the short-term effects Bartels, S.A.L. Link to publication Citation for published version (APA): Bartels, S. A. L. (2013).
More informationDiagnostic research in perspective: examples of retrieval, synthesis and analysis Bachmann, L.M.
UvA-DARE (Digital Academic Repository) Diagnostic research in perspective: examples of retrieval, synthesis and analysis Bachmann, L.M. Link to publication Citation for published version (APA): Bachmann,
More informationUvA-DARE (Digital Academic Repository) Functional defecation disorders in children Kuizenga-Wessel, S. Link to publication
UvA-DARE (Digital Academic Repository) Functional defecation disorders in children Kuizenga-Wessel, S. Link to publication Citation for published version (APA): Kuizenga-Wessel, S. (2017). Functional defecation
More informationPharmaceutical Misuse and its Challenges: Opioid Use in Ontario. Ontario Harm Reduction Conference Tara Gomes Tuesday January 31, 2012
Pharmaceutical Misuse and its Challenges: Opioid Use in Ontario Ontario Harm Reduction Conference Tara Gomes Tuesday January 31, 2012 Objectives To review the prescription opioid crisis To understand the
More informationCitation for published version (APA): Oderkerk, A. E. (1999). De preliminaire fase van het rechtsvergelijkend onderzoek Nijmegen: Ars Aequi Libri
UvA-DARE (Digital Academic Repository) De preliminaire fase van het rechtsvergelijkend onderzoek Oderkerk, A.E. Link to publication Citation for published version (APA): Oderkerk, A. E. (1999). De preliminaire
More informationUvA-DARE (Digital Academic Repository) Genetic basis of hypertrophic cardiomyopathy Bos, J.M. Link to publication
UvA-DARE (Digital Academic Repository) Genetic basis of hypertrophic cardiomyopathy Bos, J.M. Link to publication Citation for published version (APA): Bos, J. M. (2010). Genetic basis of hypertrophic
More informationAdvances in Abdominal Aortic Aneurysm Care - Towards personalized, centralized and endovascular care van Beek, S.C.
UvA-DARE (Digital Academic Repository) Advances in Abdominal Aortic Aneurysm Care - Towards personalized, centralized and endovascular care van Beek, S.C. Link to publication Citation for published version
More informationUse of the comprehensive geriatric assessment to improve patient-centred care in complex patient populations Parlevliet, J.L.
UvA-DARE (Digital Academic Repository) Use of the comprehensive geriatric assessment to improve patient-centred care in complex patient populations Parlevliet, J.L. Link to publication Citation for published
More informationCitation for published version (APA): Parigger, E. M. (2012). Language and executive functioning in children with ADHD Den Bosch: Boxpress
UvA-DARE (Digital Academic Repository) Language and executive functioning in children with ADHD Parigger, E.M. Link to publication Citation for published version (APA): Parigger, E. M. (2012). Language
More informationUvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) Standaarden voor kerndoelen basisonderwijs : de ontwikkeling van standaarden voor kerndoelen basisonderwijs op basis van resultaten uit peilingsonderzoek van der
More informationUvA-DARE (Digital Academic Repository) Anorectal malformations and hirschsprung disease Witvliet, M.J. Link to publication
UvA-DARE (Digital Academic Repository) Anorectal malformations and hirschsprung disease Witvliet, M.J. Link to publication Citation for published version (APA): Witvliet, M. J. (2017). Anorectal malformations
More informationUvA-DARE (Digital Academic Repository) Toothbrushing efficacy Rosema, N.A.M. Link to publication
UvA-DARE (Digital Academic Repository) Toothbrushing efficacy Rosema, N.A.M. Link to publication Citation for published version (APA): Rosema, N. A. M. (2015). Toothbrushing efficacy. General rights It
More informationThyroid disease and haemostasis: a relationship with clinical implications? Squizzato, A.
UvA-DARE (Digital Academic Repository) Thyroid disease and haemostasis: a relationship with clinical implications? Squizzato, A. Link to publication Citation for published version (APA): Squizzato, A.
More informationCitation for published version (APA): Owusu, E. D. A. (2018). Malaria, HIV and sickle cell disease in Ghana: Towards tailor-made interventions
UvA-DARE (Digital Academic Repository) Malaria, HIV and sickle cell disease in Ghana Owusu, E.D.A. Link to publication Citation for published version (APA): Owusu, E. D. A. (2018). Malaria, HIV and sickle
More informationOperational research on implementation of tuberculosis guidelines in Mozambique Brouwer, Miranda
UvA-DARE (Digital Academic Repository) Operational research on implementation of tuberculosis guidelines in Mozambique Brouwer, Miranda Link to publication Citation for published version (APA): Brouwer,
More informationFecal Microbiota Transplantation: Clinical and experimental studies van Nood, E.
UvA-DARE (Digital Academic Repository) Fecal Microbiota Transplantation: Clinical and experimental studies van Nood, E. Link to publication Citation for published version (APA): van Nood, E. (2015). Fecal
More informationUvA-DARE (Digital Academic Repository) Falling: should one blame the heart? Jansen, Sofie. Link to publication
UvA-DARE (Digital Academic Repository) Falling: should one blame the heart? Jansen, Sofie Link to publication Citation for published version (APA): Jansen, S. (2015). Falling: should one blame the heart?
More informationDual-therapy stent technology for patients with coronary artery disease Kalkman, D.N.
UvA-DARE (Digital Academic Repository) Dual-therapy stent technology for patients with coronary artery disease Kalkman, D.N. Link to publication Citation for published version (APA): Kalkman, D. N. (2018).
More informationUvA-DARE (Digital Academic Repository) Malaria during pregnancy in Rwanda Rulisa, S. Link to publication
UvA-DARE (Digital Academic Repository) Malaria during pregnancy in Rwanda Rulisa, S. Link to publication Citation for published version (APA): Rulisa, S. (2014). Malaria during pregnancy in Rwanda General
More informationCitation for published version (APA): Braakhekke, M. W. M. (2017). Randomized controlled trials in reproductive medicine: Disclosing the caveats
UvA-DARE (Digital Academic Repository) Randomized controlled trials in reproductive medicine Braakhekke, M.W.M. Link to publication Citation for published version (APA): Braakhekke, M. W. M. (2017). Randomized
More informationCitation for published version (APA): van der Paardt, M. P. (2015). Advances in MRI for colorectal cancer and bowel motility
UvA-DARE (Digital Academic Repository) Advances in MRI for colorectal cancer and bowel motility van der Paardt, M.P. Link to publication Citation for published version (APA): van der Paardt, M. P. (2015).
More informationEnzyme replacement therapy in Fabry disease, towards individualized treatment Arends, M.
UvA-DARE (Digital Academic Repository) Enzyme replacement therapy in Fabry disease, towards individualized treatment Arends, M. Link to publication Citation for published version (APA): Arends, M. (2017).
More informationUvA-DARE (Digital Academic Repository) What tumor cells cannot resist Ebbing, E.A. Link to publication
UvA-DARE (Digital Academic Repository) What tumor cells cannot resist Ebbing, E.A. Link to publication Citation for published version (APA): Ebbing, E. A. (2018). What tumor cells cannot resist: Mechanisms
More informationUvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) Clinical studies and tissue analyses in the earliest phases of rheumatoid arthritis: In search of the transition from being at risk to having clinically apparent
More informationCitation for published version (APA): Tjon-Kon-Fat, R. I. (2017). Unexplained subfertility: Illuminating the path to treatment.
UvA-DARE (Digital Academic Repository) Unexplained subfertility Tjon-Kon-Fat, R.I. Link to publication Citation for published version (APA): Tjon-Kon-Fat, R. I. (2017). Unexplained subfertility: Illuminating
More informationUvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort Bartha, I.; Assel, M.; Sloot, P.M.A.;
More informationUvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) Brain training improves recovery after stroke but waiting list improves equally: A multicenter randomized controlled trial of a computer-based cognitive flexibility
More informationUvA-DARE (Digital Academic Repository) Intraarterial treatment for acute ischemic stroke Berkhemer, O.A. Link to publication
UvA-DARE (Digital Academic Repository) Intraarterial treatment for acute ischemic stroke Berkhemer, O.A. Link to publication Citation for published version (APA): Berkhemer, O. A. (2016). Intraarterial
More informationThe role of media entertainment in children s and adolescents ADHD-related behaviors: A reason for concern? Nikkelen, S.W.C.
UvA-DARE (Digital Academic Repository) The role of media entertainment in children s and adolescents ADHD-related behaviors: A reason for concern? Nikkelen, S.W.C. Link to publication Citation for published
More informationDissecting Lyme borreliosis; Clinical aspects, pathogenesis and prevention Coumou, J.
UvA-DARE (Digital Academic Repository) Dissecting Lyme borreliosis; Clinical aspects, pathogenesis and prevention Coumou, J. Link to publication Citation for published version (APA): Coumou, J. (2016).
More informationAntimicrobial drug resistance at the human-animal interface in Vietnam Nguyen, V.T.
UvA-DARE (Digital Academic Repository) Antimicrobial drug resistance at the human-animal interface in Vietnam Nguyen, V.T. Link to publication Citation for published version (APA): Nguyen, V. T. (2017).
More informationMoving the brain: Neuroimaging motivational changes of deep brain stimulation in obsessive-compulsive disorder Figee, M.
UvA-DARE (Digital Academic Repository) Moving the brain: Neuroimaging motivational changes of deep brain stimulation in obsessive-compulsive disorder Figee, M. Link to publication Citation for published
More informationCitation for published version (APA): Wijkerslooth de Weerdesteyn, T. R. (2013). Population screening for colorectal cancer by colonoscopy
UvA-DARE (Digital Academic Repository) Population screening for colorectal cancer by colonoscopy de Wijkerslooth, T.R. Link to publication Citation for published version (APA): Wijkerslooth de Weerdesteyn,
More informationCitation for published version (APA): Luijendijk, P. (2014). Aortic coarctation: late complications and treatment strategies.
UvA-DARE (Digital Academic Repository) Aortic coarctation: late complications and treatment strategies Luijendijk, P. Link to publication Citation for published version (APA): Luijendijk, P. (2014). Aortic
More informationUvA-DARE (Digital Academic Repository) Mucorales between food and infection Dolat Abadi, S. Link to publication
UvA-DARE (Digital Academic Repository) Mucorales between food and infection Dolat Abadi, S. Link to publication Citation for published version (APA): Dolatabadi, S. (2015). Mucorales between food and infection
More informationUvA-DARE (Digital Academic Repository) Genetic variation in Helicobacter pylori Pan, Z. Link to publication
UvA-DARE (Digital Academic Repository) Genetic variation in Helicobacter pylori Pan, Z. Link to publication Citation for published version (APA): Pan, Z. (1999). Genetic variation in Helicobacter pylori
More informationCitation for published version (APA): Donker, M. (2014). Improvements in locoregional treatment of breast cancer
UvA-DARE (Digital Academic Repository) Improvements in locoregional treatment of breast cancer Donker, Mila Link to publication Citation for published version (APA): Donker, M. (2014). Improvements in
More informationUvA-DARE (Digital Academic Repository) Treatment of osteochondral defects of the talus van Bergen, C.J.A. Link to publication
UvA-DARE (Digital Academic Repository) Treatment of osteochondral defects of the talus van Bergen, C.J.A. Link to publication Citation for published version (APA): van Bergen, C. J. A. (2014). Treatment
More informationCitation for published version (APA): Kruizinga, R. (2017). Out of the blue: Experiences of contingency in advanced cancer patients
UvA-DARE (Digital Academic Repository) Out of the blue Kruizinga, R. Link to publication Citation for published version (APA): Kruizinga, R. (2017). Out of the blue: Experiences of contingency in advanced
More informationCitation for published version (APA): Diederen, K. (2018). Pediatric inflammatory bowel disease: Monitoring, nutrition and surgery.
UvA-DARE (Digital Academic Repository) Pediatric inflammatory bowel disease Diederen, K. Link to publication Citation for published version (APA): Diederen, K. (2018). Pediatric inflammatory bowel disease:
More informationIron and vitamin D deficiency in children living in Western-Europe Akkermans, M.D.
UvA-DARE (Digital Academic Repository) Iron and vitamin D deficiency in children living in Western-Europe Akkermans, M.D. Link to publication Citation for published version (APA): Akkermans, M. D. (2017).
More informationCitation for published version (APA): Zeddies, S. (2015). Novel regulators of megakaryopoiesis: The road less traveled by
UvA-DARE (Digital Academic Repository) Novel regulators of megakaryopoiesis: The road less traveled by Zeddies, S. Link to publication Citation for published version (APA): Zeddies, S. (2015). Novel regulators
More informationFunctional abdominal pain disorders in children: therapeutic strategies focusing on hypnotherapy Rutten, J.M.T.M.
UvA-DARE (Digital Academic Repository) Functional abdominal pain disorders in children: therapeutic strategies focusing on hypnotherapy Rutten, J.M.T.M. Link to publication Citation for published version
More informationCitation for published version (APA): Von Eije, K. J. (2009). RNAi based gene therapy for HIV-1, from bench to bedside
UvA-DARE (Digital Academic Repository) RNAi based gene therapy for HIV-1, from bench to bedside Von Eije, K.J. Link to publication Citation for published version (APA): Von Eije, K. J. (2009). RNAi based
More informationUvA-DARE (Digital Academic Repository) Obesity, ectopic lipids, and insulin resistance ter Horst, K.W. Link to publication
UvA-DARE (Digital Academic Repository) Obesity, ectopic lipids, and insulin resistance ter Horst, K.W. Link to publication Citation for published version (APA): ter Horst, K. W. (2017). Obesity, ectopic
More informationGeographic variations in prescription opioid dispensations and deaths among women and men in British Columbia, Canada
Geographic variations in prescription opioid dispensations and deaths among women and men in British Columbia, Canada Emilie J. Gladstone, Kate Smolina, Deirdre Weymann, Kimberly Rutherford, and Steven
More informationBacterial meningitis in adults: Host and pathogen factors, treatment and outcome Heckenberg, S.G.B.
UvA-DARE (Digital Academic Repository) Bacterial meningitis in adults: Host and pathogen factors, treatment and outcome Heckenberg, S.G.B. Link to publication Citation for published version (APA): Heckenberg,
More informationSignificance of radiologically determined prognostic factors for head and neck cancer Lodder, W.L.
UvA-DARE (Digital Academic Repository) Significance of radiologically determined prognostic factors for head and neck cancer Lodder, W.L. Link to publication Citation for published version (APA): Lodder,
More informationTumor control and normal tissue toxicity: The two faces of radiotherapy van Oorschot, B.
UvA-DARE (Digital Academic Repository) Tumor control and normal tissue toxicity: The two faces of radiotherapy van Oorschot, B. Link to publication Citation for published version (APA): van Oorschot, B.
More informationBreaking the chain of transmission: Immunisation and outbreak investigation Whelan, Jane
UvA-DARE (Digital Academic Repository) Breaking the chain of transmission: Immunisation and outbreak investigation Whelan, Jane Link to publication Citation for published version (APA): Whelan, E. J. (2013).
More informationFurther insights into inheritable arrhythmia syndromes: Focus on electrocardiograms Postema, P.G.
UvA-DARE (Digital Academic Repository) Further insights into inheritable arrhythmia syndromes: Focus on electrocardiograms Postema, P.G. Link to publication Citation for published version (APA): Postema,
More informationCitation for published version (APA): de Groof, E. J. (2017). Surgery and medical therapy in Crohn s disease: Improving treatment strategies
UvA-DARE (Digital Academic Repository) Surgery and medical therapy in Crohn s disease de Groof, E.J. Link to publication Citation for published version (APA): de Groof, E. J. (2017). Surgery and medical
More informationLactase, sucrase-isomaltase, and carbamoyl phosphate synthase I expression in human intestine van Beers, E.H.
UvA-DARE (Digital Academic Repository) Lactase, sucrase-isomaltase, and carbamoyl phosphate synthase I expression in human intestine van Beers, E.H. Link to publication Citation for published version (APA):
More informationMolecular and mechanical functions of the intermediate filament protein GFAP Stassen, O.M.J.A.
UvA-DARE (Digital Academic Repository) Molecular and mechanical functions of the intermediate filament protein GFAP Stassen, O.M.J.A. Link to publication Citation for published version (APA): Stassen,
More informationFamilial hypercholesterolemia in childhood: diagnostics, therapeutical options and risk stratification Rodenburg, J.
UvADARE (Digital Academic Repository) Familial hypercholesterolemia in childhood: diagnostics, therapeutical options and risk stratification Rodenburg, J. Link to publication Citation for published version
More informationComprehensive Research Plan: Inhaled corticosteroids + long-acting beta agonists (ICS+LABA) for the treatment of asthma
Comprehensive Research Plan: Inhaled corticosteroids + long-acting beta agonists (ICS+LABA) for the treatment of asthma Pharmacoepidemiology Unit July 10, 2014 30 Bond Street, Toronto ON, M5B 1W8 www.odprn.ca
More informationUvA-DARE (Digital Academic Repository) Bronchial Thermoplasty in severe asthma d'hooghe, J.N.S. Link to publication
UvA-DARE (Digital Academic Repository) Bronchial Thermoplasty in severe asthma d'hooghe, J.N.S. Link to publication Citation for published version (APA): d'hooghe, J. N. S. (2018). Bronchial Thermoplasty
More informationCitation for published version (APA): Azaripour, A. (2016). Structure and function of the human periodontium: Science meets the clinician
UvA-DARE (Digital Academic Repository) Structure and function of the human periodontium Azaripour, A. Link to publication Citation for published version (APA): Azaripour, A. (2016). Structure and function
More informationCitation for published version (APA): Timmermans, A. (2009). Postmenopausal bleeding : studies on the diagnostic work-up
UvA-DARE (Digital Academic Repository) Postmenopausal bleeding : studies on the diagnostic work-up Timmermans, A. Link to publication Citation for published version (APA): Timmermans, A. (2009). Postmenopausal
More informationCitation for published version (APA): Lammers-van der Holst, H. M. (2016). Individual differences in shift work tolerance
UvA-DARE (Digital Academic Repository) Individual differences in shift work tolerance Lammers-van der Holst, H.M. Link to publication Citation for published version (APA): Lammers-van der Holst, H. M.
More informationCitation for published version (APA): van der Put, C. E. (2011). Risk and needs assessment for juvenile delinquents
UvA-DARE (Digital Academic Repository) Risk and needs assessment for juvenile delinquents van der Put, C.E. Link to publication Citation for published version (APA): van der Put, C. E. (2011). Risk and
More informationeappendix A. Opioids and Nonsteroidal Anti-Inflammatory Drugs
eappendix A. Opioids and Nonsteroidal Anti-Inflammatory Drugs Nonsteroidal Anti-Inflammatory Drugs Nonselective nonsteroidal anti-inflammatory drugs Diclofenac, etodolac, flurbiprofen, ketorolac, ibuprofen,
More informationKawasaki disease: Studies on etiology, treatment and long-term follow-up Tacke, C.E.A.
UvA-DARE (Digital Academic Repository) Kawasaki disease: Studies on etiology, treatment and long-term follow-up Tacke, C.E.A. Link to publication Citation for published version (APA): Tacke, C. E. A. (2014).
More informationCitation for published version (APA): Benzian, H. (2014). The neglect of global oral health: symptoms and solutions
UvA-DARE (Digital Academic Repository) The neglect of global oral health: symptoms and solutions Benzian, H. Link to publication Citation for published version (APA): Benzian, H. (2014). The neglect of
More informationCitation for published version (APA): van Es, N. (2017). Cancer and thrombosis: Improvements in strategies for prediction, diagnosis, and treatment
UvA-DARE (Digital Academic Repository) Cancer and thrombosis van Es, N. Link to publication Citation for published version (APA): van Es, N. (2017). Cancer and thrombosis: Improvements in strategies for
More informationFinding the balance between overtreatment and undertreatment of ductal carcinoma in situ Elshof, L.E.
UvA-DARE (Digital Academic Repository) Finding the balance between overtreatment and undertreatment of ductal carcinoma in situ Elshof, L.E. Link to publication Citation for published version (APA): Elshof,
More informationLife and death with HIV/AIDS: life stories from Karawang, West Java Hidayana, I.M.
UvA-DARE (Digital Academic Repository) Life and death with HIV/AIDS: life stories from Karawang, West Java Hidayana, I.M. Link to publication Citation for published version (APA): Hidayana, I. M. (2012).
More informationUvA-DARE (Digital Academic Repository) Marfan syndrome: Getting to the root of the problem Franken, Romy. Link to publication
UvA-DARE (Digital Academic Repository) Marfan syndrome: Getting to the root of the problem Franken, Romy Link to publication Citation for published version (APA): Franken, R. (2016). Marfan syndrome: Getting
More informationMina Tadrous, Diana Martins, Zhan Yao, Kimberly Fernandes, Samantha Singh, Nikita Arora, David Juurlink, Muhammad Mamdani and Tara Gomes
Cognitive Enhancers Pharmacoepidemiology Report: FINAL CENSORED Report Mina Tadrous, Diana Martins, Zhan Yao, Kimberly Fernandes, Samantha Singh, Nikita Arora, David Juurlink, Muhammad Mamdani and Tara
More informationUvA-DARE (Digital Academic Repository) Hip and groin pain in athletes Tak, I.J.R. Link to publication
UvA-DARE (Digital Academic Repository) Hip and groin pain in athletes Tak, I.J.R. Link to publication Citation for published version (APA): Tak, I. J. R. (2017). Hip and groin pain in athletes: Morphology,
More informationNotice from the Executive Officer: Promoting Compliance with the Existing Limited Use Criteria for Fentanyl Transdermal Patch
Notice from the Executive Officer: Promoting Compliance with the Existing Limited Use Criteria for Fentanyl Transdermal Patch Frequently Asked Questions 1. What is the new Health Network System feature
More informationUvA-DARE (Digital Academic Repository) Workplace coaching: Processes and effects Theeboom, T. Link to publication
UvA-DARE (Digital Academic Repository) Workplace coaching: Processes and effects Theeboom, T. Link to publication Citation for published version (APA): Theeboom, T. (2016). Workplace coaching: Processes
More informationUvA-DARE (Digital Academic Repository) On the innovative genius of Andreas Vesalius Brinkman, R.J.C. Link to publication
UvA-DARE (Digital Academic Repository) On the innovative genius of Andreas Vesalius Brinkman, R.J.C. Link to publication Citation for published version (APA): Brinkman, R. J. C. (2017). On the innovative
More informationUvA-DARE (Digital Academic Repository) Tick-host-pathogen interactions in Lyme borreliosis Hovius, J.W.R. Link to publication
UvA-DARE (Digital Academic Repository) Tick-host-pathogen interactions in Lyme borreliosis Hovius, J.W.R. Link to publication Citation for published version (APA): Hovius, J. W. R. (2009). Tick-host-pathogen
More informationElectronic patient and parent reported outcomes in pediatric clinical practice Haverman, L.
UvA-DARE (Digital Academic Repository) Electronic patient and parent reported outcomes in pediatric clinical practice Haverman, L. Link to publication Citation for published version (APA): Haverman, L.
More informationInflammation in chronic obstructive pulmonary disease : its assessment and the effects of corticosteroids Boorsma, M.
UvA-DARE (Digital Academic Repository) Inflammation in chronic obstructive pulmonary disease : its assessment and the effects of corticosteroids Boorsma, M. Link to publication Citation for published version
More informationEsthetic and bonding enhancements of tooth colored indirect restorations El-Zohairy, A.A.
UvA-DARE (Digital Academic Repository) Esthetic and bonding enhancements of tooth colored indirect restorations El-Zohairy, A.A. Link to publication Citation for published version (APA): El-Zohairy, A.
More informationNarcotics Monitoring System (NMS) Update
Narcotics Monitoring System (NMS) Update DISCLOSURE OF COMMERCIAL SUPPORT This program has received no financial or in-kind support. Potential for conflict(s) of interest: None Faculty/Presenter Disclosure
More informationUvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository) A classification model for the Leiden proteomics competition Hoefsloot, H.C.J.; Berkenbos-Smit, S.; Smilde, A.K. Published in: Statistical Applications in Genetics
More informationUvA-DARE (Digital Academic Repository) Bronchial Thermoplasty in severe asthma d'hooghe, J.N.S. Link to publication
UvA-DARE (Digital Academic Repository) Bronchial Thermoplasty in severe asthma d'hooghe, J.N.S. Link to publication Citation for published version (APA): d'hooghe, J. N. S. (2018). Bronchial Thermoplasty
More information